Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail

Autores
Chemes, Hector Edgardo; Alvarez Sedó, Cristian
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This article presents an update on the variable prognostic significance of different sperm pathologies in patients with severe male factor infertility due to morphology and motility disorders. Severe asthenozoospermia is one of the leading causes of male infertility as spermatozoa cannot reach the oocyte and/or penetrate normally. Identifying structural causes of sperm immotility was of great concern before the advent of intracytoplasmic sperm injection (ICSI), because immotility was the limiting factor in the treatment of these patients. In these cases, in vitro methods are used to identify live spermatozoa or stimulate sperm motility to avoid selection of non-viable cells. With these advances, fertilization and pregnancy results have improved dramatically. The identification of genetic phenotypes in asthenozoospermia is important to adequately inform patients of treatment outcomes and risks. The one sperm characteristic that seriously affects fertility prognosis is teratozoospermia, primarily sperm head and neck anomalies. Defects of chromatin condensation and acrosomal hypoplasia are the two most common abnormalities in severe teratozoospermia. The introduction of microscopic methods to select spermatozoa and the development of new ones to evaluate sperm quality before ICSI will assure that ultrastructural identification of sperm pathologies will not only be of academic interest, but will also be an essential tool to inform treatment choice. Herein, we review the differential roles played by sperm components in normal fertilization and early embryo development and explore how assisted reproductive technologies have modified our concepts on the prognostic significance of sperm pathologies affecting the head, neck, mid-piece and tail.
Fil: Chemes, Hector Edgardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Alvarez Sedó, Cristian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina. Centro de Estudios en Ginecología y Reproducción; Argentina
Materia
ACROSOMAL HYPOPLASIA
CHROMATIN ANOMALIES
FERTILITY PROGNOSIS
INTRACYTOPLASMIC INJECTION OF MORPHOLOGICALLY SELECTED SPERMATOZOA
INTRACYTOPLASMIC SPERM INJECTION
SPERM NECK DEFECTS
SPERM PATHOLOGIES
TAIL ABNORMALITIES
TERATOZOOSPERMIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67842
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/67842
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tailChemes, Hector EdgardoAlvarez Sedó, CristianACROSOMAL HYPOPLASIACHROMATIN ANOMALIESFERTILITY PROGNOSISINTRACYTOPLASMIC INJECTION OF MORPHOLOGICALLY SELECTED SPERMATOZOAINTRACYTOPLASMIC SPERM INJECTIONSPERM NECK DEFECTSSPERM PATHOLOGIESTAIL ABNORMALITIESTERATOZOOSPERMIAhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3This article presents an update on the variable prognostic significance of different sperm pathologies in patients with severe male factor infertility due to morphology and motility disorders. Severe asthenozoospermia is one of the leading causes of male infertility as spermatozoa cannot reach the oocyte and/or penetrate normally. Identifying structural causes of sperm immotility was of great concern before the advent of intracytoplasmic sperm injection (ICSI), because immotility was the limiting factor in the treatment of these patients. In these cases, in vitro methods are used to identify live spermatozoa or stimulate sperm motility to avoid selection of non-viable cells. With these advances, fertilization and pregnancy results have improved dramatically. The identification of genetic phenotypes in asthenozoospermia is important to adequately inform patients of treatment outcomes and risks. The one sperm characteristic that seriously affects fertility prognosis is teratozoospermia, primarily sperm head and neck anomalies. Defects of chromatin condensation and acrosomal hypoplasia are the two most common abnormalities in severe teratozoospermia. The introduction of microscopic methods to select spermatozoa and the development of new ones to evaluate sperm quality before ICSI will assure that ultrastructural identification of sperm pathologies will not only be of academic interest, but will also be an essential tool to inform treatment choice. Herein, we review the differential roles played by sperm components in normal fertilization and early embryo development and explore how assisted reproductive technologies have modified our concepts on the prognostic significance of sperm pathologies affecting the head, neck, mid-piece and tail.Fil: Chemes, Hector Edgardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Alvarez Sedó, Cristian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina. Centro de Estudios en Ginecología y Reproducción; ArgentinaShanghai Institute of Materia Medica2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67842Chemes, Hector Edgardo; Alvarez Sedó, Cristian; Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail; Shanghai Institute of Materia Medica; Asian Journal of Andrology; 14; 1; 1-2012; 14-231008-682X1745-7262CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/aja.2011.168info:eu-repo/semantics/altIdentifier/url/http://www.asiaandro.com/Abstract.asp?doi=10.1038/aja.2011.168info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:15:30Zoai:ri.conicet.gov.ar:11336/67842instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:15:30.927CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail
title Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail
spellingShingle Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail
Chemes, Hector Edgardo
ACROSOMAL HYPOPLASIA
CHROMATIN ANOMALIES
FERTILITY PROGNOSIS
INTRACYTOPLASMIC INJECTION OF MORPHOLOGICALLY SELECTED SPERMATOZOA
INTRACYTOPLASMIC SPERM INJECTION
SPERM NECK DEFECTS
SPERM PATHOLOGIES
TAIL ABNORMALITIES
TERATOZOOSPERMIA
title_short Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail
title_full Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail
title_fullStr Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail
title_full_unstemmed Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail
title_sort Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail
dc.creator.none.fl_str_mv Chemes, Hector Edgardo
Alvarez Sedó, Cristian
author Chemes, Hector Edgardo
author_facet Chemes, Hector Edgardo
Alvarez Sedó, Cristian
author_role author
author2 Alvarez Sedó, Cristian
author2_role author
dc.subject.none.fl_str_mv ACROSOMAL HYPOPLASIA
CHROMATIN ANOMALIES
FERTILITY PROGNOSIS
INTRACYTOPLASMIC INJECTION OF MORPHOLOGICALLY SELECTED SPERMATOZOA
INTRACYTOPLASMIC SPERM INJECTION
SPERM NECK DEFECTS
SPERM PATHOLOGIES
TAIL ABNORMALITIES
TERATOZOOSPERMIA
topic ACROSOMAL HYPOPLASIA
CHROMATIN ANOMALIES
FERTILITY PROGNOSIS
INTRACYTOPLASMIC INJECTION OF MORPHOLOGICALLY SELECTED SPERMATOZOA
INTRACYTOPLASMIC SPERM INJECTION
SPERM NECK DEFECTS
SPERM PATHOLOGIES
TAIL ABNORMALITIES
TERATOZOOSPERMIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This article presents an update on the variable prognostic significance of different sperm pathologies in patients with severe male factor infertility due to morphology and motility disorders. Severe asthenozoospermia is one of the leading causes of male infertility as spermatozoa cannot reach the oocyte and/or penetrate normally. Identifying structural causes of sperm immotility was of great concern before the advent of intracytoplasmic sperm injection (ICSI), because immotility was the limiting factor in the treatment of these patients. In these cases, in vitro methods are used to identify live spermatozoa or stimulate sperm motility to avoid selection of non-viable cells. With these advances, fertilization and pregnancy results have improved dramatically. The identification of genetic phenotypes in asthenozoospermia is important to adequately inform patients of treatment outcomes and risks. The one sperm characteristic that seriously affects fertility prognosis is teratozoospermia, primarily sperm head and neck anomalies. Defects of chromatin condensation and acrosomal hypoplasia are the two most common abnormalities in severe teratozoospermia. The introduction of microscopic methods to select spermatozoa and the development of new ones to evaluate sperm quality before ICSI will assure that ultrastructural identification of sperm pathologies will not only be of academic interest, but will also be an essential tool to inform treatment choice. Herein, we review the differential roles played by sperm components in normal fertilization and early embryo development and explore how assisted reproductive technologies have modified our concepts on the prognostic significance of sperm pathologies affecting the head, neck, mid-piece and tail.
Fil: Chemes, Hector Edgardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Alvarez Sedó, Cristian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina. Centro de Estudios en Ginecología y Reproducción; Argentina
description This article presents an update on the variable prognostic significance of different sperm pathologies in patients with severe male factor infertility due to morphology and motility disorders. Severe asthenozoospermia is one of the leading causes of male infertility as spermatozoa cannot reach the oocyte and/or penetrate normally. Identifying structural causes of sperm immotility was of great concern before the advent of intracytoplasmic sperm injection (ICSI), because immotility was the limiting factor in the treatment of these patients. In these cases, in vitro methods are used to identify live spermatozoa or stimulate sperm motility to avoid selection of non-viable cells. With these advances, fertilization and pregnancy results have improved dramatically. The identification of genetic phenotypes in asthenozoospermia is important to adequately inform patients of treatment outcomes and risks. The one sperm characteristic that seriously affects fertility prognosis is teratozoospermia, primarily sperm head and neck anomalies. Defects of chromatin condensation and acrosomal hypoplasia are the two most common abnormalities in severe teratozoospermia. The introduction of microscopic methods to select spermatozoa and the development of new ones to evaluate sperm quality before ICSI will assure that ultrastructural identification of sperm pathologies will not only be of academic interest, but will also be an essential tool to inform treatment choice. Herein, we review the differential roles played by sperm components in normal fertilization and early embryo development and explore how assisted reproductive technologies have modified our concepts on the prognostic significance of sperm pathologies affecting the head, neck, mid-piece and tail.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67842
Chemes, Hector Edgardo; Alvarez Sedó, Cristian; Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail; Shanghai Institute of Materia Medica; Asian Journal of Andrology; 14; 1; 1-2012; 14-23
1008-682X
1745-7262
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67842
identifier_str_mv Chemes, Hector Edgardo; Alvarez Sedó, Cristian; Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail; Shanghai Institute of Materia Medica; Asian Journal of Andrology; 14; 1; 1-2012; 14-23
1008-682X
1745-7262
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/aja.2011.168
info:eu-repo/semantics/altIdentifier/url/http://www.asiaandro.com/Abstract.asp?doi=10.1038/aja.2011.168
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Shanghai Institute of Materia Medica
publisher.none.fl_str_mv Shanghai Institute of Materia Medica
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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