Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail
- Autores
- Chemes, Hector Edgardo; Alvarez Sedó, Cristian
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This article presents an update on the variable prognostic significance of different sperm pathologies in patients with severe male factor infertility due to morphology and motility disorders. Severe asthenozoospermia is one of the leading causes of male infertility as spermatozoa cannot reach the oocyte and/or penetrate normally. Identifying structural causes of sperm immotility was of great concern before the advent of intracytoplasmic sperm injection (ICSI), because immotility was the limiting factor in the treatment of these patients. In these cases, in vitro methods are used to identify live spermatozoa or stimulate sperm motility to avoid selection of non-viable cells. With these advances, fertilization and pregnancy results have improved dramatically. The identification of genetic phenotypes in asthenozoospermia is important to adequately inform patients of treatment outcomes and risks. The one sperm characteristic that seriously affects fertility prognosis is teratozoospermia, primarily sperm head and neck anomalies. Defects of chromatin condensation and acrosomal hypoplasia are the two most common abnormalities in severe teratozoospermia. The introduction of microscopic methods to select spermatozoa and the development of new ones to evaluate sperm quality before ICSI will assure that ultrastructural identification of sperm pathologies will not only be of academic interest, but will also be an essential tool to inform treatment choice. Herein, we review the differential roles played by sperm components in normal fertilization and early embryo development and explore how assisted reproductive technologies have modified our concepts on the prognostic significance of sperm pathologies affecting the head, neck, mid-piece and tail.
Fil: Chemes, Hector Edgardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Alvarez Sedó, Cristian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina. Centro de Estudios en Ginecología y Reproducción; Argentina - Materia
-
ACROSOMAL HYPOPLASIA
CHROMATIN ANOMALIES
FERTILITY PROGNOSIS
INTRACYTOPLASMIC INJECTION OF MORPHOLOGICALLY SELECTED SPERMATOZOA
INTRACYTOPLASMIC SPERM INJECTION
SPERM NECK DEFECTS
SPERM PATHOLOGIES
TAIL ABNORMALITIES
TERATOZOOSPERMIA - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/67842
Ver los metadatos del registro completo
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Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tailChemes, Hector EdgardoAlvarez Sedó, CristianACROSOMAL HYPOPLASIACHROMATIN ANOMALIESFERTILITY PROGNOSISINTRACYTOPLASMIC INJECTION OF MORPHOLOGICALLY SELECTED SPERMATOZOAINTRACYTOPLASMIC SPERM INJECTIONSPERM NECK DEFECTSSPERM PATHOLOGIESTAIL ABNORMALITIESTERATOZOOSPERMIAhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3This article presents an update on the variable prognostic significance of different sperm pathologies in patients with severe male factor infertility due to morphology and motility disorders. Severe asthenozoospermia is one of the leading causes of male infertility as spermatozoa cannot reach the oocyte and/or penetrate normally. Identifying structural causes of sperm immotility was of great concern before the advent of intracytoplasmic sperm injection (ICSI), because immotility was the limiting factor in the treatment of these patients. In these cases, in vitro methods are used to identify live spermatozoa or stimulate sperm motility to avoid selection of non-viable cells. With these advances, fertilization and pregnancy results have improved dramatically. The identification of genetic phenotypes in asthenozoospermia is important to adequately inform patients of treatment outcomes and risks. The one sperm characteristic that seriously affects fertility prognosis is teratozoospermia, primarily sperm head and neck anomalies. Defects of chromatin condensation and acrosomal hypoplasia are the two most common abnormalities in severe teratozoospermia. The introduction of microscopic methods to select spermatozoa and the development of new ones to evaluate sperm quality before ICSI will assure that ultrastructural identification of sperm pathologies will not only be of academic interest, but will also be an essential tool to inform treatment choice. Herein, we review the differential roles played by sperm components in normal fertilization and early embryo development and explore how assisted reproductive technologies have modified our concepts on the prognostic significance of sperm pathologies affecting the head, neck, mid-piece and tail.Fil: Chemes, Hector Edgardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Alvarez Sedó, Cristian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina. Centro de Estudios en Ginecología y Reproducción; ArgentinaShanghai Institute of Materia Medica2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67842Chemes, Hector Edgardo; Alvarez Sedó, Cristian; Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail; Shanghai Institute of Materia Medica; Asian Journal of Andrology; 14; 1; 1-2012; 14-231008-682X1745-7262CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/aja.2011.168info:eu-repo/semantics/altIdentifier/url/http://www.asiaandro.com/Abstract.asp?doi=10.1038/aja.2011.168info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:42:49Zoai:ri.conicet.gov.ar:11336/67842instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:42:49.785CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail |
title |
Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail |
spellingShingle |
Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail Chemes, Hector Edgardo ACROSOMAL HYPOPLASIA CHROMATIN ANOMALIES FERTILITY PROGNOSIS INTRACYTOPLASMIC INJECTION OF MORPHOLOGICALLY SELECTED SPERMATOZOA INTRACYTOPLASMIC SPERM INJECTION SPERM NECK DEFECTS SPERM PATHOLOGIES TAIL ABNORMALITIES TERATOZOOSPERMIA |
title_short |
Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail |
title_full |
Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail |
title_fullStr |
Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail |
title_full_unstemmed |
Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail |
title_sort |
Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail |
dc.creator.none.fl_str_mv |
Chemes, Hector Edgardo Alvarez Sedó, Cristian |
author |
Chemes, Hector Edgardo |
author_facet |
Chemes, Hector Edgardo Alvarez Sedó, Cristian |
author_role |
author |
author2 |
Alvarez Sedó, Cristian |
author2_role |
author |
dc.subject.none.fl_str_mv |
ACROSOMAL HYPOPLASIA CHROMATIN ANOMALIES FERTILITY PROGNOSIS INTRACYTOPLASMIC INJECTION OF MORPHOLOGICALLY SELECTED SPERMATOZOA INTRACYTOPLASMIC SPERM INJECTION SPERM NECK DEFECTS SPERM PATHOLOGIES TAIL ABNORMALITIES TERATOZOOSPERMIA |
topic |
ACROSOMAL HYPOPLASIA CHROMATIN ANOMALIES FERTILITY PROGNOSIS INTRACYTOPLASMIC INJECTION OF MORPHOLOGICALLY SELECTED SPERMATOZOA INTRACYTOPLASMIC SPERM INJECTION SPERM NECK DEFECTS SPERM PATHOLOGIES TAIL ABNORMALITIES TERATOZOOSPERMIA |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
This article presents an update on the variable prognostic significance of different sperm pathologies in patients with severe male factor infertility due to morphology and motility disorders. Severe asthenozoospermia is one of the leading causes of male infertility as spermatozoa cannot reach the oocyte and/or penetrate normally. Identifying structural causes of sperm immotility was of great concern before the advent of intracytoplasmic sperm injection (ICSI), because immotility was the limiting factor in the treatment of these patients. In these cases, in vitro methods are used to identify live spermatozoa or stimulate sperm motility to avoid selection of non-viable cells. With these advances, fertilization and pregnancy results have improved dramatically. The identification of genetic phenotypes in asthenozoospermia is important to adequately inform patients of treatment outcomes and risks. The one sperm characteristic that seriously affects fertility prognosis is teratozoospermia, primarily sperm head and neck anomalies. Defects of chromatin condensation and acrosomal hypoplasia are the two most common abnormalities in severe teratozoospermia. The introduction of microscopic methods to select spermatozoa and the development of new ones to evaluate sperm quality before ICSI will assure that ultrastructural identification of sperm pathologies will not only be of academic interest, but will also be an essential tool to inform treatment choice. Herein, we review the differential roles played by sperm components in normal fertilization and early embryo development and explore how assisted reproductive technologies have modified our concepts on the prognostic significance of sperm pathologies affecting the head, neck, mid-piece and tail. Fil: Chemes, Hector Edgardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina Fil: Alvarez Sedó, Cristian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina. Centro de Estudios en Ginecología y Reproducción; Argentina |
description |
This article presents an update on the variable prognostic significance of different sperm pathologies in patients with severe male factor infertility due to morphology and motility disorders. Severe asthenozoospermia is one of the leading causes of male infertility as spermatozoa cannot reach the oocyte and/or penetrate normally. Identifying structural causes of sperm immotility was of great concern before the advent of intracytoplasmic sperm injection (ICSI), because immotility was the limiting factor in the treatment of these patients. In these cases, in vitro methods are used to identify live spermatozoa or stimulate sperm motility to avoid selection of non-viable cells. With these advances, fertilization and pregnancy results have improved dramatically. The identification of genetic phenotypes in asthenozoospermia is important to adequately inform patients of treatment outcomes and risks. The one sperm characteristic that seriously affects fertility prognosis is teratozoospermia, primarily sperm head and neck anomalies. Defects of chromatin condensation and acrosomal hypoplasia are the two most common abnormalities in severe teratozoospermia. The introduction of microscopic methods to select spermatozoa and the development of new ones to evaluate sperm quality before ICSI will assure that ultrastructural identification of sperm pathologies will not only be of academic interest, but will also be an essential tool to inform treatment choice. Herein, we review the differential roles played by sperm components in normal fertilization and early embryo development and explore how assisted reproductive technologies have modified our concepts on the prognostic significance of sperm pathologies affecting the head, neck, mid-piece and tail. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/67842 Chemes, Hector Edgardo; Alvarez Sedó, Cristian; Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail; Shanghai Institute of Materia Medica; Asian Journal of Andrology; 14; 1; 1-2012; 14-23 1008-682X 1745-7262 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/67842 |
identifier_str_mv |
Chemes, Hector Edgardo; Alvarez Sedó, Cristian; Tales of the Tail and Sperm Head Aches : Changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail; Shanghai Institute of Materia Medica; Asian Journal of Andrology; 14; 1; 1-2012; 14-23 1008-682X 1745-7262 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1038/aja.2011.168 info:eu-repo/semantics/altIdentifier/url/http://www.asiaandro.com/Abstract.asp?doi=10.1038/aja.2011.168 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Shanghai Institute of Materia Medica |
publisher.none.fl_str_mv |
Shanghai Institute of Materia Medica |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614461776723968 |
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13.070432 |