A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation

Autores: Adhikari, Kaustubh; Fuentes Guajardo, Macarena; Quinto Sanchez, Mirsha Emmanuel; Mendoza Revilla, Javier; Chacon Duque, Juan Camilo; Acuña Alonzo, Víctor; Jaramillo, Claudia; Arias, William; Barquera Lozano, Rodrigo; Macín Pérez, Gastón; Gómez Valdés, Jorge; Villamil Ramírez, Hugo; Hunemeier, Tábita; Ramallo, Virginia; Silva de Cerqueira, Caio Cesar; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Gallo, Carla; Poletti, Giovanni; Schuler Faccini, Lavinia; Salzano, Francisco M.; Bortolini, Maria Catira; Canizales Quinteros, Samuel; Cheeseman, Michael; Rosique, Javier; Bedoya Berrío, Gabriel; Rothhammer, Francisco; Headon, Denis; González José, Rolando; Balding, David; Ruiz Linares, Andrés
Año de publicación: 2016
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: We report a genome-wide association scan for facial features in â 1/46,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values<5 × 10 â '8) at single-nucleotide polymorphisms (SNPs) in four genomic regions for three nose-related traits: columella inclination (4q31), nose bridge breadth (6p21) and nose wing breadth (7p13 and 20p11). In a subsample of â 1/43,000 individuals we obtained quantitative traits related to 9 of the ordinal phenotypes and, also, a measure of nasion position. Quantitative analyses confirmed the ordinal-based associations, identified SNPs in 2q12 associated to chin protrusion, and replicated the reported association of nasion position with SNPs in PAX3. Strongest association in 2q12, 4q31, 6p21 and 7p13 was observed for SNPs in the EDAR, DCHS2, RUNX2 and GLI3 genes, respectively. Associated SNPs in 20p11 extend to PAX1. Consistent with the effect of EDAR on chin protrusion, we documented alterations of mandible length in mice with modified Edar funtion.
Fil: Adhikari, Kaustubh. University College London; Estados Unidos
Fil: Fuentes Guajardo, Macarena. University College London; Estados Unidos. Universidad de Tarapacá; Chile
Fil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
Fil: Mendoza Revilla, Javier. University College London; Estados Unidos. Universidad Peruana Cayetano Heredia; Perú
Fil: Chacon Duque, Juan Camilo. University College London; Estados Unidos
Fil: Acuña Alonzo, Víctor. University College London; Estados Unidos. Escuela Nacional de Antropología e Historia; México
Fil: Jaramillo, Claudia. Universidad de Antioquia; Colombia
Fil: Arias, William. Universidad de Antioquia; Colombia
Fil: Barquera Lozano, Rodrigo. Escuela Nacional de Antropología e Historia; México. Universidad Nacional Autónoma de México; México
Fil: Macín Pérez, Gastón. Escuela Nacional de Antropología e Historia; México. Universidad Nacional Autónoma de México; México
Fil: Gómez Valdés, Jorge. Universidad Nacional Autónoma de México; México
Fil: Villamil Ramírez, Hugo. Universidad Nacional Autónoma de México; México
Fil: Hunemeier, Tábita. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Silva de Cerqueira, Caio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Hurtado, Malena. Universidad Peruana Cayetano Heredia; Perú
Fil: Villegas, Valeria. Universidad Peruana Cayetano Heredia; Perú
Fil: Granja, Vanessa. Universidad Peruana Cayetano Heredia; Perú
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; Perú
Fil: Schuler Faccini, Lavinia. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Salzano, Francisco M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México
Fil: Cheeseman, Michael. University of Edinburgh; Reino Unido
Fil: Rosique, Javier. Universidad de Antioquia; Colombia
Fil: Bedoya Berrío, Gabriel. Universidad de Antioquia; Colombia
Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile
Fil: Headon, Denis. University of Edinburgh; Reino Unido
Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
Fil: Balding, David. University College London; Estados Unidos. University of Melbourne; Australia
Fil: Ruiz Linares, Andrés. University College London; Estados Unidos
Materia: genome-wide association studies
Population genetics
morphogenesis
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/39487

Acceder

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network_name_str	CONICET Digital (CONICET)
spelling	A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variationAdhikari, KaustubhFuentes Guajardo, MacarenaQuinto Sanchez, Mirsha EmmanuelMendoza Revilla, JavierChacon Duque, Juan CamiloAcuña Alonzo, VíctorJaramillo, ClaudiaArias, WilliamBarquera Lozano, RodrigoMacín Pérez, GastónGómez Valdés, JorgeVillamil Ramírez, HugoHunemeier, TábitaRamallo, VirginiaSilva de Cerqueira, Caio CesarHurtado, MalenaVillegas, ValeriaGranja, VanessaGallo, CarlaPoletti, GiovanniSchuler Faccini, LaviniaSalzano, Francisco M.Bortolini, Maria CatiraCanizales Quinteros, SamuelCheeseman, MichaelRosique, JavierBedoya Berrío, GabrielRothhammer, FranciscoHeadon, DenisGonzález José, RolandoBalding, DavidRuiz Linares, Andrésgenome-wide association studiesPopulation geneticsmorphogenesishttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We report a genome-wide association scan for facial features in â 1/46,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values<5 × 10 â '8) at single-nucleotide polymorphisms (SNPs) in four genomic regions for three nose-related traits: columella inclination (4q31), nose bridge breadth (6p21) and nose wing breadth (7p13 and 20p11). In a subsample of â 1/43,000 individuals we obtained quantitative traits related to 9 of the ordinal phenotypes and, also, a measure of nasion position. Quantitative analyses confirmed the ordinal-based associations, identified SNPs in 2q12 associated to chin protrusion, and replicated the reported association of nasion position with SNPs in PAX3. Strongest association in 2q12, 4q31, 6p21 and 7p13 was observed for SNPs in the EDAR, DCHS2, RUNX2 and GLI3 genes, respectively. Associated SNPs in 20p11 extend to PAX1. Consistent with the effect of EDAR on chin protrusion, we documented alterations of mandible length in mice with modified Edar funtion.Fil: Adhikari, Kaustubh. University College London; Estados UnidosFil: Fuentes Guajardo, Macarena. University College London; Estados Unidos. Universidad de Tarapacá; ChileFil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaFil: Mendoza Revilla, Javier. University College London; Estados Unidos. Universidad Peruana Cayetano Heredia; PerúFil: Chacon Duque, Juan Camilo. University College London; Estados UnidosFil: Acuña Alonzo, Víctor. University College London; Estados Unidos. Escuela Nacional de Antropología e Historia; MéxicoFil: Jaramillo, Claudia. Universidad de Antioquia; ColombiaFil: Arias, William. Universidad de Antioquia; ColombiaFil: Barquera Lozano, Rodrigo. Escuela Nacional de Antropología e Historia; México. Universidad Nacional Autónoma de México; MéxicoFil: Macín Pérez, Gastón. Escuela Nacional de Antropología e Historia; México. Universidad Nacional Autónoma de México; MéxicoFil: Gómez Valdés, Jorge. Universidad Nacional Autónoma de México; MéxicoFil: Villamil Ramírez, Hugo. Universidad Nacional Autónoma de México; MéxicoFil: Hunemeier, Tábita. Universidade Federal do Rio Grande do Sul; BrasilFil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina. Universidade Federal do Rio Grande do Sul; BrasilFil: Silva de Cerqueira, Caio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina. Universidade Federal do Rio Grande do Sul; BrasilFil: Hurtado, Malena. Universidad Peruana Cayetano Heredia; PerúFil: Villegas, Valeria. Universidad Peruana Cayetano Heredia; PerúFil: Granja, Vanessa. Universidad Peruana Cayetano Heredia; PerúFil: Gallo, Carla. Universidad Peruana Cayetano Heredia; PerúFil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; PerúFil: Schuler Faccini, Lavinia. Universidade Federal do Rio Grande do Sul; BrasilFil: Salzano, Francisco M.. Universidade Federal do Rio Grande do Sul; BrasilFil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; BrasilFil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; MéxicoFil: Cheeseman, Michael. University of Edinburgh; Reino UnidoFil: Rosique, Javier. Universidad de Antioquia; ColombiaFil: Bedoya Berrío, Gabriel. Universidad de Antioquia; ColombiaFil: Rothhammer, Francisco. Universidad de Tarapacá; ChileFil: Headon, Denis. University of Edinburgh; Reino UnidoFil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaFil: Balding, David. University College London; Estados Unidos. University of Melbourne; AustraliaFil: Ruiz Linares, Andrés. University College London; Estados UnidosNature2016-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39487Adhikari, Kaustubh; Fuentes Guajardo, Macarena; Quinto Sanchez, Mirsha Emmanuel; Mendoza Revilla, Javier; Chacon Duque, Juan Camilo; et al.; A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation; Nature; Nature Communications; 7; 5-2016; 1-11; 116162041-1723CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/ncomms11616info:eu-repo/semantics/altIdentifier/doi/10.1038/ncomms11616info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:35:47Zoai:ri.conicet.gov.ar:11336/39487instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:35:47.43CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
title	A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
spellingShingle	A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation Adhikari, Kaustubh genome-wide association studies Population genetics morphogenesis
title_short	A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
title_full	A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
title_fullStr	A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
title_full_unstemmed	A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
title_sort	A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
dc.creator.none.fl_str_mv	Adhikari, Kaustubh Fuentes Guajardo, Macarena Quinto Sanchez, Mirsha Emmanuel Mendoza Revilla, Javier Chacon Duque, Juan Camilo Acuña Alonzo, Víctor Jaramillo, Claudia Arias, William Barquera Lozano, Rodrigo Macín Pérez, Gastón Gómez Valdés, Jorge Villamil Ramírez, Hugo Hunemeier, Tábita Ramallo, Virginia Silva de Cerqueira, Caio Cesar Hurtado, Malena Villegas, Valeria Granja, Vanessa Gallo, Carla Poletti, Giovanni Schuler Faccini, Lavinia Salzano, Francisco M. Bortolini, Maria Catira Canizales Quinteros, Samuel Cheeseman, Michael Rosique, Javier Bedoya Berrío, Gabriel Rothhammer, Francisco Headon, Denis González José, Rolando Balding, David Ruiz Linares, Andrés
author	Adhikari, Kaustubh
author_facet	Adhikari, Kaustubh Fuentes Guajardo, Macarena Quinto Sanchez, Mirsha Emmanuel Mendoza Revilla, Javier Chacon Duque, Juan Camilo Acuña Alonzo, Víctor Jaramillo, Claudia Arias, William Barquera Lozano, Rodrigo Macín Pérez, Gastón Gómez Valdés, Jorge Villamil Ramírez, Hugo Hunemeier, Tábita Ramallo, Virginia Silva de Cerqueira, Caio Cesar Hurtado, Malena Villegas, Valeria Granja, Vanessa Gallo, Carla Poletti, Giovanni Schuler Faccini, Lavinia Salzano, Francisco M. Bortolini, Maria Catira Canizales Quinteros, Samuel Cheeseman, Michael Rosique, Javier Bedoya Berrío, Gabriel Rothhammer, Francisco Headon, Denis González José, Rolando Balding, David Ruiz Linares, Andrés
author_role	author
author2	Fuentes Guajardo, Macarena Quinto Sanchez, Mirsha Emmanuel Mendoza Revilla, Javier Chacon Duque, Juan Camilo Acuña Alonzo, Víctor Jaramillo, Claudia Arias, William Barquera Lozano, Rodrigo Macín Pérez, Gastón Gómez Valdés, Jorge Villamil Ramírez, Hugo Hunemeier, Tábita Ramallo, Virginia Silva de Cerqueira, Caio Cesar Hurtado, Malena Villegas, Valeria Granja, Vanessa Gallo, Carla Poletti, Giovanni Schuler Faccini, Lavinia Salzano, Francisco M. Bortolini, Maria Catira Canizales Quinteros, Samuel Cheeseman, Michael Rosique, Javier Bedoya Berrío, Gabriel Rothhammer, Francisco Headon, Denis González José, Rolando Balding, David Ruiz Linares, Andrés
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	genome-wide association studies Population genetics morphogenesis
topic	genome-wide association studies Population genetics morphogenesis
purl_subject.fl_str_mv	https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv	We report a genome-wide association scan for facial features in â 1/46,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values<5 × 10 â '8) at single-nucleotide polymorphisms (SNPs) in four genomic regions for three nose-related traits: columella inclination (4q31), nose bridge breadth (6p21) and nose wing breadth (7p13 and 20p11). In a subsample of â 1/43,000 individuals we obtained quantitative traits related to 9 of the ordinal phenotypes and, also, a measure of nasion position. Quantitative analyses confirmed the ordinal-based associations, identified SNPs in 2q12 associated to chin protrusion, and replicated the reported association of nasion position with SNPs in PAX3. Strongest association in 2q12, 4q31, 6p21 and 7p13 was observed for SNPs in the EDAR, DCHS2, RUNX2 and GLI3 genes, respectively. Associated SNPs in 20p11 extend to PAX1. Consistent with the effect of EDAR on chin protrusion, we documented alterations of mandible length in mice with modified Edar funtion. Fil: Adhikari, Kaustubh. University College London; Estados Unidos Fil: Fuentes Guajardo, Macarena. University College London; Estados Unidos. Universidad de Tarapacá; Chile Fil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina Fil: Mendoza Revilla, Javier. University College London; Estados Unidos. Universidad Peruana Cayetano Heredia; Perú Fil: Chacon Duque, Juan Camilo. University College London; Estados Unidos Fil: Acuña Alonzo, Víctor. University College London; Estados Unidos. Escuela Nacional de Antropología e Historia; México Fil: Jaramillo, Claudia. Universidad de Antioquia; Colombia Fil: Arias, William. Universidad de Antioquia; Colombia Fil: Barquera Lozano, Rodrigo. Escuela Nacional de Antropología e Historia; México. Universidad Nacional Autónoma de México; México Fil: Macín Pérez, Gastón. Escuela Nacional de Antropología e Historia; México. Universidad Nacional Autónoma de México; México Fil: Gómez Valdés, Jorge. Universidad Nacional Autónoma de México; México Fil: Villamil Ramírez, Hugo. Universidad Nacional Autónoma de México; México Fil: Hunemeier, Tábita. Universidade Federal do Rio Grande do Sul; Brasil Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina. Universidade Federal do Rio Grande do Sul; Brasil Fil: Silva de Cerqueira, Caio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina. Universidade Federal do Rio Grande do Sul; Brasil Fil: Hurtado, Malena. Universidad Peruana Cayetano Heredia; Perú Fil: Villegas, Valeria. Universidad Peruana Cayetano Heredia; Perú Fil: Granja, Vanessa. Universidad Peruana Cayetano Heredia; Perú Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú Fil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; Perú Fil: Schuler Faccini, Lavinia. Universidade Federal do Rio Grande do Sul; Brasil Fil: Salzano, Francisco M.. Universidade Federal do Rio Grande do Sul; Brasil Fil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México Fil: Cheeseman, Michael. University of Edinburgh; Reino Unido Fil: Rosique, Javier. Universidad de Antioquia; Colombia Fil: Bedoya Berrío, Gabriel. Universidad de Antioquia; Colombia Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile Fil: Headon, Denis. University of Edinburgh; Reino Unido Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina Fil: Balding, David. University College London; Estados Unidos. University of Melbourne; Australia Fil: Ruiz Linares, Andrés. University College London; Estados Unidos
description	We report a genome-wide association scan for facial features in â 1/46,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values<5 × 10 â '8) at single-nucleotide polymorphisms (SNPs) in four genomic regions for three nose-related traits: columella inclination (4q31), nose bridge breadth (6p21) and nose wing breadth (7p13 and 20p11). In a subsample of â 1/43,000 individuals we obtained quantitative traits related to 9 of the ordinal phenotypes and, also, a measure of nasion position. Quantitative analyses confirmed the ordinal-based associations, identified SNPs in 2q12 associated to chin protrusion, and replicated the reported association of nasion position with SNPs in PAX3. Strongest association in 2q12, 4q31, 6p21 and 7p13 was observed for SNPs in the EDAR, DCHS2, RUNX2 and GLI3 genes, respectively. Associated SNPs in 20p11 extend to PAX1. Consistent with the effect of EDAR on chin protrusion, we documented alterations of mandible length in mice with modified Edar funtion.
publishDate	2016
dc.date.none.fl_str_mv	2016-05
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/39487 Adhikari, Kaustubh; Fuentes Guajardo, Macarena; Quinto Sanchez, Mirsha Emmanuel; Mendoza Revilla, Javier; Chacon Duque, Juan Camilo; et al.; A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation; Nature; Nature Communications; 7; 5-2016; 1-11; 11616 2041-1723 CONICET Digital CONICET
url	http://hdl.handle.net/11336/39487
identifier_str_mv	Adhikari, Kaustubh; Fuentes Guajardo, Macarena; Quinto Sanchez, Mirsha Emmanuel; Mendoza Revilla, Javier; Chacon Duque, Juan Camilo; et al.; A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation; Nature; Nature Communications; 7; 5-2016; 1-11; 11616 2041-1723 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/ncomms11616 info:eu-repo/semantics/altIdentifier/doi/10.1038/ncomms11616
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	Nature
publisher.none.fl_str_mv	Nature
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
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instname_str	Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation

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