A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation

Autores
Adhikari, Kaustubh; Fuentes Guajardo, Macarena; Quinto Sanchez, Mirsha Emmanuel; Mendoza Revilla, Javier; Chacon Duque, Juan Camilo; Acuña Alonzo, Víctor; Jaramillo, Claudia; Arias, William; Barquera Lozano, Rodrigo; Macín Pérez, Gastón; Gómez Valdés, Jorge; Villamil Ramírez, Hugo; Hunemeier, Tábita; Ramallo, Virginia; Silva de Cerqueira, Caio Cesar; Hurtado, Malena; Villegas, Valeria; Granja, Vanessa; Gallo, Carla; Poletti, Giovanni; Schuler Faccini, Lavinia; Salzano, Francisco M.; Bortolini, Maria Catira; Canizales Quinteros, Samuel; Cheeseman, Michael; Rosique, Javier; Bedoya Berrío, Gabriel; Rothhammer, Francisco; Headon, Denis; González José, Rolando; Balding, David; Ruiz Linares, Andrés
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We report a genome-wide association scan for facial features in â 1/46,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values<5 × 10 â '8) at single-nucleotide polymorphisms (SNPs) in four genomic regions for three nose-related traits: columella inclination (4q31), nose bridge breadth (6p21) and nose wing breadth (7p13 and 20p11). In a subsample of â 1/43,000 individuals we obtained quantitative traits related to 9 of the ordinal phenotypes and, also, a measure of nasion position. Quantitative analyses confirmed the ordinal-based associations, identified SNPs in 2q12 associated to chin protrusion, and replicated the reported association of nasion position with SNPs in PAX3. Strongest association in 2q12, 4q31, 6p21 and 7p13 was observed for SNPs in the EDAR, DCHS2, RUNX2 and GLI3 genes, respectively. Associated SNPs in 20p11 extend to PAX1. Consistent with the effect of EDAR on chin protrusion, we documented alterations of mandible length in mice with modified Edar funtion.
Fil: Adhikari, Kaustubh. University College London; Estados Unidos
Fil: Fuentes Guajardo, Macarena. University College London; Estados Unidos. Universidad de Tarapacá; Chile
Fil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
Fil: Mendoza Revilla, Javier. University College London; Estados Unidos. Universidad Peruana Cayetano Heredia; Perú
Fil: Chacon Duque, Juan Camilo. University College London; Estados Unidos
Fil: Acuña Alonzo, Víctor. University College London; Estados Unidos. Escuela Nacional de Antropología e Historia; México
Fil: Jaramillo, Claudia. Universidad de Antioquia; Colombia
Fil: Arias, William. Universidad de Antioquia; Colombia
Fil: Barquera Lozano, Rodrigo. Escuela Nacional de Antropología e Historia; México. Universidad Nacional Autónoma de México; México
Fil: Macín Pérez, Gastón. Escuela Nacional de Antropología e Historia; México. Universidad Nacional Autónoma de México; México
Fil: Gómez Valdés, Jorge. Universidad Nacional Autónoma de México; México
Fil: Villamil Ramírez, Hugo. Universidad Nacional Autónoma de México; México
Fil: Hunemeier, Tábita. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Silva de Cerqueira, Caio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Hurtado, Malena. Universidad Peruana Cayetano Heredia; Perú
Fil: Villegas, Valeria. Universidad Peruana Cayetano Heredia; Perú
Fil: Granja, Vanessa. Universidad Peruana Cayetano Heredia; Perú
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; Perú
Fil: Schuler Faccini, Lavinia. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Salzano, Francisco M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México
Fil: Cheeseman, Michael. University of Edinburgh; Reino Unido
Fil: Rosique, Javier. Universidad de Antioquia; Colombia
Fil: Bedoya Berrío, Gabriel. Universidad de Antioquia; Colombia
Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile
Fil: Headon, Denis. University of Edinburgh; Reino Unido
Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
Fil: Balding, David. University College London; Estados Unidos. University of Melbourne; Australia
Fil: Ruiz Linares, Andrés. University College London; Estados Unidos
Materia
genome-wide association studies
Population genetics
morphogenesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/39487

id CONICETDig_3b647f2f9e993a47b18be93962ea98b5
oai_identifier_str oai:ri.conicet.gov.ar:11336/39487
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variationAdhikari, KaustubhFuentes Guajardo, MacarenaQuinto Sanchez, Mirsha EmmanuelMendoza Revilla, JavierChacon Duque, Juan CamiloAcuña Alonzo, VíctorJaramillo, ClaudiaArias, WilliamBarquera Lozano, RodrigoMacín Pérez, GastónGómez Valdés, JorgeVillamil Ramírez, HugoHunemeier, TábitaRamallo, VirginiaSilva de Cerqueira, Caio CesarHurtado, MalenaVillegas, ValeriaGranja, VanessaGallo, CarlaPoletti, GiovanniSchuler Faccini, LaviniaSalzano, Francisco M.Bortolini, Maria CatiraCanizales Quinteros, SamuelCheeseman, MichaelRosique, JavierBedoya Berrío, GabrielRothhammer, FranciscoHeadon, DenisGonzález José, RolandoBalding, DavidRuiz Linares, Andrésgenome-wide association studiesPopulation geneticsmorphogenesishttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We report a genome-wide association scan for facial features in â 1/46,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values<5 × 10 â '8) at single-nucleotide polymorphisms (SNPs) in four genomic regions for three nose-related traits: columella inclination (4q31), nose bridge breadth (6p21) and nose wing breadth (7p13 and 20p11). In a subsample of â 1/43,000 individuals we obtained quantitative traits related to 9 of the ordinal phenotypes and, also, a measure of nasion position. Quantitative analyses confirmed the ordinal-based associations, identified SNPs in 2q12 associated to chin protrusion, and replicated the reported association of nasion position with SNPs in PAX3. Strongest association in 2q12, 4q31, 6p21 and 7p13 was observed for SNPs in the EDAR, DCHS2, RUNX2 and GLI3 genes, respectively. Associated SNPs in 20p11 extend to PAX1. Consistent with the effect of EDAR on chin protrusion, we documented alterations of mandible length in mice with modified Edar funtion.Fil: Adhikari, Kaustubh. University College London; Estados UnidosFil: Fuentes Guajardo, Macarena. University College London; Estados Unidos. Universidad de Tarapacá; ChileFil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaFil: Mendoza Revilla, Javier. University College London; Estados Unidos. Universidad Peruana Cayetano Heredia; PerúFil: Chacon Duque, Juan Camilo. University College London; Estados UnidosFil: Acuña Alonzo, Víctor. University College London; Estados Unidos. Escuela Nacional de Antropología e Historia; MéxicoFil: Jaramillo, Claudia. Universidad de Antioquia; ColombiaFil: Arias, William. Universidad de Antioquia; ColombiaFil: Barquera Lozano, Rodrigo. Escuela Nacional de Antropología e Historia; México. Universidad Nacional Autónoma de México; MéxicoFil: Macín Pérez, Gastón. Escuela Nacional de Antropología e Historia; México. Universidad Nacional Autónoma de México; MéxicoFil: Gómez Valdés, Jorge. Universidad Nacional Autónoma de México; MéxicoFil: Villamil Ramírez, Hugo. Universidad Nacional Autónoma de México; MéxicoFil: Hunemeier, Tábita. Universidade Federal do Rio Grande do Sul; BrasilFil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina. Universidade Federal do Rio Grande do Sul; BrasilFil: Silva de Cerqueira, Caio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina. Universidade Federal do Rio Grande do Sul; BrasilFil: Hurtado, Malena. Universidad Peruana Cayetano Heredia; PerúFil: Villegas, Valeria. Universidad Peruana Cayetano Heredia; PerúFil: Granja, Vanessa. Universidad Peruana Cayetano Heredia; PerúFil: Gallo, Carla. Universidad Peruana Cayetano Heredia; PerúFil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; PerúFil: Schuler Faccini, Lavinia. Universidade Federal do Rio Grande do Sul; BrasilFil: Salzano, Francisco M.. Universidade Federal do Rio Grande do Sul; BrasilFil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; BrasilFil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; MéxicoFil: Cheeseman, Michael. University of Edinburgh; Reino UnidoFil: Rosique, Javier. Universidad de Antioquia; ColombiaFil: Bedoya Berrío, Gabriel. Universidad de Antioquia; ColombiaFil: Rothhammer, Francisco. Universidad de Tarapacá; ChileFil: Headon, Denis. University of Edinburgh; Reino UnidoFil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaFil: Balding, David. University College London; Estados Unidos. University of Melbourne; AustraliaFil: Ruiz Linares, Andrés. University College London; Estados UnidosNature2016-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39487Adhikari, Kaustubh; Fuentes Guajardo, Macarena; Quinto Sanchez, Mirsha Emmanuel; Mendoza Revilla, Javier; Chacon Duque, Juan Camilo; et al.; A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation; Nature; Nature Communications; 7; 5-2016; 1-11; 116162041-1723CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/ncomms11616info:eu-repo/semantics/altIdentifier/doi/10.1038/ncomms11616info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:41Zoai:ri.conicet.gov.ar:11336/39487instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:41.751CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
title A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
spellingShingle A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
Adhikari, Kaustubh
genome-wide association studies
Population genetics
morphogenesis
title_short A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
title_full A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
title_fullStr A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
title_full_unstemmed A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
title_sort A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation
dc.creator.none.fl_str_mv Adhikari, Kaustubh
Fuentes Guajardo, Macarena
Quinto Sanchez, Mirsha Emmanuel
Mendoza Revilla, Javier
Chacon Duque, Juan Camilo
Acuña Alonzo, Víctor
Jaramillo, Claudia
Arias, William
Barquera Lozano, Rodrigo
Macín Pérez, Gastón
Gómez Valdés, Jorge
Villamil Ramírez, Hugo
Hunemeier, Tábita
Ramallo, Virginia
Silva de Cerqueira, Caio Cesar
Hurtado, Malena
Villegas, Valeria
Granja, Vanessa
Gallo, Carla
Poletti, Giovanni
Schuler Faccini, Lavinia
Salzano, Francisco M.
Bortolini, Maria Catira
Canizales Quinteros, Samuel
Cheeseman, Michael
Rosique, Javier
Bedoya Berrío, Gabriel
Rothhammer, Francisco
Headon, Denis
González José, Rolando
Balding, David
Ruiz Linares, Andrés
author Adhikari, Kaustubh
author_facet Adhikari, Kaustubh
Fuentes Guajardo, Macarena
Quinto Sanchez, Mirsha Emmanuel
Mendoza Revilla, Javier
Chacon Duque, Juan Camilo
Acuña Alonzo, Víctor
Jaramillo, Claudia
Arias, William
Barquera Lozano, Rodrigo
Macín Pérez, Gastón
Gómez Valdés, Jorge
Villamil Ramírez, Hugo
Hunemeier, Tábita
Ramallo, Virginia
Silva de Cerqueira, Caio Cesar
Hurtado, Malena
Villegas, Valeria
Granja, Vanessa
Gallo, Carla
Poletti, Giovanni
Schuler Faccini, Lavinia
Salzano, Francisco M.
Bortolini, Maria Catira
Canizales Quinteros, Samuel
Cheeseman, Michael
Rosique, Javier
Bedoya Berrío, Gabriel
Rothhammer, Francisco
Headon, Denis
González José, Rolando
Balding, David
Ruiz Linares, Andrés
author_role author
author2 Fuentes Guajardo, Macarena
Quinto Sanchez, Mirsha Emmanuel
Mendoza Revilla, Javier
Chacon Duque, Juan Camilo
Acuña Alonzo, Víctor
Jaramillo, Claudia
Arias, William
Barquera Lozano, Rodrigo
Macín Pérez, Gastón
Gómez Valdés, Jorge
Villamil Ramírez, Hugo
Hunemeier, Tábita
Ramallo, Virginia
Silva de Cerqueira, Caio Cesar
Hurtado, Malena
Villegas, Valeria
Granja, Vanessa
Gallo, Carla
Poletti, Giovanni
Schuler Faccini, Lavinia
Salzano, Francisco M.
Bortolini, Maria Catira
Canizales Quinteros, Samuel
Cheeseman, Michael
Rosique, Javier
Bedoya Berrío, Gabriel
Rothhammer, Francisco
Headon, Denis
González José, Rolando
Balding, David
Ruiz Linares, Andrés
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv genome-wide association studies
Population genetics
morphogenesis
topic genome-wide association studies
Population genetics
morphogenesis
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We report a genome-wide association scan for facial features in â 1/46,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values<5 × 10 â '8) at single-nucleotide polymorphisms (SNPs) in four genomic regions for three nose-related traits: columella inclination (4q31), nose bridge breadth (6p21) and nose wing breadth (7p13 and 20p11). In a subsample of â 1/43,000 individuals we obtained quantitative traits related to 9 of the ordinal phenotypes and, also, a measure of nasion position. Quantitative analyses confirmed the ordinal-based associations, identified SNPs in 2q12 associated to chin protrusion, and replicated the reported association of nasion position with SNPs in PAX3. Strongest association in 2q12, 4q31, 6p21 and 7p13 was observed for SNPs in the EDAR, DCHS2, RUNX2 and GLI3 genes, respectively. Associated SNPs in 20p11 extend to PAX1. Consistent with the effect of EDAR on chin protrusion, we documented alterations of mandible length in mice with modified Edar funtion.
Fil: Adhikari, Kaustubh. University College London; Estados Unidos
Fil: Fuentes Guajardo, Macarena. University College London; Estados Unidos. Universidad de Tarapacá; Chile
Fil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
Fil: Mendoza Revilla, Javier. University College London; Estados Unidos. Universidad Peruana Cayetano Heredia; Perú
Fil: Chacon Duque, Juan Camilo. University College London; Estados Unidos
Fil: Acuña Alonzo, Víctor. University College London; Estados Unidos. Escuela Nacional de Antropología e Historia; México
Fil: Jaramillo, Claudia. Universidad de Antioquia; Colombia
Fil: Arias, William. Universidad de Antioquia; Colombia
Fil: Barquera Lozano, Rodrigo. Escuela Nacional de Antropología e Historia; México. Universidad Nacional Autónoma de México; México
Fil: Macín Pérez, Gastón. Escuela Nacional de Antropología e Historia; México. Universidad Nacional Autónoma de México; México
Fil: Gómez Valdés, Jorge. Universidad Nacional Autónoma de México; México
Fil: Villamil Ramírez, Hugo. Universidad Nacional Autónoma de México; México
Fil: Hunemeier, Tábita. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Silva de Cerqueira, Caio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Hurtado, Malena. Universidad Peruana Cayetano Heredia; Perú
Fil: Villegas, Valeria. Universidad Peruana Cayetano Heredia; Perú
Fil: Granja, Vanessa. Universidad Peruana Cayetano Heredia; Perú
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Poletti, Giovanni. Universidad Peruana Cayetano Heredia; Perú
Fil: Schuler Faccini, Lavinia. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Salzano, Francisco M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México
Fil: Cheeseman, Michael. University of Edinburgh; Reino Unido
Fil: Rosique, Javier. Universidad de Antioquia; Colombia
Fil: Bedoya Berrío, Gabriel. Universidad de Antioquia; Colombia
Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile
Fil: Headon, Denis. University of Edinburgh; Reino Unido
Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
Fil: Balding, David. University College London; Estados Unidos. University of Melbourne; Australia
Fil: Ruiz Linares, Andrés. University College London; Estados Unidos
description We report a genome-wide association scan for facial features in â 1/46,000 Latin Americans. We evaluated 14 traits on an ordinal scale and found significant association (P values<5 × 10 â '8) at single-nucleotide polymorphisms (SNPs) in four genomic regions for three nose-related traits: columella inclination (4q31), nose bridge breadth (6p21) and nose wing breadth (7p13 and 20p11). In a subsample of â 1/43,000 individuals we obtained quantitative traits related to 9 of the ordinal phenotypes and, also, a measure of nasion position. Quantitative analyses confirmed the ordinal-based associations, identified SNPs in 2q12 associated to chin protrusion, and replicated the reported association of nasion position with SNPs in PAX3. Strongest association in 2q12, 4q31, 6p21 and 7p13 was observed for SNPs in the EDAR, DCHS2, RUNX2 and GLI3 genes, respectively. Associated SNPs in 20p11 extend to PAX1. Consistent with the effect of EDAR on chin protrusion, we documented alterations of mandible length in mice with modified Edar funtion.
publishDate 2016
dc.date.none.fl_str_mv 2016-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39487
Adhikari, Kaustubh; Fuentes Guajardo, Macarena; Quinto Sanchez, Mirsha Emmanuel; Mendoza Revilla, Javier; Chacon Duque, Juan Camilo; et al.; A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation; Nature; Nature Communications; 7; 5-2016; 1-11; 11616
2041-1723
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39487
identifier_str_mv Adhikari, Kaustubh; Fuentes Guajardo, Macarena; Quinto Sanchez, Mirsha Emmanuel; Mendoza Revilla, Javier; Chacon Duque, Juan Camilo; et al.; A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation; Nature; Nature Communications; 7; 5-2016; 1-11; 11616
2041-1723
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/ncomms11616
info:eu-repo/semantics/altIdentifier/doi/10.1038/ncomms11616
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613344738148352
score 13.070432