The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation

Autores
Kent, Brianne A.; Beynon, Amy L.; Hornsby, Amanda K. E.; Bekinschtein, Pedro Alejandro; Bussey, Timothy J.; Davies, Jeffrey S.; Saksida, Lisa M.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
An important link exists between intact metabolic processes and normal cognitive functioning; however, the underlying mechanisms remain unknown. There is accumulating evidence that the gut hormone ghrelin, an orexigenic peptide that is elevated during calorie restriction (CR) and known primarily for stimulating growth hormone release, has important extra-hypothalamic functions, such as enhancing synaptic plasticity and hippocampal neurogenesis. The present study was designed to evaluate the long-term effects of elevating acyl-ghrelin levels, albeit within the physiological range, on the number of new adult born neurons in the dentate gyrus (DG) and performance on the Spontaneous Location Recognition (SLR) task, previously shown to be DG-dependent and sensitive to manipulations of plasticity mechanisms and cell proliferation. The results revealed that peripheral treatment of rats with acyl-ghrelin enhanced both adult hippocampal neurogenesis and performance on SLR when measured 8-10 days after the end of acyl-ghrelin treatment. Our data show that systemic administration of physiological levels of acyl-ghrelin can produce long-lasting improvements in spatial memory that persist following the end of treatment. As ghrelin is potentially involved in regulating the relationship between metabolic and cognitive dysfunction in ageing and neurodegenerative disease, elucidating the underlying mechanisms holds promise for identifying novel therapeutic targets and modifiable lifestyle factors that may have beneficial effects on the brain.
Fil: Kent, Brianne A.. University of Cambridge; Reino Unido
Fil: Beynon, Amy L.. Swansea University; Reino Unido
Fil: Hornsby, Amanda K. E.. Swansea University; Reino Unido
Fil: Bekinschtein, Pedro Alejandro. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bussey, Timothy J.. University of Cambridge; Reino Unido
Fil: Davies, Jeffrey S.. Swansea University; Reino Unido
Fil: Saksida, Lisa M.. University of Cambridge; Reino Unido
Materia
ADULT HIPPOCAMPAL NEUROGENESIS
GHRELIN
PATTERN SEPARATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15761
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separationKent, Brianne A.Beynon, Amy L.Hornsby, Amanda K. E.Bekinschtein, Pedro AlejandroBussey, Timothy J.Davies, Jeffrey S.Saksida, Lisa M.ADULT HIPPOCAMPAL NEUROGENESISGHRELINPATTERN SEPARATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1An important link exists between intact metabolic processes and normal cognitive functioning; however, the underlying mechanisms remain unknown. There is accumulating evidence that the gut hormone ghrelin, an orexigenic peptide that is elevated during calorie restriction (CR) and known primarily for stimulating growth hormone release, has important extra-hypothalamic functions, such as enhancing synaptic plasticity and hippocampal neurogenesis. The present study was designed to evaluate the long-term effects of elevating acyl-ghrelin levels, albeit within the physiological range, on the number of new adult born neurons in the dentate gyrus (DG) and performance on the Spontaneous Location Recognition (SLR) task, previously shown to be DG-dependent and sensitive to manipulations of plasticity mechanisms and cell proliferation. The results revealed that peripheral treatment of rats with acyl-ghrelin enhanced both adult hippocampal neurogenesis and performance on SLR when measured 8-10 days after the end of acyl-ghrelin treatment. Our data show that systemic administration of physiological levels of acyl-ghrelin can produce long-lasting improvements in spatial memory that persist following the end of treatment. As ghrelin is potentially involved in regulating the relationship between metabolic and cognitive dysfunction in ageing and neurodegenerative disease, elucidating the underlying mechanisms holds promise for identifying novel therapeutic targets and modifiable lifestyle factors that may have beneficial effects on the brain.Fil: Kent, Brianne A.. University of Cambridge; Reino UnidoFil: Beynon, Amy L.. Swansea University; Reino UnidoFil: Hornsby, Amanda K. E.. Swansea University; Reino UnidoFil: Bekinschtein, Pedro Alejandro. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bussey, Timothy J.. University of Cambridge; Reino UnidoFil: Davies, Jeffrey S.. Swansea University; Reino UnidoFil: Saksida, Lisa M.. University of Cambridge; Reino UnidoPergamon-Elsevier Science Ltd2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15761Kent, Brianne A.; Beynon, Amy L.; Hornsby, Amanda K. E.; Bekinschtein, Pedro Alejandro; Bussey, Timothy J.; et al.; The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation; Pergamon-Elsevier Science Ltd; Psychoneuroendocrinology; 51; 1-2015; 431-4390306-4530enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0306453014003990info:eu-repo/semantics/altIdentifier/doi/10.1016/j.psyneuen.2014.10.015info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:44:24Zoai:ri.conicet.gov.ar:11336/15761instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:44:24.418CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
title The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
spellingShingle The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
Kent, Brianne A.
ADULT HIPPOCAMPAL NEUROGENESIS
GHRELIN
PATTERN SEPARATION
title_short The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
title_full The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
title_fullStr The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
title_full_unstemmed The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
title_sort The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation
dc.creator.none.fl_str_mv Kent, Brianne A.
Beynon, Amy L.
Hornsby, Amanda K. E.
Bekinschtein, Pedro Alejandro
Bussey, Timothy J.
Davies, Jeffrey S.
Saksida, Lisa M.
author Kent, Brianne A.
author_facet Kent, Brianne A.
Beynon, Amy L.
Hornsby, Amanda K. E.
Bekinschtein, Pedro Alejandro
Bussey, Timothy J.
Davies, Jeffrey S.
Saksida, Lisa M.
author_role author
author2 Beynon, Amy L.
Hornsby, Amanda K. E.
Bekinschtein, Pedro Alejandro
Bussey, Timothy J.
Davies, Jeffrey S.
Saksida, Lisa M.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ADULT HIPPOCAMPAL NEUROGENESIS
GHRELIN
PATTERN SEPARATION
topic ADULT HIPPOCAMPAL NEUROGENESIS
GHRELIN
PATTERN SEPARATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv An important link exists between intact metabolic processes and normal cognitive functioning; however, the underlying mechanisms remain unknown. There is accumulating evidence that the gut hormone ghrelin, an orexigenic peptide that is elevated during calorie restriction (CR) and known primarily for stimulating growth hormone release, has important extra-hypothalamic functions, such as enhancing synaptic plasticity and hippocampal neurogenesis. The present study was designed to evaluate the long-term effects of elevating acyl-ghrelin levels, albeit within the physiological range, on the number of new adult born neurons in the dentate gyrus (DG) and performance on the Spontaneous Location Recognition (SLR) task, previously shown to be DG-dependent and sensitive to manipulations of plasticity mechanisms and cell proliferation. The results revealed that peripheral treatment of rats with acyl-ghrelin enhanced both adult hippocampal neurogenesis and performance on SLR when measured 8-10 days after the end of acyl-ghrelin treatment. Our data show that systemic administration of physiological levels of acyl-ghrelin can produce long-lasting improvements in spatial memory that persist following the end of treatment. As ghrelin is potentially involved in regulating the relationship between metabolic and cognitive dysfunction in ageing and neurodegenerative disease, elucidating the underlying mechanisms holds promise for identifying novel therapeutic targets and modifiable lifestyle factors that may have beneficial effects on the brain.
Fil: Kent, Brianne A.. University of Cambridge; Reino Unido
Fil: Beynon, Amy L.. Swansea University; Reino Unido
Fil: Hornsby, Amanda K. E.. Swansea University; Reino Unido
Fil: Bekinschtein, Pedro Alejandro. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bussey, Timothy J.. University of Cambridge; Reino Unido
Fil: Davies, Jeffrey S.. Swansea University; Reino Unido
Fil: Saksida, Lisa M.. University of Cambridge; Reino Unido
description An important link exists between intact metabolic processes and normal cognitive functioning; however, the underlying mechanisms remain unknown. There is accumulating evidence that the gut hormone ghrelin, an orexigenic peptide that is elevated during calorie restriction (CR) and known primarily for stimulating growth hormone release, has important extra-hypothalamic functions, such as enhancing synaptic plasticity and hippocampal neurogenesis. The present study was designed to evaluate the long-term effects of elevating acyl-ghrelin levels, albeit within the physiological range, on the number of new adult born neurons in the dentate gyrus (DG) and performance on the Spontaneous Location Recognition (SLR) task, previously shown to be DG-dependent and sensitive to manipulations of plasticity mechanisms and cell proliferation. The results revealed that peripheral treatment of rats with acyl-ghrelin enhanced both adult hippocampal neurogenesis and performance on SLR when measured 8-10 days after the end of acyl-ghrelin treatment. Our data show that systemic administration of physiological levels of acyl-ghrelin can produce long-lasting improvements in spatial memory that persist following the end of treatment. As ghrelin is potentially involved in regulating the relationship between metabolic and cognitive dysfunction in ageing and neurodegenerative disease, elucidating the underlying mechanisms holds promise for identifying novel therapeutic targets and modifiable lifestyle factors that may have beneficial effects on the brain.
publishDate 2015
dc.date.none.fl_str_mv 2015-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15761
Kent, Brianne A.; Beynon, Amy L.; Hornsby, Amanda K. E.; Bekinschtein, Pedro Alejandro; Bussey, Timothy J.; et al.; The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation; Pergamon-Elsevier Science Ltd; Psychoneuroendocrinology; 51; 1-2015; 431-439
0306-4530
url http://hdl.handle.net/11336/15761
identifier_str_mv Kent, Brianne A.; Beynon, Amy L.; Hornsby, Amanda K. E.; Bekinschtein, Pedro Alejandro; Bussey, Timothy J.; et al.; The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation; Pergamon-Elsevier Science Ltd; Psychoneuroendocrinology; 51; 1-2015; 431-439
0306-4530
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0306453014003990
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.psyneuen.2014.10.015
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613397184774144
score 13.070432

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