Natural multi-target inhibitors of cholinesterases and monoamine oxidase enzymes with antioxidant potential from skin extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hyli...

Autores
Spinelli, Roque; Sanchis, Ivan; Aimaretti, Florencia Maria; Attademo, Andres Maximiliano; Portela, Madelon; Húmpola, Maria Veronica; Tonarelli, Georgina Guadalupe; Siano, Alvaro Sebastían
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Alzheimer´s disease (AD) is the most common cause of dementia, characterized by loss of selective neuronal and normal brain functions. Every year, ten million new cases are diagnosed worldwide. AD is a complex disease associated with all kind of different pathways, making their simultaneous modulation necessary. Nowadays anti-AD treatments are focused on enzymatic inhibitors. The study of the amphibians? skin had acquired great importance in the fields of biology and human health and represents an attractive and novel source for natural compounds with high potential in the development of new drugs. The present work exhibits the power of amphibian skins as a source of bioactive compounds. Herein we report the activity of extracts of two species from Hylidae family (H. cordobae and P. minuta) as reversible inhibitors of acetylcholinesterase and butyrylcholinesterase enzymes. Furthermore, the extracts inhibit MAO−B enzyme and showed antioxidant activities, acting on four important pathways of AD.
Fil: Spinelli, Roque. Universidad Nacional del Litoral; Argentina
Fil: Sanchis, Ivan. Universidad Nacional del Litoral; Argentina
Fil: Aimaretti, Florencia Maria. Universidad Nacional del Litoral; Argentina
Fil: Attademo, Andres Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Portela, Madelon. Institut Pasteur;
Fil: Húmpola, Maria Veronica. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química Organica; Argentina
Fil: Tonarelli, Georgina Guadalupe. Universidad Nacional del Litoral; Argentina
Fil: Siano, Alvaro Sebastían. Universidad Nacional del Litoral; Argentina
Materia
AMPHIBIAN SKIN
BIOACTIVE COMPOUNDS
CHOLINESTERASE
MONOAMINE OXIDASE
ANTIOXIDANT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/104708
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/104708
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Natural multi-target inhibitors of cholinesterases and monoamine oxidase enzymes with antioxidant potential from skin extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hylidae)Spinelli, RoqueSanchis, IvanAimaretti, Florencia MariaAttademo, Andres MaximilianoPortela, MadelonHúmpola, Maria VeronicaTonarelli, Georgina GuadalupeSiano, Alvaro SebastíanAMPHIBIAN SKINBIOACTIVE COMPOUNDSCHOLINESTERASEMONOAMINE OXIDASEANTIOXIDANThttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Alzheimer´s disease (AD) is the most common cause of dementia, characterized by loss of selective neuronal and normal brain functions. Every year, ten million new cases are diagnosed worldwide. AD is a complex disease associated with all kind of different pathways, making their simultaneous modulation necessary. Nowadays anti-AD treatments are focused on enzymatic inhibitors. The study of the amphibians? skin had acquired great importance in the fields of biology and human health and represents an attractive and novel source for natural compounds with high potential in the development of new drugs. The present work exhibits the power of amphibian skins as a source of bioactive compounds. Herein we report the activity of extracts of two species from Hylidae family (H. cordobae and P. minuta) as reversible inhibitors of acetylcholinesterase and butyrylcholinesterase enzymes. Furthermore, the extracts inhibit MAO−B enzyme and showed antioxidant activities, acting on four important pathways of AD.Fil: Spinelli, Roque. Universidad Nacional del Litoral; ArgentinaFil: Sanchis, Ivan. Universidad Nacional del Litoral; ArgentinaFil: Aimaretti, Florencia Maria. Universidad Nacional del Litoral; ArgentinaFil: Attademo, Andres Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Portela, Madelon. Institut Pasteur; Fil: Húmpola, Maria Veronica. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química Organica; ArgentinaFil: Tonarelli, Georgina Guadalupe. Universidad Nacional del Litoral; ArgentinaFil: Siano, Alvaro Sebastían. Universidad Nacional del Litoral; ArgentinaWiley VCH Verlag2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/104708Spinelli, Roque; Sanchis, Ivan; Aimaretti, Florencia Maria; Attademo, Andres Maximiliano; Portela, Madelon; et al.; Natural multi-target inhibitors of cholinesterases and monoamine oxidase enzymes with antioxidant potential from skin extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hylidae); Wiley VCH Verlag; Chemistry and Biodiversity; 11-20181612-1872CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1002/cbdv.201800472info:eu-repo/semantics/altIdentifier/doi/10.1002/cbdv.201800472info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:20:00Zoai:ri.conicet.gov.ar:11336/104708instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:20:00.792CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Natural multi-target inhibitors of cholinesterases and monoamine oxidase enzymes with antioxidant potential from skin extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hylidae)
title Natural multi-target inhibitors of cholinesterases and monoamine oxidase enzymes with antioxidant potential from skin extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hylidae)
spellingShingle Natural multi-target inhibitors of cholinesterases and monoamine oxidase enzymes with antioxidant potential from skin extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hylidae)
Spinelli, Roque
AMPHIBIAN SKIN
BIOACTIVE COMPOUNDS
CHOLINESTERASE
MONOAMINE OXIDASE
ANTIOXIDANT
title_short Natural multi-target inhibitors of cholinesterases and monoamine oxidase enzymes with antioxidant potential from skin extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hylidae)
title_full Natural multi-target inhibitors of cholinesterases and monoamine oxidase enzymes with antioxidant potential from skin extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hylidae)
title_fullStr Natural multi-target inhibitors of cholinesterases and monoamine oxidase enzymes with antioxidant potential from skin extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hylidae)
title_full_unstemmed Natural multi-target inhibitors of cholinesterases and monoamine oxidase enzymes with antioxidant potential from skin extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hylidae)
title_sort Natural multi-target inhibitors of cholinesterases and monoamine oxidase enzymes with antioxidant potential from skin extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hylidae)
dc.creator.none.fl_str_mv Spinelli, Roque
Sanchis, Ivan
Aimaretti, Florencia Maria
Attademo, Andres Maximiliano
Portela, Madelon
Húmpola, Maria Veronica
Tonarelli, Georgina Guadalupe
Siano, Alvaro Sebastían
author Spinelli, Roque
author_facet Spinelli, Roque
Sanchis, Ivan
Aimaretti, Florencia Maria
Attademo, Andres Maximiliano
Portela, Madelon
Húmpola, Maria Veronica
Tonarelli, Georgina Guadalupe
Siano, Alvaro Sebastían
author_role author
author2 Sanchis, Ivan
Aimaretti, Florencia Maria
Attademo, Andres Maximiliano
Portela, Madelon
Húmpola, Maria Veronica
Tonarelli, Georgina Guadalupe
Siano, Alvaro Sebastían
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv AMPHIBIAN SKIN
BIOACTIVE COMPOUNDS
CHOLINESTERASE
MONOAMINE OXIDASE
ANTIOXIDANT
topic AMPHIBIAN SKIN
BIOACTIVE COMPOUNDS
CHOLINESTERASE
MONOAMINE OXIDASE
ANTIOXIDANT
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Alzheimer´s disease (AD) is the most common cause of dementia, characterized by loss of selective neuronal and normal brain functions. Every year, ten million new cases are diagnosed worldwide. AD is a complex disease associated with all kind of different pathways, making their simultaneous modulation necessary. Nowadays anti-AD treatments are focused on enzymatic inhibitors. The study of the amphibians? skin had acquired great importance in the fields of biology and human health and represents an attractive and novel source for natural compounds with high potential in the development of new drugs. The present work exhibits the power of amphibian skins as a source of bioactive compounds. Herein we report the activity of extracts of two species from Hylidae family (H. cordobae and P. minuta) as reversible inhibitors of acetylcholinesterase and butyrylcholinesterase enzymes. Furthermore, the extracts inhibit MAO−B enzyme and showed antioxidant activities, acting on four important pathways of AD.
Fil: Spinelli, Roque. Universidad Nacional del Litoral; Argentina
Fil: Sanchis, Ivan. Universidad Nacional del Litoral; Argentina
Fil: Aimaretti, Florencia Maria. Universidad Nacional del Litoral; Argentina
Fil: Attademo, Andres Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Portela, Madelon. Institut Pasteur;
Fil: Húmpola, Maria Veronica. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Química Organica; Argentina
Fil: Tonarelli, Georgina Guadalupe. Universidad Nacional del Litoral; Argentina
Fil: Siano, Alvaro Sebastían. Universidad Nacional del Litoral; Argentina
description Alzheimer´s disease (AD) is the most common cause of dementia, characterized by loss of selective neuronal and normal brain functions. Every year, ten million new cases are diagnosed worldwide. AD is a complex disease associated with all kind of different pathways, making their simultaneous modulation necessary. Nowadays anti-AD treatments are focused on enzymatic inhibitors. The study of the amphibians? skin had acquired great importance in the fields of biology and human health and represents an attractive and novel source for natural compounds with high potential in the development of new drugs. The present work exhibits the power of amphibian skins as a source of bioactive compounds. Herein we report the activity of extracts of two species from Hylidae family (H. cordobae and P. minuta) as reversible inhibitors of acetylcholinesterase and butyrylcholinesterase enzymes. Furthermore, the extracts inhibit MAO−B enzyme and showed antioxidant activities, acting on four important pathways of AD.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/104708
Spinelli, Roque; Sanchis, Ivan; Aimaretti, Florencia Maria; Attademo, Andres Maximiliano; Portela, Madelon; et al.; Natural multi-target inhibitors of cholinesterases and monoamine oxidase enzymes with antioxidant potential from skin extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hylidae); Wiley VCH Verlag; Chemistry and Biodiversity; 11-2018
1612-1872
CONICET Digital
CONICET
url http://hdl.handle.net/11336/104708
identifier_str_mv Spinelli, Roque; Sanchis, Ivan; Aimaretti, Florencia Maria; Attademo, Andres Maximiliano; Portela, Madelon; et al.; Natural multi-target inhibitors of cholinesterases and monoamine oxidase enzymes with antioxidant potential from skin extracts of Hypsiboas cordobae and Pseudis minuta (Anura: Hylidae); Wiley VCH Verlag; Chemistry and Biodiversity; 11-2018
1612-1872
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1002/cbdv.201800472
info:eu-repo/semantics/altIdentifier/doi/10.1002/cbdv.201800472
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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