Treating alcohol use disorder in U.S. veterans: The role of traumatic brain injury
- Autores
- Jorge, Ricardo E.; Li, Ruosha; Liu, Xiangyu; McGavin, Jill K.; Shorter, Daryl I.; Acion, Laura; Arndt, Stephan
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Objective: The authors examined the efficacy of valproate to reduce relapse to heavy drinking among veterans with alcohol use disorder (AUD) and neuropsychiatric comorbidities and whether antecedent traumatic brain injury (TBI) or posttraumatic stress disorder (PTSD) affected treatment response. Methods: Participants were male veterans 18–60 years old with an AUD and no other substance use besides nicotine or cannabis. Sixty-two patients were randomly assigned to receive either valproate or naltrexone. Participants were evaluated at baseline and followed weekly for 24 weeks. All participants received standardized psychosocial interventions as well as treatment for coexistent psychiatric conditions. Results: During the follow-up period, nine study subjects in the naltrexone group and 14 in the valproate group relapsed to heavy drinking, but the difference did not reach statistical significance. Participants with a history of moderate to severe TBI were more likely to relapse to heavy drinking compared with those with no TBI (hazard ratio=4.834, 95% CI=1.103–21.194, p=0.033). PTSD status did not significantly affect outcome. Conclusions: Intensive outpatient programs are efficacious alternatives to treat AUD in veterans, although the role of pharmacological treatment is not completely elucidated. Glutamatergic agents appear to be less effective than opiate antagonists to prevent relapse to heavy drinking and to increase cumulative abstinence. Future studies should examine novel pharmacological and nonpharmacological options.
Fil: Jorge, Ricardo E.. Baylor College of Medicine;
Fil: Li, Ruosha. Baylor College of Medicine;
Fil: Liu, Xiangyu. Baylor College of Medicine;
Fil: McGavin, Jill K.. Baylor College of Medicine;
Fil: Shorter, Daryl I.. Baylor College of Medicine;
Fil: Acion, Laura. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Calculo. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Calculo; Argentina
Fil: Arndt, Stephan. University of Iowa; Estados Unidos - Materia
-
Traumatic Brain Injury
AUD
Veterans - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/143188
Ver los metadatos del registro completo
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Treating alcohol use disorder in U.S. veterans: The role of traumatic brain injuryJorge, Ricardo E.Li, RuoshaLiu, XiangyuMcGavin, Jill K.Shorter, Daryl I.Acion, LauraArndt, StephanTraumatic Brain InjuryAUDVeteranshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objective: The authors examined the efficacy of valproate to reduce relapse to heavy drinking among veterans with alcohol use disorder (AUD) and neuropsychiatric comorbidities and whether antecedent traumatic brain injury (TBI) or posttraumatic stress disorder (PTSD) affected treatment response. Methods: Participants were male veterans 18–60 years old with an AUD and no other substance use besides nicotine or cannabis. Sixty-two patients were randomly assigned to receive either valproate or naltrexone. Participants were evaluated at baseline and followed weekly for 24 weeks. All participants received standardized psychosocial interventions as well as treatment for coexistent psychiatric conditions. Results: During the follow-up period, nine study subjects in the naltrexone group and 14 in the valproate group relapsed to heavy drinking, but the difference did not reach statistical significance. Participants with a history of moderate to severe TBI were more likely to relapse to heavy drinking compared with those with no TBI (hazard ratio=4.834, 95% CI=1.103–21.194, p=0.033). PTSD status did not significantly affect outcome. Conclusions: Intensive outpatient programs are efficacious alternatives to treat AUD in veterans, although the role of pharmacological treatment is not completely elucidated. Glutamatergic agents appear to be less effective than opiate antagonists to prevent relapse to heavy drinking and to increase cumulative abstinence. Future studies should examine novel pharmacological and nonpharmacological options.Fil: Jorge, Ricardo E.. Baylor College of Medicine;Fil: Li, Ruosha. Baylor College of Medicine;Fil: Liu, Xiangyu. Baylor College of Medicine;Fil: McGavin, Jill K.. Baylor College of Medicine;Fil: Shorter, Daryl I.. Baylor College of Medicine;Fil: Acion, Laura. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Calculo. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Calculo; ArgentinaFil: Arndt, Stephan. University of Iowa; Estados UnidosAmerican Neuropsychiatric Association2019-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/143188Jorge, Ricardo E.; Li, Ruosha; Liu, Xiangyu; McGavin, Jill K.; Shorter, Daryl I.; et al.; Treating alcohol use disorder in U.S. veterans: The role of traumatic brain injury; American Neuropsychiatric Association; Journal of Neuropsychiatry and Clinical Neurosciences; 31; 4; 10-2019; 319-3270895-0172CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://psychiatryonline.org/doi/10.1176/appi.neuropsych.18110250info:eu-repo/semantics/altIdentifier/doi/10.1176/appi.neuropsych.18110250info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:54Zoai:ri.conicet.gov.ar:11336/143188instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:55.155CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Treating alcohol use disorder in U.S. veterans: The role of traumatic brain injury |
title |
Treating alcohol use disorder in U.S. veterans: The role of traumatic brain injury |
spellingShingle |
Treating alcohol use disorder in U.S. veterans: The role of traumatic brain injury Jorge, Ricardo E. Traumatic Brain Injury AUD Veterans |
title_short |
Treating alcohol use disorder in U.S. veterans: The role of traumatic brain injury |
title_full |
Treating alcohol use disorder in U.S. veterans: The role of traumatic brain injury |
title_fullStr |
Treating alcohol use disorder in U.S. veterans: The role of traumatic brain injury |
title_full_unstemmed |
Treating alcohol use disorder in U.S. veterans: The role of traumatic brain injury |
title_sort |
Treating alcohol use disorder in U.S. veterans: The role of traumatic brain injury |
dc.creator.none.fl_str_mv |
Jorge, Ricardo E. Li, Ruosha Liu, Xiangyu McGavin, Jill K. Shorter, Daryl I. Acion, Laura Arndt, Stephan |
author |
Jorge, Ricardo E. |
author_facet |
Jorge, Ricardo E. Li, Ruosha Liu, Xiangyu McGavin, Jill K. Shorter, Daryl I. Acion, Laura Arndt, Stephan |
author_role |
author |
author2 |
Li, Ruosha Liu, Xiangyu McGavin, Jill K. Shorter, Daryl I. Acion, Laura Arndt, Stephan |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Traumatic Brain Injury AUD Veterans |
topic |
Traumatic Brain Injury AUD Veterans |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Objective: The authors examined the efficacy of valproate to reduce relapse to heavy drinking among veterans with alcohol use disorder (AUD) and neuropsychiatric comorbidities and whether antecedent traumatic brain injury (TBI) or posttraumatic stress disorder (PTSD) affected treatment response. Methods: Participants were male veterans 18–60 years old with an AUD and no other substance use besides nicotine or cannabis. Sixty-two patients were randomly assigned to receive either valproate or naltrexone. Participants were evaluated at baseline and followed weekly for 24 weeks. All participants received standardized psychosocial interventions as well as treatment for coexistent psychiatric conditions. Results: During the follow-up period, nine study subjects in the naltrexone group and 14 in the valproate group relapsed to heavy drinking, but the difference did not reach statistical significance. Participants with a history of moderate to severe TBI were more likely to relapse to heavy drinking compared with those with no TBI (hazard ratio=4.834, 95% CI=1.103–21.194, p=0.033). PTSD status did not significantly affect outcome. Conclusions: Intensive outpatient programs are efficacious alternatives to treat AUD in veterans, although the role of pharmacological treatment is not completely elucidated. Glutamatergic agents appear to be less effective than opiate antagonists to prevent relapse to heavy drinking and to increase cumulative abstinence. Future studies should examine novel pharmacological and nonpharmacological options. Fil: Jorge, Ricardo E.. Baylor College of Medicine; Fil: Li, Ruosha. Baylor College of Medicine; Fil: Liu, Xiangyu. Baylor College of Medicine; Fil: McGavin, Jill K.. Baylor College of Medicine; Fil: Shorter, Daryl I.. Baylor College of Medicine; Fil: Acion, Laura. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Calculo. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Calculo; Argentina Fil: Arndt, Stephan. University of Iowa; Estados Unidos |
description |
Objective: The authors examined the efficacy of valproate to reduce relapse to heavy drinking among veterans with alcohol use disorder (AUD) and neuropsychiatric comorbidities and whether antecedent traumatic brain injury (TBI) or posttraumatic stress disorder (PTSD) affected treatment response. Methods: Participants were male veterans 18–60 years old with an AUD and no other substance use besides nicotine or cannabis. Sixty-two patients were randomly assigned to receive either valproate or naltrexone. Participants were evaluated at baseline and followed weekly for 24 weeks. All participants received standardized psychosocial interventions as well as treatment for coexistent psychiatric conditions. Results: During the follow-up period, nine study subjects in the naltrexone group and 14 in the valproate group relapsed to heavy drinking, but the difference did not reach statistical significance. Participants with a history of moderate to severe TBI were more likely to relapse to heavy drinking compared with those with no TBI (hazard ratio=4.834, 95% CI=1.103–21.194, p=0.033). PTSD status did not significantly affect outcome. Conclusions: Intensive outpatient programs are efficacious alternatives to treat AUD in veterans, although the role of pharmacological treatment is not completely elucidated. Glutamatergic agents appear to be less effective than opiate antagonists to prevent relapse to heavy drinking and to increase cumulative abstinence. Future studies should examine novel pharmacological and nonpharmacological options. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/143188 Jorge, Ricardo E.; Li, Ruosha; Liu, Xiangyu; McGavin, Jill K.; Shorter, Daryl I.; et al.; Treating alcohol use disorder in U.S. veterans: The role of traumatic brain injury; American Neuropsychiatric Association; Journal of Neuropsychiatry and Clinical Neurosciences; 31; 4; 10-2019; 319-327 0895-0172 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/143188 |
identifier_str_mv |
Jorge, Ricardo E.; Li, Ruosha; Liu, Xiangyu; McGavin, Jill K.; Shorter, Daryl I.; et al.; Treating alcohol use disorder in U.S. veterans: The role of traumatic brain injury; American Neuropsychiatric Association; Journal of Neuropsychiatry and Clinical Neurosciences; 31; 4; 10-2019; 319-327 0895-0172 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://psychiatryonline.org/doi/10.1176/appi.neuropsych.18110250 info:eu-repo/semantics/altIdentifier/doi/10.1176/appi.neuropsych.18110250 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Neuropsychiatric Association |
publisher.none.fl_str_mv |
American Neuropsychiatric Association |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613516908036096 |
score |
13.070432 |