Paracellular absorption in laboratory mice: Molecule size-dependent but low capacity

Autores
Fasulo, Verónica; Zhang, Zhiqiang; Price, Edwin; Chediack, Juan Gabriel; Karasov, William H.; Caviedes Vidal, Enrique Juan Raul
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Water-soluble nutrients are absorbed by the small intestine via transcellular and paracellular processes. The capacity for paracellular absorption seems lower in nonfliers than in fliers, although that conclusion rests largely on a comparison of relatively larger nonflying mammals (> 155 g) and relatively smaller flying birds (< 155 g). We report on paracellular absorption in laboratory mice, the smallest nonflying mammal species studied to date. Using a standard pharmacokinetic technique, we measured the extent of absorption (fractional absorption = f) of inert carbohydrate probes: l-arabinose (Mr = 150.13 Da) and cellobiose (342.3) that are absorbed exclusively by the paracellular route, and 3-O-methyl d-glucose (3OMD-glucose) (Mr = 194) absorbed both paracellularly and transcellularly. f was measured accurately in urine collection trials of 5?10 h duration. Absorption of 3OMD-glucose by mice was essentially complete (f = 0.95 ± 0.07) and much higher than that for l-arabinose (f = 0.21 ± 0.02), indicating that in mice, like other nonflying mammals, > 80% of glucose is absorbed by mediated process(es) rather than the passive, paracellular route. As in all other vertebrates, absorption of cellobiose (f = 0.13 ± 0.02) was even lower than that for l-arabinose, suggesting an equivalent molecular size cut-off for flying and nonflying animals and thus a comparable effective TJ aperture. An important ecological implication is that smaller water-soluble plant secondary metabolites that have been shown to be absorbed by the paracellular path in cell culture, such as phenolics and alkaloids, might be absorbed in substantial amounts by bats and small birds relative to nonflying mammals such as mice.
Fil: Fasulo, Verónica. Universidad Nacional de San Luis. Facultad de Ciencias Humanas. Laboratorio de Biología "Profesor Enrique Cavides Codelia"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias Humanas; Argentina
Fil: Zhang, Zhiqiang. Universidad Nacional de San Luis. Facultad de Ciencias Humanas. Laboratorio de Biología "Profesor Enrique Cavides Codelia"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Price, Edwin. University of Wisconsin. Department of Forestry and Wildlife Ecology; Estados Unidos
Fil: Chediack, Juan Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigación Biológica de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias Humanas. Laboratorio de Biología "Profesor Enrique Cavides Codelia"; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina
Fil: Karasov, William H.. University of Wisconsin. Department of Forestry and Wildlife Ecology; Estados Unidos
Fil: Caviedes Vidal, Enrique Juan Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigación Biológica de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias Humanas. Laboratorio de Biología "Profesor Enrique Cavides Codelia"; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina
Materia
Intestine
L-Arabinose
Mediated Absorption
Paracellular Absorption
3-O-Methyl-D-Glucose
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/4360

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network_name_str CONICET Digital (CONICET)
spelling Paracellular absorption in laboratory mice: Molecule size-dependent but low capacityFasulo, VerónicaZhang, ZhiqiangPrice, EdwinChediack, Juan GabrielKarasov, William H.Caviedes Vidal, Enrique Juan RaulIntestineL-ArabinoseMediated AbsorptionParacellular Absorption3-O-Methyl-D-Glucosehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Water-soluble nutrients are absorbed by the small intestine via transcellular and paracellular processes. The capacity for paracellular absorption seems lower in nonfliers than in fliers, although that conclusion rests largely on a comparison of relatively larger nonflying mammals (> 155 g) and relatively smaller flying birds (< 155 g). We report on paracellular absorption in laboratory mice, the smallest nonflying mammal species studied to date. Using a standard pharmacokinetic technique, we measured the extent of absorption (fractional absorption = f) of inert carbohydrate probes: l-arabinose (Mr = 150.13 Da) and cellobiose (342.3) that are absorbed exclusively by the paracellular route, and 3-O-methyl d-glucose (3OMD-glucose) (Mr = 194) absorbed both paracellularly and transcellularly. f was measured accurately in urine collection trials of 5?10 h duration. Absorption of 3OMD-glucose by mice was essentially complete (f = 0.95 ± 0.07) and much higher than that for l-arabinose (f = 0.21 ± 0.02), indicating that in mice, like other nonflying mammals, > 80% of glucose is absorbed by mediated process(es) rather than the passive, paracellular route. As in all other vertebrates, absorption of cellobiose (f = 0.13 ± 0.02) was even lower than that for l-arabinose, suggesting an equivalent molecular size cut-off for flying and nonflying animals and thus a comparable effective TJ aperture. An important ecological implication is that smaller water-soluble plant secondary metabolites that have been shown to be absorbed by the paracellular path in cell culture, such as phenolics and alkaloids, might be absorbed in substantial amounts by bats and small birds relative to nonflying mammals such as mice.Fil: Fasulo, Verónica. Universidad Nacional de San Luis. Facultad de Ciencias Humanas. Laboratorio de Biología "Profesor Enrique Cavides Codelia"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias Humanas; ArgentinaFil: Zhang, Zhiqiang. Universidad Nacional de San Luis. Facultad de Ciencias Humanas. Laboratorio de Biología "Profesor Enrique Cavides Codelia"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Price, Edwin. University of Wisconsin. Department of Forestry and Wildlife Ecology; Estados UnidosFil: Chediack, Juan Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigación Biológica de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias Humanas. Laboratorio de Biología "Profesor Enrique Cavides Codelia"; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; ArgentinaFil: Karasov, William H.. University of Wisconsin. Department of Forestry and Wildlife Ecology; Estados UnidosFil: Caviedes Vidal, Enrique Juan Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigación Biológica de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias Humanas. Laboratorio de Biología "Profesor Enrique Cavides Codelia"; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; ArgentinaElsevier2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/4360Fasulo, Verónica; Zhang, Zhiqiang; Price, Edwin; Chediack, Juan Gabriel; Karasov, William H.; et al.; Paracellular absorption in laboratory mice: Molecule size-dependent but low capacity; Elsevier; Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology; 164; 1; 2-2013; 71-761095-6433enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1095643312004710info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cbpa.2012.09.008info:eu-repo/semantics/altIdentifier/issn/1095-6433info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:05Zoai:ri.conicet.gov.ar:11336/4360instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:05.313CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Paracellular absorption in laboratory mice: Molecule size-dependent but low capacity
title Paracellular absorption in laboratory mice: Molecule size-dependent but low capacity
spellingShingle Paracellular absorption in laboratory mice: Molecule size-dependent but low capacity
Fasulo, Verónica
Intestine
L-Arabinose
Mediated Absorption
Paracellular Absorption
3-O-Methyl-D-Glucose
title_short Paracellular absorption in laboratory mice: Molecule size-dependent but low capacity
title_full Paracellular absorption in laboratory mice: Molecule size-dependent but low capacity
title_fullStr Paracellular absorption in laboratory mice: Molecule size-dependent but low capacity
title_full_unstemmed Paracellular absorption in laboratory mice: Molecule size-dependent but low capacity
title_sort Paracellular absorption in laboratory mice: Molecule size-dependent but low capacity
dc.creator.none.fl_str_mv Fasulo, Verónica
Zhang, Zhiqiang
Price, Edwin
Chediack, Juan Gabriel
Karasov, William H.
Caviedes Vidal, Enrique Juan Raul
author Fasulo, Verónica
author_facet Fasulo, Verónica
Zhang, Zhiqiang
Price, Edwin
Chediack, Juan Gabriel
Karasov, William H.
Caviedes Vidal, Enrique Juan Raul
author_role author
author2 Zhang, Zhiqiang
Price, Edwin
Chediack, Juan Gabriel
Karasov, William H.
Caviedes Vidal, Enrique Juan Raul
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Intestine
L-Arabinose
Mediated Absorption
Paracellular Absorption
3-O-Methyl-D-Glucose
topic Intestine
L-Arabinose
Mediated Absorption
Paracellular Absorption
3-O-Methyl-D-Glucose
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Water-soluble nutrients are absorbed by the small intestine via transcellular and paracellular processes. The capacity for paracellular absorption seems lower in nonfliers than in fliers, although that conclusion rests largely on a comparison of relatively larger nonflying mammals (> 155 g) and relatively smaller flying birds (< 155 g). We report on paracellular absorption in laboratory mice, the smallest nonflying mammal species studied to date. Using a standard pharmacokinetic technique, we measured the extent of absorption (fractional absorption = f) of inert carbohydrate probes: l-arabinose (Mr = 150.13 Da) and cellobiose (342.3) that are absorbed exclusively by the paracellular route, and 3-O-methyl d-glucose (3OMD-glucose) (Mr = 194) absorbed both paracellularly and transcellularly. f was measured accurately in urine collection trials of 5?10 h duration. Absorption of 3OMD-glucose by mice was essentially complete (f = 0.95 ± 0.07) and much higher than that for l-arabinose (f = 0.21 ± 0.02), indicating that in mice, like other nonflying mammals, > 80% of glucose is absorbed by mediated process(es) rather than the passive, paracellular route. As in all other vertebrates, absorption of cellobiose (f = 0.13 ± 0.02) was even lower than that for l-arabinose, suggesting an equivalent molecular size cut-off for flying and nonflying animals and thus a comparable effective TJ aperture. An important ecological implication is that smaller water-soluble plant secondary metabolites that have been shown to be absorbed by the paracellular path in cell culture, such as phenolics and alkaloids, might be absorbed in substantial amounts by bats and small birds relative to nonflying mammals such as mice.
Fil: Fasulo, Verónica. Universidad Nacional de San Luis. Facultad de Ciencias Humanas. Laboratorio de Biología "Profesor Enrique Cavides Codelia"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias Humanas; Argentina
Fil: Zhang, Zhiqiang. Universidad Nacional de San Luis. Facultad de Ciencias Humanas. Laboratorio de Biología "Profesor Enrique Cavides Codelia"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Price, Edwin. University of Wisconsin. Department of Forestry and Wildlife Ecology; Estados Unidos
Fil: Chediack, Juan Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigación Biológica de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias Humanas. Laboratorio de Biología "Profesor Enrique Cavides Codelia"; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina
Fil: Karasov, William H.. University of Wisconsin. Department of Forestry and Wildlife Ecology; Estados Unidos
Fil: Caviedes Vidal, Enrique Juan Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigación Biológica de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias Humanas. Laboratorio de Biología "Profesor Enrique Cavides Codelia"; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina
description Water-soluble nutrients are absorbed by the small intestine via transcellular and paracellular processes. The capacity for paracellular absorption seems lower in nonfliers than in fliers, although that conclusion rests largely on a comparison of relatively larger nonflying mammals (> 155 g) and relatively smaller flying birds (< 155 g). We report on paracellular absorption in laboratory mice, the smallest nonflying mammal species studied to date. Using a standard pharmacokinetic technique, we measured the extent of absorption (fractional absorption = f) of inert carbohydrate probes: l-arabinose (Mr = 150.13 Da) and cellobiose (342.3) that are absorbed exclusively by the paracellular route, and 3-O-methyl d-glucose (3OMD-glucose) (Mr = 194) absorbed both paracellularly and transcellularly. f was measured accurately in urine collection trials of 5?10 h duration. Absorption of 3OMD-glucose by mice was essentially complete (f = 0.95 ± 0.07) and much higher than that for l-arabinose (f = 0.21 ± 0.02), indicating that in mice, like other nonflying mammals, > 80% of glucose is absorbed by mediated process(es) rather than the passive, paracellular route. As in all other vertebrates, absorption of cellobiose (f = 0.13 ± 0.02) was even lower than that for l-arabinose, suggesting an equivalent molecular size cut-off for flying and nonflying animals and thus a comparable effective TJ aperture. An important ecological implication is that smaller water-soluble plant secondary metabolites that have been shown to be absorbed by the paracellular path in cell culture, such as phenolics and alkaloids, might be absorbed in substantial amounts by bats and small birds relative to nonflying mammals such as mice.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/4360
Fasulo, Verónica; Zhang, Zhiqiang; Price, Edwin; Chediack, Juan Gabriel; Karasov, William H.; et al.; Paracellular absorption in laboratory mice: Molecule size-dependent but low capacity; Elsevier; Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology; 164; 1; 2-2013; 71-76
1095-6433
url http://hdl.handle.net/11336/4360
identifier_str_mv Fasulo, Verónica; Zhang, Zhiqiang; Price, Edwin; Chediack, Juan Gabriel; Karasov, William H.; et al.; Paracellular absorption in laboratory mice: Molecule size-dependent but low capacity; Elsevier; Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology; 164; 1; 2-2013; 71-76
1095-6433
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cbpa.2012.09.008
info:eu-repo/semantics/altIdentifier/issn/1095-6433
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
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