Integrated dynamic physiological model for drug infusion simulation studies

Autores
Montain, María Elisa; Blanco, Anibal Manuel; Bandoni, Jose Alberto
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This work presents a dynamic model that integrates some of the main processes of the human physiology. It is aimed at simulating the behavior of most relevant variables in response to the administration of typical drugs used in medical procedures. The model integrates the following submodels available in the open literature: (i) cardiovascular, (ii) baroreflex, (iii) respiration, (iv) transport and distribution of substances, (v) pharmacological effects of drugs. The integrated model has a difficult mathematical structure due to the nonlinearity present in most relationships and the occurrence of time events associated with heart valves and other discontinuous phenomena. An efficient computational implementation was developed in the Fortran programming language and applied to several case studies. The results are in reasonable agreement with published experimental data although further studies are required to improve the model accuracy for real applications. The simulation model can be used as a computational tool for medical training and off-line diagnosis, as well as the basis for a patient specific online decision support system.
Fil: Montain, María Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur; Argentina
Fil: Blanco, Anibal Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur; Argentina
Fil: Bandoni, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur; Argentina
Materia
Physiological Model
Drug Infusion
Simulation Studies
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13421
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/13421
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Integrated dynamic physiological model for drug infusion simulation studiesMontain, María ElisaBlanco, Anibal ManuelBandoni, Jose AlbertoPhysiological ModelDrug InfusionSimulation Studieshttps://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1This work presents a dynamic model that integrates some of the main processes of the human physiology. It is aimed at simulating the behavior of most relevant variables in response to the administration of typical drugs used in medical procedures. The model integrates the following submodels available in the open literature: (i) cardiovascular, (ii) baroreflex, (iii) respiration, (iv) transport and distribution of substances, (v) pharmacological effects of drugs. The integrated model has a difficult mathematical structure due to the nonlinearity present in most relationships and the occurrence of time events associated with heart valves and other discontinuous phenomena. An efficient computational implementation was developed in the Fortran programming language and applied to several case studies. The results are in reasonable agreement with published experimental data although further studies are required to improve the model accuracy for real applications. The simulation model can be used as a computational tool for medical training and off-line diagnosis, as well as the basis for a patient specific online decision support system.Fil: Montain, María Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur; ArgentinaFil: Blanco, Anibal Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur; ArgentinaFil: Bandoni, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur; ArgentinaAmerican Chemical Society2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13421Montain, María Elisa; Blanco, Anibal Manuel; Bandoni, Jose Alberto; Integrated dynamic physiological model for drug infusion simulation studies; American Chemical Society; Industrial & Engineering Chemical Research; 53; 44; 8-2014; 17267-172810888-5885enginfo:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/ie5008823info:eu-repo/semantics/altIdentifier/doi/10.1021/ie5008823info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:02:54Zoai:ri.conicet.gov.ar:11336/13421instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:02:55.181CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Integrated dynamic physiological model for drug infusion simulation studies
title Integrated dynamic physiological model for drug infusion simulation studies
spellingShingle Integrated dynamic physiological model for drug infusion simulation studies
Montain, María Elisa
Physiological Model
Drug Infusion
Simulation Studies
title_short Integrated dynamic physiological model for drug infusion simulation studies
title_full Integrated dynamic physiological model for drug infusion simulation studies
title_fullStr Integrated dynamic physiological model for drug infusion simulation studies
title_full_unstemmed Integrated dynamic physiological model for drug infusion simulation studies
title_sort Integrated dynamic physiological model for drug infusion simulation studies
dc.creator.none.fl_str_mv Montain, María Elisa
Blanco, Anibal Manuel
Bandoni, Jose Alberto
author Montain, María Elisa
author_facet Montain, María Elisa
Blanco, Anibal Manuel
Bandoni, Jose Alberto
author_role author
author2 Blanco, Anibal Manuel
Bandoni, Jose Alberto
author2_role author
author
dc.subject.none.fl_str_mv Physiological Model
Drug Infusion
Simulation Studies
topic Physiological Model
Drug Infusion
Simulation Studies
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This work presents a dynamic model that integrates some of the main processes of the human physiology. It is aimed at simulating the behavior of most relevant variables in response to the administration of typical drugs used in medical procedures. The model integrates the following submodels available in the open literature: (i) cardiovascular, (ii) baroreflex, (iii) respiration, (iv) transport and distribution of substances, (v) pharmacological effects of drugs. The integrated model has a difficult mathematical structure due to the nonlinearity present in most relationships and the occurrence of time events associated with heart valves and other discontinuous phenomena. An efficient computational implementation was developed in the Fortran programming language and applied to several case studies. The results are in reasonable agreement with published experimental data although further studies are required to improve the model accuracy for real applications. The simulation model can be used as a computational tool for medical training and off-line diagnosis, as well as the basis for a patient specific online decision support system.
Fil: Montain, María Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur; Argentina
Fil: Blanco, Anibal Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur; Argentina
Fil: Bandoni, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Planta Piloto de Ingeniería Química (i); Argentina. Universidad Nacional del Sur; Argentina
description This work presents a dynamic model that integrates some of the main processes of the human physiology. It is aimed at simulating the behavior of most relevant variables in response to the administration of typical drugs used in medical procedures. The model integrates the following submodels available in the open literature: (i) cardiovascular, (ii) baroreflex, (iii) respiration, (iv) transport and distribution of substances, (v) pharmacological effects of drugs. The integrated model has a difficult mathematical structure due to the nonlinearity present in most relationships and the occurrence of time events associated with heart valves and other discontinuous phenomena. An efficient computational implementation was developed in the Fortran programming language and applied to several case studies. The results are in reasonable agreement with published experimental data although further studies are required to improve the model accuracy for real applications. The simulation model can be used as a computational tool for medical training and off-line diagnosis, as well as the basis for a patient specific online decision support system.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13421
Montain, María Elisa; Blanco, Anibal Manuel; Bandoni, Jose Alberto; Integrated dynamic physiological model for drug infusion simulation studies; American Chemical Society; Industrial & Engineering Chemical Research; 53; 44; 8-2014; 17267-17281
0888-5885
url http://hdl.handle.net/11336/13421
identifier_str_mv Montain, María Elisa; Blanco, Anibal Manuel; Bandoni, Jose Alberto; Integrated dynamic physiological model for drug infusion simulation studies; American Chemical Society; Industrial & Engineering Chemical Research; 53; 44; 8-2014; 17267-17281
0888-5885
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/ie5008823
info:eu-repo/semantics/altIdentifier/doi/10.1021/ie5008823
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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