Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies

Autores
Fernández Esteberena, Pablo Ricardo; Cortese, Lorenzo; Zanoletti, Marta; Lo Presti, Giuseppe; Aranda Velazquez, Gloria; Ruiz Janer, Sabina; Buttafava, Mauro; Renna, Marco; Di Sieno, Laura; Tosi, Alberto; Dalla Mora, Alberto; Wojtkiewicz, Stanislaw; Dehghani, Hamid; de Fraguier, Sixte; Nguyen-Dinh, An; Rosinski, Bogdan; Weigel, Udo M.; Sarangi, Dibya J.; Squarcia, Mattia; Hanzu, Felicia A.; Contini, Davide; Mora Porta, Mireia; Durduran, Turgut
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Thyroid vascularization and hemodynamics become altered in thyroid pathologies and could thus inform diagnostics, therapy planning, and follow-up. However, the current non-invasive monitoring methods available in clinics lack the necessary sensitivity and/or are impractical for large-scale deployment. As a step towards proposing a new modality, we applied the first platform, to our knowledge, designed to do simultaneous measurements of neck anatomy and thyroid microvascular hemodynamics and metabolism in a single probe placement, integrating state-of-the-art near-infrared spectroscopy techniques and clinical ultrasound. A rich dataset was formed with sixty-five subjects (forty-eight females), including eighteen healthy volunteers and forty-seven patients with thyroid nodules, characterizing thyroid tissue and the effects of demographic and anatomical variables while preserving the standard clinical workflow. We have found marked reductions with age and body mass index in thyroid total hemoglobin concentration (THC), tissue oxygen saturation (StO2), and blood flow index (BFi), among others. Patients showed lower THC and BFi than healthy subjects, and the limited sample of malignant nodules showed a higher StO2 than the benign. These findings support the need for personalized clinical approaches.
Fil: Fernández Esteberena, Pablo Ricardo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Instituto de Física Arroyo Seco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. The Barcelona Institute of Science and Technology; España
Fil: Cortese, Lorenzo. The Barcelona Institute of Science and Technology; España
Fil: Zanoletti, Marta. Politecnico di Milano; Italia. The Barcelona Institute of Science and Technology; España
Fil: Lo Presti, Giuseppe. The Barcelona Institute of Science and Technology; España
Fil: Aranda Velazquez, Gloria. The Barcelona Institute of Science and Technology; España
Fil: Ruiz Janer, Sabina. The Barcelona Institute of Science and Technology; España
Fil: Buttafava, Mauro. Now At Pionirs S.r.l.; Italia. Politecnico di Milano; Italia
Fil: Renna, Marco. Athinoula Martinos Center For Biomedical Imaging ; Massachusetts General Hospital ; Department Of Medicine ; Harvard Medical School; . Politecnico di Milano; Italia
Fil: Di Sieno, Laura. Politecnico di Milano; Italia
Fil: Tosi, Alberto. Politecnico di Milano; Italia
Fil: Dalla Mora, Alberto. Politecnico di Milano; Italia
Fil: Wojtkiewicz, Stanislaw. University Of Birmingham; . Polish Academy of Sciences; Argentina
Fil: Dehghani, Hamid. University Of Birmingham;
Fil: de Fraguier, Sixte. IMV Imaging; Francia
Fil: Nguyen-Dinh, An. Vermon S. A.; Francia
Fil: Rosinski, Bogdan. Vermon S. A.; Francia
Fil: Weigel, Udo M.. Hemophotonics S. L.; España
Fil: Sarangi, Dibya J.. The Barcelona Institute of Science and Technology; España
Fil: Squarcia, Mattia. Hospital Clinic Barcelona; España
Fil: Hanzu, Felicia A.. Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas; España. Hospital Clinic Barcelona; España
Fil: Contini, Davide. Politecnico di Milano; Italia
Fil: Mora Porta, Mireia. Fundació Clínic per la Recerca Biomèdica; España. Hospital Clinic Barcelona; España. Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas; España
Fil: Durduran, Turgut. Institució Catalana de Recerca i Estudis Avancats; España. The Barcelona Institute of Science and Technology; España
Materia
THYROID HEMODYNAMICS
NEAR INFRARED SPECTROSCOPY
ULTRASOUND
THYROID NODULE HEMODYNAMICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/274378
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopiesFernández Esteberena, Pablo RicardoCortese, LorenzoZanoletti, MartaLo Presti, GiuseppeAranda Velazquez, GloriaRuiz Janer, SabinaButtafava, MauroRenna, MarcoDi Sieno, LauraTosi, AlbertoDalla Mora, AlbertoWojtkiewicz, StanislawDehghani, Hamidde Fraguier, SixteNguyen-Dinh, AnRosinski, BogdanWeigel, Udo M.Sarangi, Dibya J.Squarcia, MattiaHanzu, Felicia A.Contini, DavideMora Porta, MireiaDurduran, TurgutTHYROID HEMODYNAMICSNEAR INFRARED SPECTROSCOPYULTRASOUNDTHYROID NODULE HEMODYNAMICShttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Thyroid vascularization and hemodynamics become altered in thyroid pathologies and could thus inform diagnostics, therapy planning, and follow-up. However, the current non-invasive monitoring methods available in clinics lack the necessary sensitivity and/or are impractical for large-scale deployment. As a step towards proposing a new modality, we applied the first platform, to our knowledge, designed to do simultaneous measurements of neck anatomy and thyroid microvascular hemodynamics and metabolism in a single probe placement, integrating state-of-the-art near-infrared spectroscopy techniques and clinical ultrasound. A rich dataset was formed with sixty-five subjects (forty-eight females), including eighteen healthy volunteers and forty-seven patients with thyroid nodules, characterizing thyroid tissue and the effects of demographic and anatomical variables while preserving the standard clinical workflow. We have found marked reductions with age and body mass index in thyroid total hemoglobin concentration (THC), tissue oxygen saturation (StO2), and blood flow index (BFi), among others. Patients showed lower THC and BFi than healthy subjects, and the limited sample of malignant nodules showed a higher StO2 than the benign. These findings support the need for personalized clinical approaches.Fil: Fernández Esteberena, Pablo Ricardo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Instituto de Física Arroyo Seco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. The Barcelona Institute of Science and Technology; EspañaFil: Cortese, Lorenzo. The Barcelona Institute of Science and Technology; EspañaFil: Zanoletti, Marta. Politecnico di Milano; Italia. The Barcelona Institute of Science and Technology; EspañaFil: Lo Presti, Giuseppe. The Barcelona Institute of Science and Technology; EspañaFil: Aranda Velazquez, Gloria. The Barcelona Institute of Science and Technology; EspañaFil: Ruiz Janer, Sabina. The Barcelona Institute of Science and Technology; EspañaFil: Buttafava, Mauro. Now At Pionirs S.r.l.; Italia. Politecnico di Milano; ItaliaFil: Renna, Marco. Athinoula Martinos Center For Biomedical Imaging ; Massachusetts General Hospital ; Department Of Medicine ; Harvard Medical School; . Politecnico di Milano; ItaliaFil: Di Sieno, Laura. Politecnico di Milano; ItaliaFil: Tosi, Alberto. Politecnico di Milano; ItaliaFil: Dalla Mora, Alberto. Politecnico di Milano; ItaliaFil: Wojtkiewicz, Stanislaw. University Of Birmingham; . Polish Academy of Sciences; ArgentinaFil: Dehghani, Hamid. University Of Birmingham;Fil: de Fraguier, Sixte. IMV Imaging; FranciaFil: Nguyen-Dinh, An. Vermon S. A.; FranciaFil: Rosinski, Bogdan. Vermon S. A.; FranciaFil: Weigel, Udo M.. Hemophotonics S. L.; EspañaFil: Sarangi, Dibya J.. The Barcelona Institute of Science and Technology; EspañaFil: Squarcia, Mattia. Hospital Clinic Barcelona; EspañaFil: Hanzu, Felicia A.. Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas; España. Hospital Clinic Barcelona; EspañaFil: Contini, Davide. Politecnico di Milano; ItaliaFil: Mora Porta, Mireia. Fundació Clínic per la Recerca Biomèdica; España. Hospital Clinic Barcelona; España. Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas; EspañaFil: Durduran, Turgut. Institució Catalana de Recerca i Estudis Avancats; España. The Barcelona Institute of Science and Technology; EspañaOptica Publishing Group2024-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/274378Fernández Esteberena, Pablo Ricardo; Cortese, Lorenzo; Zanoletti, Marta; Lo Presti, Giuseppe; Aranda Velazquez, Gloria; et al.; Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies; Optica Publishing Group; Biomedical Optics Express; 15; 12; 11-2024; 1-212156-70852156-7085CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://opg.optica.org/abstract.cfm?URI=boe-15-12-7035info:eu-repo/semantics/altIdentifier/doi/10.1364/BOE.538141info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T10:37:07Zoai:ri.conicet.gov.ar:11336/274378instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 10:37:07.518CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies
title Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies
spellingShingle Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies
Fernández Esteberena, Pablo Ricardo
THYROID HEMODYNAMICS
NEAR INFRARED SPECTROSCOPY
ULTRASOUND
THYROID NODULE HEMODYNAMICS
title_short Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies
title_full Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies
title_fullStr Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies
title_full_unstemmed Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies
title_sort Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies
dc.creator.none.fl_str_mv Fernández Esteberena, Pablo Ricardo
Cortese, Lorenzo
Zanoletti, Marta
Lo Presti, Giuseppe
Aranda Velazquez, Gloria
Ruiz Janer, Sabina
Buttafava, Mauro
Renna, Marco
Di Sieno, Laura
Tosi, Alberto
Dalla Mora, Alberto
Wojtkiewicz, Stanislaw
Dehghani, Hamid
de Fraguier, Sixte
Nguyen-Dinh, An
Rosinski, Bogdan
Weigel, Udo M.
Sarangi, Dibya J.
Squarcia, Mattia
Hanzu, Felicia A.
Contini, Davide
Mora Porta, Mireia
Durduran, Turgut
author Fernández Esteberena, Pablo Ricardo
author_facet Fernández Esteberena, Pablo Ricardo
Cortese, Lorenzo
Zanoletti, Marta
Lo Presti, Giuseppe
Aranda Velazquez, Gloria
Ruiz Janer, Sabina
Buttafava, Mauro
Renna, Marco
Di Sieno, Laura
Tosi, Alberto
Dalla Mora, Alberto
Wojtkiewicz, Stanislaw
Dehghani, Hamid
de Fraguier, Sixte
Nguyen-Dinh, An
Rosinski, Bogdan
Weigel, Udo M.
Sarangi, Dibya J.
Squarcia, Mattia
Hanzu, Felicia A.
Contini, Davide
Mora Porta, Mireia
Durduran, Turgut
author_role author
author2 Cortese, Lorenzo
Zanoletti, Marta
Lo Presti, Giuseppe
Aranda Velazquez, Gloria
Ruiz Janer, Sabina
Buttafava, Mauro
Renna, Marco
Di Sieno, Laura
Tosi, Alberto
Dalla Mora, Alberto
Wojtkiewicz, Stanislaw
Dehghani, Hamid
de Fraguier, Sixte
Nguyen-Dinh, An
Rosinski, Bogdan
Weigel, Udo M.
Sarangi, Dibya J.
Squarcia, Mattia
Hanzu, Felicia A.
Contini, Davide
Mora Porta, Mireia
Durduran, Turgut
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv THYROID HEMODYNAMICS
NEAR INFRARED SPECTROSCOPY
ULTRASOUND
THYROID NODULE HEMODYNAMICS
topic THYROID HEMODYNAMICS
NEAR INFRARED SPECTROSCOPY
ULTRASOUND
THYROID NODULE HEMODYNAMICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Thyroid vascularization and hemodynamics become altered in thyroid pathologies and could thus inform diagnostics, therapy planning, and follow-up. However, the current non-invasive monitoring methods available in clinics lack the necessary sensitivity and/or are impractical for large-scale deployment. As a step towards proposing a new modality, we applied the first platform, to our knowledge, designed to do simultaneous measurements of neck anatomy and thyroid microvascular hemodynamics and metabolism in a single probe placement, integrating state-of-the-art near-infrared spectroscopy techniques and clinical ultrasound. A rich dataset was formed with sixty-five subjects (forty-eight females), including eighteen healthy volunteers and forty-seven patients with thyroid nodules, characterizing thyroid tissue and the effects of demographic and anatomical variables while preserving the standard clinical workflow. We have found marked reductions with age and body mass index in thyroid total hemoglobin concentration (THC), tissue oxygen saturation (StO2), and blood flow index (BFi), among others. Patients showed lower THC and BFi than healthy subjects, and the limited sample of malignant nodules showed a higher StO2 than the benign. These findings support the need for personalized clinical approaches.
Fil: Fernández Esteberena, Pablo Ricardo. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Instituto de Física Arroyo Seco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. The Barcelona Institute of Science and Technology; España
Fil: Cortese, Lorenzo. The Barcelona Institute of Science and Technology; España
Fil: Zanoletti, Marta. Politecnico di Milano; Italia. The Barcelona Institute of Science and Technology; España
Fil: Lo Presti, Giuseppe. The Barcelona Institute of Science and Technology; España
Fil: Aranda Velazquez, Gloria. The Barcelona Institute of Science and Technology; España
Fil: Ruiz Janer, Sabina. The Barcelona Institute of Science and Technology; España
Fil: Buttafava, Mauro. Now At Pionirs S.r.l.; Italia. Politecnico di Milano; Italia
Fil: Renna, Marco. Athinoula Martinos Center For Biomedical Imaging ; Massachusetts General Hospital ; Department Of Medicine ; Harvard Medical School; . Politecnico di Milano; Italia
Fil: Di Sieno, Laura. Politecnico di Milano; Italia
Fil: Tosi, Alberto. Politecnico di Milano; Italia
Fil: Dalla Mora, Alberto. Politecnico di Milano; Italia
Fil: Wojtkiewicz, Stanislaw. University Of Birmingham; . Polish Academy of Sciences; Argentina
Fil: Dehghani, Hamid. University Of Birmingham;
Fil: de Fraguier, Sixte. IMV Imaging; Francia
Fil: Nguyen-Dinh, An. Vermon S. A.; Francia
Fil: Rosinski, Bogdan. Vermon S. A.; Francia
Fil: Weigel, Udo M.. Hemophotonics S. L.; España
Fil: Sarangi, Dibya J.. The Barcelona Institute of Science and Technology; España
Fil: Squarcia, Mattia. Hospital Clinic Barcelona; España
Fil: Hanzu, Felicia A.. Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas; España. Hospital Clinic Barcelona; España
Fil: Contini, Davide. Politecnico di Milano; Italia
Fil: Mora Porta, Mireia. Fundació Clínic per la Recerca Biomèdica; España. Hospital Clinic Barcelona; España. Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas; España
Fil: Durduran, Turgut. Institució Catalana de Recerca i Estudis Avancats; España. The Barcelona Institute of Science and Technology; España
description Thyroid vascularization and hemodynamics become altered in thyroid pathologies and could thus inform diagnostics, therapy planning, and follow-up. However, the current non-invasive monitoring methods available in clinics lack the necessary sensitivity and/or are impractical for large-scale deployment. As a step towards proposing a new modality, we applied the first platform, to our knowledge, designed to do simultaneous measurements of neck anatomy and thyroid microvascular hemodynamics and metabolism in a single probe placement, integrating state-of-the-art near-infrared spectroscopy techniques and clinical ultrasound. A rich dataset was formed with sixty-five subjects (forty-eight females), including eighteen healthy volunteers and forty-seven patients with thyroid nodules, characterizing thyroid tissue and the effects of demographic and anatomical variables while preserving the standard clinical workflow. We have found marked reductions with age and body mass index in thyroid total hemoglobin concentration (THC), tissue oxygen saturation (StO2), and blood flow index (BFi), among others. Patients showed lower THC and BFi than healthy subjects, and the limited sample of malignant nodules showed a higher StO2 than the benign. These findings support the need for personalized clinical approaches.
publishDate 2024
dc.date.none.fl_str_mv 2024-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/274378
Fernández Esteberena, Pablo Ricardo; Cortese, Lorenzo; Zanoletti, Marta; Lo Presti, Giuseppe; Aranda Velazquez, Gloria; et al.; Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies; Optica Publishing Group; Biomedical Optics Express; 15; 12; 11-2024; 1-21
2156-7085
2156-7085
CONICET Digital
CONICET
url http://hdl.handle.net/11336/274378
identifier_str_mv Fernández Esteberena, Pablo Ricardo; Cortese, Lorenzo; Zanoletti, Marta; Lo Presti, Giuseppe; Aranda Velazquez, Gloria; et al.; Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies; Optica Publishing Group; Biomedical Optics Express; 15; 12; 11-2024; 1-21
2156-7085
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://opg.optica.org/abstract.cfm?URI=boe-15-12-7035
info:eu-repo/semantics/altIdentifier/doi/10.1364/BOE.538141
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Optica Publishing Group
publisher.none.fl_str_mv Optica Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.087074

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