Growth model for cholesterol accumulation in the wall of a simplified 3D geometry of the carotid bifurcation

Autores
Gessaghi, Valeria Cristina; Raschi, Marcelo A.; Tanoni, Debora Y.; Perazzo, Carlos Alberto; Larreteguy, Axel Eduardo
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Atherosclerosis is one of the leading causes of death in the first world countries nowadays. It is a vascular disease that affects medium and large size arteries, involving the formation of plaques within the artery wall. These plaques result from the accumulation of fat, cholesterol, cell debris, smooth muscle cells and other cells and substances, and may cause temporary or definitive lack of blood supply to an organ.This article proposes a model for cholesterol accumulation and plaque growth. The model is basically a mass balance of low density lipoproteins (LDL) in the intima. The inflow, outflow, oxidation, and consumption of LDL is modeled combining partial models and correlations available in the literature.The model was implemented into an open source finite volume code. Assuming steady blood flow, the code was used to predict lesion formation on a three-dimensional model of the carotid artery bifurcation, a location greatly studied for its role in supplying blood to some parts of the brain and for being related to strokes due to formation of atheromas. The simulation was carried out under physiologic conditions for blood pressure and LDL blood concentration.Results for LDL mass accumulation and intimal thickening over time, plaque shape, and location of thicker spots are reported, showing that the proposed model approximates reasonably well the intimal thickening obtained from post-mortem aortic fatty streaks and from B-mode ultrasonography of the carotid artery of healthy subjects reported by other authors.
Fil: Gessaghi, Valeria Cristina. Universidad Nacional de la Pampa. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Raschi, Marcelo A.. Universidad Argentina de la Empresa. Facultad de Ingeniería y Ciencias Exactas; Argentina
Fil: Tanoni, Debora Y.. Universidad Argentina de la Empresa. Facultad de Ingeniería y Ciencias Exactas; Argentina
Fil: Perazzo, Carlos Alberto. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Larreteguy, Axel Eduardo. Universidad Argentina de la Empresa. Facultad de Ingeniería y Ciencias Exactas; Argentina
Materia
ATHEROSCLEROSIS
CHOLESTEROL TRANSPORT
HEMODYNAMICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/188708
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Growth model for cholesterol accumulation in the wall of a simplified 3D geometry of the carotid bifurcationGessaghi, Valeria CristinaRaschi, Marcelo A.Tanoni, Debora Y.Perazzo, Carlos AlbertoLarreteguy, Axel EduardoATHEROSCLEROSISCHOLESTEROL TRANSPORTHEMODYNAMICShttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Atherosclerosis is one of the leading causes of death in the first world countries nowadays. It is a vascular disease that affects medium and large size arteries, involving the formation of plaques within the artery wall. These plaques result from the accumulation of fat, cholesterol, cell debris, smooth muscle cells and other cells and substances, and may cause temporary or definitive lack of blood supply to an organ.This article proposes a model for cholesterol accumulation and plaque growth. The model is basically a mass balance of low density lipoproteins (LDL) in the intima. The inflow, outflow, oxidation, and consumption of LDL is modeled combining partial models and correlations available in the literature.The model was implemented into an open source finite volume code. Assuming steady blood flow, the code was used to predict lesion formation on a three-dimensional model of the carotid artery bifurcation, a location greatly studied for its role in supplying blood to some parts of the brain and for being related to strokes due to formation of atheromas. The simulation was carried out under physiologic conditions for blood pressure and LDL blood concentration.Results for LDL mass accumulation and intimal thickening over time, plaque shape, and location of thicker spots are reported, showing that the proposed model approximates reasonably well the intimal thickening obtained from post-mortem aortic fatty streaks and from B-mode ultrasonography of the carotid artery of healthy subjects reported by other authors.Fil: Gessaghi, Valeria Cristina. Universidad Nacional de la Pampa. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Raschi, Marcelo A.. Universidad Argentina de la Empresa. Facultad de Ingeniería y Ciencias Exactas; ArgentinaFil: Tanoni, Debora Y.. Universidad Argentina de la Empresa. Facultad de Ingeniería y Ciencias Exactas; ArgentinaFil: Perazzo, Carlos Alberto. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Larreteguy, Axel Eduardo. Universidad Argentina de la Empresa. Facultad de Ingeniería y Ciencias Exactas; ArgentinaElsevier Science SA2011-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/188708Gessaghi, Valeria Cristina; Raschi, Marcelo A.; Tanoni, Debora Y.; Perazzo, Carlos Alberto; Larreteguy, Axel Eduardo; Growth model for cholesterol accumulation in the wall of a simplified 3D geometry of the carotid bifurcation; Elsevier Science SA; Computer Methods in Applied Mechanics and Engineering; 200; 23-24; 6-2011; 2117-21250045-7825CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S004578251100106Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cma.2011.03.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:36:48Zoai:ri.conicet.gov.ar:11336/188708instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:36:48.63CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Growth model for cholesterol accumulation in the wall of a simplified 3D geometry of the carotid bifurcation
title Growth model for cholesterol accumulation in the wall of a simplified 3D geometry of the carotid bifurcation
spellingShingle Growth model for cholesterol accumulation in the wall of a simplified 3D geometry of the carotid bifurcation
Gessaghi, Valeria Cristina
ATHEROSCLEROSIS
CHOLESTEROL TRANSPORT
HEMODYNAMICS
title_short Growth model for cholesterol accumulation in the wall of a simplified 3D geometry of the carotid bifurcation
title_full Growth model for cholesterol accumulation in the wall of a simplified 3D geometry of the carotid bifurcation
title_fullStr Growth model for cholesterol accumulation in the wall of a simplified 3D geometry of the carotid bifurcation
title_full_unstemmed Growth model for cholesterol accumulation in the wall of a simplified 3D geometry of the carotid bifurcation
title_sort Growth model for cholesterol accumulation in the wall of a simplified 3D geometry of the carotid bifurcation
dc.creator.none.fl_str_mv Gessaghi, Valeria Cristina
Raschi, Marcelo A.
Tanoni, Debora Y.
Perazzo, Carlos Alberto
Larreteguy, Axel Eduardo
author Gessaghi, Valeria Cristina
author_facet Gessaghi, Valeria Cristina
Raschi, Marcelo A.
Tanoni, Debora Y.
Perazzo, Carlos Alberto
Larreteguy, Axel Eduardo
author_role author
author2 Raschi, Marcelo A.
Tanoni, Debora Y.
Perazzo, Carlos Alberto
Larreteguy, Axel Eduardo
author2_role author
author
author
author
dc.subject.none.fl_str_mv ATHEROSCLEROSIS
CHOLESTEROL TRANSPORT
HEMODYNAMICS
topic ATHEROSCLEROSIS
CHOLESTEROL TRANSPORT
HEMODYNAMICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Atherosclerosis is one of the leading causes of death in the first world countries nowadays. It is a vascular disease that affects medium and large size arteries, involving the formation of plaques within the artery wall. These plaques result from the accumulation of fat, cholesterol, cell debris, smooth muscle cells and other cells and substances, and may cause temporary or definitive lack of blood supply to an organ.This article proposes a model for cholesterol accumulation and plaque growth. The model is basically a mass balance of low density lipoproteins (LDL) in the intima. The inflow, outflow, oxidation, and consumption of LDL is modeled combining partial models and correlations available in the literature.The model was implemented into an open source finite volume code. Assuming steady blood flow, the code was used to predict lesion formation on a three-dimensional model of the carotid artery bifurcation, a location greatly studied for its role in supplying blood to some parts of the brain and for being related to strokes due to formation of atheromas. The simulation was carried out under physiologic conditions for blood pressure and LDL blood concentration.Results for LDL mass accumulation and intimal thickening over time, plaque shape, and location of thicker spots are reported, showing that the proposed model approximates reasonably well the intimal thickening obtained from post-mortem aortic fatty streaks and from B-mode ultrasonography of the carotid artery of healthy subjects reported by other authors.
Fil: Gessaghi, Valeria Cristina. Universidad Nacional de la Pampa. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Raschi, Marcelo A.. Universidad Argentina de la Empresa. Facultad de Ingeniería y Ciencias Exactas; Argentina
Fil: Tanoni, Debora Y.. Universidad Argentina de la Empresa. Facultad de Ingeniería y Ciencias Exactas; Argentina
Fil: Perazzo, Carlos Alberto. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Larreteguy, Axel Eduardo. Universidad Argentina de la Empresa. Facultad de Ingeniería y Ciencias Exactas; Argentina
description Atherosclerosis is one of the leading causes of death in the first world countries nowadays. It is a vascular disease that affects medium and large size arteries, involving the formation of plaques within the artery wall. These plaques result from the accumulation of fat, cholesterol, cell debris, smooth muscle cells and other cells and substances, and may cause temporary or definitive lack of blood supply to an organ.This article proposes a model for cholesterol accumulation and plaque growth. The model is basically a mass balance of low density lipoproteins (LDL) in the intima. The inflow, outflow, oxidation, and consumption of LDL is modeled combining partial models and correlations available in the literature.The model was implemented into an open source finite volume code. Assuming steady blood flow, the code was used to predict lesion formation on a three-dimensional model of the carotid artery bifurcation, a location greatly studied for its role in supplying blood to some parts of the brain and for being related to strokes due to formation of atheromas. The simulation was carried out under physiologic conditions for blood pressure and LDL blood concentration.Results for LDL mass accumulation and intimal thickening over time, plaque shape, and location of thicker spots are reported, showing that the proposed model approximates reasonably well the intimal thickening obtained from post-mortem aortic fatty streaks and from B-mode ultrasonography of the carotid artery of healthy subjects reported by other authors.
publishDate 2011
dc.date.none.fl_str_mv 2011-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/188708
Gessaghi, Valeria Cristina; Raschi, Marcelo A.; Tanoni, Debora Y.; Perazzo, Carlos Alberto; Larreteguy, Axel Eduardo; Growth model for cholesterol accumulation in the wall of a simplified 3D geometry of the carotid bifurcation; Elsevier Science SA; Computer Methods in Applied Mechanics and Engineering; 200; 23-24; 6-2011; 2117-2125
0045-7825
CONICET Digital
CONICET
url http://hdl.handle.net/11336/188708
identifier_str_mv Gessaghi, Valeria Cristina; Raschi, Marcelo A.; Tanoni, Debora Y.; Perazzo, Carlos Alberto; Larreteguy, Axel Eduardo; Growth model for cholesterol accumulation in the wall of a simplified 3D geometry of the carotid bifurcation; Elsevier Science SA; Computer Methods in Applied Mechanics and Engineering; 200; 23-24; 6-2011; 2117-2125
0045-7825
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S004578251100106X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cma.2011.03.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science SA
publisher.none.fl_str_mv Elsevier Science SA
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083490345385984
score 13.22299

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