Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population

Autores
Vera, María Inés; Meroño, Tomás; Urrutia, María Agustina; Parisi, Carina; Morosan, Yanina; Rosmarin, Melanie; Schnitman, Marta; Brites, Fernando Daniel; Grisendi, Silvio; Serrano, María Sol; Luciani, Wilfredo; Serrano, Leonardo; Zuk, Carlos; de Barrio, Guillermo; Cejas, Claudia; Faingold, María Cristina; Brenta, Gabriela
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective. Ultrasonographic characteristics are associated with thyroid malignancy. Our aim was to compare the diagnostic value of ultrasound features in the detection of thyroid malignancy in both solid and mixed nodules. Methods. We prospectively studied female patients (≥50 years) referred to ultrasound-guided fine needle aspiration biopsy. Ultrasound features considered suspicious were hypoechogenicity, microcalcifications, irregular margins, high anteroposterior (AP)/axial-ratio, and absent halo. Associations were separately assessed in mixed and solid nodules. Results. In a group of 504 elderly female patients (age =  years), the frequency of malignant cytology was 6%. Thirty-one percent of nodules were mixed and 60% were solid. The rate of malignant cytology was similar for mixed and solid nodules (7.4 versus 5.8%, : 0.56). While in mixed nodules none of the ultrasound characteristics were associated with malignant cytology, in solid nodules irregular margins and microcalcifications were significant (all ). The combination of irregular margins and/or microcalcifications significantly increased the association with malignant cytology only in solid nodules (OR: 2.76 (95% CI: 1.25–6.10), : 0.012). Conclusions. Ultrasound features were of poor diagnostic value in mixed nodules, which harbored malignant lesions as often as solid nodules. Our findings challenge the recommended minimal size for ultrasound-guided fine needle aspiration biopsy in mixed nodules.
Fil: Vera, María Inés. Dr. Cesar Milstein Hospital; Argentina
Fil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Urrutia, María Agustina. Dr. Cesar Milstein Hospital; Argentina
Fil: Parisi, Carina. Dr. Cesar Milstein Hospital; Argentina
Fil: Morosan, Yanina. Dr. Cesar Milstein Hospital; Argentina
Fil: Rosmarin, Melanie. Dr. Cesar Milstein Hospital; Argentina
Fil: Schnitman, Marta. Dr. Cesar Milstein Hospital; Argentina
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Grisendi, Silvio. Dr. Cesar Milstein Hospital; Argentina
Fil: Serrano, María Sol. Dr. Cesar Milstein Hospital; Argentina
Fil: Luciani, Wilfredo. Dr. Cesar Milstein Hospital; Argentina
Fil: Serrano, Leonardo. Dr. Cesar Milstein Hospital; Argentina
Fil: Zuk, Carlos. Dr. Cesar Milstein Hospital; Argentina
Fil: de Barrio, Guillermo. Dr. Cesar Milstein Hospital; Argentina
Fil: Cejas, Claudia. Dr. Cesar Milstein Hospital; Argentina
Fil: Faingold, María Cristina. Dr. Cesar Milstein Hospital; Argentina
Fil: Brenta, Gabriela. Dr. Cesar Milstein Hospital; Argentina
Materia
Thyroid Nodules
Ultrasonographic
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15806

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oai_identifier_str oai:ri.conicet.gov.ar:11336/15806
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female populationVera, María InésMeroño, TomásUrrutia, María AgustinaParisi, CarinaMorosan, YaninaRosmarin, MelanieSchnitman, MartaBrites, Fernando DanielGrisendi, SilvioSerrano, María SolLuciani, WilfredoSerrano, LeonardoZuk, Carlosde Barrio, GuillermoCejas, ClaudiaFaingold, María CristinaBrenta, GabrielaThyroid NodulesUltrasonographichttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective. Ultrasonographic characteristics are associated with thyroid malignancy. Our aim was to compare the diagnostic value of ultrasound features in the detection of thyroid malignancy in both solid and mixed nodules. Methods. We prospectively studied female patients (≥50 years) referred to ultrasound-guided fine needle aspiration biopsy. Ultrasound features considered suspicious were hypoechogenicity, microcalcifications, irregular margins, high anteroposterior (AP)/axial-ratio, and absent halo. Associations were separately assessed in mixed and solid nodules. Results. In a group of 504 elderly female patients (age =  years), the frequency of malignant cytology was 6%. Thirty-one percent of nodules were mixed and 60% were solid. The rate of malignant cytology was similar for mixed and solid nodules (7.4 versus 5.8%, : 0.56). While in mixed nodules none of the ultrasound characteristics were associated with malignant cytology, in solid nodules irregular margins and microcalcifications were significant (all ). The combination of irregular margins and/or microcalcifications significantly increased the association with malignant cytology only in solid nodules (OR: 2.76 (95% CI: 1.25–6.10), : 0.012). Conclusions. Ultrasound features were of poor diagnostic value in mixed nodules, which harbored malignant lesions as often as solid nodules. Our findings challenge the recommended minimal size for ultrasound-guided fine needle aspiration biopsy in mixed nodules.Fil: Vera, María Inés. Dr. Cesar Milstein Hospital; ArgentinaFil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Urrutia, María Agustina. Dr. Cesar Milstein Hospital; ArgentinaFil: Parisi, Carina. Dr. Cesar Milstein Hospital; ArgentinaFil: Morosan, Yanina. Dr. Cesar Milstein Hospital; ArgentinaFil: Rosmarin, Melanie. Dr. Cesar Milstein Hospital; ArgentinaFil: Schnitman, Marta. Dr. Cesar Milstein Hospital; ArgentinaFil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Grisendi, Silvio. Dr. Cesar Milstein Hospital; ArgentinaFil: Serrano, María Sol. Dr. Cesar Milstein Hospital; ArgentinaFil: Luciani, Wilfredo. Dr. Cesar Milstein Hospital; ArgentinaFil: Serrano, Leonardo. Dr. Cesar Milstein Hospital; ArgentinaFil: Zuk, Carlos. Dr. Cesar Milstein Hospital; ArgentinaFil: de Barrio, Guillermo. Dr. Cesar Milstein Hospital; ArgentinaFil: Cejas, Claudia. Dr. Cesar Milstein Hospital; ArgentinaFil: Faingold, María Cristina. Dr. Cesar Milstein Hospital; ArgentinaFil: Brenta, Gabriela. Dr. Cesar Milstein Hospital; ArgentinaHindawi Publishing Corporation2014-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15806Vera, María Inés; Meroño, Tomás; Urrutia, María Agustina; Parisi, Carina; Morosan, Yanina; et al.; Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population; Hindawi Publishing Corporation; Journal of Thyroid Research; 2014; 5-2014; 1-72042-0072enginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/jtr/2014/761653/info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/761653info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:36Zoai:ri.conicet.gov.ar:11336/15806instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:37.211CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population
title Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population
spellingShingle Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population
Vera, María Inés
Thyroid Nodules
Ultrasonographic
title_short Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population
title_full Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population
title_fullStr Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population
title_full_unstemmed Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population
title_sort Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population
dc.creator.none.fl_str_mv Vera, María Inés
Meroño, Tomás
Urrutia, María Agustina
Parisi, Carina
Morosan, Yanina
Rosmarin, Melanie
Schnitman, Marta
Brites, Fernando Daniel
Grisendi, Silvio
Serrano, María Sol
Luciani, Wilfredo
Serrano, Leonardo
Zuk, Carlos
de Barrio, Guillermo
Cejas, Claudia
Faingold, María Cristina
Brenta, Gabriela
author Vera, María Inés
author_facet Vera, María Inés
Meroño, Tomás
Urrutia, María Agustina
Parisi, Carina
Morosan, Yanina
Rosmarin, Melanie
Schnitman, Marta
Brites, Fernando Daniel
Grisendi, Silvio
Serrano, María Sol
Luciani, Wilfredo
Serrano, Leonardo
Zuk, Carlos
de Barrio, Guillermo
Cejas, Claudia
Faingold, María Cristina
Brenta, Gabriela
author_role author
author2 Meroño, Tomás
Urrutia, María Agustina
Parisi, Carina
Morosan, Yanina
Rosmarin, Melanie
Schnitman, Marta
Brites, Fernando Daniel
Grisendi, Silvio
Serrano, María Sol
Luciani, Wilfredo
Serrano, Leonardo
Zuk, Carlos
de Barrio, Guillermo
Cejas, Claudia
Faingold, María Cristina
Brenta, Gabriela
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Thyroid Nodules
Ultrasonographic
topic Thyroid Nodules
Ultrasonographic
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective. Ultrasonographic characteristics are associated with thyroid malignancy. Our aim was to compare the diagnostic value of ultrasound features in the detection of thyroid malignancy in both solid and mixed nodules. Methods. We prospectively studied female patients (≥50 years) referred to ultrasound-guided fine needle aspiration biopsy. Ultrasound features considered suspicious were hypoechogenicity, microcalcifications, irregular margins, high anteroposterior (AP)/axial-ratio, and absent halo. Associations were separately assessed in mixed and solid nodules. Results. In a group of 504 elderly female patients (age =  years), the frequency of malignant cytology was 6%. Thirty-one percent of nodules were mixed and 60% were solid. The rate of malignant cytology was similar for mixed and solid nodules (7.4 versus 5.8%, : 0.56). While in mixed nodules none of the ultrasound characteristics were associated with malignant cytology, in solid nodules irregular margins and microcalcifications were significant (all ). The combination of irregular margins and/or microcalcifications significantly increased the association with malignant cytology only in solid nodules (OR: 2.76 (95% CI: 1.25–6.10), : 0.012). Conclusions. Ultrasound features were of poor diagnostic value in mixed nodules, which harbored malignant lesions as often as solid nodules. Our findings challenge the recommended minimal size for ultrasound-guided fine needle aspiration biopsy in mixed nodules.
Fil: Vera, María Inés. Dr. Cesar Milstein Hospital; Argentina
Fil: Meroño, Tomás. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Urrutia, María Agustina. Dr. Cesar Milstein Hospital; Argentina
Fil: Parisi, Carina. Dr. Cesar Milstein Hospital; Argentina
Fil: Morosan, Yanina. Dr. Cesar Milstein Hospital; Argentina
Fil: Rosmarin, Melanie. Dr. Cesar Milstein Hospital; Argentina
Fil: Schnitman, Marta. Dr. Cesar Milstein Hospital; Argentina
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Grisendi, Silvio. Dr. Cesar Milstein Hospital; Argentina
Fil: Serrano, María Sol. Dr. Cesar Milstein Hospital; Argentina
Fil: Luciani, Wilfredo. Dr. Cesar Milstein Hospital; Argentina
Fil: Serrano, Leonardo. Dr. Cesar Milstein Hospital; Argentina
Fil: Zuk, Carlos. Dr. Cesar Milstein Hospital; Argentina
Fil: de Barrio, Guillermo. Dr. Cesar Milstein Hospital; Argentina
Fil: Cejas, Claudia. Dr. Cesar Milstein Hospital; Argentina
Fil: Faingold, María Cristina. Dr. Cesar Milstein Hospital; Argentina
Fil: Brenta, Gabriela. Dr. Cesar Milstein Hospital; Argentina
description Objective. Ultrasonographic characteristics are associated with thyroid malignancy. Our aim was to compare the diagnostic value of ultrasound features in the detection of thyroid malignancy in both solid and mixed nodules. Methods. We prospectively studied female patients (≥50 years) referred to ultrasound-guided fine needle aspiration biopsy. Ultrasound features considered suspicious were hypoechogenicity, microcalcifications, irregular margins, high anteroposterior (AP)/axial-ratio, and absent halo. Associations were separately assessed in mixed and solid nodules. Results. In a group of 504 elderly female patients (age =  years), the frequency of malignant cytology was 6%. Thirty-one percent of nodules were mixed and 60% were solid. The rate of malignant cytology was similar for mixed and solid nodules (7.4 versus 5.8%, : 0.56). While in mixed nodules none of the ultrasound characteristics were associated with malignant cytology, in solid nodules irregular margins and microcalcifications were significant (all ). The combination of irregular margins and/or microcalcifications significantly increased the association with malignant cytology only in solid nodules (OR: 2.76 (95% CI: 1.25–6.10), : 0.012). Conclusions. Ultrasound features were of poor diagnostic value in mixed nodules, which harbored malignant lesions as often as solid nodules. Our findings challenge the recommended minimal size for ultrasound-guided fine needle aspiration biopsy in mixed nodules.
publishDate 2014
dc.date.none.fl_str_mv 2014-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15806
Vera, María Inés; Meroño, Tomás; Urrutia, María Agustina; Parisi, Carina; Morosan, Yanina; et al.; Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population; Hindawi Publishing Corporation; Journal of Thyroid Research; 2014; 5-2014; 1-7
2042-0072
url http://hdl.handle.net/11336/15806
identifier_str_mv Vera, María Inés; Meroño, Tomás; Urrutia, María Agustina; Parisi, Carina; Morosan, Yanina; et al.; Differential profile of ultrasound findings associated with malignancy in mixed and solid thyroid nodules in an elderly female population; Hindawi Publishing Corporation; Journal of Thyroid Research; 2014; 5-2014; 1-7
2042-0072
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/jtr/2014/761653/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/761653
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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