Efficient enhancement of information in the prefrontal cortex during the presence of reward predicting stimuli

Autores
Mininni, Camilo Juan; Caiafa, César Federico; Zanutto, Bonifacio Silvano; Tseng, Kuei Y.; Lew, Sergio Eduardo
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The prefrontal cortex (PFC) is a key brain structure for decision making, behavioural flexibility and working memory. Neurons in PFC encode relevant stimuli through changes in their firing rate, although the metabolic cost of spiking activity puts strong constrains to neural codes based on firing rate modulation. Thus, how PFC neural populations code relevant information in an efficient way is not clearly understood. To address this issue we made single unit recordings in the PFC of rats performing a GO/NOGO discrimination task and ana-lysed how entropy between pairs of neurons changes during cue presentation. We found that entropy rises only during reward-predicting cues. Moreover, this change in entropy occurred along an increase in the efficiency of the whole process. We studied possible mechanisms behind the efficient gain in entropy by means of a two neuron leaky integrate- and-fire model, and found that a precise relationship between synaptic efficacy and firing rate is required to explain the experimentally observed results.
Fil: Mininni, Camilo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Caiafa, César Federico. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; Argentina
Fil: Zanutto, Bonifacio Silvano. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Tseng, Kuei Y.. University of Illinois; Estados Unidos
Fil: Lew, Sergio Eduardo. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; Argentina
Materia
Spiking Neuron
Pre-Frontal Cortex
Neural Coding
Information Theory
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/63271
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Efficient enhancement of information in the prefrontal cortex during the presence of reward predicting stimuliMininni, Camilo JuanCaiafa, César FedericoZanutto, Bonifacio SilvanoTseng, Kuei Y.Lew, Sergio EduardoSpiking NeuronPre-Frontal CortexNeural CodingInformation Theoryhttps://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1The prefrontal cortex (PFC) is a key brain structure for decision making, behavioural flexibility and working memory. Neurons in PFC encode relevant stimuli through changes in their firing rate, although the metabolic cost of spiking activity puts strong constrains to neural codes based on firing rate modulation. Thus, how PFC neural populations code relevant information in an efficient way is not clearly understood. To address this issue we made single unit recordings in the PFC of rats performing a GO/NOGO discrimination task and ana-lysed how entropy between pairs of neurons changes during cue presentation. We found that entropy rises only during reward-predicting cues. Moreover, this change in entropy occurred along an increase in the efficiency of the whole process. We studied possible mechanisms behind the efficient gain in entropy by means of a two neuron leaky integrate- and-fire model, and found that a precise relationship between synaptic efficacy and firing rate is required to explain the experimentally observed results.Fil: Mininni, Camilo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Caiafa, César Federico. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Zanutto, Bonifacio Silvano. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Tseng, Kuei Y.. University of Illinois; Estados UnidosFil: Lew, Sergio Eduardo. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; ArgentinaPublic Library of Science2017-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/63271Mininni, Camilo Juan; Caiafa, César Federico; Zanutto, Bonifacio Silvano; Tseng, Kuei Y.; Lew, Sergio Eduardo; Efficient enhancement of information in the prefrontal cortex during the presence of reward predicting stimuli; Public Library of Science; Plos One; 12; 12-2017; 1-161932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0188579info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188579info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:42Zoai:ri.conicet.gov.ar:11336/63271instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:42.868CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Efficient enhancement of information in the prefrontal cortex during the presence of reward predicting stimuli
title Efficient enhancement of information in the prefrontal cortex during the presence of reward predicting stimuli
spellingShingle Efficient enhancement of information in the prefrontal cortex during the presence of reward predicting stimuli
Mininni, Camilo Juan
Spiking Neuron
Pre-Frontal Cortex
Neural Coding
Information Theory
title_short Efficient enhancement of information in the prefrontal cortex during the presence of reward predicting stimuli
title_full Efficient enhancement of information in the prefrontal cortex during the presence of reward predicting stimuli
title_fullStr Efficient enhancement of information in the prefrontal cortex during the presence of reward predicting stimuli
title_full_unstemmed Efficient enhancement of information in the prefrontal cortex during the presence of reward predicting stimuli
title_sort Efficient enhancement of information in the prefrontal cortex during the presence of reward predicting stimuli
dc.creator.none.fl_str_mv Mininni, Camilo Juan
Caiafa, César Federico
Zanutto, Bonifacio Silvano
Tseng, Kuei Y.
Lew, Sergio Eduardo
author Mininni, Camilo Juan
author_facet Mininni, Camilo Juan
Caiafa, César Federico
Zanutto, Bonifacio Silvano
Tseng, Kuei Y.
Lew, Sergio Eduardo
author_role author
author2 Caiafa, César Federico
Zanutto, Bonifacio Silvano
Tseng, Kuei Y.
Lew, Sergio Eduardo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Spiking Neuron
Pre-Frontal Cortex
Neural Coding
Information Theory
topic Spiking Neuron
Pre-Frontal Cortex
Neural Coding
Information Theory
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The prefrontal cortex (PFC) is a key brain structure for decision making, behavioural flexibility and working memory. Neurons in PFC encode relevant stimuli through changes in their firing rate, although the metabolic cost of spiking activity puts strong constrains to neural codes based on firing rate modulation. Thus, how PFC neural populations code relevant information in an efficient way is not clearly understood. To address this issue we made single unit recordings in the PFC of rats performing a GO/NOGO discrimination task and ana-lysed how entropy between pairs of neurons changes during cue presentation. We found that entropy rises only during reward-predicting cues. Moreover, this change in entropy occurred along an increase in the efficiency of the whole process. We studied possible mechanisms behind the efficient gain in entropy by means of a two neuron leaky integrate- and-fire model, and found that a precise relationship between synaptic efficacy and firing rate is required to explain the experimentally observed results.
Fil: Mininni, Camilo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Caiafa, César Federico. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; Argentina
Fil: Zanutto, Bonifacio Silvano. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Tseng, Kuei Y.. University of Illinois; Estados Unidos
Fil: Lew, Sergio Eduardo. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; Argentina
description The prefrontal cortex (PFC) is a key brain structure for decision making, behavioural flexibility and working memory. Neurons in PFC encode relevant stimuli through changes in their firing rate, although the metabolic cost of spiking activity puts strong constrains to neural codes based on firing rate modulation. Thus, how PFC neural populations code relevant information in an efficient way is not clearly understood. To address this issue we made single unit recordings in the PFC of rats performing a GO/NOGO discrimination task and ana-lysed how entropy between pairs of neurons changes during cue presentation. We found that entropy rises only during reward-predicting cues. Moreover, this change in entropy occurred along an increase in the efficiency of the whole process. We studied possible mechanisms behind the efficient gain in entropy by means of a two neuron leaky integrate- and-fire model, and found that a precise relationship between synaptic efficacy and firing rate is required to explain the experimentally observed results.
publishDate 2017
dc.date.none.fl_str_mv 2017-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/63271
Mininni, Camilo Juan; Caiafa, César Federico; Zanutto, Bonifacio Silvano; Tseng, Kuei Y.; Lew, Sergio Eduardo; Efficient enhancement of information in the prefrontal cortex during the presence of reward predicting stimuli; Public Library of Science; Plos One; 12; 12-2017; 1-16
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/63271
identifier_str_mv Mininni, Camilo Juan; Caiafa, César Federico; Zanutto, Bonifacio Silvano; Tseng, Kuei Y.; Lew, Sergio Eduardo; Efficient enhancement of information in the prefrontal cortex during the presence of reward predicting stimuli; Public Library of Science; Plos One; 12; 12-2017; 1-16
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0188579
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188579
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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