Putative dopamine neurons in the ventral tegmental area enhance information coding in the prefrontal cortex

Autores
Mininni, Camilo Juan; Caiafa, César Federico; Zanutto, Bonifacio Silvano; Tseng, Kuei Y.; Lew, Sergio Eduardo
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It has been proposed that neuronal populations in the prefrontal cortex (PFC) robustly encode task-relevant information through an interplay with the ventral tegmental area (VTA). Yet, the precise computation underlying such functional interaction remains elusive. Here, we conducted simultaneous recordings of single-unit activity in PFC and VTA of rats performing a GO/NoGO task. We found that mutual information between stimuli and neural activity increases in the PFC as soon as stimuli are presented. Notably, it is the activity of putative dopamine neurons in the VTA that contributes critically to enhance information coding in the PFC. The higher the activity of these VTA neurons, the better the conditioned stimuli are encoded in the PFC.
Fil: Mininni, Camilo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Caiafa, César Federico. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; Argentina
Fil: Zanutto, Bonifacio Silvano. Universidad de Buenos Aires. Facultad de Ingenieria. Instituto de Ingeniería Biomédica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tseng, Kuei Y.. University of Illinois; Estados Unidos
Fil: Lew, Sergio Eduardo. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina
Materia
Dopamina
Código neuronal
Corteza frontal
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/82649
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Putative dopamine neurons in the ventral tegmental area enhance information coding in the prefrontal cortexMininni, Camilo JuanCaiafa, César FedericoZanutto, Bonifacio SilvanoTseng, Kuei Y.Lew, Sergio EduardoDopaminaCódigo neuronalCorteza frontalhttps://purl.org/becyt/ford/2.2https://purl.org/becyt/ford/2It has been proposed that neuronal populations in the prefrontal cortex (PFC) robustly encode task-relevant information through an interplay with the ventral tegmental area (VTA). Yet, the precise computation underlying such functional interaction remains elusive. Here, we conducted simultaneous recordings of single-unit activity in PFC and VTA of rats performing a GO/NoGO task. We found that mutual information between stimuli and neural activity increases in the PFC as soon as stimuli are presented. Notably, it is the activity of putative dopamine neurons in the VTA that contributes critically to enhance information coding in the PFC. The higher the activity of these VTA neurons, the better the conditioned stimuli are encoded in the PFC.Fil: Mininni, Camilo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Caiafa, César Federico. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Zanutto, Bonifacio Silvano. Universidad de Buenos Aires. Facultad de Ingenieria. Instituto de Ingeniería Biomédica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tseng, Kuei Y.. University of Illinois; Estados UnidosFil: Lew, Sergio Eduardo. Universidad de Buenos Aires. Facultad de Ingeniería; ArgentinaNature Publishing Group2018-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/82649Mininni, Camilo Juan; Caiafa, César Federico; Zanutto, Bonifacio Silvano; Tseng, Kuei Y.; Lew, Sergio Eduardo; Putative dopamine neurons in the ventral tegmental area enhance information coding in the prefrontal cortex; Nature Publishing Group; Scientific Reports; 8; 1; 12-2018; 1-112045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41598-018-29979-2info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-018-29979-2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:13:22Zoai:ri.conicet.gov.ar:11336/82649instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:13:23.22CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Putative dopamine neurons in the ventral tegmental area enhance information coding in the prefrontal cortex
title Putative dopamine neurons in the ventral tegmental area enhance information coding in the prefrontal cortex
spellingShingle Putative dopamine neurons in the ventral tegmental area enhance information coding in the prefrontal cortex
Mininni, Camilo Juan
Dopamina
Código neuronal
Corteza frontal
title_short Putative dopamine neurons in the ventral tegmental area enhance information coding in the prefrontal cortex
title_full Putative dopamine neurons in the ventral tegmental area enhance information coding in the prefrontal cortex
title_fullStr Putative dopamine neurons in the ventral tegmental area enhance information coding in the prefrontal cortex
title_full_unstemmed Putative dopamine neurons in the ventral tegmental area enhance information coding in the prefrontal cortex
title_sort Putative dopamine neurons in the ventral tegmental area enhance information coding in the prefrontal cortex
dc.creator.none.fl_str_mv Mininni, Camilo Juan
Caiafa, César Federico
Zanutto, Bonifacio Silvano
Tseng, Kuei Y.
Lew, Sergio Eduardo
author Mininni, Camilo Juan
author_facet Mininni, Camilo Juan
Caiafa, César Federico
Zanutto, Bonifacio Silvano
Tseng, Kuei Y.
Lew, Sergio Eduardo
author_role author
author2 Caiafa, César Federico
Zanutto, Bonifacio Silvano
Tseng, Kuei Y.
Lew, Sergio Eduardo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Dopamina
Código neuronal
Corteza frontal
topic Dopamina
Código neuronal
Corteza frontal
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.2
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv It has been proposed that neuronal populations in the prefrontal cortex (PFC) robustly encode task-relevant information through an interplay with the ventral tegmental area (VTA). Yet, the precise computation underlying such functional interaction remains elusive. Here, we conducted simultaneous recordings of single-unit activity in PFC and VTA of rats performing a GO/NoGO task. We found that mutual information between stimuli and neural activity increases in the PFC as soon as stimuli are presented. Notably, it is the activity of putative dopamine neurons in the VTA that contributes critically to enhance information coding in the PFC. The higher the activity of these VTA neurons, the better the conditioned stimuli are encoded in the PFC.
Fil: Mininni, Camilo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Caiafa, César Federico. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; Argentina
Fil: Zanutto, Bonifacio Silvano. Universidad de Buenos Aires. Facultad de Ingenieria. Instituto de Ingeniería Biomédica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tseng, Kuei Y.. University of Illinois; Estados Unidos
Fil: Lew, Sergio Eduardo. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina
description It has been proposed that neuronal populations in the prefrontal cortex (PFC) robustly encode task-relevant information through an interplay with the ventral tegmental area (VTA). Yet, the precise computation underlying such functional interaction remains elusive. Here, we conducted simultaneous recordings of single-unit activity in PFC and VTA of rats performing a GO/NoGO task. We found that mutual information between stimuli and neural activity increases in the PFC as soon as stimuli are presented. Notably, it is the activity of putative dopamine neurons in the VTA that contributes critically to enhance information coding in the PFC. The higher the activity of these VTA neurons, the better the conditioned stimuli are encoded in the PFC.
publishDate 2018
dc.date.none.fl_str_mv 2018-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/82649
Mininni, Camilo Juan; Caiafa, César Federico; Zanutto, Bonifacio Silvano; Tseng, Kuei Y.; Lew, Sergio Eduardo; Putative dopamine neurons in the ventral tegmental area enhance information coding in the prefrontal cortex; Nature Publishing Group; Scientific Reports; 8; 1; 12-2018; 1-11
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/82649
identifier_str_mv Mininni, Camilo Juan; Caiafa, César Federico; Zanutto, Bonifacio Silvano; Tseng, Kuei Y.; Lew, Sergio Eduardo; Putative dopamine neurons in the ventral tegmental area enhance information coding in the prefrontal cortex; Nature Publishing Group; Scientific Reports; 8; 1; 12-2018; 1-11
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41598-018-29979-2
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-018-29979-2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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