Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals

Autores
Bosch, Pablo; Forcato, Diego Oscar; Alustiza, Fabrisio Eduardo; Alessio, Ana Paula; Fili, Alejandro; Olmos Nicotra, Maria Florencia; Liaudat, Ana Cecilia; Rodriguez, Nancy; Talluri, Thirumala R.; Kues, Wilfried A.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Abstract Transgenic farm animals are attractive alternative mammalian models to rodents for the study of developmental, genetic, reproductive and disease-related biological questions, as well for the production of recombinant proteins, or the assessment of xenotransplants for human patients. Until recently, the ability to generate transgenic farm animals relied on methods of passive transgenesis. In recent years, significant improvements have been made to introduce and apply active techniques of transgenesis and genetic engineering in these species. These new approaches dramatically enhance the ease and speed with which livestock species can be genetically modified, and allow to performing precise genetic modifications. This paper provides a synopsis of enzyme-mediated genetic engineering in livestock species covering the early attempts employing naturally occurring DNA-modifying proteins to recent approaches working with tailored enzymatic systems.
Fil: Bosch, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
Fil: Forcato, Diego Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
Fil: Alustiza, Fabrisio Eduardo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
Fil: Alessio, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
Fil: Fili, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
Fil: Olmos Nicotra, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
Fil: Liaudat, Ana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
Fil: Rodriguez, Nancy. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
Fil: Talluri, Thirumala R.. Institute of Farm Animal Genetics. Neustadt; Alemania
Fil: Kues, Wilfried A.. Institute of Farm Animal Genetics. Neustadt; Alemania
Materia
Active Transgenesis
Binary Transposon System
Designer Nuclease
Integrase
Livestock
Recombinase
Synthetic Biology
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/39107
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/39107
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Exogenous enzymes upgrade transgenesis and genetic engineering of farm animalsBosch, PabloForcato, Diego OscarAlustiza, Fabrisio EduardoAlessio, Ana PaulaFili, AlejandroOlmos Nicotra, Maria FlorenciaLiaudat, Ana CeciliaRodriguez, NancyTalluri, Thirumala R.Kues, Wilfried A.Active TransgenesisBinary Transposon SystemDesigner NucleaseIntegraseLivestockRecombinaseSynthetic Biologyhttps://purl.org/becyt/ford/4.4https://purl.org/becyt/ford/4Abstract Transgenic farm animals are attractive alternative mammalian models to rodents for the study of developmental, genetic, reproductive and disease-related biological questions, as well for the production of recombinant proteins, or the assessment of xenotransplants for human patients. Until recently, the ability to generate transgenic farm animals relied on methods of passive transgenesis. In recent years, significant improvements have been made to introduce and apply active techniques of transgenesis and genetic engineering in these species. These new approaches dramatically enhance the ease and speed with which livestock species can be genetically modified, and allow to performing precise genetic modifications. This paper provides a synopsis of enzyme-mediated genetic engineering in livestock species covering the early attempts employing naturally occurring DNA-modifying proteins to recent approaches working with tailored enzymatic systems.Fil: Bosch, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; ArgentinaFil: Forcato, Diego Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; ArgentinaFil: Alustiza, Fabrisio Eduardo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; ArgentinaFil: Alessio, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; ArgentinaFil: Fili, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; ArgentinaFil: Olmos Nicotra, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; ArgentinaFil: Liaudat, Ana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; ArgentinaFil: Rodriguez, Nancy. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; ArgentinaFil: Talluri, Thirumala R.. Institute of Farm Animal Genetics. Neustadt; AlemaniaFil: Kues, Wilfried A.. Institute of Farm Animal Genetics. Neustadt; AlemaniaBirkhauser Verlag Ag2015-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39107Bosch, Pablo; Forcato, Diego Oscar; Alustiza, Fabrisio Eduardo; Alessio, Ana Paula; Fili, Alejandro; et al.; Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals; Birkhauser Verlag Ag; Cellular and Molecular Life Sciences; 72; 10; 5-2015; 1907-19291420-682XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00018-015-1842-1info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00018-015-1842-1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:38:11Zoai:ri.conicet.gov.ar:11336/39107instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:38:12.134CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals
title Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals
spellingShingle Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals
Bosch, Pablo
Active Transgenesis
Binary Transposon System
Designer Nuclease
Integrase
Livestock
Recombinase
Synthetic Biology
title_short Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals
title_full Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals
title_fullStr Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals
title_full_unstemmed Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals
title_sort Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals
dc.creator.none.fl_str_mv Bosch, Pablo
Forcato, Diego Oscar
Alustiza, Fabrisio Eduardo
Alessio, Ana Paula
Fili, Alejandro
Olmos Nicotra, Maria Florencia
Liaudat, Ana Cecilia
Rodriguez, Nancy
Talluri, Thirumala R.
Kues, Wilfried A.
author Bosch, Pablo
author_facet Bosch, Pablo
Forcato, Diego Oscar
Alustiza, Fabrisio Eduardo
Alessio, Ana Paula
Fili, Alejandro
Olmos Nicotra, Maria Florencia
Liaudat, Ana Cecilia
Rodriguez, Nancy
Talluri, Thirumala R.
Kues, Wilfried A.
author_role author
author2 Forcato, Diego Oscar
Alustiza, Fabrisio Eduardo
Alessio, Ana Paula
Fili, Alejandro
Olmos Nicotra, Maria Florencia
Liaudat, Ana Cecilia
Rodriguez, Nancy
Talluri, Thirumala R.
Kues, Wilfried A.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Active Transgenesis
Binary Transposon System
Designer Nuclease
Integrase
Livestock
Recombinase
Synthetic Biology
topic Active Transgenesis
Binary Transposon System
Designer Nuclease
Integrase
Livestock
Recombinase
Synthetic Biology
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.4
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Abstract Transgenic farm animals are attractive alternative mammalian models to rodents for the study of developmental, genetic, reproductive and disease-related biological questions, as well for the production of recombinant proteins, or the assessment of xenotransplants for human patients. Until recently, the ability to generate transgenic farm animals relied on methods of passive transgenesis. In recent years, significant improvements have been made to introduce and apply active techniques of transgenesis and genetic engineering in these species. These new approaches dramatically enhance the ease and speed with which livestock species can be genetically modified, and allow to performing precise genetic modifications. This paper provides a synopsis of enzyme-mediated genetic engineering in livestock species covering the early attempts employing naturally occurring DNA-modifying proteins to recent approaches working with tailored enzymatic systems.
Fil: Bosch, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
Fil: Forcato, Diego Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
Fil: Alustiza, Fabrisio Eduardo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
Fil: Alessio, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
Fil: Fili, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
Fil: Olmos Nicotra, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
Fil: Liaudat, Ana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
Fil: Rodriguez, Nancy. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; Argentina
Fil: Talluri, Thirumala R.. Institute of Farm Animal Genetics. Neustadt; Alemania
Fil: Kues, Wilfried A.. Institute of Farm Animal Genetics. Neustadt; Alemania
description Abstract Transgenic farm animals are attractive alternative mammalian models to rodents for the study of developmental, genetic, reproductive and disease-related biological questions, as well for the production of recombinant proteins, or the assessment of xenotransplants for human patients. Until recently, the ability to generate transgenic farm animals relied on methods of passive transgenesis. In recent years, significant improvements have been made to introduce and apply active techniques of transgenesis and genetic engineering in these species. These new approaches dramatically enhance the ease and speed with which livestock species can be genetically modified, and allow to performing precise genetic modifications. This paper provides a synopsis of enzyme-mediated genetic engineering in livestock species covering the early attempts employing naturally occurring DNA-modifying proteins to recent approaches working with tailored enzymatic systems.
publishDate 2015
dc.date.none.fl_str_mv 2015-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39107
Bosch, Pablo; Forcato, Diego Oscar; Alustiza, Fabrisio Eduardo; Alessio, Ana Paula; Fili, Alejandro; et al.; Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals; Birkhauser Verlag Ag; Cellular and Molecular Life Sciences; 72; 10; 5-2015; 1907-1929
1420-682X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39107
identifier_str_mv Bosch, Pablo; Forcato, Diego Oscar; Alustiza, Fabrisio Eduardo; Alessio, Ana Paula; Fili, Alejandro; et al.; Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals; Birkhauser Verlag Ag; Cellular and Molecular Life Sciences; 72; 10; 5-2015; 1907-1929
1420-682X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s00018-015-1842-1
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00018-015-1842-1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
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application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Birkhauser Verlag Ag
publisher.none.fl_str_mv Birkhauser Verlag Ag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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