New Micellar Electrokinetic Chromatographic Method for Analyzing Idebenone in Pediatric Formulations
- Autores
- Contin, Mario Daniel; Buontempo, Fabián; García Becerra, Cristian Ezequiel; Dobrecky, Cecilia Beatriz; Lucangioli, Silvia Edith; Tripodi, Valeria Paula
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A novel, simple and reliable method based on micellar electrokinetic chromatography with ultraviolet detection was developed to analyze idebenone in a pediatric formulation. Idebenone is a synthetic short chain benzoquinone that acts as an electron carrier in the mitochondrial electron transport chain facilitating the production of adenosine triphosphate. It can be found in two different redox states that differ in their physiological properties. Idebenone has been investigated as a treatment in several neurological disorders like Friedreich's ataxia, Leber's hereditary optic neuropathy, mitochondrial encephalomyopathies and senile dementia. Accordingly, a micellar electrokinetic chromatography was employed to discriminate both redox forms. The final optimized system was validated in terms of selectivity, linearity (r2 0.992), limit of detection (0.5 μg/mL), limit of quantification (1.8 μg/mL), intra- and inter-day precision (RSD ≤ 2) and accuracy in terms of recovery studies (99.3-100.5%). Robustness was studied following a Plackett-Burman design. Finally, the validated system was applied to the analysis of idebenone in a pediatric formulation.
Fil: Contin, Mario Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Buontempo, Fabián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: García Becerra, Cristian Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Dobrecky, Cecilia Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Lucangioli, Silvia Edith. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tripodi, Valeria Paula. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
IDEBENONE
MICELLAR ELECTROKINETIC CHROMATOGRAHY
FORMULATION
PEDIATRIC - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/212523
Ver los metadatos del registro completo
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New Micellar Electrokinetic Chromatographic Method for Analyzing Idebenone in Pediatric FormulationsContin, Mario DanielBuontempo, FabiánGarcía Becerra, Cristian EzequielDobrecky, Cecilia BeatrizLucangioli, Silvia EdithTripodi, Valeria PaulaIDEBENONEMICELLAR ELECTROKINETIC CHROMATOGRAHYFORMULATIONPEDIATRIChttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3A novel, simple and reliable method based on micellar electrokinetic chromatography with ultraviolet detection was developed to analyze idebenone in a pediatric formulation. Idebenone is a synthetic short chain benzoquinone that acts as an electron carrier in the mitochondrial electron transport chain facilitating the production of adenosine triphosphate. It can be found in two different redox states that differ in their physiological properties. Idebenone has been investigated as a treatment in several neurological disorders like Friedreich's ataxia, Leber's hereditary optic neuropathy, mitochondrial encephalomyopathies and senile dementia. Accordingly, a micellar electrokinetic chromatography was employed to discriminate both redox forms. The final optimized system was validated in terms of selectivity, linearity (r2 0.992), limit of detection (0.5 μg/mL), limit of quantification (1.8 μg/mL), intra- and inter-day precision (RSD ≤ 2) and accuracy in terms of recovery studies (99.3-100.5%). Robustness was studied following a Plackett-Burman design. Finally, the validated system was applied to the analysis of idebenone in a pediatric formulation.Fil: Contin, Mario Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Buontempo, Fabián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: García Becerra, Cristian Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Dobrecky, Cecilia Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Lucangioli, Silvia Edith. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tripodi, Valeria Paula. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaPreston Publ Inc2017-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/212523Contin, Mario Daniel; Buontempo, Fabián; García Becerra, Cristian Ezequiel; Dobrecky, Cecilia Beatriz; Lucangioli, Silvia Edith; et al.; New Micellar Electrokinetic Chromatographic Method for Analyzing Idebenone in Pediatric Formulations; Preston Publ Inc; Journal Of Chromatographic Science; 55; 3; 11-2017; 351-3570021-9665CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/chromsci/bmw172info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:21Zoai:ri.conicet.gov.ar:11336/212523instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:21.431CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
New Micellar Electrokinetic Chromatographic Method for Analyzing Idebenone in Pediatric Formulations |
title |
New Micellar Electrokinetic Chromatographic Method for Analyzing Idebenone in Pediatric Formulations |
spellingShingle |
New Micellar Electrokinetic Chromatographic Method for Analyzing Idebenone in Pediatric Formulations Contin, Mario Daniel IDEBENONE MICELLAR ELECTROKINETIC CHROMATOGRAHY FORMULATION PEDIATRIC |
title_short |
New Micellar Electrokinetic Chromatographic Method for Analyzing Idebenone in Pediatric Formulations |
title_full |
New Micellar Electrokinetic Chromatographic Method for Analyzing Idebenone in Pediatric Formulations |
title_fullStr |
New Micellar Electrokinetic Chromatographic Method for Analyzing Idebenone in Pediatric Formulations |
title_full_unstemmed |
New Micellar Electrokinetic Chromatographic Method for Analyzing Idebenone in Pediatric Formulations |
title_sort |
New Micellar Electrokinetic Chromatographic Method for Analyzing Idebenone in Pediatric Formulations |
dc.creator.none.fl_str_mv |
Contin, Mario Daniel Buontempo, Fabián García Becerra, Cristian Ezequiel Dobrecky, Cecilia Beatriz Lucangioli, Silvia Edith Tripodi, Valeria Paula |
author |
Contin, Mario Daniel |
author_facet |
Contin, Mario Daniel Buontempo, Fabián García Becerra, Cristian Ezequiel Dobrecky, Cecilia Beatriz Lucangioli, Silvia Edith Tripodi, Valeria Paula |
author_role |
author |
author2 |
Buontempo, Fabián García Becerra, Cristian Ezequiel Dobrecky, Cecilia Beatriz Lucangioli, Silvia Edith Tripodi, Valeria Paula |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
IDEBENONE MICELLAR ELECTROKINETIC CHROMATOGRAHY FORMULATION PEDIATRIC |
topic |
IDEBENONE MICELLAR ELECTROKINETIC CHROMATOGRAHY FORMULATION PEDIATRIC |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
A novel, simple and reliable method based on micellar electrokinetic chromatography with ultraviolet detection was developed to analyze idebenone in a pediatric formulation. Idebenone is a synthetic short chain benzoquinone that acts as an electron carrier in the mitochondrial electron transport chain facilitating the production of adenosine triphosphate. It can be found in two different redox states that differ in their physiological properties. Idebenone has been investigated as a treatment in several neurological disorders like Friedreich's ataxia, Leber's hereditary optic neuropathy, mitochondrial encephalomyopathies and senile dementia. Accordingly, a micellar electrokinetic chromatography was employed to discriminate both redox forms. The final optimized system was validated in terms of selectivity, linearity (r2 0.992), limit of detection (0.5 μg/mL), limit of quantification (1.8 μg/mL), intra- and inter-day precision (RSD ≤ 2) and accuracy in terms of recovery studies (99.3-100.5%). Robustness was studied following a Plackett-Burman design. Finally, the validated system was applied to the analysis of idebenone in a pediatric formulation. Fil: Contin, Mario Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Buontempo, Fabián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina Fil: García Becerra, Cristian Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina Fil: Dobrecky, Cecilia Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina Fil: Lucangioli, Silvia Edith. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Tripodi, Valeria Paula. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
A novel, simple and reliable method based on micellar electrokinetic chromatography with ultraviolet detection was developed to analyze idebenone in a pediatric formulation. Idebenone is a synthetic short chain benzoquinone that acts as an electron carrier in the mitochondrial electron transport chain facilitating the production of adenosine triphosphate. It can be found in two different redox states that differ in their physiological properties. Idebenone has been investigated as a treatment in several neurological disorders like Friedreich's ataxia, Leber's hereditary optic neuropathy, mitochondrial encephalomyopathies and senile dementia. Accordingly, a micellar electrokinetic chromatography was employed to discriminate both redox forms. The final optimized system was validated in terms of selectivity, linearity (r2 0.992), limit of detection (0.5 μg/mL), limit of quantification (1.8 μg/mL), intra- and inter-day precision (RSD ≤ 2) and accuracy in terms of recovery studies (99.3-100.5%). Robustness was studied following a Plackett-Burman design. Finally, the validated system was applied to the analysis of idebenone in a pediatric formulation. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/212523 Contin, Mario Daniel; Buontempo, Fabián; García Becerra, Cristian Ezequiel; Dobrecky, Cecilia Beatriz; Lucangioli, Silvia Edith; et al.; New Micellar Electrokinetic Chromatographic Method for Analyzing Idebenone in Pediatric Formulations; Preston Publ Inc; Journal Of Chromatographic Science; 55; 3; 11-2017; 351-357 0021-9665 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/212523 |
identifier_str_mv |
Contin, Mario Daniel; Buontempo, Fabián; García Becerra, Cristian Ezequiel; Dobrecky, Cecilia Beatriz; Lucangioli, Silvia Edith; et al.; New Micellar Electrokinetic Chromatographic Method for Analyzing Idebenone in Pediatric Formulations; Preston Publ Inc; Journal Of Chromatographic Science; 55; 3; 11-2017; 351-357 0021-9665 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1093/chromsci/bmw172 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Preston Publ Inc |
publisher.none.fl_str_mv |
Preston Publ Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613551858122752 |
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13.070432 |