Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H2LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H2LASSBio-1064) and Their Zinc(I...

Autores
Júnior, Walfrido Bispo; Alexandre Moreira, Magna S.; Alves, Marina A.; Perez Rebolledo, Anayive; Parrilha, Gabrieli L.; Castellano, Eduardo E.; Piro, Oscar Enrique; Barreiro, Eliezer J.; Lima, Lídia Moreira; Beraldo, Heloisa
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Salicylaldehyde 2-chlorobenzoyl hydrazone(H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H2LASSBio-1064) and their complexes [Zn(LASSBio-466)H2O]2 (1) and [Zn(HLASSBio-1064)Cl]2 (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation. All studied compounds significantly inhibited acetic acid-induced writhing response. Upon coordination the anti-nociceptive activity was favored in the complex1. H2LASSBio-466 inhibited only the first phase of the formalin test, while1was active in the second phase, like indomethacin, indicating its ability to inhibit nociception associated with the inflammatory response. Hence coordination to zinc(II) altered thepharmacological profile of H2LASSBio-466.H2LASSBio-1064 inhibited both phases but this effect was not improved by coordination. The studied compounds did not increase the latency of response in the hot plate model, indicating their lack of central anti-nociceptive activity. All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile.
Fil: Júnior, Walfrido Bispo. Universidade Federal de Alagoas; Brasil
Fil: Alexandre Moreira, Magna S.. Universidade Federal de Alagoas; Brasil
Fil: Alves, Marina A.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Perez Rebolledo, Anayive. Universidade Federal de Minas Gerais; Brasil
Fil: Parrilha, Gabrieli L.. Universidade Federal de Minas Gerais; Brasil
Fil: Castellano, Eduardo E.. Universidade de Sao Paulo; Brasil
Fil: Piro, Oscar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Barreiro, Eliezer J.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Lima, Lídia Moreira. Universidade Federal do Rio de Janeiro; Brasil
Fil: Beraldo, Heloisa. Universidade Federal de Minas Gerais; Brasil
Materia
Acylhydrazones
Zinc(II) complexes
Analgesic activity
Anti-inflammatory activity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/279999
Acceder
id CONICETDig_34791613fb51362864130b1c06231112
oai_identifier_str oai:ri.conicet.gov.ar:11336/279999
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H2LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H2LASSBio-1064) and Their Zinc(II) ComplexesJúnior, Walfrido BispoAlexandre Moreira, Magna S.Alves, Marina A.Perez Rebolledo, AnayiveParrilha, Gabrieli L.Castellano, Eduardo E.Piro, Oscar EnriqueBarreiro, Eliezer J.Lima, Lídia MoreiraBeraldo, HeloisaAcylhydrazonesZinc(II) complexesAnalgesic activityAnti-inflammatory activityhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Salicylaldehyde 2-chlorobenzoyl hydrazone(H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H2LASSBio-1064) and their complexes [Zn(LASSBio-466)H2O]2 (1) and [Zn(HLASSBio-1064)Cl]2 (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation. All studied compounds significantly inhibited acetic acid-induced writhing response. Upon coordination the anti-nociceptive activity was favored in the complex1. H2LASSBio-466 inhibited only the first phase of the formalin test, while1was active in the second phase, like indomethacin, indicating its ability to inhibit nociception associated with the inflammatory response. Hence coordination to zinc(II) altered thepharmacological profile of H2LASSBio-466.H2LASSBio-1064 inhibited both phases but this effect was not improved by coordination. The studied compounds did not increase the latency of response in the hot plate model, indicating their lack of central anti-nociceptive activity. All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile.Fil: Júnior, Walfrido Bispo. Universidade Federal de Alagoas; BrasilFil: Alexandre Moreira, Magna S.. Universidade Federal de Alagoas; BrasilFil: Alves, Marina A.. Universidade Federal do Rio de Janeiro; BrasilFil: Perez Rebolledo, Anayive. Universidade Federal de Minas Gerais; BrasilFil: Parrilha, Gabrieli L.. Universidade Federal de Minas Gerais; BrasilFil: Castellano, Eduardo E.. Universidade de Sao Paulo; BrasilFil: Piro, Oscar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Barreiro, Eliezer J.. Universidade Federal do Rio de Janeiro; BrasilFil: Lima, Lídia Moreira. Universidade Federal do Rio de Janeiro; BrasilFil: Beraldo, Heloisa. Universidade Federal de Minas Gerais; BrasilMolecular Diversity Preservation International2011-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/279999Júnior, Walfrido Bispo; Alexandre Moreira, Magna S.; Alves, Marina A.; Perez Rebolledo, Anayive; Parrilha, Gabrieli L.; et al.; Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H2LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H2LASSBio-1064) and Their Zinc(II) Complexes; Molecular Diversity Preservation International; Molecules; 16; 8; 8-2011; 6902-69151420-3049CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/16/8/6902info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules16086902info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-05-06T16:47:47Zoai:ri.conicet.gov.ar:11336/279999instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-05-06 16:47:48.383CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H2LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H2LASSBio-1064) and Their Zinc(II) Complexes
title Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H2LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H2LASSBio-1064) and Their Zinc(II) Complexes
spellingShingle Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H2LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H2LASSBio-1064) and Their Zinc(II) Complexes
Júnior, Walfrido Bispo
Acylhydrazones
Zinc(II) complexes
Analgesic activity
Anti-inflammatory activity
title_short Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H2LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H2LASSBio-1064) and Their Zinc(II) Complexes
title_full Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H2LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H2LASSBio-1064) and Their Zinc(II) Complexes
title_fullStr Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H2LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H2LASSBio-1064) and Their Zinc(II) Complexes
title_full_unstemmed Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H2LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H2LASSBio-1064) and Their Zinc(II) Complexes
title_sort Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H2LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H2LASSBio-1064) and Their Zinc(II) Complexes
dc.creator.none.fl_str_mv Júnior, Walfrido Bispo
Alexandre Moreira, Magna S.
Alves, Marina A.
Perez Rebolledo, Anayive
Parrilha, Gabrieli L.
Castellano, Eduardo E.
Piro, Oscar Enrique
Barreiro, Eliezer J.
Lima, Lídia Moreira
Beraldo, Heloisa
author Júnior, Walfrido Bispo
author_facet Júnior, Walfrido Bispo
Alexandre Moreira, Magna S.
Alves, Marina A.
Perez Rebolledo, Anayive
Parrilha, Gabrieli L.
Castellano, Eduardo E.
Piro, Oscar Enrique
Barreiro, Eliezer J.
Lima, Lídia Moreira
Beraldo, Heloisa
author_role author
author2 Alexandre Moreira, Magna S.
Alves, Marina A.
Perez Rebolledo, Anayive
Parrilha, Gabrieli L.
Castellano, Eduardo E.
Piro, Oscar Enrique
Barreiro, Eliezer J.
Lima, Lídia Moreira
Beraldo, Heloisa
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Acylhydrazones
Zinc(II) complexes
Analgesic activity
Anti-inflammatory activity
topic Acylhydrazones
Zinc(II) complexes
Analgesic activity
Anti-inflammatory activity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Salicylaldehyde 2-chlorobenzoyl hydrazone(H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H2LASSBio-1064) and their complexes [Zn(LASSBio-466)H2O]2 (1) and [Zn(HLASSBio-1064)Cl]2 (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation. All studied compounds significantly inhibited acetic acid-induced writhing response. Upon coordination the anti-nociceptive activity was favored in the complex1. H2LASSBio-466 inhibited only the first phase of the formalin test, while1was active in the second phase, like indomethacin, indicating its ability to inhibit nociception associated with the inflammatory response. Hence coordination to zinc(II) altered thepharmacological profile of H2LASSBio-466.H2LASSBio-1064 inhibited both phases but this effect was not improved by coordination. The studied compounds did not increase the latency of response in the hot plate model, indicating their lack of central anti-nociceptive activity. All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile.
Fil: Júnior, Walfrido Bispo. Universidade Federal de Alagoas; Brasil
Fil: Alexandre Moreira, Magna S.. Universidade Federal de Alagoas; Brasil
Fil: Alves, Marina A.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Perez Rebolledo, Anayive. Universidade Federal de Minas Gerais; Brasil
Fil: Parrilha, Gabrieli L.. Universidade Federal de Minas Gerais; Brasil
Fil: Castellano, Eduardo E.. Universidade de Sao Paulo; Brasil
Fil: Piro, Oscar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Barreiro, Eliezer J.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Lima, Lídia Moreira. Universidade Federal do Rio de Janeiro; Brasil
Fil: Beraldo, Heloisa. Universidade Federal de Minas Gerais; Brasil
description Salicylaldehyde 2-chlorobenzoyl hydrazone(H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H2LASSBio-1064) and their complexes [Zn(LASSBio-466)H2O]2 (1) and [Zn(HLASSBio-1064)Cl]2 (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation. All studied compounds significantly inhibited acetic acid-induced writhing response. Upon coordination the anti-nociceptive activity was favored in the complex1. H2LASSBio-466 inhibited only the first phase of the formalin test, while1was active in the second phase, like indomethacin, indicating its ability to inhibit nociception associated with the inflammatory response. Hence coordination to zinc(II) altered thepharmacological profile of H2LASSBio-466.H2LASSBio-1064 inhibited both phases but this effect was not improved by coordination. The studied compounds did not increase the latency of response in the hot plate model, indicating their lack of central anti-nociceptive activity. All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile.
publishDate 2011
dc.date.none.fl_str_mv 2011-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/279999
Júnior, Walfrido Bispo; Alexandre Moreira, Magna S.; Alves, Marina A.; Perez Rebolledo, Anayive; Parrilha, Gabrieli L.; et al.; Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H2LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H2LASSBio-1064) and Their Zinc(II) Complexes; Molecular Diversity Preservation International; Molecules; 16; 8; 8-2011; 6902-6915
1420-3049
CONICET Digital
CONICET
url http://hdl.handle.net/11336/279999
identifier_str_mv Júnior, Walfrido Bispo; Alexandre Moreira, Magna S.; Alves, Marina A.; Perez Rebolledo, Anayive; Parrilha, Gabrieli L.; et al.; Analgesic and Anti-Inflammatory Activities of Salicylaldehyde 2-Chlorobenzoyl Hydrazone (H2LASSBio-466), Salicylaldehyde 4-Chlorobenzoyl Hydrazone (H2LASSBio-1064) and Their Zinc(II) Complexes; Molecular Diversity Preservation International; Molecules; 16; 8; 8-2011; 6902-6915
1420-3049
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/16/8/6902
info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules16086902
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1864650627240427520
score 13.1485815

Publicaciones similares