Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(...

Autores
Júnior, Walfrido Bispo; Alexandre Moreira, Magna S.; Alves, Marina A.; Pérez Rebolledo, Anayive; Parrilha, Gabrieli L.; Castellano, Eduardo Ernesto; Piro, Oscar Enrique; Barreiro, Eliezer Jesus de Lacerda; Lima, Lídia Moreira; Beraldo, Heloisa
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Salicylaldehyde 2-chlorobenzoyl hydrazone (H 2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their complexes [Zn(LASSBio- 466)H 2O] 2 (1) and [Zn(HLASSBio-1064)Cl] 2 (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation. All studied compounds significantly inhibited acetic acid-induced writhing response. Upon coordination the antinociceptive activity was favored in the complex 1. H 2LASSBio-466 inhibited only the first phase of the formalin test, while 1 was active in the second phase, like indomethacin, indicating its ability to inhibit nociception associated with the inflammatory response. Hence coordination to zinc(II) altered the pharmacological profile of H 2LASSBio-466. H2LASSBio-1064 inhibited both phases but this effect was not improved by coordination. The studied compounds did not increase the latency of response in the hot plate model, indicating their lack of central anti-nociceptive activity. All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile.
Facultad de Ciencias Exactas
Materia
Ciencias Exactas
Química
acylhydrazones
analgesic agent
analgesic activity
antiinflammatory agent
anti-inflammatory activity
dipyrone
zinc (II) complexes
formaldehyde
hydrazone derivative
morphine
salicylaldehyde
metabolism
pathophysiology
peritonitis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/3.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/35112

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oai_identifier_str oai:sedici.unlp.edu.ar:10915/35112
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexesJúnior, Walfrido BispoAlexandre Moreira, Magna S.Alves, Marina A.Pérez Rebolledo, AnayiveParrilha, Gabrieli L.Castellano, Eduardo ErnestoPiro, Oscar EnriqueBarreiro, Eliezer Jesus de LacerdaLima, Lídia MoreiraBeraldo, HeloisaCiencias ExactasQuímicaacylhydrazonesanalgesic agentanalgesic activityantiinflammatory agentanti-inflammatory activitydipyronezinc (II) complexesformaldehydehydrazone derivativemorphinesalicylaldehydemetabolismpathophysiologyperitonitisSalicylaldehyde 2-chlorobenzoyl hydrazone (H 2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their complexes [Zn(LASSBio- 466)H 2O] 2 (1) and [Zn(HLASSBio-1064)Cl] 2 (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation. All studied compounds significantly inhibited acetic acid-induced writhing response. Upon coordination the antinociceptive activity was favored in the complex 1. H 2LASSBio-466 inhibited only the first phase of the formalin test, while 1 was active in the second phase, like indomethacin, indicating its ability to inhibit nociception associated with the inflammatory response. Hence coordination to zinc(II) altered the pharmacological profile of H 2LASSBio-466. H2LASSBio-1064 inhibited both phases but this effect was not improved by coordination. The studied compounds did not increase the latency of response in the hot plate model, indicating their lack of central anti-nociceptive activity. All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile.Facultad de Ciencias Exactas2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf6902-6915http://sedici.unlp.edu.ar/handle/10915/35112enginfo:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1420-3049/16/8/6902info:eu-repo/semantics/altIdentifier/issn/1420-3049info:eu-repo/semantics/altIdentifier/pmid/21844840info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules16086902info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/Creative Commons Attribution 3.0 Unported (CC BY 3.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T10:57:08Zoai:sedici.unlp.edu.ar:10915/35112Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 10:57:09.128SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes
title Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes
spellingShingle Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes
Júnior, Walfrido Bispo
Ciencias Exactas
Química
acylhydrazones
analgesic agent
analgesic activity
antiinflammatory agent
anti-inflammatory activity
dipyrone
zinc (II) complexes
formaldehyde
hydrazone derivative
morphine
salicylaldehyde
metabolism
pathophysiology
peritonitis
title_short Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes
title_full Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes
title_fullStr Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes
title_full_unstemmed Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes
title_sort Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes
dc.creator.none.fl_str_mv Júnior, Walfrido Bispo
Alexandre Moreira, Magna S.
Alves, Marina A.
Pérez Rebolledo, Anayive
Parrilha, Gabrieli L.
Castellano, Eduardo Ernesto
Piro, Oscar Enrique
Barreiro, Eliezer Jesus de Lacerda
Lima, Lídia Moreira
Beraldo, Heloisa
author Júnior, Walfrido Bispo
author_facet Júnior, Walfrido Bispo
Alexandre Moreira, Magna S.
Alves, Marina A.
Pérez Rebolledo, Anayive
Parrilha, Gabrieli L.
Castellano, Eduardo Ernesto
Piro, Oscar Enrique
Barreiro, Eliezer Jesus de Lacerda
Lima, Lídia Moreira
Beraldo, Heloisa
author_role author
author2 Alexandre Moreira, Magna S.
Alves, Marina A.
Pérez Rebolledo, Anayive
Parrilha, Gabrieli L.
Castellano, Eduardo Ernesto
Piro, Oscar Enrique
Barreiro, Eliezer Jesus de Lacerda
Lima, Lídia Moreira
Beraldo, Heloisa
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Química
acylhydrazones
analgesic agent
analgesic activity
antiinflammatory agent
anti-inflammatory activity
dipyrone
zinc (II) complexes
formaldehyde
hydrazone derivative
morphine
salicylaldehyde
metabolism
pathophysiology
peritonitis
topic Ciencias Exactas
Química
acylhydrazones
analgesic agent
analgesic activity
antiinflammatory agent
anti-inflammatory activity
dipyrone
zinc (II) complexes
formaldehyde
hydrazone derivative
morphine
salicylaldehyde
metabolism
pathophysiology
peritonitis
dc.description.none.fl_txt_mv Salicylaldehyde 2-chlorobenzoyl hydrazone (H 2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their complexes [Zn(LASSBio- 466)H 2O] 2 (1) and [Zn(HLASSBio-1064)Cl] 2 (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation. All studied compounds significantly inhibited acetic acid-induced writhing response. Upon coordination the antinociceptive activity was favored in the complex 1. H 2LASSBio-466 inhibited only the first phase of the formalin test, while 1 was active in the second phase, like indomethacin, indicating its ability to inhibit nociception associated with the inflammatory response. Hence coordination to zinc(II) altered the pharmacological profile of H 2LASSBio-466. H2LASSBio-1064 inhibited both phases but this effect was not improved by coordination. The studied compounds did not increase the latency of response in the hot plate model, indicating their lack of central anti-nociceptive activity. All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile.
Facultad de Ciencias Exactas
description Salicylaldehyde 2-chlorobenzoyl hydrazone (H 2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their complexes [Zn(LASSBio- 466)H 2O] 2 (1) and [Zn(HLASSBio-1064)Cl] 2 (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation. All studied compounds significantly inhibited acetic acid-induced writhing response. Upon coordination the antinociceptive activity was favored in the complex 1. H 2LASSBio-466 inhibited only the first phase of the formalin test, while 1 was active in the second phase, like indomethacin, indicating its ability to inhibit nociception associated with the inflammatory response. Hence coordination to zinc(II) altered the pharmacological profile of H 2LASSBio-466. H2LASSBio-1064 inhibited both phases but this effect was not improved by coordination. The studied compounds did not increase the latency of response in the hot plate model, indicating their lack of central anti-nociceptive activity. All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile.
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/35112
url http://sedici.unlp.edu.ar/handle/10915/35112
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1420-3049/16/8/6902
info:eu-repo/semantics/altIdentifier/issn/1420-3049
info:eu-repo/semantics/altIdentifier/pmid/21844840
info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules16086902
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/
Creative Commons Attribution 3.0 Unported (CC BY 3.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/
Creative Commons Attribution 3.0 Unported (CC BY 3.0)
dc.format.none.fl_str_mv application/pdf
6902-6915
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
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instname_str Universidad Nacional de La Plata
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institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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