Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(...
- Autores
- Júnior, Walfrido Bispo; Alexandre Moreira, Magna S.; Alves, Marina A.; Pérez Rebolledo, Anayive; Parrilha, Gabrieli L.; Castellano, Eduardo Ernesto; Piro, Oscar Enrique; Barreiro, Eliezer Jesus de Lacerda; Lima, Lídia Moreira; Beraldo, Heloisa
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Salicylaldehyde 2-chlorobenzoyl hydrazone (H 2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their complexes [Zn(LASSBio- 466)H 2O] 2 (1) and [Zn(HLASSBio-1064)Cl] 2 (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation. All studied compounds significantly inhibited acetic acid-induced writhing response. Upon coordination the antinociceptive activity was favored in the complex 1. H 2LASSBio-466 inhibited only the first phase of the formalin test, while 1 was active in the second phase, like indomethacin, indicating its ability to inhibit nociception associated with the inflammatory response. Hence coordination to zinc(II) altered the pharmacological profile of H 2LASSBio-466. H2LASSBio-1064 inhibited both phases but this effect was not improved by coordination. The studied compounds did not increase the latency of response in the hot plate model, indicating their lack of central anti-nociceptive activity. All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile.
Facultad de Ciencias Exactas - Materia
-
Ciencias Exactas
Química
acylhydrazones
analgesic agent
analgesic activity
antiinflammatory agent
anti-inflammatory activity
dipyrone
zinc (II) complexes
formaldehyde
hydrazone derivative
morphine
salicylaldehyde
metabolism
pathophysiology
peritonitis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/3.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/35112
Ver los metadatos del registro completo
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Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexesJúnior, Walfrido BispoAlexandre Moreira, Magna S.Alves, Marina A.Pérez Rebolledo, AnayiveParrilha, Gabrieli L.Castellano, Eduardo ErnestoPiro, Oscar EnriqueBarreiro, Eliezer Jesus de LacerdaLima, Lídia MoreiraBeraldo, HeloisaCiencias ExactasQuímicaacylhydrazonesanalgesic agentanalgesic activityantiinflammatory agentanti-inflammatory activitydipyronezinc (II) complexesformaldehydehydrazone derivativemorphinesalicylaldehydemetabolismpathophysiologyperitonitisSalicylaldehyde 2-chlorobenzoyl hydrazone (H 2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their complexes [Zn(LASSBio- 466)H 2O] 2 (1) and [Zn(HLASSBio-1064)Cl] 2 (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation. All studied compounds significantly inhibited acetic acid-induced writhing response. Upon coordination the antinociceptive activity was favored in the complex 1. H 2LASSBio-466 inhibited only the first phase of the formalin test, while 1 was active in the second phase, like indomethacin, indicating its ability to inhibit nociception associated with the inflammatory response. Hence coordination to zinc(II) altered the pharmacological profile of H 2LASSBio-466. H2LASSBio-1064 inhibited both phases but this effect was not improved by coordination. The studied compounds did not increase the latency of response in the hot plate model, indicating their lack of central anti-nociceptive activity. All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile.Facultad de Ciencias Exactas2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf6902-6915http://sedici.unlp.edu.ar/handle/10915/35112enginfo:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1420-3049/16/8/6902info:eu-repo/semantics/altIdentifier/issn/1420-3049info:eu-repo/semantics/altIdentifier/pmid/21844840info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules16086902info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/Creative Commons Attribution 3.0 Unported (CC BY 3.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T10:57:08Zoai:sedici.unlp.edu.ar:10915/35112Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 10:57:09.128SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes |
title |
Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes |
spellingShingle |
Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes Júnior, Walfrido Bispo Ciencias Exactas Química acylhydrazones analgesic agent analgesic activity antiinflammatory agent anti-inflammatory activity dipyrone zinc (II) complexes formaldehyde hydrazone derivative morphine salicylaldehyde metabolism pathophysiology peritonitis |
title_short |
Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes |
title_full |
Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes |
title_fullStr |
Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes |
title_full_unstemmed |
Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes |
title_sort |
Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their zinc(II) complexes |
dc.creator.none.fl_str_mv |
Júnior, Walfrido Bispo Alexandre Moreira, Magna S. Alves, Marina A. Pérez Rebolledo, Anayive Parrilha, Gabrieli L. Castellano, Eduardo Ernesto Piro, Oscar Enrique Barreiro, Eliezer Jesus de Lacerda Lima, Lídia Moreira Beraldo, Heloisa |
author |
Júnior, Walfrido Bispo |
author_facet |
Júnior, Walfrido Bispo Alexandre Moreira, Magna S. Alves, Marina A. Pérez Rebolledo, Anayive Parrilha, Gabrieli L. Castellano, Eduardo Ernesto Piro, Oscar Enrique Barreiro, Eliezer Jesus de Lacerda Lima, Lídia Moreira Beraldo, Heloisa |
author_role |
author |
author2 |
Alexandre Moreira, Magna S. Alves, Marina A. Pérez Rebolledo, Anayive Parrilha, Gabrieli L. Castellano, Eduardo Ernesto Piro, Oscar Enrique Barreiro, Eliezer Jesus de Lacerda Lima, Lídia Moreira Beraldo, Heloisa |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
Ciencias Exactas Química acylhydrazones analgesic agent analgesic activity antiinflammatory agent anti-inflammatory activity dipyrone zinc (II) complexes formaldehyde hydrazone derivative morphine salicylaldehyde metabolism pathophysiology peritonitis |
topic |
Ciencias Exactas Química acylhydrazones analgesic agent analgesic activity antiinflammatory agent anti-inflammatory activity dipyrone zinc (II) complexes formaldehyde hydrazone derivative morphine salicylaldehyde metabolism pathophysiology peritonitis |
dc.description.none.fl_txt_mv |
Salicylaldehyde 2-chlorobenzoyl hydrazone (H 2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their complexes [Zn(LASSBio- 466)H 2O] 2 (1) and [Zn(HLASSBio-1064)Cl] 2 (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation. All studied compounds significantly inhibited acetic acid-induced writhing response. Upon coordination the antinociceptive activity was favored in the complex 1. H 2LASSBio-466 inhibited only the first phase of the formalin test, while 1 was active in the second phase, like indomethacin, indicating its ability to inhibit nociception associated with the inflammatory response. Hence coordination to zinc(II) altered the pharmacological profile of H 2LASSBio-466. H2LASSBio-1064 inhibited both phases but this effect was not improved by coordination. The studied compounds did not increase the latency of response in the hot plate model, indicating their lack of central anti-nociceptive activity. All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile. Facultad de Ciencias Exactas |
description |
Salicylaldehyde 2-chlorobenzoyl hydrazone (H 2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H 2LASSBio-1064) and their complexes [Zn(LASSBio- 466)H 2O] 2 (1) and [Zn(HLASSBio-1064)Cl] 2 (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation. All studied compounds significantly inhibited acetic acid-induced writhing response. Upon coordination the antinociceptive activity was favored in the complex 1. H 2LASSBio-466 inhibited only the first phase of the formalin test, while 1 was active in the second phase, like indomethacin, indicating its ability to inhibit nociception associated with the inflammatory response. Hence coordination to zinc(II) altered the pharmacological profile of H 2LASSBio-466. H2LASSBio-1064 inhibited both phases but this effect was not improved by coordination. The studied compounds did not increase the latency of response in the hot plate model, indicating their lack of central anti-nociceptive activity. All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/35112 |
url |
http://sedici.unlp.edu.ar/handle/10915/35112 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1420-3049/16/8/6902 info:eu-repo/semantics/altIdentifier/issn/1420-3049 info:eu-repo/semantics/altIdentifier/pmid/21844840 info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules16086902 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/3.0/ Creative Commons Attribution 3.0 Unported (CC BY 3.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/3.0/ Creative Commons Attribution 3.0 Unported (CC BY 3.0) |
dc.format.none.fl_str_mv |
application/pdf 6902-6915 |
dc.source.none.fl_str_mv |
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Universidad Nacional de La Plata |
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UNLP |
repository.name.fl_str_mv |
SEDICI (UNLP) - Universidad Nacional de La Plata |
repository.mail.fl_str_mv |
alira@sedici.unlp.edu.ar |
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