Complexation of 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones to copper(II) as an effective strategy for antimicrobial activity improvement

Autores
Recio Despaigne, Angel A.; Da Costa, Fernanda B.; Piro, Oscar Enrique; Castellano, Eduardo E.; Louro, Sonia R.W.; Beraldo, Heloisa
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Complexes [Cu(2AcPh)Cl]·2H 2O (1), [Cu(2AcpClPh)Cl] ·2H 2O (2), [Cu(2AcpNO 2Ph)Cl] (3), [Cu(2BzPh)Cl] (4). [Cu(2BzpClPh)Cl] (5) and [Cu(2BzpNO 2Ph)Cl] (6) were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh), 2-acetylpyridine-para-chloro- phenylhydrazone (H2AcpClPh), 2-acetylpyridine-para-nitro-phenylhydrazone (H2AcpNO 2Ph), 2-benzoylpyridine-phenylhydrazone (H2BzPh), 2-benzoylpyridine-para-chloro-phenylhydrazone (H2BzpClPh) and 2-benzoylpyridine-para-nitro-phenylhydrazone (H2BzpNO 2Ph). The hydrazones showed poor antibacterial effect against Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa but demonstrated significant antifungal activity against Candida albicans. Upon coordination to copper(II) the antibacterial and antifungal activities appreciably increased. H2AcpClPh, H2BzpClPh and their copper(II) complexes (2) and (5), respectively, were as active as fluconazole against C. albicans. © 2012 Elsevier Ltd. All rights reserved.
Fil: Recio Despaigne, Angel A.. Universidade Federal de Minas Gerais; Brasil
Fil: Da Costa, Fernanda B.. Universidade Federal de Minas Gerais; Brasil
Fil: Piro, Oscar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Castellano, Eduardo E.. Universidade de Sao Paulo; Brasil
Fil: Louro, Sonia R.W.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
Fil: Beraldo, Heloisa. Universidade Federal de Minas Gerais; Brasil
Materia
Hydrazones
Copper(Ii) Hydrazones Complexes
Antimicrobial Activity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/76539
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/76539
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Complexation of 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones to copper(II) as an effective strategy for antimicrobial activity improvementRecio Despaigne, Angel A.Da Costa, Fernanda B.Piro, Oscar EnriqueCastellano, Eduardo E.Louro, Sonia R.W.Beraldo, HeloisaHydrazonesCopper(Ii) Hydrazones ComplexesAntimicrobial Activityhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Complexes [Cu(2AcPh)Cl]·2H 2O (1), [Cu(2AcpClPh)Cl] ·2H 2O (2), [Cu(2AcpNO 2Ph)Cl] (3), [Cu(2BzPh)Cl] (4). [Cu(2BzpClPh)Cl] (5) and [Cu(2BzpNO 2Ph)Cl] (6) were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh), 2-acetylpyridine-para-chloro- phenylhydrazone (H2AcpClPh), 2-acetylpyridine-para-nitro-phenylhydrazone (H2AcpNO 2Ph), 2-benzoylpyridine-phenylhydrazone (H2BzPh), 2-benzoylpyridine-para-chloro-phenylhydrazone (H2BzpClPh) and 2-benzoylpyridine-para-nitro-phenylhydrazone (H2BzpNO 2Ph). The hydrazones showed poor antibacterial effect against Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa but demonstrated significant antifungal activity against Candida albicans. Upon coordination to copper(II) the antibacterial and antifungal activities appreciably increased. H2AcpClPh, H2BzpClPh and their copper(II) complexes (2) and (5), respectively, were as active as fluconazole against C. albicans. © 2012 Elsevier Ltd. All rights reserved.Fil: Recio Despaigne, Angel A.. Universidade Federal de Minas Gerais; BrasilFil: Da Costa, Fernanda B.. Universidade Federal de Minas Gerais; BrasilFil: Piro, Oscar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Castellano, Eduardo E.. Universidade de Sao Paulo; BrasilFil: Louro, Sonia R.W.. Pontifícia Universidade Católica do Rio de Janeiro; BrasilFil: Beraldo, Heloisa. Universidade Federal de Minas Gerais; BrasilPergamon-Elsevier Science Ltd2012-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/76539Recio Despaigne, Angel A.; Da Costa, Fernanda B.; Piro, Oscar Enrique; Castellano, Eduardo E.; Louro, Sonia R.W.; et al.; Complexation of 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones to copper(II) as an effective strategy for antimicrobial activity improvement; Pergamon-Elsevier Science Ltd; Polyhedron; 38; 1; 3-2012; 285-2900277-5387CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.poly.2012.03.017info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S027753871200143X?via%3Dihubinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:10Zoai:ri.conicet.gov.ar:11336/76539instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:11.048CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Complexation of 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones to copper(II) as an effective strategy for antimicrobial activity improvement
title Complexation of 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones to copper(II) as an effective strategy for antimicrobial activity improvement
spellingShingle Complexation of 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones to copper(II) as an effective strategy for antimicrobial activity improvement
Recio Despaigne, Angel A.
Hydrazones
Copper(Ii) Hydrazones Complexes
Antimicrobial Activity
title_short Complexation of 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones to copper(II) as an effective strategy for antimicrobial activity improvement
title_full Complexation of 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones to copper(II) as an effective strategy for antimicrobial activity improvement
title_fullStr Complexation of 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones to copper(II) as an effective strategy for antimicrobial activity improvement
title_full_unstemmed Complexation of 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones to copper(II) as an effective strategy for antimicrobial activity improvement
title_sort Complexation of 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones to copper(II) as an effective strategy for antimicrobial activity improvement
dc.creator.none.fl_str_mv Recio Despaigne, Angel A.
Da Costa, Fernanda B.
Piro, Oscar Enrique
Castellano, Eduardo E.
Louro, Sonia R.W.
Beraldo, Heloisa
author Recio Despaigne, Angel A.
author_facet Recio Despaigne, Angel A.
Da Costa, Fernanda B.
Piro, Oscar Enrique
Castellano, Eduardo E.
Louro, Sonia R.W.
Beraldo, Heloisa
author_role author
author2 Da Costa, Fernanda B.
Piro, Oscar Enrique
Castellano, Eduardo E.
Louro, Sonia R.W.
Beraldo, Heloisa
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Hydrazones
Copper(Ii) Hydrazones Complexes
Antimicrobial Activity
topic Hydrazones
Copper(Ii) Hydrazones Complexes
Antimicrobial Activity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Complexes [Cu(2AcPh)Cl]·2H 2O (1), [Cu(2AcpClPh)Cl] ·2H 2O (2), [Cu(2AcpNO 2Ph)Cl] (3), [Cu(2BzPh)Cl] (4). [Cu(2BzpClPh)Cl] (5) and [Cu(2BzpNO 2Ph)Cl] (6) were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh), 2-acetylpyridine-para-chloro- phenylhydrazone (H2AcpClPh), 2-acetylpyridine-para-nitro-phenylhydrazone (H2AcpNO 2Ph), 2-benzoylpyridine-phenylhydrazone (H2BzPh), 2-benzoylpyridine-para-chloro-phenylhydrazone (H2BzpClPh) and 2-benzoylpyridine-para-nitro-phenylhydrazone (H2BzpNO 2Ph). The hydrazones showed poor antibacterial effect against Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa but demonstrated significant antifungal activity against Candida albicans. Upon coordination to copper(II) the antibacterial and antifungal activities appreciably increased. H2AcpClPh, H2BzpClPh and their copper(II) complexes (2) and (5), respectively, were as active as fluconazole against C. albicans. © 2012 Elsevier Ltd. All rights reserved.
Fil: Recio Despaigne, Angel A.. Universidade Federal de Minas Gerais; Brasil
Fil: Da Costa, Fernanda B.. Universidade Federal de Minas Gerais; Brasil
Fil: Piro, Oscar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Castellano, Eduardo E.. Universidade de Sao Paulo; Brasil
Fil: Louro, Sonia R.W.. Pontifícia Universidade Católica do Rio de Janeiro; Brasil
Fil: Beraldo, Heloisa. Universidade Federal de Minas Gerais; Brasil
description Complexes [Cu(2AcPh)Cl]·2H 2O (1), [Cu(2AcpClPh)Cl] ·2H 2O (2), [Cu(2AcpNO 2Ph)Cl] (3), [Cu(2BzPh)Cl] (4). [Cu(2BzpClPh)Cl] (5) and [Cu(2BzpNO 2Ph)Cl] (6) were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh), 2-acetylpyridine-para-chloro- phenylhydrazone (H2AcpClPh), 2-acetylpyridine-para-nitro-phenylhydrazone (H2AcpNO 2Ph), 2-benzoylpyridine-phenylhydrazone (H2BzPh), 2-benzoylpyridine-para-chloro-phenylhydrazone (H2BzpClPh) and 2-benzoylpyridine-para-nitro-phenylhydrazone (H2BzpNO 2Ph). The hydrazones showed poor antibacterial effect against Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa but demonstrated significant antifungal activity against Candida albicans. Upon coordination to copper(II) the antibacterial and antifungal activities appreciably increased. H2AcpClPh, H2BzpClPh and their copper(II) complexes (2) and (5), respectively, were as active as fluconazole against C. albicans. © 2012 Elsevier Ltd. All rights reserved.
publishDate 2012
dc.date.none.fl_str_mv 2012-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/76539
Recio Despaigne, Angel A.; Da Costa, Fernanda B.; Piro, Oscar Enrique; Castellano, Eduardo E.; Louro, Sonia R.W.; et al.; Complexation of 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones to copper(II) as an effective strategy for antimicrobial activity improvement; Pergamon-Elsevier Science Ltd; Polyhedron; 38; 1; 3-2012; 285-290
0277-5387
CONICET Digital
CONICET
url http://hdl.handle.net/11336/76539
identifier_str_mv Recio Despaigne, Angel A.; Da Costa, Fernanda B.; Piro, Oscar Enrique; Castellano, Eduardo E.; Louro, Sonia R.W.; et al.; Complexation of 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones to copper(II) as an effective strategy for antimicrobial activity improvement; Pergamon-Elsevier Science Ltd; Polyhedron; 38; 1; 3-2012; 285-290
0277-5387
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.poly.2012.03.017
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S027753871200143X?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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