Gas antisolvent crystallization of organic salts from aqueous solutions

Autores
Amaro González, Daniel; Mabe, Guillermo Domingo; Zabaloy, Marcelo Santiago; Brignole, Esteban Alberto
Año de publicación
2000
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The selection of process conditions for the crystallization of an organic salt for pharmaceutical applications is studied in the present work. The crystallization process is carried out using the gas anti-solvent (GAS) technique to obtain particles with specific size and size distribution. The application of this process to organic salt aqueous solutions requires the use of cosolvents to increase the solubility of the antisolvent gas in the aqueous phase. The solubility of lobenzarit has been measured in water, methanol and water + methanol mixtures. The low solubility of lobenzarit in organic solvents is taken into account in the selection of the process scheme. Favorable operating conditions are found on the basis of a group contribution with association equation of state coupled with a non-linear optimizer. The feasibility of the proposed scheme and operating conditions are confirmed by experimental studies in a high pressure crystallizer, using CO2 as the antisolvent agent. The particles morphology is found to be strongly dependent on the feed capillary diameter.
Fil: Amaro González, Daniel. Centro de Quimica Farmaceutica; Cuba
Fil: Mabe, Guillermo Domingo. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Zabaloy, Marcelo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur; Argentina
Fil: Brignole, Esteban Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur; Argentina
Materia
Antisolvent
Aqueous Mixtures
Crystallization
Lobenzarit
Methanol
Solubility
Supercritical Fluids
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/37705
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/37705
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Gas antisolvent crystallization of organic salts from aqueous solutionsAmaro González, DanielMabe, Guillermo DomingoZabaloy, Marcelo SantiagoBrignole, Esteban AlbertoAntisolventAqueous MixturesCrystallizationLobenzaritMethanolSolubilitySupercritical Fluidshttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2The selection of process conditions for the crystallization of an organic salt for pharmaceutical applications is studied in the present work. The crystallization process is carried out using the gas anti-solvent (GAS) technique to obtain particles with specific size and size distribution. The application of this process to organic salt aqueous solutions requires the use of cosolvents to increase the solubility of the antisolvent gas in the aqueous phase. The solubility of lobenzarit has been measured in water, methanol and water + methanol mixtures. The low solubility of lobenzarit in organic solvents is taken into account in the selection of the process scheme. Favorable operating conditions are found on the basis of a group contribution with association equation of state coupled with a non-linear optimizer. The feasibility of the proposed scheme and operating conditions are confirmed by experimental studies in a high pressure crystallizer, using CO2 as the antisolvent agent. The particles morphology is found to be strongly dependent on the feed capillary diameter.Fil: Amaro González, Daniel. Centro de Quimica Farmaceutica; CubaFil: Mabe, Guillermo Domingo. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Zabaloy, Marcelo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur; ArgentinaFil: Brignole, Esteban Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur; ArgentinaElsevier Science2000-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/37705Amaro González, Daniel; Mabe, Guillermo Domingo; Zabaloy, Marcelo Santiago; Brignole, Esteban Alberto; Gas antisolvent crystallization of organic salts from aqueous solutions; Elsevier Science; Journal of Supercritical Fluids; 17; 3; 6-2000; 249-2580896-8446CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S089684469900056Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/S0896-8446(99)00056-Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:35Zoai:ri.conicet.gov.ar:11336/37705instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:35.568CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Gas antisolvent crystallization of organic salts from aqueous solutions
title Gas antisolvent crystallization of organic salts from aqueous solutions
spellingShingle Gas antisolvent crystallization of organic salts from aqueous solutions
Amaro González, Daniel
Antisolvent
Aqueous Mixtures
Crystallization
Lobenzarit
Methanol
Solubility
Supercritical Fluids
title_short Gas antisolvent crystallization of organic salts from aqueous solutions
title_full Gas antisolvent crystallization of organic salts from aqueous solutions
title_fullStr Gas antisolvent crystallization of organic salts from aqueous solutions
title_full_unstemmed Gas antisolvent crystallization of organic salts from aqueous solutions
title_sort Gas antisolvent crystallization of organic salts from aqueous solutions
dc.creator.none.fl_str_mv Amaro González, Daniel
Mabe, Guillermo Domingo
Zabaloy, Marcelo Santiago
Brignole, Esteban Alberto
author Amaro González, Daniel
author_facet Amaro González, Daniel
Mabe, Guillermo Domingo
Zabaloy, Marcelo Santiago
Brignole, Esteban Alberto
author_role author
author2 Mabe, Guillermo Domingo
Zabaloy, Marcelo Santiago
Brignole, Esteban Alberto
author2_role author
author
author
dc.subject.none.fl_str_mv Antisolvent
Aqueous Mixtures
Crystallization
Lobenzarit
Methanol
Solubility
Supercritical Fluids
topic Antisolvent
Aqueous Mixtures
Crystallization
Lobenzarit
Methanol
Solubility
Supercritical Fluids
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The selection of process conditions for the crystallization of an organic salt for pharmaceutical applications is studied in the present work. The crystallization process is carried out using the gas anti-solvent (GAS) technique to obtain particles with specific size and size distribution. The application of this process to organic salt aqueous solutions requires the use of cosolvents to increase the solubility of the antisolvent gas in the aqueous phase. The solubility of lobenzarit has been measured in water, methanol and water + methanol mixtures. The low solubility of lobenzarit in organic solvents is taken into account in the selection of the process scheme. Favorable operating conditions are found on the basis of a group contribution with association equation of state coupled with a non-linear optimizer. The feasibility of the proposed scheme and operating conditions are confirmed by experimental studies in a high pressure crystallizer, using CO2 as the antisolvent agent. The particles morphology is found to be strongly dependent on the feed capillary diameter.
Fil: Amaro González, Daniel. Centro de Quimica Farmaceutica; Cuba
Fil: Mabe, Guillermo Domingo. Universidad Nacional del Sur; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Zabaloy, Marcelo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur; Argentina
Fil: Brignole, Esteban Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur; Argentina
description The selection of process conditions for the crystallization of an organic salt for pharmaceutical applications is studied in the present work. The crystallization process is carried out using the gas anti-solvent (GAS) technique to obtain particles with specific size and size distribution. The application of this process to organic salt aqueous solutions requires the use of cosolvents to increase the solubility of the antisolvent gas in the aqueous phase. The solubility of lobenzarit has been measured in water, methanol and water + methanol mixtures. The low solubility of lobenzarit in organic solvents is taken into account in the selection of the process scheme. Favorable operating conditions are found on the basis of a group contribution with association equation of state coupled with a non-linear optimizer. The feasibility of the proposed scheme and operating conditions are confirmed by experimental studies in a high pressure crystallizer, using CO2 as the antisolvent agent. The particles morphology is found to be strongly dependent on the feed capillary diameter.
publishDate 2000
dc.date.none.fl_str_mv 2000-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/37705
Amaro González, Daniel; Mabe, Guillermo Domingo; Zabaloy, Marcelo Santiago; Brignole, Esteban Alberto; Gas antisolvent crystallization of organic salts from aqueous solutions; Elsevier Science; Journal of Supercritical Fluids; 17; 3; 6-2000; 249-258
0896-8446
CONICET Digital
CONICET
url http://hdl.handle.net/11336/37705
identifier_str_mv Amaro González, Daniel; Mabe, Guillermo Domingo; Zabaloy, Marcelo Santiago; Brignole, Esteban Alberto; Gas antisolvent crystallization of organic salts from aqueous solutions; Elsevier Science; Journal of Supercritical Fluids; 17; 3; 6-2000; 249-258
0896-8446
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S089684469900056X
info:eu-repo/semantics/altIdentifier/doi/10.1016/S0896-8446(99)00056-X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613341160407040
score 13.070432

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