Green tea encapsulation by means of high pressure antisolvent coprecipitation

Autores
Sosa, M. V.; Rodríguez Rojo, S.; Mattea, Facundo; Cismondi Duarte, Martín; Cocero, María José
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this work, green tea polyphenols were coprecipitated with a biodegradable polymer (poly-ε-caprolactone, MW: 25,000) by a semi continuous supercritical antisolvent process (SAS). Carbon dioxide was used as antisolvent in addition to be a dispersing agent. Green tea extracts were obtained by microwaved assisted extraction (MAE) technique with acetone. The influence of different process parameters, including the operating pressure (8-12 MPa) and temperature (283-307 K), the polymer to solutes concentration (w/w) ratio (4-58), and the CO2 to solution mass flow rate ratio (4-10) have been studied experimentally. Total content of polyphenols, quantified according to the Folin-Cicalteu method, showed concentrations from 60 to 100% of the maximum theoretical composition. Also HPLC analyses were performed to verify the presence of some of the major tea catechins. SEM images of the products show small particles (3-5 μm) with narrow particle size distribution with a high degree of agglomeration. Drug release profiles in phosphate buffer (pH = 6.8) reveal that the majority of catechins are encapsulated in the crystalline domains of the polymer. © 2010 Elsevier B.V.
Fil: Sosa, M. V.. Universidad de Valladolid; España. Universidad Nacional de Rio Cuarto. Facultad de Ingeniería. Departamento de Tecnología Química; Argentina
Fil: Rodríguez Rojo, S.. Universidad de Valladolid; España
Fil: Mattea, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Valladolid; España
Fil: Cismondi Duarte, Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina
Fil: Cocero, María José. Universidad de Valladolid; España
Materia
Catechins
Co-Precipitation
Green Tea
Poly(Ε-Caprolactone)
Supercritical Antisolvent (Sas)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/66914
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Green tea encapsulation by means of high pressure antisolvent coprecipitationSosa, M. V.Rodríguez Rojo, S.Mattea, FacundoCismondi Duarte, MartínCocero, María JoséCatechinsCo-PrecipitationGreen TeaPoly(Ε-Caprolactone)Supercritical Antisolvent (Sas)https://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2In this work, green tea polyphenols were coprecipitated with a biodegradable polymer (poly-ε-caprolactone, MW: 25,000) by a semi continuous supercritical antisolvent process (SAS). Carbon dioxide was used as antisolvent in addition to be a dispersing agent. Green tea extracts were obtained by microwaved assisted extraction (MAE) technique with acetone. The influence of different process parameters, including the operating pressure (8-12 MPa) and temperature (283-307 K), the polymer to solutes concentration (w/w) ratio (4-58), and the CO2 to solution mass flow rate ratio (4-10) have been studied experimentally. Total content of polyphenols, quantified according to the Folin-Cicalteu method, showed concentrations from 60 to 100% of the maximum theoretical composition. Also HPLC analyses were performed to verify the presence of some of the major tea catechins. SEM images of the products show small particles (3-5 μm) with narrow particle size distribution with a high degree of agglomeration. Drug release profiles in phosphate buffer (pH = 6.8) reveal that the majority of catechins are encapsulated in the crystalline domains of the polymer. © 2010 Elsevier B.V.Fil: Sosa, M. V.. Universidad de Valladolid; España. Universidad Nacional de Rio Cuarto. Facultad de Ingeniería. Departamento de Tecnología Química; ArgentinaFil: Rodríguez Rojo, S.. Universidad de Valladolid; EspañaFil: Mattea, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Valladolid; EspañaFil: Cismondi Duarte, Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; ArgentinaFil: Cocero, María José. Universidad de Valladolid; EspañaElsevier Science2011-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66914Sosa, M. V.; Rodríguez Rojo, S.; Mattea, Facundo; Cismondi Duarte, Martín; Cocero, María José; Green tea encapsulation by means of high pressure antisolvent coprecipitation; Elsevier Science; Journal of Supercritical Fluids; 56; 3; 4-2011; 304-3110896-8446CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0896844610004018info:eu-repo/semantics/altIdentifier/doi/10.1016/j.supflu.2010.10.038info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:08Zoai:ri.conicet.gov.ar:11336/66914instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:08.929CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Green tea encapsulation by means of high pressure antisolvent coprecipitation
title Green tea encapsulation by means of high pressure antisolvent coprecipitation
spellingShingle Green tea encapsulation by means of high pressure antisolvent coprecipitation
Sosa, M. V.
Catechins
Co-Precipitation
Green Tea
Poly(Ε-Caprolactone)
Supercritical Antisolvent (Sas)
title_short Green tea encapsulation by means of high pressure antisolvent coprecipitation
title_full Green tea encapsulation by means of high pressure antisolvent coprecipitation
title_fullStr Green tea encapsulation by means of high pressure antisolvent coprecipitation
title_full_unstemmed Green tea encapsulation by means of high pressure antisolvent coprecipitation
title_sort Green tea encapsulation by means of high pressure antisolvent coprecipitation
dc.creator.none.fl_str_mv Sosa, M. V.
Rodríguez Rojo, S.
Mattea, Facundo
Cismondi Duarte, Martín
Cocero, María José
author Sosa, M. V.
author_facet Sosa, M. V.
Rodríguez Rojo, S.
Mattea, Facundo
Cismondi Duarte, Martín
Cocero, María José
author_role author
author2 Rodríguez Rojo, S.
Mattea, Facundo
Cismondi Duarte, Martín
Cocero, María José
author2_role author
author
author
author
dc.subject.none.fl_str_mv Catechins
Co-Precipitation
Green Tea
Poly(Ε-Caprolactone)
Supercritical Antisolvent (Sas)
topic Catechins
Co-Precipitation
Green Tea
Poly(Ε-Caprolactone)
Supercritical Antisolvent (Sas)
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv In this work, green tea polyphenols were coprecipitated with a biodegradable polymer (poly-ε-caprolactone, MW: 25,000) by a semi continuous supercritical antisolvent process (SAS). Carbon dioxide was used as antisolvent in addition to be a dispersing agent. Green tea extracts were obtained by microwaved assisted extraction (MAE) technique with acetone. The influence of different process parameters, including the operating pressure (8-12 MPa) and temperature (283-307 K), the polymer to solutes concentration (w/w) ratio (4-58), and the CO2 to solution mass flow rate ratio (4-10) have been studied experimentally. Total content of polyphenols, quantified according to the Folin-Cicalteu method, showed concentrations from 60 to 100% of the maximum theoretical composition. Also HPLC analyses were performed to verify the presence of some of the major tea catechins. SEM images of the products show small particles (3-5 μm) with narrow particle size distribution with a high degree of agglomeration. Drug release profiles in phosphate buffer (pH = 6.8) reveal that the majority of catechins are encapsulated in the crystalline domains of the polymer. © 2010 Elsevier B.V.
Fil: Sosa, M. V.. Universidad de Valladolid; España. Universidad Nacional de Rio Cuarto. Facultad de Ingeniería. Departamento de Tecnología Química; Argentina
Fil: Rodríguez Rojo, S.. Universidad de Valladolid; España
Fil: Mattea, Facundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Valladolid; España
Fil: Cismondi Duarte, Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina
Fil: Cocero, María José. Universidad de Valladolid; España
description In this work, green tea polyphenols were coprecipitated with a biodegradable polymer (poly-ε-caprolactone, MW: 25,000) by a semi continuous supercritical antisolvent process (SAS). Carbon dioxide was used as antisolvent in addition to be a dispersing agent. Green tea extracts were obtained by microwaved assisted extraction (MAE) technique with acetone. The influence of different process parameters, including the operating pressure (8-12 MPa) and temperature (283-307 K), the polymer to solutes concentration (w/w) ratio (4-58), and the CO2 to solution mass flow rate ratio (4-10) have been studied experimentally. Total content of polyphenols, quantified according to the Folin-Cicalteu method, showed concentrations from 60 to 100% of the maximum theoretical composition. Also HPLC analyses were performed to verify the presence of some of the major tea catechins. SEM images of the products show small particles (3-5 μm) with narrow particle size distribution with a high degree of agglomeration. Drug release profiles in phosphate buffer (pH = 6.8) reveal that the majority of catechins are encapsulated in the crystalline domains of the polymer. © 2010 Elsevier B.V.
publishDate 2011
dc.date.none.fl_str_mv 2011-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/66914
Sosa, M. V.; Rodríguez Rojo, S.; Mattea, Facundo; Cismondi Duarte, Martín; Cocero, María José; Green tea encapsulation by means of high pressure antisolvent coprecipitation; Elsevier Science; Journal of Supercritical Fluids; 56; 3; 4-2011; 304-311
0896-8446
CONICET Digital
CONICET
url http://hdl.handle.net/11336/66914
identifier_str_mv Sosa, M. V.; Rodríguez Rojo, S.; Mattea, Facundo; Cismondi Duarte, Martín; Cocero, María José; Green tea encapsulation by means of high pressure antisolvent coprecipitation; Elsevier Science; Journal of Supercritical Fluids; 56; 3; 4-2011; 304-311
0896-8446
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0896844610004018
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.supflu.2010.10.038
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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