Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals

Autores
Trigila, Anabella Paola; Pisciottano, Francisco; Franchini, Lucia Florencia
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mammals possess unique hearing capacities that differ significantly from those of the rest of the amniotes. In order to gain insights into the evolution of the mammalian inner ear, we aim to identify the set of genetic changes and the evolutionary forces that underlie this process. We hypothesize that genes that impair hearing when mutated in humans or in mice (hearing loss (HL) genes) must play important roles in the development and physiology of the inner ear and may have been targets of selective forces across the evolution of mammals. Additionally, we investigated if these HL genes underwent a human-specific evolutionary process that could underlie the evolution of phenotypic traits that characterize human hearing.
Fil: Trigila, Anabella Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Pisciottano, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Franchini, Lucia Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Materia
INNER EAR,
EVOLUTION
HEARING LOSS
MAMMALS
TSARS
HARS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/150123
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/150123
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammalsTrigila, Anabella PaolaPisciottano, FranciscoFranchini, Lucia FlorenciaINNER EAR,EVOLUTIONHEARING LOSSMAMMALSTSARSHARShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Mammals possess unique hearing capacities that differ significantly from those of the rest of the amniotes. In order to gain insights into the evolution of the mammalian inner ear, we aim to identify the set of genetic changes and the evolutionary forces that underlie this process. We hypothesize that genes that impair hearing when mutated in humans or in mice (hearing loss (HL) genes) must play important roles in the development and physiology of the inner ear and may have been targets of selective forces across the evolution of mammals. Additionally, we investigated if these HL genes underwent a human-specific evolutionary process that could underlie the evolution of phenotypic traits that characterize human hearing.Fil: Trigila, Anabella Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Pisciottano, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Franchini, Lucia Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaBioMed Central2021-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/150123Trigila, Anabella Paola; Pisciottano, Francisco; Franchini, Lucia Florencia; Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals; BioMed Central; Bmc Biology; 19; 1; 11-2021; 1-241741-7007CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-01170-6info:eu-repo/semantics/altIdentifier/doi/10.1186/s12915-021-01170-6info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:01Zoai:ri.conicet.gov.ar:11336/150123instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:01.547CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals
title Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals
spellingShingle Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals
Trigila, Anabella Paola
INNER EAR,
EVOLUTION
HEARING LOSS
MAMMALS
TSARS
HARS
title_short Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals
title_full Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals
title_fullStr Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals
title_full_unstemmed Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals
title_sort Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals
dc.creator.none.fl_str_mv Trigila, Anabella Paola
Pisciottano, Francisco
Franchini, Lucia Florencia
author Trigila, Anabella Paola
author_facet Trigila, Anabella Paola
Pisciottano, Francisco
Franchini, Lucia Florencia
author_role author
author2 Pisciottano, Francisco
Franchini, Lucia Florencia
author2_role author
author
dc.subject.none.fl_str_mv INNER EAR,
EVOLUTION
HEARING LOSS
MAMMALS
TSARS
HARS
topic INNER EAR,
EVOLUTION
HEARING LOSS
MAMMALS
TSARS
HARS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Mammals possess unique hearing capacities that differ significantly from those of the rest of the amniotes. In order to gain insights into the evolution of the mammalian inner ear, we aim to identify the set of genetic changes and the evolutionary forces that underlie this process. We hypothesize that genes that impair hearing when mutated in humans or in mice (hearing loss (HL) genes) must play important roles in the development and physiology of the inner ear and may have been targets of selective forces across the evolution of mammals. Additionally, we investigated if these HL genes underwent a human-specific evolutionary process that could underlie the evolution of phenotypic traits that characterize human hearing.
Fil: Trigila, Anabella Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Pisciottano, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Franchini, Lucia Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
description Mammals possess unique hearing capacities that differ significantly from those of the rest of the amniotes. In order to gain insights into the evolution of the mammalian inner ear, we aim to identify the set of genetic changes and the evolutionary forces that underlie this process. We hypothesize that genes that impair hearing when mutated in humans or in mice (hearing loss (HL) genes) must play important roles in the development and physiology of the inner ear and may have been targets of selective forces across the evolution of mammals. Additionally, we investigated if these HL genes underwent a human-specific evolutionary process that could underlie the evolution of phenotypic traits that characterize human hearing.
publishDate 2021
dc.date.none.fl_str_mv 2021-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/150123
Trigila, Anabella Paola; Pisciottano, Francisco; Franchini, Lucia Florencia; Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals; BioMed Central; Bmc Biology; 19; 1; 11-2021; 1-24
1741-7007
CONICET Digital
CONICET
url http://hdl.handle.net/11336/150123
identifier_str_mv Trigila, Anabella Paola; Pisciottano, Francisco; Franchini, Lucia Florencia; Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals; BioMed Central; Bmc Biology; 19; 1; 11-2021; 1-24
1741-7007
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-01170-6
info:eu-repo/semantics/altIdentifier/doi/10.1186/s12915-021-01170-6
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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