Prestin and the cholinergic receptor of hair cells: Positively-selected proteins in mammals

Autores
Elgoyhen, Ana Belen; Franchini, Lucia Florencia
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The hair cells of the vertebrate inner ear posses an active mechanical process to amplify their inputs. The stereocilia bundle of various vertebrate animals can produce active movements. Though standard stereocilia-based mechanisms to promote amplification persist in mammals, an additional radically different mechanism evolved: the so called somatic electromotility which refers to the elongation/contraction of the outer hair cells? (OHC) cylindrical cell body in response to membrane voltage changes. Somatic electromotility in OHCs, as the basis for cochlear amplification, is a mammalian novelty and it is largely dependent upon the properties of the unique motor protein prestin, which is densely packed in the OHC?s lateral wall. We review recent literature which has demonstrated that although the gene encoding prestin is present in all vertebrate species, mammalian prestin has been under positive selective pressure to acquire motor properties, probably rendering it fit to serve somatic motility in outer hair cells. Moreover, we discuss data which indicates that a modified a10 nicotinic cholinergic subunit has coevolved in mammals most likely to give the auditory feedback system the capability to control somatic electromotility.
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; Argentina
Fil: Franchini, Lucia Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Materia
INNER
EAR
EVOLUTION
MAMMALS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/238269
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Prestin and the cholinergic receptor of hair cells: Positively-selected proteins in mammalsElgoyhen, Ana BelenFranchini, Lucia FlorenciaINNEREAREVOLUTIONMAMMALShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The hair cells of the vertebrate inner ear posses an active mechanical process to amplify their inputs. The stereocilia bundle of various vertebrate animals can produce active movements. Though standard stereocilia-based mechanisms to promote amplification persist in mammals, an additional radically different mechanism evolved: the so called somatic electromotility which refers to the elongation/contraction of the outer hair cells? (OHC) cylindrical cell body in response to membrane voltage changes. Somatic electromotility in OHCs, as the basis for cochlear amplification, is a mammalian novelty and it is largely dependent upon the properties of the unique motor protein prestin, which is densely packed in the OHC?s lateral wall. We review recent literature which has demonstrated that although the gene encoding prestin is present in all vertebrate species, mammalian prestin has been under positive selective pressure to acquire motor properties, probably rendering it fit to serve somatic motility in outer hair cells. Moreover, we discuss data which indicates that a modified a10 nicotinic cholinergic subunit has coevolved in mammals most likely to give the auditory feedback system the capability to control somatic electromotility.Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; ArgentinaFil: Franchini, Lucia Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaElsevier Science2011-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/238269Elgoyhen, Ana Belen; Franchini, Lucia Florencia; Prestin and the cholinergic receptor of hair cells: Positively-selected proteins in mammals; Elsevier Science; Hearing Research; 273; 1-2; 3-2011; 100-1080378-5955CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.heares.2009.12.028info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0378595509003281info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:21Zoai:ri.conicet.gov.ar:11336/238269instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:21.935CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Prestin and the cholinergic receptor of hair cells: Positively-selected proteins in mammals
title Prestin and the cholinergic receptor of hair cells: Positively-selected proteins in mammals
spellingShingle Prestin and the cholinergic receptor of hair cells: Positively-selected proteins in mammals
Elgoyhen, Ana Belen
INNER
EAR
EVOLUTION
MAMMALS
title_short Prestin and the cholinergic receptor of hair cells: Positively-selected proteins in mammals
title_full Prestin and the cholinergic receptor of hair cells: Positively-selected proteins in mammals
title_fullStr Prestin and the cholinergic receptor of hair cells: Positively-selected proteins in mammals
title_full_unstemmed Prestin and the cholinergic receptor of hair cells: Positively-selected proteins in mammals
title_sort Prestin and the cholinergic receptor of hair cells: Positively-selected proteins in mammals
dc.creator.none.fl_str_mv Elgoyhen, Ana Belen
Franchini, Lucia Florencia
author Elgoyhen, Ana Belen
author_facet Elgoyhen, Ana Belen
Franchini, Lucia Florencia
author_role author
author2 Franchini, Lucia Florencia
author2_role author
dc.subject.none.fl_str_mv INNER
EAR
EVOLUTION
MAMMALS
topic INNER
EAR
EVOLUTION
MAMMALS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The hair cells of the vertebrate inner ear posses an active mechanical process to amplify their inputs. The stereocilia bundle of various vertebrate animals can produce active movements. Though standard stereocilia-based mechanisms to promote amplification persist in mammals, an additional radically different mechanism evolved: the so called somatic electromotility which refers to the elongation/contraction of the outer hair cells? (OHC) cylindrical cell body in response to membrane voltage changes. Somatic electromotility in OHCs, as the basis for cochlear amplification, is a mammalian novelty and it is largely dependent upon the properties of the unique motor protein prestin, which is densely packed in the OHC?s lateral wall. We review recent literature which has demonstrated that although the gene encoding prestin is present in all vertebrate species, mammalian prestin has been under positive selective pressure to acquire motor properties, probably rendering it fit to serve somatic motility in outer hair cells. Moreover, we discuss data which indicates that a modified a10 nicotinic cholinergic subunit has coevolved in mammals most likely to give the auditory feedback system the capability to control somatic electromotility.
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; Argentina
Fil: Franchini, Lucia Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
description The hair cells of the vertebrate inner ear posses an active mechanical process to amplify their inputs. The stereocilia bundle of various vertebrate animals can produce active movements. Though standard stereocilia-based mechanisms to promote amplification persist in mammals, an additional radically different mechanism evolved: the so called somatic electromotility which refers to the elongation/contraction of the outer hair cells? (OHC) cylindrical cell body in response to membrane voltage changes. Somatic electromotility in OHCs, as the basis for cochlear amplification, is a mammalian novelty and it is largely dependent upon the properties of the unique motor protein prestin, which is densely packed in the OHC?s lateral wall. We review recent literature which has demonstrated that although the gene encoding prestin is present in all vertebrate species, mammalian prestin has been under positive selective pressure to acquire motor properties, probably rendering it fit to serve somatic motility in outer hair cells. Moreover, we discuss data which indicates that a modified a10 nicotinic cholinergic subunit has coevolved in mammals most likely to give the auditory feedback system the capability to control somatic electromotility.
publishDate 2011
dc.date.none.fl_str_mv 2011-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/238269
Elgoyhen, Ana Belen; Franchini, Lucia Florencia; Prestin and the cholinergic receptor of hair cells: Positively-selected proteins in mammals; Elsevier Science; Hearing Research; 273; 1-2; 3-2011; 100-108
0378-5955
CONICET Digital
CONICET
url http://hdl.handle.net/11336/238269
identifier_str_mv Elgoyhen, Ana Belen; Franchini, Lucia Florencia; Prestin and the cholinergic receptor of hair cells: Positively-selected proteins in mammals; Elsevier Science; Hearing Research; 273; 1-2; 3-2011; 100-108
0378-5955
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.heares.2009.12.028
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0378595509003281
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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