Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels

Autores
Gaspar Tosato, Maira; Orallo, Dalila Elisabet; Churio, Maria Sandra; Abrahao Martin, Airton; Tellez Soto, Claudio; Dicelio, Lelia Elina
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
BACKGROUND: The amphiphilic nature of polymers allows them to be widely incorporated as carriers in different pharmaceutical applications since they are able to work as vehicles for hydro- or lipo-soluble actives. OBJECTIVE: The aim of this study was to determine the rheological behavior and vibrational spectral variations of two hydrophilic gels prepared with Poloxamer 407 (PO) or Pluronic F-127 (PL) with the addition of the actives mycosporine-like amino acids and gadusol. METHODS: The structures of these polymers in two different concentrations (20% w/w and 27% w/w) were characterized by rheological studies and Raman spectroscopy. RESULTS: Gels prepared with higher polymer concentration showed larger G′ (storage modulus) values. The C–C stretch and the CH2 rocking predominated in the gels containing PL (20% w/w) and this correlated with a less viscous behavior. The mixture of the actives induced higher contributions of Raman peaks related to trans conformation of the C–C bonds located in hydrophilic polymer blocks, whereas the same peaks decreased in the sample containing only gadusol. CONCLUSIONS: Larger tensile strength and elastic component were observed upon increasing polymer concentration, thus evidencing polymer–polymer and/or polymer–polymer–actives interactions. The presence of the actives affected the mechanical properties of the polymer gels. Gadusol particularly seems to alter the conformation of the polymer chains by favoring gauche orientations, in parallel with rising viscoelastic parameters. More stretched arrangements of the polymer are probably induced in the presence of larger concentration of actives, due to specific interactions with their hydrophilic groups.
Fil: Gaspar Tosato, Maira. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Orallo, Dalila Elisabet. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Churio, Maria Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Abrahao Martin, Airton. Universidade do Vale doParaíba. Sao José dos Campos; Brasil
Fil: Tellez Soto, Claudio. Universidade do Vale doParaíba. Sao José dos Campos; Brasil
Fil: Dicelio, Lelia Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Materia
Triblock Copolymers
Viscoelastic
Mycosporine-Like Amino Acids
Gadusol
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/35276
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/35276
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gelsGaspar Tosato, MairaOrallo, Dalila ElisabetChurio, Maria SandraAbrahao Martin, AirtonTellez Soto, ClaudioDicelio, Lelia ElinaTriblock CopolymersViscoelasticMycosporine-Like Amino AcidsGadusolBACKGROUND: The amphiphilic nature of polymers allows them to be widely incorporated as carriers in different pharmaceutical applications since they are able to work as vehicles for hydro- or lipo-soluble actives. OBJECTIVE: The aim of this study was to determine the rheological behavior and vibrational spectral variations of two hydrophilic gels prepared with Poloxamer 407 (PO) or Pluronic F-127 (PL) with the addition of the actives mycosporine-like amino acids and gadusol. METHODS: The structures of these polymers in two different concentrations (20% w/w and 27% w/w) were characterized by rheological studies and Raman spectroscopy. RESULTS: Gels prepared with higher polymer concentration showed larger G′ (storage modulus) values. The C–C stretch and the CH2 rocking predominated in the gels containing PL (20% w/w) and this correlated with a less viscous behavior. The mixture of the actives induced higher contributions of Raman peaks related to trans conformation of the C–C bonds located in hydrophilic polymer blocks, whereas the same peaks decreased in the sample containing only gadusol. CONCLUSIONS: Larger tensile strength and elastic component were observed upon increasing polymer concentration, thus evidencing polymer–polymer and/or polymer–polymer–actives interactions. The presence of the actives affected the mechanical properties of the polymer gels. Gadusol particularly seems to alter the conformation of the polymer chains by favoring gauche orientations, in parallel with rising viscoelastic parameters. More stretched arrangements of the polymer are probably induced in the presence of larger concentration of actives, due to specific interactions with their hydrophilic groups.Fil: Gaspar Tosato, Maira. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Orallo, Dalila Elisabet. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Churio, Maria Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Abrahao Martin, Airton. Universidade do Vale doParaíba. Sao José dos Campos; BrasilFil: Tellez Soto, Claudio. Universidade do Vale doParaíba. Sao José dos Campos; BrasilFil: Dicelio, Lelia Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaIOS Press2014-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/35276Gaspar Tosato, Maira; Orallo, Dalila Elisabet; Churio, Maria Sandra; Abrahao Martin, Airton; Tellez Soto, Claudio; et al.; Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels; IOS Press; Biorheology; 51; 5; 11-2014; 315-3280006-355XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3233/BIR-14014info:eu-repo/semantics/altIdentifier/url/https://content.iospress.com/articles/biorheology/bir14014info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:03:10Zoai:ri.conicet.gov.ar:11336/35276instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:03:10.298CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels
title Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels
spellingShingle Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels
Gaspar Tosato, Maira
Triblock Copolymers
Viscoelastic
Mycosporine-Like Amino Acids
Gadusol
title_short Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels
title_full Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels
title_fullStr Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels
title_full_unstemmed Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels
title_sort Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels
dc.creator.none.fl_str_mv Gaspar Tosato, Maira
Orallo, Dalila Elisabet
Churio, Maria Sandra
Abrahao Martin, Airton
Tellez Soto, Claudio
Dicelio, Lelia Elina
author Gaspar Tosato, Maira
author_facet Gaspar Tosato, Maira
Orallo, Dalila Elisabet
Churio, Maria Sandra
Abrahao Martin, Airton
Tellez Soto, Claudio
Dicelio, Lelia Elina
author_role author
author2 Orallo, Dalila Elisabet
Churio, Maria Sandra
Abrahao Martin, Airton
Tellez Soto, Claudio
Dicelio, Lelia Elina
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Triblock Copolymers
Viscoelastic
Mycosporine-Like Amino Acids
Gadusol
topic Triblock Copolymers
Viscoelastic
Mycosporine-Like Amino Acids
Gadusol
dc.description.none.fl_txt_mv BACKGROUND: The amphiphilic nature of polymers allows them to be widely incorporated as carriers in different pharmaceutical applications since they are able to work as vehicles for hydro- or lipo-soluble actives. OBJECTIVE: The aim of this study was to determine the rheological behavior and vibrational spectral variations of two hydrophilic gels prepared with Poloxamer 407 (PO) or Pluronic F-127 (PL) with the addition of the actives mycosporine-like amino acids and gadusol. METHODS: The structures of these polymers in two different concentrations (20% w/w and 27% w/w) were characterized by rheological studies and Raman spectroscopy. RESULTS: Gels prepared with higher polymer concentration showed larger G′ (storage modulus) values. The C–C stretch and the CH2 rocking predominated in the gels containing PL (20% w/w) and this correlated with a less viscous behavior. The mixture of the actives induced higher contributions of Raman peaks related to trans conformation of the C–C bonds located in hydrophilic polymer blocks, whereas the same peaks decreased in the sample containing only gadusol. CONCLUSIONS: Larger tensile strength and elastic component were observed upon increasing polymer concentration, thus evidencing polymer–polymer and/or polymer–polymer–actives interactions. The presence of the actives affected the mechanical properties of the polymer gels. Gadusol particularly seems to alter the conformation of the polymer chains by favoring gauche orientations, in parallel with rising viscoelastic parameters. More stretched arrangements of the polymer are probably induced in the presence of larger concentration of actives, due to specific interactions with their hydrophilic groups.
Fil: Gaspar Tosato, Maira. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Orallo, Dalila Elisabet. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Churio, Maria Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Abrahao Martin, Airton. Universidade do Vale doParaíba. Sao José dos Campos; Brasil
Fil: Tellez Soto, Claudio. Universidade do Vale doParaíba. Sao José dos Campos; Brasil
Fil: Dicelio, Lelia Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
description BACKGROUND: The amphiphilic nature of polymers allows them to be widely incorporated as carriers in different pharmaceutical applications since they are able to work as vehicles for hydro- or lipo-soluble actives. OBJECTIVE: The aim of this study was to determine the rheological behavior and vibrational spectral variations of two hydrophilic gels prepared with Poloxamer 407 (PO) or Pluronic F-127 (PL) with the addition of the actives mycosporine-like amino acids and gadusol. METHODS: The structures of these polymers in two different concentrations (20% w/w and 27% w/w) were characterized by rheological studies and Raman spectroscopy. RESULTS: Gels prepared with higher polymer concentration showed larger G′ (storage modulus) values. The C–C stretch and the CH2 rocking predominated in the gels containing PL (20% w/w) and this correlated with a less viscous behavior. The mixture of the actives induced higher contributions of Raman peaks related to trans conformation of the C–C bonds located in hydrophilic polymer blocks, whereas the same peaks decreased in the sample containing only gadusol. CONCLUSIONS: Larger tensile strength and elastic component were observed upon increasing polymer concentration, thus evidencing polymer–polymer and/or polymer–polymer–actives interactions. The presence of the actives affected the mechanical properties of the polymer gels. Gadusol particularly seems to alter the conformation of the polymer chains by favoring gauche orientations, in parallel with rising viscoelastic parameters. More stretched arrangements of the polymer are probably induced in the presence of larger concentration of actives, due to specific interactions with their hydrophilic groups.
publishDate 2014
dc.date.none.fl_str_mv 2014-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/35276
Gaspar Tosato, Maira; Orallo, Dalila Elisabet; Churio, Maria Sandra; Abrahao Martin, Airton; Tellez Soto, Claudio; et al.; Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels; IOS Press; Biorheology; 51; 5; 11-2014; 315-328
0006-355X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/35276
identifier_str_mv Gaspar Tosato, Maira; Orallo, Dalila Elisabet; Churio, Maria Sandra; Abrahao Martin, Airton; Tellez Soto, Claudio; et al.; Influence of mycosporine-like amino acids and gadusol on the rheology and Raman spectroscopy of polymer gels; IOS Press; Biorheology; 51; 5; 11-2014; 315-328
0006-355X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3233/BIR-14014
info:eu-repo/semantics/altIdentifier/url/https://content.iospress.com/articles/biorheology/bir14014
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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