Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update

Autores
Robello, Elizabeth; Bonetto, Julián Gerardo; Puntarulo, Susana Ángela
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Both epidemiological and experimental data indicate that ionizing radiation (IR) may disrupt developmental processes leading to deleterious effects on brain functions. A central role of reactive oxygen (ROS) and nitrogen species (RNS), as important mediators in neurotoxicity and neuroprotection, has been demonstrated. Primary ionization events triggered by IR are amplified and propagated by mechanisms involving ROS and RNS, which activate several signaling pathways leading to final radiation effects. The immature and adult brain display clear differences in the way they respond to insults. Moreover, a great deal of attention is being focus on the limited antioxidant capacity and the particular lipid composition of cell membranes of the developing brain that render it more vulnerable to oxidative stress. The goal of this review is to summarize the current knowledge on the role of alterations in the balance between oxidative/nitrosative stress and antioxidant capacity in the pathways involved in cellular radiation response, with particular focus on the possible therapies proposed to limit radiation-induced effects in the brain.
Fil: Robello, Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Bonetto, Julián Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Materia
Antioxidant Protection
Fetal Brain
Gamma Irradiation
Oxidative And Nitrosative Stress
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47388

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spelling Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An UpdateRobello, ElizabethBonetto, Julián GerardoPuntarulo, Susana ÁngelaAntioxidant ProtectionFetal BrainGamma IrradiationOxidative And Nitrosative Stresshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Both epidemiological and experimental data indicate that ionizing radiation (IR) may disrupt developmental processes leading to deleterious effects on brain functions. A central role of reactive oxygen (ROS) and nitrogen species (RNS), as important mediators in neurotoxicity and neuroprotection, has been demonstrated. Primary ionization events triggered by IR are amplified and propagated by mechanisms involving ROS and RNS, which activate several signaling pathways leading to final radiation effects. The immature and adult brain display clear differences in the way they respond to insults. Moreover, a great deal of attention is being focus on the limited antioxidant capacity and the particular lipid composition of cell membranes of the developing brain that render it more vulnerable to oxidative stress. The goal of this review is to summarize the current knowledge on the role of alterations in the balance between oxidative/nitrosative stress and antioxidant capacity in the pathways involved in cellular radiation response, with particular focus on the possible therapies proposed to limit radiation-induced effects in the brain.Fil: Robello, Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Bonetto, Julián Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaBentham Science Publishers2016-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47388Robello, Elizabeth; Bonetto, Julián Gerardo; Puntarulo, Susana Ángela; Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 16; 12; 7-2016; 937-9461389-5575CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2174/1389557516666160611021840info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/143226/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:45:55Zoai:ri.conicet.gov.ar:11336/47388instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:45:55.584CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update
title Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update
spellingShingle Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update
Robello, Elizabeth
Antioxidant Protection
Fetal Brain
Gamma Irradiation
Oxidative And Nitrosative Stress
title_short Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update
title_full Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update
title_fullStr Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update
title_full_unstemmed Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update
title_sort Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update
dc.creator.none.fl_str_mv Robello, Elizabeth
Bonetto, Julián Gerardo
Puntarulo, Susana Ángela
author Robello, Elizabeth
author_facet Robello, Elizabeth
Bonetto, Julián Gerardo
Puntarulo, Susana Ángela
author_role author
author2 Bonetto, Julián Gerardo
Puntarulo, Susana Ángela
author2_role author
author
dc.subject.none.fl_str_mv Antioxidant Protection
Fetal Brain
Gamma Irradiation
Oxidative And Nitrosative Stress
topic Antioxidant Protection
Fetal Brain
Gamma Irradiation
Oxidative And Nitrosative Stress
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Both epidemiological and experimental data indicate that ionizing radiation (IR) may disrupt developmental processes leading to deleterious effects on brain functions. A central role of reactive oxygen (ROS) and nitrogen species (RNS), as important mediators in neurotoxicity and neuroprotection, has been demonstrated. Primary ionization events triggered by IR are amplified and propagated by mechanisms involving ROS and RNS, which activate several signaling pathways leading to final radiation effects. The immature and adult brain display clear differences in the way they respond to insults. Moreover, a great deal of attention is being focus on the limited antioxidant capacity and the particular lipid composition of cell membranes of the developing brain that render it more vulnerable to oxidative stress. The goal of this review is to summarize the current knowledge on the role of alterations in the balance between oxidative/nitrosative stress and antioxidant capacity in the pathways involved in cellular radiation response, with particular focus on the possible therapies proposed to limit radiation-induced effects in the brain.
Fil: Robello, Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Bonetto, Julián Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
description Both epidemiological and experimental data indicate that ionizing radiation (IR) may disrupt developmental processes leading to deleterious effects on brain functions. A central role of reactive oxygen (ROS) and nitrogen species (RNS), as important mediators in neurotoxicity and neuroprotection, has been demonstrated. Primary ionization events triggered by IR are amplified and propagated by mechanisms involving ROS and RNS, which activate several signaling pathways leading to final radiation effects. The immature and adult brain display clear differences in the way they respond to insults. Moreover, a great deal of attention is being focus on the limited antioxidant capacity and the particular lipid composition of cell membranes of the developing brain that render it more vulnerable to oxidative stress. The goal of this review is to summarize the current knowledge on the role of alterations in the balance between oxidative/nitrosative stress and antioxidant capacity in the pathways involved in cellular radiation response, with particular focus on the possible therapies proposed to limit radiation-induced effects in the brain.
publishDate 2016
dc.date.none.fl_str_mv 2016-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47388
Robello, Elizabeth; Bonetto, Julián Gerardo; Puntarulo, Susana Ángela; Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 16; 12; 7-2016; 937-946
1389-5575
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47388
identifier_str_mv Robello, Elizabeth; Bonetto, Julián Gerardo; Puntarulo, Susana Ángela; Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 16; 12; 7-2016; 937-946
1389-5575
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/143226/article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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