Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update
- Autores
- Robello, Elizabeth; Bonetto, Julián Gerardo; Puntarulo, Susana Ángela
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Both epidemiological and experimental data indicate that ionizing radiation (IR) may disrupt developmental processes leading to deleterious effects on brain functions. A central role of reactive oxygen (ROS) and nitrogen species (RNS), as important mediators in neurotoxicity and neuroprotection, has been demonstrated. Primary ionization events triggered by IR are amplified and propagated by mechanisms involving ROS and RNS, which activate several signaling pathways leading to final radiation effects. The immature and adult brain display clear differences in the way they respond to insults. Moreover, a great deal of attention is being focus on the limited antioxidant capacity and the particular lipid composition of cell membranes of the developing brain that render it more vulnerable to oxidative stress. The goal of this review is to summarize the current knowledge on the role of alterations in the balance between oxidative/nitrosative stress and antioxidant capacity in the pathways involved in cellular radiation response, with particular focus on the possible therapies proposed to limit radiation-induced effects in the brain.
Fil: Robello, Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Bonetto, Julián Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina - Materia
-
Antioxidant Protection
Fetal Brain
Gamma Irradiation
Oxidative And Nitrosative Stress - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/47388
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Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An UpdateRobello, ElizabethBonetto, Julián GerardoPuntarulo, Susana ÁngelaAntioxidant ProtectionFetal BrainGamma IrradiationOxidative And Nitrosative Stresshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Both epidemiological and experimental data indicate that ionizing radiation (IR) may disrupt developmental processes leading to deleterious effects on brain functions. A central role of reactive oxygen (ROS) and nitrogen species (RNS), as important mediators in neurotoxicity and neuroprotection, has been demonstrated. Primary ionization events triggered by IR are amplified and propagated by mechanisms involving ROS and RNS, which activate several signaling pathways leading to final radiation effects. The immature and adult brain display clear differences in the way they respond to insults. Moreover, a great deal of attention is being focus on the limited antioxidant capacity and the particular lipid composition of cell membranes of the developing brain that render it more vulnerable to oxidative stress. The goal of this review is to summarize the current knowledge on the role of alterations in the balance between oxidative/nitrosative stress and antioxidant capacity in the pathways involved in cellular radiation response, with particular focus on the possible therapies proposed to limit radiation-induced effects in the brain.Fil: Robello, Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Bonetto, Julián Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaBentham Science Publishers2016-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47388Robello, Elizabeth; Bonetto, Julián Gerardo; Puntarulo, Susana Ángela; Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 16; 12; 7-2016; 937-9461389-5575CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2174/1389557516666160611021840info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/143226/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:45:55Zoai:ri.conicet.gov.ar:11336/47388instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:45:55.584CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update |
title |
Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update |
spellingShingle |
Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update Robello, Elizabeth Antioxidant Protection Fetal Brain Gamma Irradiation Oxidative And Nitrosative Stress |
title_short |
Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update |
title_full |
Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update |
title_fullStr |
Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update |
title_full_unstemmed |
Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update |
title_sort |
Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update |
dc.creator.none.fl_str_mv |
Robello, Elizabeth Bonetto, Julián Gerardo Puntarulo, Susana Ángela |
author |
Robello, Elizabeth |
author_facet |
Robello, Elizabeth Bonetto, Julián Gerardo Puntarulo, Susana Ángela |
author_role |
author |
author2 |
Bonetto, Julián Gerardo Puntarulo, Susana Ángela |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Antioxidant Protection Fetal Brain Gamma Irradiation Oxidative And Nitrosative Stress |
topic |
Antioxidant Protection Fetal Brain Gamma Irradiation Oxidative And Nitrosative Stress |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Both epidemiological and experimental data indicate that ionizing radiation (IR) may disrupt developmental processes leading to deleterious effects on brain functions. A central role of reactive oxygen (ROS) and nitrogen species (RNS), as important mediators in neurotoxicity and neuroprotection, has been demonstrated. Primary ionization events triggered by IR are amplified and propagated by mechanisms involving ROS and RNS, which activate several signaling pathways leading to final radiation effects. The immature and adult brain display clear differences in the way they respond to insults. Moreover, a great deal of attention is being focus on the limited antioxidant capacity and the particular lipid composition of cell membranes of the developing brain that render it more vulnerable to oxidative stress. The goal of this review is to summarize the current knowledge on the role of alterations in the balance between oxidative/nitrosative stress and antioxidant capacity in the pathways involved in cellular radiation response, with particular focus on the possible therapies proposed to limit radiation-induced effects in the brain. Fil: Robello, Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina Fil: Bonetto, Julián Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina Fil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina |
description |
Both epidemiological and experimental data indicate that ionizing radiation (IR) may disrupt developmental processes leading to deleterious effects on brain functions. A central role of reactive oxygen (ROS) and nitrogen species (RNS), as important mediators in neurotoxicity and neuroprotection, has been demonstrated. Primary ionization events triggered by IR are amplified and propagated by mechanisms involving ROS and RNS, which activate several signaling pathways leading to final radiation effects. The immature and adult brain display clear differences in the way they respond to insults. Moreover, a great deal of attention is being focus on the limited antioxidant capacity and the particular lipid composition of cell membranes of the developing brain that render it more vulnerable to oxidative stress. The goal of this review is to summarize the current knowledge on the role of alterations in the balance between oxidative/nitrosative stress and antioxidant capacity in the pathways involved in cellular radiation response, with particular focus on the possible therapies proposed to limit radiation-induced effects in the brain. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/47388 Robello, Elizabeth; Bonetto, Julián Gerardo; Puntarulo, Susana Ángela; Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 16; 12; 7-2016; 937-946 1389-5575 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/47388 |
identifier_str_mv |
Robello, Elizabeth; Bonetto, Julián Gerardo; Puntarulo, Susana Ángela; Cellular Oxidative/Antioxidant Balance in γ-Irradiated Brain: An Update; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 16; 12; 7-2016; 937-946 1389-5575 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.2174/1389557516666160611021840 info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/143226/article |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Bentham Science Publishers |
publisher.none.fl_str_mv |
Bentham Science Publishers |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |