A clustering phenomenon among HCV-1a strains characterized among HIV-coinfected patients from Buenos Aires, Argentina

Autores
Bolcic, Federico Martin; Laufer, Natalia Lorna; Trinchero Hernandez, Juan Sebastian; Jones, Leandro Roberto; Quarleri, Jorge Fabian
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) share the same transmission routes which lead to high coinfection rates. Among HIV-infected individuals such rates reached 21% in Argentina, being HCV-1a the most predominant subtype. In this work, twenty-five HCV subtype 1a (HCV-1a) strains from Argentinean patients that were coinfected with HIV were studied based on E2 and NS5A sequences. Phylogenetic analyses indicated that 12 strains were highly related to each other, constituting a highly supported (posterior probability = 0.95) monophyletic group that we called ?Argentinean Cluster?. The remaining HCV strains (?Other Argentinean Strains?) were interspersed along the phylogenetic trees. When comparing both groups of HCV-1a, 10 amino acid differences were located in functional domains of E2 and NS5A proteins related with the mechanisms underlying HCV resistance to IFN as well as appear to affect the peptides binding to MHC-I molecules thus favoring the immuno-surveillance and contributing to the divergence of the HCV genotypes.
Fil: Bolcic, Federico Martin. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Laufer, Natalia Lorna. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Trinchero Hernandez, Juan Sebastian. Fundación Playa Unión; Argentina
Fil: Jones, Leandro Roberto. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
Fil: Quarleri, Jorge Fabian. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
HCV
phylogenetic
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/241238
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A clustering phenomenon among HCV-1a strains characterized among HIV-coinfected patients from Buenos Aires, ArgentinaBolcic, Federico MartinLaufer, Natalia LornaTrinchero Hernandez, Juan SebastianJones, Leandro RobertoQuarleri, Jorge FabianHCVphylogenetichttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) share the same transmission routes which lead to high coinfection rates. Among HIV-infected individuals such rates reached 21% in Argentina, being HCV-1a the most predominant subtype. In this work, twenty-five HCV subtype 1a (HCV-1a) strains from Argentinean patients that were coinfected with HIV were studied based on E2 and NS5A sequences. Phylogenetic analyses indicated that 12 strains were highly related to each other, constituting a highly supported (posterior probability = 0.95) monophyletic group that we called ?Argentinean Cluster?. The remaining HCV strains (?Other Argentinean Strains?) were interspersed along the phylogenetic trees. When comparing both groups of HCV-1a, 10 amino acid differences were located in functional domains of E2 and NS5A proteins related with the mechanisms underlying HCV resistance to IFN as well as appear to affect the peptides binding to MHC-I molecules thus favoring the immuno-surveillance and contributing to the divergence of the HCV genotypes.Fil: Bolcic, Federico Martin. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Laufer, Natalia Lorna. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Trinchero Hernandez, Juan Sebastian. Fundación Playa Unión; ArgentinaFil: Jones, Leandro Roberto. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; ArgentinaFil: Quarleri, Jorge Fabian. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley-liss, div John Wiley & Sons Inc.2012-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/241238Bolcic, Federico Martin; Laufer, Natalia Lorna; Trinchero Hernandez, Juan Sebastian; Jones, Leandro Roberto; Quarleri, Jorge Fabian; A clustering phenomenon among HCV-1a strains characterized among HIV-coinfected patients from Buenos Aires, Argentina; Wiley-liss, div John Wiley & Sons Inc.; Journal of Medical Virology; 84; 4; 2-2012; 570-5810146-6615CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/jmv.23243info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:47Zoai:ri.conicet.gov.ar:11336/241238instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:47.784CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A clustering phenomenon among HCV-1a strains characterized among HIV-coinfected patients from Buenos Aires, Argentina
title A clustering phenomenon among HCV-1a strains characterized among HIV-coinfected patients from Buenos Aires, Argentina
spellingShingle A clustering phenomenon among HCV-1a strains characterized among HIV-coinfected patients from Buenos Aires, Argentina
Bolcic, Federico Martin
HCV
phylogenetic
title_short A clustering phenomenon among HCV-1a strains characterized among HIV-coinfected patients from Buenos Aires, Argentina
title_full A clustering phenomenon among HCV-1a strains characterized among HIV-coinfected patients from Buenos Aires, Argentina
title_fullStr A clustering phenomenon among HCV-1a strains characterized among HIV-coinfected patients from Buenos Aires, Argentina
title_full_unstemmed A clustering phenomenon among HCV-1a strains characterized among HIV-coinfected patients from Buenos Aires, Argentina
title_sort A clustering phenomenon among HCV-1a strains characterized among HIV-coinfected patients from Buenos Aires, Argentina
dc.creator.none.fl_str_mv Bolcic, Federico Martin
Laufer, Natalia Lorna
Trinchero Hernandez, Juan Sebastian
Jones, Leandro Roberto
Quarleri, Jorge Fabian
author Bolcic, Federico Martin
author_facet Bolcic, Federico Martin
Laufer, Natalia Lorna
Trinchero Hernandez, Juan Sebastian
Jones, Leandro Roberto
Quarleri, Jorge Fabian
author_role author
author2 Laufer, Natalia Lorna
Trinchero Hernandez, Juan Sebastian
Jones, Leandro Roberto
Quarleri, Jorge Fabian
author2_role author
author
author
author
dc.subject.none.fl_str_mv HCV
phylogenetic
topic HCV
phylogenetic
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) share the same transmission routes which lead to high coinfection rates. Among HIV-infected individuals such rates reached 21% in Argentina, being HCV-1a the most predominant subtype. In this work, twenty-five HCV subtype 1a (HCV-1a) strains from Argentinean patients that were coinfected with HIV were studied based on E2 and NS5A sequences. Phylogenetic analyses indicated that 12 strains were highly related to each other, constituting a highly supported (posterior probability = 0.95) monophyletic group that we called ?Argentinean Cluster?. The remaining HCV strains (?Other Argentinean Strains?) were interspersed along the phylogenetic trees. When comparing both groups of HCV-1a, 10 amino acid differences were located in functional domains of E2 and NS5A proteins related with the mechanisms underlying HCV resistance to IFN as well as appear to affect the peptides binding to MHC-I molecules thus favoring the immuno-surveillance and contributing to the divergence of the HCV genotypes.
Fil: Bolcic, Federico Martin. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Laufer, Natalia Lorna. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Trinchero Hernandez, Juan Sebastian. Fundación Playa Unión; Argentina
Fil: Jones, Leandro Roberto. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
Fil: Quarleri, Jorge Fabian. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) share the same transmission routes which lead to high coinfection rates. Among HIV-infected individuals such rates reached 21% in Argentina, being HCV-1a the most predominant subtype. In this work, twenty-five HCV subtype 1a (HCV-1a) strains from Argentinean patients that were coinfected with HIV were studied based on E2 and NS5A sequences. Phylogenetic analyses indicated that 12 strains were highly related to each other, constituting a highly supported (posterior probability = 0.95) monophyletic group that we called ?Argentinean Cluster?. The remaining HCV strains (?Other Argentinean Strains?) were interspersed along the phylogenetic trees. When comparing both groups of HCV-1a, 10 amino acid differences were located in functional domains of E2 and NS5A proteins related with the mechanisms underlying HCV resistance to IFN as well as appear to affect the peptides binding to MHC-I molecules thus favoring the immuno-surveillance and contributing to the divergence of the HCV genotypes.
publishDate 2012
dc.date.none.fl_str_mv 2012-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/241238
Bolcic, Federico Martin; Laufer, Natalia Lorna; Trinchero Hernandez, Juan Sebastian; Jones, Leandro Roberto; Quarleri, Jorge Fabian; A clustering phenomenon among HCV-1a strains characterized among HIV-coinfected patients from Buenos Aires, Argentina; Wiley-liss, div John Wiley & Sons Inc.; Journal of Medical Virology; 84; 4; 2-2012; 570-581
0146-6615
CONICET Digital
CONICET
url http://hdl.handle.net/11336/241238
identifier_str_mv Bolcic, Federico Martin; Laufer, Natalia Lorna; Trinchero Hernandez, Juan Sebastian; Jones, Leandro Roberto; Quarleri, Jorge Fabian; A clustering phenomenon among HCV-1a strains characterized among HIV-coinfected patients from Buenos Aires, Argentina; Wiley-liss, div John Wiley & Sons Inc.; Journal of Medical Virology; 84; 4; 2-2012; 570-581
0146-6615
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/jmv.23243
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, div John Wiley & Sons Inc.
publisher.none.fl_str_mv Wiley-liss, div John Wiley & Sons Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269182713921536
score 13.13397

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