Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients

Autores
Reynoso, Rita Paola; Laufer, Natalia Lorna; Bolcic, Federico Martin; Quarleri, Jorge Fabian
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Replicative senescence of peripheral blood mononuclear cells (PBMC) plays an important role in the pathophysiology of chronic viral infections. Although there are controversial reports concerning telomerase activity in HIV monoinfected subjects, no data on HIV–HCV coinfected individuals is available. In this cross-sectional study telomerase activity was quantified in non-stimulated and mitogen-stimulated PBMC lysates from HIV-1 monoinfected and HIV–HCV coinfected individuals using real-time PCR. Up-regulation of telomerase activity after mitogen stimulation was impaired in PBMC of HIV monoinfected and HIV–HCV coinfected patients. The lack of an appropriate induction of this enzymatic activity after stimulus could partly account for immunosuppressive conditions observed in such patients.
Fil: Reynoso, Rita Paola. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
Fil: Laufer, Natalia Lorna. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
Fil: Bolcic, Federico Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
Fil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
Materia
Hiv
Hcv
Coinfection
Telomerase Activity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14171
Acceder
id CONICETDig_f8172258b1a62ccaee81200985db54a6
oai_identifier_str oai:ri.conicet.gov.ar:11336/14171
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patientsReynoso, Rita PaolaLaufer, Natalia LornaBolcic, Federico MartinQuarleri, Jorge FabianHivHcvCoinfectionTelomerase Activityhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Replicative senescence of peripheral blood mononuclear cells (PBMC) plays an important role in the pathophysiology of chronic viral infections. Although there are controversial reports concerning telomerase activity in HIV monoinfected subjects, no data on HIV–HCV coinfected individuals is available. In this cross-sectional study telomerase activity was quantified in non-stimulated and mitogen-stimulated PBMC lysates from HIV-1 monoinfected and HIV–HCV coinfected individuals using real-time PCR. Up-regulation of telomerase activity after mitogen stimulation was impaired in PBMC of HIV monoinfected and HIV–HCV coinfected patients. The lack of an appropriate induction of this enzymatic activity after stimulus could partly account for immunosuppressive conditions observed in such patients.Fil: Reynoso, Rita Paola. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; ArgentinaFil: Laufer, Natalia Lorna. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; ArgentinaFil: Bolcic, Federico Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; ArgentinaFil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; ArgentinaElsevier Science2010-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14171Reynoso, Rita Paola; Laufer, Natalia Lorna; Bolcic, Federico Martin; Quarleri, Jorge Fabian; Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients; Elsevier Science; Virus Research; 147; 2; 2-2010; 284-2870168-1702enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0168170209004079info:eu-repo/semantics/altIdentifier/doi/10.1016/j.virusres.2009.11.006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:12Zoai:ri.conicet.gov.ar:11336/14171instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:12.663CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients
title Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients
spellingShingle Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients
Reynoso, Rita Paola
Hiv
Hcv
Coinfection
Telomerase Activity
title_short Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients
title_full Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients
title_fullStr Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients
title_full_unstemmed Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients
title_sort Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients
dc.creator.none.fl_str_mv Reynoso, Rita Paola
Laufer, Natalia Lorna
Bolcic, Federico Martin
Quarleri, Jorge Fabian
author Reynoso, Rita Paola
author_facet Reynoso, Rita Paola
Laufer, Natalia Lorna
Bolcic, Federico Martin
Quarleri, Jorge Fabian
author_role author
author2 Laufer, Natalia Lorna
Bolcic, Federico Martin
Quarleri, Jorge Fabian
author2_role author
author
author
dc.subject.none.fl_str_mv Hiv
Hcv
Coinfection
Telomerase Activity
topic Hiv
Hcv
Coinfection
Telomerase Activity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Replicative senescence of peripheral blood mononuclear cells (PBMC) plays an important role in the pathophysiology of chronic viral infections. Although there are controversial reports concerning telomerase activity in HIV monoinfected subjects, no data on HIV–HCV coinfected individuals is available. In this cross-sectional study telomerase activity was quantified in non-stimulated and mitogen-stimulated PBMC lysates from HIV-1 monoinfected and HIV–HCV coinfected individuals using real-time PCR. Up-regulation of telomerase activity after mitogen stimulation was impaired in PBMC of HIV monoinfected and HIV–HCV coinfected patients. The lack of an appropriate induction of this enzymatic activity after stimulus could partly account for immunosuppressive conditions observed in such patients.
Fil: Reynoso, Rita Paola. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
Fil: Laufer, Natalia Lorna. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
Fil: Bolcic, Federico Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
Fil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
description Replicative senescence of peripheral blood mononuclear cells (PBMC) plays an important role in the pathophysiology of chronic viral infections. Although there are controversial reports concerning telomerase activity in HIV monoinfected subjects, no data on HIV–HCV coinfected individuals is available. In this cross-sectional study telomerase activity was quantified in non-stimulated and mitogen-stimulated PBMC lysates from HIV-1 monoinfected and HIV–HCV coinfected individuals using real-time PCR. Up-regulation of telomerase activity after mitogen stimulation was impaired in PBMC of HIV monoinfected and HIV–HCV coinfected patients. The lack of an appropriate induction of this enzymatic activity after stimulus could partly account for immunosuppressive conditions observed in such patients.
publishDate 2010
dc.date.none.fl_str_mv 2010-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14171
Reynoso, Rita Paola; Laufer, Natalia Lorna; Bolcic, Federico Martin; Quarleri, Jorge Fabian; Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients; Elsevier Science; Virus Research; 147; 2; 2-2010; 284-287
0168-1702
url http://hdl.handle.net/11336/14171
identifier_str_mv Reynoso, Rita Paola; Laufer, Natalia Lorna; Bolcic, Federico Martin; Quarleri, Jorge Fabian; Telomerase activity in peripheral blood mononuclear cells from HIV and HIV-HCV coinfected patients; Elsevier Science; Virus Research; 147; 2; 2-2010; 284-287
0168-1702
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0168170209004079
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.virusres.2009.11.006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269946949664768
score 13.13397

Publicaciones similares