Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects

Autores
Maarouf, Chera L.; Andacht, Tracy M.; Kokjohn, Tyler A.; Castaño, Eduardo Miguel; Sue, Lucia I.; Beach, Thomas G.; Roher, Alex E.
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A crucial need exists for reliable Alzheimer's disease (AD) diagnostic and prognostic tests. Given its intimate communication with the brain, the cerebrospinal fluid (CSF) has been surveyed intensively for reliable AD biomarkers. The heterogeneity of AD pathology and the unavoidable difficulties associated with the clinical diagnosis and differentiation of this dementia from other pathologies have confounded biomarker studies in antemortem CSF samples. Using postmortem ventricular CSF (V-CSF) pools, two-dimensional difference gel electrophoresis (2D DIGE) analyses revealed a set of proteins that showed significant differences between neuropathologically-diagnosed AD and elderly non-demented controls (NDC), as well as subjects with non-AD dementias. The 2D DIGE system identified a set of 21 different protein biomarkers. This panel of proteins probably reflects fundamental pathological changes that are divergent from both normal aging and non-AD dementias.
Fil: Maarouf, Chera L.. Sun Health Research Institute; Estados Unidos
Fil: Andacht, Tracy M.. University of Georgia; Grecia
Fil: Kokjohn, Tyler A.. Sun Health Research Institute; Estados Unidos
Fil: Castaño, Eduardo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Sue, Lucia I.. Sun Health Research Institute; Estados Unidos
Fil: Beach, Thomas G.. Sun Health Research Institute; Estados Unidos
Fil: Roher, Alex E.. Sun Health Research Institute; Estados Unidos
Materia
Alzheimer'S Disease
Cerebrospinal Fluid
Proteomics
Biomarkers
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20618
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjectsMaarouf, Chera L.Andacht, Tracy M.Kokjohn, Tyler A.Castaño, Eduardo MiguelSue, Lucia I.Beach, Thomas G.Roher, Alex E.Alzheimer'S DiseaseCerebrospinal FluidProteomicsBiomarkershttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3A crucial need exists for reliable Alzheimer's disease (AD) diagnostic and prognostic tests. Given its intimate communication with the brain, the cerebrospinal fluid (CSF) has been surveyed intensively for reliable AD biomarkers. The heterogeneity of AD pathology and the unavoidable difficulties associated with the clinical diagnosis and differentiation of this dementia from other pathologies have confounded biomarker studies in antemortem CSF samples. Using postmortem ventricular CSF (V-CSF) pools, two-dimensional difference gel electrophoresis (2D DIGE) analyses revealed a set of proteins that showed significant differences between neuropathologically-diagnosed AD and elderly non-demented controls (NDC), as well as subjects with non-AD dementias. The 2D DIGE system identified a set of 21 different protein biomarkers. This panel of proteins probably reflects fundamental pathological changes that are divergent from both normal aging and non-AD dementias.Fil: Maarouf, Chera L.. Sun Health Research Institute; Estados UnidosFil: Andacht, Tracy M.. University of Georgia; GreciaFil: Kokjohn, Tyler A.. Sun Health Research Institute; Estados UnidosFil: Castaño, Eduardo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Sue, Lucia I.. Sun Health Research Institute; Estados UnidosFil: Beach, Thomas G.. Sun Health Research Institute; Estados UnidosFil: Roher, Alex E.. Sun Health Research Institute; Estados UnidosBentham Science Publishers2009-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20618Maarouf, Chera L.; Andacht, Tracy M.; Kokjohn, Tyler A.; Castaño, Eduardo Miguel; Sue, Lucia I.; et al.; Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects; Bentham Science Publishers; Current Alzheimer Research; 6; 4; 8-2009; 339-4061567-20501875-5828CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/84772/articleinfo:eu-repo/semantics/altIdentifier/doi/10.2174/156720509788929318info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:03Zoai:ri.conicet.gov.ar:11336/20618instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:04.021CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects
title Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects
spellingShingle Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects
Maarouf, Chera L.
Alzheimer'S Disease
Cerebrospinal Fluid
Proteomics
Biomarkers
title_short Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects
title_full Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects
title_fullStr Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects
title_full_unstemmed Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects
title_sort Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects
dc.creator.none.fl_str_mv Maarouf, Chera L.
Andacht, Tracy M.
Kokjohn, Tyler A.
Castaño, Eduardo Miguel
Sue, Lucia I.
Beach, Thomas G.
Roher, Alex E.
author Maarouf, Chera L.
author_facet Maarouf, Chera L.
Andacht, Tracy M.
Kokjohn, Tyler A.
Castaño, Eduardo Miguel
Sue, Lucia I.
Beach, Thomas G.
Roher, Alex E.
author_role author
author2 Andacht, Tracy M.
Kokjohn, Tyler A.
Castaño, Eduardo Miguel
Sue, Lucia I.
Beach, Thomas G.
Roher, Alex E.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Alzheimer'S Disease
Cerebrospinal Fluid
Proteomics
Biomarkers
topic Alzheimer'S Disease
Cerebrospinal Fluid
Proteomics
Biomarkers
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv A crucial need exists for reliable Alzheimer's disease (AD) diagnostic and prognostic tests. Given its intimate communication with the brain, the cerebrospinal fluid (CSF) has been surveyed intensively for reliable AD biomarkers. The heterogeneity of AD pathology and the unavoidable difficulties associated with the clinical diagnosis and differentiation of this dementia from other pathologies have confounded biomarker studies in antemortem CSF samples. Using postmortem ventricular CSF (V-CSF) pools, two-dimensional difference gel electrophoresis (2D DIGE) analyses revealed a set of proteins that showed significant differences between neuropathologically-diagnosed AD and elderly non-demented controls (NDC), as well as subjects with non-AD dementias. The 2D DIGE system identified a set of 21 different protein biomarkers. This panel of proteins probably reflects fundamental pathological changes that are divergent from both normal aging and non-AD dementias.
Fil: Maarouf, Chera L.. Sun Health Research Institute; Estados Unidos
Fil: Andacht, Tracy M.. University of Georgia; Grecia
Fil: Kokjohn, Tyler A.. Sun Health Research Institute; Estados Unidos
Fil: Castaño, Eduardo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Sue, Lucia I.. Sun Health Research Institute; Estados Unidos
Fil: Beach, Thomas G.. Sun Health Research Institute; Estados Unidos
Fil: Roher, Alex E.. Sun Health Research Institute; Estados Unidos
description A crucial need exists for reliable Alzheimer's disease (AD) diagnostic and prognostic tests. Given its intimate communication with the brain, the cerebrospinal fluid (CSF) has been surveyed intensively for reliable AD biomarkers. The heterogeneity of AD pathology and the unavoidable difficulties associated with the clinical diagnosis and differentiation of this dementia from other pathologies have confounded biomarker studies in antemortem CSF samples. Using postmortem ventricular CSF (V-CSF) pools, two-dimensional difference gel electrophoresis (2D DIGE) analyses revealed a set of proteins that showed significant differences between neuropathologically-diagnosed AD and elderly non-demented controls (NDC), as well as subjects with non-AD dementias. The 2D DIGE system identified a set of 21 different protein biomarkers. This panel of proteins probably reflects fundamental pathological changes that are divergent from both normal aging and non-AD dementias.
publishDate 2009
dc.date.none.fl_str_mv 2009-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20618
Maarouf, Chera L.; Andacht, Tracy M.; Kokjohn, Tyler A.; Castaño, Eduardo Miguel; Sue, Lucia I.; et al.; Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects; Bentham Science Publishers; Current Alzheimer Research; 6; 4; 8-2009; 339-406
1567-2050
1875-5828
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20618
identifier_str_mv Maarouf, Chera L.; Andacht, Tracy M.; Kokjohn, Tyler A.; Castaño, Eduardo Miguel; Sue, Lucia I.; et al.; Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects; Bentham Science Publishers; Current Alzheimer Research; 6; 4; 8-2009; 339-406
1567-2050
1875-5828
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/84772/article
info:eu-repo/semantics/altIdentifier/doi/10.2174/156720509788929318
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269321953280000
score 13.13397

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