The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells

Autores
Chaves Ferreira, Miguel; Krenn, Gerald; Vasseur, Florence; Barinov, Aleksandr; Gonçalves, Pedro; Azogui, Orly; Cumano, Ana; Li, Zhi; Pellegrini, Sandra; Rocha, Benedita; Laderach, Diego Jose
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: The family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion of mutual redundancy and therefore this concept is still a matter of debate. Results: Our data show that the cyclin D1 is indispensable for normal hematopoiesis. Indeed, in the absence of D1, either in genetic deficient mice, or after acute ablation by RNA interference, cyclins D2 and D3 are also not expressed preventing hematopoietic cell division and differentiation at its earliest stage. This role does not depend on the cyclin box, but on the carboxyl regulatory domain of D1 coded by exons 4-5, since hematopoietic differentiation is also blocked by the conditional ablation of this region. Conclusion: These results demonstrate that not all functions of individual D cyclins are redundant and highlight a master role of cyclin D1 in hematopoiesis.
Fil: Chaves Ferreira, Miguel. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia. Instituto de Medicina Molecular; Portugal
Fil: Krenn, Gerald. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia
Fil: Vasseur, Florence. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia. Institut Pasteur; Francia
Fil: Barinov, Aleksandr. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia. Institut Pasteur; Francia
Fil: Gonçalves, Pedro. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia
Fil: Azogui, Orly. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia
Fil: Cumano, Ana. Inserm; Francia. Institut Pasteur; Francia
Fil: Li, Zhi. Inserm; Francia. Institut Pasteur; Francia
Fil: Pellegrini, Sandra. Inserm; Francia. Institut Pasteur; Francia
Fil: Rocha, Benedita. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia. Institut Pasteur; Francia
Fil: Laderach, Diego Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Inserm. Inmmunology- Immunopathology Immunotherapy; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia
Materia
CELL CYCLE
D CYCLINS
HEMATOPOIESIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/52795
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/52795
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cellsChaves Ferreira, MiguelKrenn, GeraldVasseur, FlorenceBarinov, AleksandrGonçalves, PedroAzogui, OrlyCumano, AnaLi, ZhiPellegrini, SandraRocha, BeneditaLaderach, Diego JoseCELL CYCLED CYCLINSHEMATOPOIESIShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: The family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion of mutual redundancy and therefore this concept is still a matter of debate. Results: Our data show that the cyclin D1 is indispensable for normal hematopoiesis. Indeed, in the absence of D1, either in genetic deficient mice, or after acute ablation by RNA interference, cyclins D2 and D3 are also not expressed preventing hematopoietic cell division and differentiation at its earliest stage. This role does not depend on the cyclin box, but on the carboxyl regulatory domain of D1 coded by exons 4-5, since hematopoietic differentiation is also blocked by the conditional ablation of this region. Conclusion: These results demonstrate that not all functions of individual D cyclins are redundant and highlight a master role of cyclin D1 in hematopoiesis.Fil: Chaves Ferreira, Miguel. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia. Instituto de Medicina Molecular; PortugalFil: Krenn, Gerald. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; FranciaFil: Vasseur, Florence. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia. Institut Pasteur; FranciaFil: Barinov, Aleksandr. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia. Institut Pasteur; FranciaFil: Gonçalves, Pedro. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; FranciaFil: Azogui, Orly. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; FranciaFil: Cumano, Ana. Inserm; Francia. Institut Pasteur; FranciaFil: Li, Zhi. Inserm; Francia. Institut Pasteur; FranciaFil: Pellegrini, Sandra. Inserm; Francia. Institut Pasteur; FranciaFil: Rocha, Benedita. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia. Institut Pasteur; FranciaFil: Laderach, Diego Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Inserm. Inmmunology- Immunopathology Immunotherapy; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; FranciaBioMed Central2016-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/52795Chaves Ferreira, Miguel; Krenn, Gerald; Vasseur, Florence; Barinov, Aleksandr; Gonçalves, Pedro; et al.; The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells; BioMed Central; Biology Direct; 11; 1; 4-2016; 11-211745-6150CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1186/s13062-016-0122-9info:eu-repo/semantics/altIdentifier/url/https://biologydirect.biomedcentral.com/articles/10.1186/s13062-016-0122-9info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:27:49Zoai:ri.conicet.gov.ar:11336/52795instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:27:50.008CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells
title The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells
spellingShingle The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells
Chaves Ferreira, Miguel
CELL CYCLE
D CYCLINS
HEMATOPOIESIS
title_short The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells
title_full The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells
title_fullStr The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells
title_full_unstemmed The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells
title_sort The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells
dc.creator.none.fl_str_mv Chaves Ferreira, Miguel
Krenn, Gerald
Vasseur, Florence
Barinov, Aleksandr
Gonçalves, Pedro
Azogui, Orly
Cumano, Ana
Li, Zhi
Pellegrini, Sandra
Rocha, Benedita
Laderach, Diego Jose
author Chaves Ferreira, Miguel
author_facet Chaves Ferreira, Miguel
Krenn, Gerald
Vasseur, Florence
Barinov, Aleksandr
Gonçalves, Pedro
Azogui, Orly
Cumano, Ana
Li, Zhi
Pellegrini, Sandra
Rocha, Benedita
Laderach, Diego Jose
author_role author
author2 Krenn, Gerald
Vasseur, Florence
Barinov, Aleksandr
Gonçalves, Pedro
Azogui, Orly
Cumano, Ana
Li, Zhi
Pellegrini, Sandra
Rocha, Benedita
Laderach, Diego Jose
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CELL CYCLE
D CYCLINS
HEMATOPOIESIS
topic CELL CYCLE
D CYCLINS
HEMATOPOIESIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Background: The family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion of mutual redundancy and therefore this concept is still a matter of debate. Results: Our data show that the cyclin D1 is indispensable for normal hematopoiesis. Indeed, in the absence of D1, either in genetic deficient mice, or after acute ablation by RNA interference, cyclins D2 and D3 are also not expressed preventing hematopoietic cell division and differentiation at its earliest stage. This role does not depend on the cyclin box, but on the carboxyl regulatory domain of D1 coded by exons 4-5, since hematopoietic differentiation is also blocked by the conditional ablation of this region. Conclusion: These results demonstrate that not all functions of individual D cyclins are redundant and highlight a master role of cyclin D1 in hematopoiesis.
Fil: Chaves Ferreira, Miguel. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia. Instituto de Medicina Molecular; Portugal
Fil: Krenn, Gerald. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia
Fil: Vasseur, Florence. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia. Institut Pasteur; Francia
Fil: Barinov, Aleksandr. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia. Institut Pasteur; Francia
Fil: Gonçalves, Pedro. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia
Fil: Azogui, Orly. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia
Fil: Cumano, Ana. Inserm; Francia. Institut Pasteur; Francia
Fil: Li, Zhi. Inserm; Francia. Institut Pasteur; Francia
Fil: Pellegrini, Sandra. Inserm; Francia. Institut Pasteur; Francia
Fil: Rocha, Benedita. Inserm; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia. Institut Pasteur; Francia
Fil: Laderach, Diego Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Inserm. Inmmunology- Immunopathology Immunotherapy; Francia. Centre National de la Recherche Scientifique; Francia. Faculté de Médecine Paris Descartes; Francia
description Background: The family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion of mutual redundancy and therefore this concept is still a matter of debate. Results: Our data show that the cyclin D1 is indispensable for normal hematopoiesis. Indeed, in the absence of D1, either in genetic deficient mice, or after acute ablation by RNA interference, cyclins D2 and D3 are also not expressed preventing hematopoietic cell division and differentiation at its earliest stage. This role does not depend on the cyclin box, but on the carboxyl regulatory domain of D1 coded by exons 4-5, since hematopoietic differentiation is also blocked by the conditional ablation of this region. Conclusion: These results demonstrate that not all functions of individual D cyclins are redundant and highlight a master role of cyclin D1 in hematopoiesis.
publishDate 2016
dc.date.none.fl_str_mv 2016-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/52795
Chaves Ferreira, Miguel; Krenn, Gerald; Vasseur, Florence; Barinov, Aleksandr; Gonçalves, Pedro; et al.; The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells; BioMed Central; Biology Direct; 11; 1; 4-2016; 11-21
1745-6150
CONICET Digital
CONICET
url http://hdl.handle.net/11336/52795
identifier_str_mv Chaves Ferreira, Miguel; Krenn, Gerald; Vasseur, Florence; Barinov, Aleksandr; Gonçalves, Pedro; et al.; The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells; BioMed Central; Biology Direct; 11; 1; 4-2016; 11-21
1745-6150
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1186/s13062-016-0122-9
info:eu-repo/semantics/altIdentifier/url/https://biologydirect.biomedcentral.com/articles/10.1186/s13062-016-0122-9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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