Determination of the Liposomal Bulk Modulus by Molecular Acoustics

Autores
Mendioroz, Pamela; Pedroni, Viviana Isabel; Morini, Marcela Ana
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the context of nanomechanics, elasticity is a notable physical property that has garnered recent interest for its roles at the nano-bio interface. This work introduces a novel application of molecular acoustics (ultrasound velocimetry and densitometry) to assess volumetric elasticity modulusor bulk modulus as a tool to characterize liposomal elasticity. One of the main advantages of the presented technique is that the liposomes remain unaltered throughout the entire measurement process, that is, without the artifacts by adsorption onto a substrate and the effect of a probe. Another strength highlighted in our proposal is that the obtained elasticity modulus does not depend on a physical model, such as the Hertz model for atomic force microscopy, and the required considerations, such as assuming the sample is homogeneous and isotropic. We consider that the bulk modulus obtained through ultrasonic velocimetry provides a genuine measure of the liposomal elasticity of the system under study.
Fil: Mendioroz, Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Pedroni, Viviana Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Morini, Marcela Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Materia
ULTRASOUND VELOCIMETRY AND DENSITOMETRY
LIPOSOMAL ELESTICITY
VOLUMETRIC ELASTIC MODULUS
DPPC
CHOLESTEROL
DHA
XANTHONE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/256956
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Determination of the Liposomal Bulk Modulus by Molecular AcousticsMendioroz, PamelaPedroni, Viviana IsabelMorini, Marcela AnaULTRASOUND VELOCIMETRY AND DENSITOMETRYLIPOSOMAL ELESTICITYVOLUMETRIC ELASTIC MODULUSDPPCCHOLESTEROLDHAXANTHONEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In the context of nanomechanics, elasticity is a notable physical property that has garnered recent interest for its roles at the nano-bio interface. This work introduces a novel application of molecular acoustics (ultrasound velocimetry and densitometry) to assess volumetric elasticity modulusor bulk modulus as a tool to characterize liposomal elasticity. One of the main advantages of the presented technique is that the liposomes remain unaltered throughout the entire measurement process, that is, without the artifacts by adsorption onto a substrate and the effect of a probe. Another strength highlighted in our proposal is that the obtained elasticity modulus does not depend on a physical model, such as the Hertz model for atomic force microscopy, and the required considerations, such as assuming the sample is homogeneous and isotropic. We consider that the bulk modulus obtained through ultrasonic velocimetry provides a genuine measure of the liposomal elasticity of the system under study.Fil: Mendioroz, Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Pedroni, Viviana Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Morini, Marcela Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaIris Publishers2024-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/256956Mendioroz, Pamela; Pedroni, Viviana Isabel; Morini, Marcela Ana; Determination of the Liposomal Bulk Modulus by Molecular Acoustics; Iris Publishers; Modern Concepts in Material Science; 2024; 9-2024; 1-52692-5397CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://irispublishers.com/mcms/pdf/MCMS.MS.ID.000642.pdfinfo:eu-repo/semantics/altIdentifier/doi/10.33552/MCMS.2024.05.000642info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:36Zoai:ri.conicet.gov.ar:11336/256956instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:36.544CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Determination of the Liposomal Bulk Modulus by Molecular Acoustics
title Determination of the Liposomal Bulk Modulus by Molecular Acoustics
spellingShingle Determination of the Liposomal Bulk Modulus by Molecular Acoustics
Mendioroz, Pamela
ULTRASOUND VELOCIMETRY AND DENSITOMETRY
LIPOSOMAL ELESTICITY
VOLUMETRIC ELASTIC MODULUS
DPPC
CHOLESTEROL
DHA
XANTHONE
title_short Determination of the Liposomal Bulk Modulus by Molecular Acoustics
title_full Determination of the Liposomal Bulk Modulus by Molecular Acoustics
title_fullStr Determination of the Liposomal Bulk Modulus by Molecular Acoustics
title_full_unstemmed Determination of the Liposomal Bulk Modulus by Molecular Acoustics
title_sort Determination of the Liposomal Bulk Modulus by Molecular Acoustics
dc.creator.none.fl_str_mv Mendioroz, Pamela
Pedroni, Viviana Isabel
Morini, Marcela Ana
author Mendioroz, Pamela
author_facet Mendioroz, Pamela
Pedroni, Viviana Isabel
Morini, Marcela Ana
author_role author
author2 Pedroni, Viviana Isabel
Morini, Marcela Ana
author2_role author
author
dc.subject.none.fl_str_mv ULTRASOUND VELOCIMETRY AND DENSITOMETRY
LIPOSOMAL ELESTICITY
VOLUMETRIC ELASTIC MODULUS
DPPC
CHOLESTEROL
DHA
XANTHONE
topic ULTRASOUND VELOCIMETRY AND DENSITOMETRY
LIPOSOMAL ELESTICITY
VOLUMETRIC ELASTIC MODULUS
DPPC
CHOLESTEROL
DHA
XANTHONE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In the context of nanomechanics, elasticity is a notable physical property that has garnered recent interest for its roles at the nano-bio interface. This work introduces a novel application of molecular acoustics (ultrasound velocimetry and densitometry) to assess volumetric elasticity modulusor bulk modulus as a tool to characterize liposomal elasticity. One of the main advantages of the presented technique is that the liposomes remain unaltered throughout the entire measurement process, that is, without the artifacts by adsorption onto a substrate and the effect of a probe. Another strength highlighted in our proposal is that the obtained elasticity modulus does not depend on a physical model, such as the Hertz model for atomic force microscopy, and the required considerations, such as assuming the sample is homogeneous and isotropic. We consider that the bulk modulus obtained through ultrasonic velocimetry provides a genuine measure of the liposomal elasticity of the system under study.
Fil: Mendioroz, Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Pedroni, Viviana Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Morini, Marcela Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
description In the context of nanomechanics, elasticity is a notable physical property that has garnered recent interest for its roles at the nano-bio interface. This work introduces a novel application of molecular acoustics (ultrasound velocimetry and densitometry) to assess volumetric elasticity modulusor bulk modulus as a tool to characterize liposomal elasticity. One of the main advantages of the presented technique is that the liposomes remain unaltered throughout the entire measurement process, that is, without the artifacts by adsorption onto a substrate and the effect of a probe. Another strength highlighted in our proposal is that the obtained elasticity modulus does not depend on a physical model, such as the Hertz model for atomic force microscopy, and the required considerations, such as assuming the sample is homogeneous and isotropic. We consider that the bulk modulus obtained through ultrasonic velocimetry provides a genuine measure of the liposomal elasticity of the system under study.
publishDate 2024
dc.date.none.fl_str_mv 2024-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/256956
Mendioroz, Pamela; Pedroni, Viviana Isabel; Morini, Marcela Ana; Determination of the Liposomal Bulk Modulus by Molecular Acoustics; Iris Publishers; Modern Concepts in Material Science; 2024; 9-2024; 1-5
2692-5397
CONICET Digital
CONICET
url http://hdl.handle.net/11336/256956
identifier_str_mv Mendioroz, Pamela; Pedroni, Viviana Isabel; Morini, Marcela Ana; Determination of the Liposomal Bulk Modulus by Molecular Acoustics; Iris Publishers; Modern Concepts in Material Science; 2024; 9-2024; 1-5
2692-5397
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://irispublishers.com/mcms/pdf/MCMS.MS.ID.000642.pdf
info:eu-repo/semantics/altIdentifier/doi/10.33552/MCMS.2024.05.000642
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Iris Publishers
publisher.none.fl_str_mv Iris Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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