Protective Role of Limosilactobacillus fermentum Lf2 and Its Exopolysaccharides (EPS) in a TNBS-Induced Chronic Colitis Mouse Model

Autores
Ale, Elisa Carmen; Irazoqui, José Matías; Ale, Analía; Peralta, Guillermo Hugo; Puntillo, Melisa Anahí; Burns, Patricia Graciela; Correa Olivar, Gabriela Alejandra; Cazenave, Jimena; Bergamini, Carina Viviana; Amadio, Ariel Fernando; Binetti, Ana Griselda
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Limosilactobacillus fermentum Lf2 (Lf2) is an autochthonous strain that produces high levelsof exopolysaccharides (EPS). The objective of this work was to evaluate the probiotic potential of Lf2and its relationship with these metabolites in a mouse model of TNBS (trinitrobenzene sulfonic acid)-induced chronic colitis. Mice were treated intrarectally with increasing doses of TNBS resuspendedin 50% ethanol for 14 days. In parallel, they received different treatments by gavage (lactose 10%as the matrix): freeze-dried Lf2 (L); purified EPS (E); and lactose 10% (T). A healthy control group(H) was treated with 50% alcohol without TNBS (intrarectally) and 10% lactose (by gavage). Inthe small intestine, there was a significant increase in IgA levels for the group that received EPSand a decrease in IFN-γ for mice treated with the strain compared to the other groups. In the largeintestine, IL-2 and IFN-γ presented the lowest levels in the groups treated with EPS and the strain.The concentrations of acetic and propionic acids in mice that received Lf2 were the highest, while thelevels of butyric acid were comparable to the healthy control group. An increase in the abundance ofSCFA-producing bacteria was observed for mice treated with EPS and the strain in comparison withthe colitis control group. The enzyme activity of catalase was higher in all the treatments comparedto the TNBS-induced colitis control mice. To summarize the results obtained, a principal componentanalysis (PCA) was performed, clearly grouping the treatments in different clusters according to thevariables studied. This is one of the first studies to address the role of a potential probiotic strain ina chronic colitis mouse model, trying to elucidate the relationship between its properties and theEPS synthesized.
Fil: Ale, Elisa Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
Fil: Irazoqui, José Matías. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Investigacion de la Cadena Lactea. - Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Instituto de Investigacion de la Cadena Lactea.; Argentina
Fil: Ale, Analía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto Nacional de Limnología. Universidad Nacional del Litoral. Instituto Nacional de Limnología; Argentina
Fil: Peralta, Guillermo Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
Fil: Puntillo, Melisa Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
Fil: Burns, Patricia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
Fil: Correa Olivar, Gabriela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
Fil: Cazenave, Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto Nacional de Limnología. Universidad Nacional del Litoral. Instituto Nacional de Limnología; Argentina
Fil: Bergamini, Carina Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
Fil: Amadio, Ariel Fernando. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Investigacion de la Cadena Lactea. - Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Instituto de Investigacion de la Cadena Lactea.; Argentina
Fil: Binetti, Ana Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
Materia
EXOPOLYSACCHARIDES
LACTOBACILLI
CHRONIC COLITIS
INTESTINAL MICROBIOTA
ANTIOXIDANT ENZYMES
IMMUNOMODULATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/243211
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/243211
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Protective Role of Limosilactobacillus fermentum Lf2 and Its Exopolysaccharides (EPS) in a TNBS-Induced Chronic Colitis Mouse ModelAle, Elisa CarmenIrazoqui, José MatíasAle, AnalíaPeralta, Guillermo HugoPuntillo, Melisa AnahíBurns, Patricia GracielaCorrea Olivar, Gabriela AlejandraCazenave, JimenaBergamini, Carina VivianaAmadio, Ariel FernandoBinetti, Ana GriseldaEXOPOLYSACCHARIDESLACTOBACILLICHRONIC COLITISINTESTINAL MICROBIOTAANTIOXIDANT ENZYMESIMMUNOMODULATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Limosilactobacillus fermentum Lf2 (Lf2) is an autochthonous strain that produces high levelsof exopolysaccharides (EPS). The objective of this work was to evaluate the probiotic potential of Lf2and its relationship with these metabolites in a mouse model of TNBS (trinitrobenzene sulfonic acid)-induced chronic colitis. Mice were treated intrarectally with increasing doses of TNBS resuspendedin 50% ethanol for 14 days. In parallel, they received different treatments by gavage (lactose 10%as the matrix): freeze-dried Lf2 (L); purified EPS (E); and lactose 10% (T). A healthy control group(H) was treated with 50% alcohol without TNBS (intrarectally) and 10% lactose (by gavage). Inthe small intestine, there was a significant increase in IgA levels for the group that received EPSand a decrease in IFN-γ for mice treated with the strain compared to the other groups. In the largeintestine, IL-2 and IFN-γ presented the lowest levels in the groups treated with EPS and the strain.The concentrations of acetic and propionic acids in mice that received Lf2 were the highest, while thelevels of butyric acid were comparable to the healthy control group. An increase in the abundance ofSCFA-producing bacteria was observed for mice treated with EPS and the strain in comparison withthe colitis control group. The enzyme activity of catalase was higher in all the treatments comparedto the TNBS-induced colitis control mice. To summarize the results obtained, a principal componentanalysis (PCA) was performed, clearly grouping the treatments in different clusters according to thevariables studied. This is one of the first studies to address the role of a potential probiotic strain ina chronic colitis mouse model, trying to elucidate the relationship between its properties and theEPS synthesized.Fil: Ale, Elisa Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; ArgentinaFil: Irazoqui, José Matías. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Investigacion de la Cadena Lactea. - Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Instituto de Investigacion de la Cadena Lactea.; ArgentinaFil: Ale, Analía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto Nacional de Limnología. Universidad Nacional del Litoral. Instituto Nacional de Limnología; ArgentinaFil: Peralta, Guillermo Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; ArgentinaFil: Puntillo, Melisa Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; ArgentinaFil: Burns, Patricia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; ArgentinaFil: Correa Olivar, Gabriela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; ArgentinaFil: Cazenave, Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto Nacional de Limnología. Universidad Nacional del Litoral. Instituto Nacional de Limnología; ArgentinaFil: Bergamini, Carina Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; ArgentinaFil: Amadio, Ariel Fernando. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Investigacion de la Cadena Lactea. - Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Instituto de Investigacion de la Cadena Lactea.; ArgentinaFil: Binetti, Ana Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; ArgentinaMDPI2024-01-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/243211Ale, Elisa Carmen; Irazoqui, José Matías; Ale, Analía; Peralta, Guillermo Hugo; Puntillo, Melisa Anahí; et al.; Protective Role of Limosilactobacillus fermentum Lf2 and Its Exopolysaccharides (EPS) in a TNBS-Induced Chronic Colitis Mouse Model; MDPI; Fermentation; 10; 2; 25-1-2024; 1-152311-5637CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2311-5637/10/2/77info:eu-repo/semantics/altIdentifier/doi/10.3390/fermentation10020077info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:55:39Zoai:ri.conicet.gov.ar:11336/243211instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:55:39.548CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Protective Role of Limosilactobacillus fermentum Lf2 and Its Exopolysaccharides (EPS) in a TNBS-Induced Chronic Colitis Mouse Model
title Protective Role of Limosilactobacillus fermentum Lf2 and Its Exopolysaccharides (EPS) in a TNBS-Induced Chronic Colitis Mouse Model
spellingShingle Protective Role of Limosilactobacillus fermentum Lf2 and Its Exopolysaccharides (EPS) in a TNBS-Induced Chronic Colitis Mouse Model
Ale, Elisa Carmen
EXOPOLYSACCHARIDES
LACTOBACILLI
CHRONIC COLITIS
INTESTINAL MICROBIOTA
ANTIOXIDANT ENZYMES
IMMUNOMODULATION
title_short Protective Role of Limosilactobacillus fermentum Lf2 and Its Exopolysaccharides (EPS) in a TNBS-Induced Chronic Colitis Mouse Model
title_full Protective Role of Limosilactobacillus fermentum Lf2 and Its Exopolysaccharides (EPS) in a TNBS-Induced Chronic Colitis Mouse Model
title_fullStr Protective Role of Limosilactobacillus fermentum Lf2 and Its Exopolysaccharides (EPS) in a TNBS-Induced Chronic Colitis Mouse Model
title_full_unstemmed Protective Role of Limosilactobacillus fermentum Lf2 and Its Exopolysaccharides (EPS) in a TNBS-Induced Chronic Colitis Mouse Model
title_sort Protective Role of Limosilactobacillus fermentum Lf2 and Its Exopolysaccharides (EPS) in a TNBS-Induced Chronic Colitis Mouse Model
dc.creator.none.fl_str_mv Ale, Elisa Carmen
Irazoqui, José Matías
Ale, Analía
Peralta, Guillermo Hugo
Puntillo, Melisa Anahí
Burns, Patricia Graciela
Correa Olivar, Gabriela Alejandra
Cazenave, Jimena
Bergamini, Carina Viviana
Amadio, Ariel Fernando
Binetti, Ana Griselda
author Ale, Elisa Carmen
author_facet Ale, Elisa Carmen
Irazoqui, José Matías
Ale, Analía
Peralta, Guillermo Hugo
Puntillo, Melisa Anahí
Burns, Patricia Graciela
Correa Olivar, Gabriela Alejandra
Cazenave, Jimena
Bergamini, Carina Viviana
Amadio, Ariel Fernando
Binetti, Ana Griselda
author_role author
author2 Irazoqui, José Matías
Ale, Analía
Peralta, Guillermo Hugo
Puntillo, Melisa Anahí
Burns, Patricia Graciela
Correa Olivar, Gabriela Alejandra
Cazenave, Jimena
Bergamini, Carina Viviana
Amadio, Ariel Fernando
Binetti, Ana Griselda
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv EXOPOLYSACCHARIDES
LACTOBACILLI
CHRONIC COLITIS
INTESTINAL MICROBIOTA
ANTIOXIDANT ENZYMES
IMMUNOMODULATION
topic EXOPOLYSACCHARIDES
LACTOBACILLI
CHRONIC COLITIS
INTESTINAL MICROBIOTA
ANTIOXIDANT ENZYMES
IMMUNOMODULATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Limosilactobacillus fermentum Lf2 (Lf2) is an autochthonous strain that produces high levelsof exopolysaccharides (EPS). The objective of this work was to evaluate the probiotic potential of Lf2and its relationship with these metabolites in a mouse model of TNBS (trinitrobenzene sulfonic acid)-induced chronic colitis. Mice were treated intrarectally with increasing doses of TNBS resuspendedin 50% ethanol for 14 days. In parallel, they received different treatments by gavage (lactose 10%as the matrix): freeze-dried Lf2 (L); purified EPS (E); and lactose 10% (T). A healthy control group(H) was treated with 50% alcohol without TNBS (intrarectally) and 10% lactose (by gavage). Inthe small intestine, there was a significant increase in IgA levels for the group that received EPSand a decrease in IFN-γ for mice treated with the strain compared to the other groups. In the largeintestine, IL-2 and IFN-γ presented the lowest levels in the groups treated with EPS and the strain.The concentrations of acetic and propionic acids in mice that received Lf2 were the highest, while thelevels of butyric acid were comparable to the healthy control group. An increase in the abundance ofSCFA-producing bacteria was observed for mice treated with EPS and the strain in comparison withthe colitis control group. The enzyme activity of catalase was higher in all the treatments comparedto the TNBS-induced colitis control mice. To summarize the results obtained, a principal componentanalysis (PCA) was performed, clearly grouping the treatments in different clusters according to thevariables studied. This is one of the first studies to address the role of a potential probiotic strain ina chronic colitis mouse model, trying to elucidate the relationship between its properties and theEPS synthesized.
Fil: Ale, Elisa Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
Fil: Irazoqui, José Matías. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Investigacion de la Cadena Lactea. - Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Instituto de Investigacion de la Cadena Lactea.; Argentina
Fil: Ale, Analía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto Nacional de Limnología. Universidad Nacional del Litoral. Instituto Nacional de Limnología; Argentina
Fil: Peralta, Guillermo Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
Fil: Puntillo, Melisa Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
Fil: Burns, Patricia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
Fil: Correa Olivar, Gabriela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
Fil: Cazenave, Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto Nacional de Limnología. Universidad Nacional del Litoral. Instituto Nacional de Limnología; Argentina
Fil: Bergamini, Carina Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
Fil: Amadio, Ariel Fernando. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Investigacion de la Cadena Lactea. - Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Instituto de Investigacion de la Cadena Lactea.; Argentina
Fil: Binetti, Ana Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina
description Limosilactobacillus fermentum Lf2 (Lf2) is an autochthonous strain that produces high levelsof exopolysaccharides (EPS). The objective of this work was to evaluate the probiotic potential of Lf2and its relationship with these metabolites in a mouse model of TNBS (trinitrobenzene sulfonic acid)-induced chronic colitis. Mice were treated intrarectally with increasing doses of TNBS resuspendedin 50% ethanol for 14 days. In parallel, they received different treatments by gavage (lactose 10%as the matrix): freeze-dried Lf2 (L); purified EPS (E); and lactose 10% (T). A healthy control group(H) was treated with 50% alcohol without TNBS (intrarectally) and 10% lactose (by gavage). Inthe small intestine, there was a significant increase in IgA levels for the group that received EPSand a decrease in IFN-γ for mice treated with the strain compared to the other groups. In the largeintestine, IL-2 and IFN-γ presented the lowest levels in the groups treated with EPS and the strain.The concentrations of acetic and propionic acids in mice that received Lf2 were the highest, while thelevels of butyric acid were comparable to the healthy control group. An increase in the abundance ofSCFA-producing bacteria was observed for mice treated with EPS and the strain in comparison withthe colitis control group. The enzyme activity of catalase was higher in all the treatments comparedto the TNBS-induced colitis control mice. To summarize the results obtained, a principal componentanalysis (PCA) was performed, clearly grouping the treatments in different clusters according to thevariables studied. This is one of the first studies to address the role of a potential probiotic strain ina chronic colitis mouse model, trying to elucidate the relationship between its properties and theEPS synthesized.
publishDate 2024
dc.date.none.fl_str_mv 2024-01-25
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/243211
Ale, Elisa Carmen; Irazoqui, José Matías; Ale, Analía; Peralta, Guillermo Hugo; Puntillo, Melisa Anahí; et al.; Protective Role of Limosilactobacillus fermentum Lf2 and Its Exopolysaccharides (EPS) in a TNBS-Induced Chronic Colitis Mouse Model; MDPI; Fermentation; 10; 2; 25-1-2024; 1-15
2311-5637
CONICET Digital
CONICET
url http://hdl.handle.net/11336/243211
identifier_str_mv Ale, Elisa Carmen; Irazoqui, José Matías; Ale, Analía; Peralta, Guillermo Hugo; Puntillo, Melisa Anahí; et al.; Protective Role of Limosilactobacillus fermentum Lf2 and Its Exopolysaccharides (EPS) in a TNBS-Induced Chronic Colitis Mouse Model; MDPI; Fermentation; 10; 2; 25-1-2024; 1-15
2311-5637
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2311-5637/10/2/77
info:eu-repo/semantics/altIdentifier/doi/10.3390/fermentation10020077
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
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dc.publisher.none.fl_str_mv MDPI
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reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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