Antifungal Activity of Ribosome-Inactivating Proteins

Autores
Iglesias, Rosario; Citores, Lucía; Gay, Claudia Carolina; Ferreras, José M.
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The control of crop diseases caused by fungi remains a major problem and there is a need to find effective fungicides that are environmentally friendly. Plants are an excellent source for this purpose because they have developed defense mechanisms to cope with fungal infections. Among the plant proteins that play a role in defense are ribosome-inactivating proteins (RIPs), enzymes obtained mainly from angiosperms that, in addition to inactivating ribosomes, have been studied as antiviral, fungicidal, and insecticidal proteins. In this review, we summarize and discuss the potential use of RIPs (and other proteins with similar activity) as antifungal agents, with special emphasis on RIP/fungus specificity, possible mechanisms of antifungal action, and the use of RIP genes to obtain fungus-resistant transgenic plants. It also highlights the fact that these proteins also have antiviral and insecticidal activity, which makes them very versatile tools for crop protection.
Fil: Iglesias, Rosario. Universidad de Valladolid. Facultad de Ciencias; España
Fil: Citores, Lucía. Universidad de Valladolid. Facultad de Ciencias; España
Fil: Gay, Claudia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; Argentina
Fil: Ferreras, José M.. Universidad de Valladolid. Facultad de Ciencias; España
Materia
ADENINE POLYNUCLEOTIDE GLYCOSYLASE
ANTIFUNGAL PROTEIN
FUNGUS-RESISTANT TRANSGENIC PLANTS
PLANT PATHOGENIC FUNGI
RIBOSOME-INACTIVATING PROTEIN (RIP)
RRNA GLYCOSYLASE (EC 3.2.2.22)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/256994
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/256994
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antifungal Activity of Ribosome-Inactivating ProteinsIglesias, RosarioCitores, LucíaGay, Claudia CarolinaFerreras, José M.ADENINE POLYNUCLEOTIDE GLYCOSYLASEANTIFUNGAL PROTEINFUNGUS-RESISTANT TRANSGENIC PLANTSPLANT PATHOGENIC FUNGIRIBOSOME-INACTIVATING PROTEIN (RIP)RRNA GLYCOSYLASE (EC 3.2.2.22)https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The control of crop diseases caused by fungi remains a major problem and there is a need to find effective fungicides that are environmentally friendly. Plants are an excellent source for this purpose because they have developed defense mechanisms to cope with fungal infections. Among the plant proteins that play a role in defense are ribosome-inactivating proteins (RIPs), enzymes obtained mainly from angiosperms that, in addition to inactivating ribosomes, have been studied as antiviral, fungicidal, and insecticidal proteins. In this review, we summarize and discuss the potential use of RIPs (and other proteins with similar activity) as antifungal agents, with special emphasis on RIP/fungus specificity, possible mechanisms of antifungal action, and the use of RIP genes to obtain fungus-resistant transgenic plants. It also highlights the fact that these proteins also have antiviral and insecticidal activity, which makes them very versatile tools for crop protection.Fil: Iglesias, Rosario. Universidad de Valladolid. Facultad de Ciencias; EspañaFil: Citores, Lucía. Universidad de Valladolid. Facultad de Ciencias; EspañaFil: Gay, Claudia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; ArgentinaFil: Ferreras, José M.. Universidad de Valladolid. Facultad de Ciencias; EspañaMultidisciplinary Digital Publishing Institute2024-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/256994Iglesias, Rosario; Citores, Lucía; Gay, Claudia Carolina; Ferreras, José M.; Antifungal Activity of Ribosome-Inactivating Proteins; Multidisciplinary Digital Publishing Institute; Toxins; 16; 4; 4-2024; 1-202072-6651CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6651/16/4/192info:eu-repo/semantics/altIdentifier/doi/10.3390/toxins16040192info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:04Zoai:ri.conicet.gov.ar:11336/256994instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:04.915CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antifungal Activity of Ribosome-Inactivating Proteins
title Antifungal Activity of Ribosome-Inactivating Proteins
spellingShingle Antifungal Activity of Ribosome-Inactivating Proteins
Iglesias, Rosario
ADENINE POLYNUCLEOTIDE GLYCOSYLASE
ANTIFUNGAL PROTEIN
FUNGUS-RESISTANT TRANSGENIC PLANTS
PLANT PATHOGENIC FUNGI
RIBOSOME-INACTIVATING PROTEIN (RIP)
RRNA GLYCOSYLASE (EC 3.2.2.22)
title_short Antifungal Activity of Ribosome-Inactivating Proteins
title_full Antifungal Activity of Ribosome-Inactivating Proteins
title_fullStr Antifungal Activity of Ribosome-Inactivating Proteins
title_full_unstemmed Antifungal Activity of Ribosome-Inactivating Proteins
title_sort Antifungal Activity of Ribosome-Inactivating Proteins
dc.creator.none.fl_str_mv Iglesias, Rosario
Citores, Lucía
Gay, Claudia Carolina
Ferreras, José M.
author Iglesias, Rosario
author_facet Iglesias, Rosario
Citores, Lucía
Gay, Claudia Carolina
Ferreras, José M.
author_role author
author2 Citores, Lucía
Gay, Claudia Carolina
Ferreras, José M.
author2_role author
author
author
dc.subject.none.fl_str_mv ADENINE POLYNUCLEOTIDE GLYCOSYLASE
ANTIFUNGAL PROTEIN
FUNGUS-RESISTANT TRANSGENIC PLANTS
PLANT PATHOGENIC FUNGI
RIBOSOME-INACTIVATING PROTEIN (RIP)
RRNA GLYCOSYLASE (EC 3.2.2.22)
topic ADENINE POLYNUCLEOTIDE GLYCOSYLASE
ANTIFUNGAL PROTEIN
FUNGUS-RESISTANT TRANSGENIC PLANTS
PLANT PATHOGENIC FUNGI
RIBOSOME-INACTIVATING PROTEIN (RIP)
RRNA GLYCOSYLASE (EC 3.2.2.22)
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The control of crop diseases caused by fungi remains a major problem and there is a need to find effective fungicides that are environmentally friendly. Plants are an excellent source for this purpose because they have developed defense mechanisms to cope with fungal infections. Among the plant proteins that play a role in defense are ribosome-inactivating proteins (RIPs), enzymes obtained mainly from angiosperms that, in addition to inactivating ribosomes, have been studied as antiviral, fungicidal, and insecticidal proteins. In this review, we summarize and discuss the potential use of RIPs (and other proteins with similar activity) as antifungal agents, with special emphasis on RIP/fungus specificity, possible mechanisms of antifungal action, and the use of RIP genes to obtain fungus-resistant transgenic plants. It also highlights the fact that these proteins also have antiviral and insecticidal activity, which makes them very versatile tools for crop protection.
Fil: Iglesias, Rosario. Universidad de Valladolid. Facultad de Ciencias; España
Fil: Citores, Lucía. Universidad de Valladolid. Facultad de Ciencias; España
Fil: Gay, Claudia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; Argentina
Fil: Ferreras, José M.. Universidad de Valladolid. Facultad de Ciencias; España
description The control of crop diseases caused by fungi remains a major problem and there is a need to find effective fungicides that are environmentally friendly. Plants are an excellent source for this purpose because they have developed defense mechanisms to cope with fungal infections. Among the plant proteins that play a role in defense are ribosome-inactivating proteins (RIPs), enzymes obtained mainly from angiosperms that, in addition to inactivating ribosomes, have been studied as antiviral, fungicidal, and insecticidal proteins. In this review, we summarize and discuss the potential use of RIPs (and other proteins with similar activity) as antifungal agents, with special emphasis on RIP/fungus specificity, possible mechanisms of antifungal action, and the use of RIP genes to obtain fungus-resistant transgenic plants. It also highlights the fact that these proteins also have antiviral and insecticidal activity, which makes them very versatile tools for crop protection.
publishDate 2024
dc.date.none.fl_str_mv 2024-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/256994
Iglesias, Rosario; Citores, Lucía; Gay, Claudia Carolina; Ferreras, José M.; Antifungal Activity of Ribosome-Inactivating Proteins; Multidisciplinary Digital Publishing Institute; Toxins; 16; 4; 4-2024; 1-20
2072-6651
CONICET Digital
CONICET
url http://hdl.handle.net/11336/256994
identifier_str_mv Iglesias, Rosario; Citores, Lucía; Gay, Claudia Carolina; Ferreras, José M.; Antifungal Activity of Ribosome-Inactivating Proteins; Multidisciplinary Digital Publishing Institute; Toxins; 16; 4; 4-2024; 1-20
2072-6651
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6651/16/4/192
info:eu-repo/semantics/altIdentifier/doi/10.3390/toxins16040192
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269559752491008
score 13.13397

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