Circaannual changes in antioxidants and oxidative stress in the heart and liver in rats

Autores
Belló Klein, A.; Morgan Martins, M. I.; Barp, J.; Llesuy, Susana Francisca; Bello, A. A.; Singal, P. K.
Año de publicación
2000
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Reactive oxygen species are formed in physiological and pathological conditions in mammalian tissues. Because of their high reactivity, they may interact with biomolecules, inducing oxidative injury. Increases in lipid peroxidation can result in oxidative damage to cellular membranes. Protection against oxidative damage is provided by enzymatic and non-enzymatic antioxidant defenses. Antioxidant enzyme activities and lipid peroxidation, as an index of oxidative stress injury, were evaluated in different seasons over one year in the heart and liver of rats, maintained on a 12 h light and dark cycle. Glutathione peroxidase and catalase activities, in both tissues, were maximal in the summer season. Lipid peroxidation in the heart was maximal in the spring as compared to the other seasons and it did not vary in the liver during the year. These findings suggest that any study of antioxidants or oxidative stress must take into account such seasonal variations for a more precise analysis of changes due to any pathological condition. © 2000 Elsevier Science Inc. All rights reserved.
Fil: Belló Klein, A.. Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saude; Brasil
Fil: Morgan Martins, M. I.. Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saude; Brasil
Fil: Barp, J.. Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saude; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Bello, A. A.. Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saude; Brasil
Fil: Singal, P. K.. St Boniface General Hospital Research Centre; Canadá
Materia
Catalase
Glutathione Peroxidase (Gshpx)
Lipid Peroxidation
Seasonal Variations
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/44493

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network_name_str CONICET Digital (CONICET)
spelling Circaannual changes in antioxidants and oxidative stress in the heart and liver in ratsBelló Klein, A.Morgan Martins, M. I.Barp, J.Llesuy, Susana FranciscaBello, A. A.Singal, P. K.CatalaseGlutathione Peroxidase (Gshpx)Lipid PeroxidationSeasonal Variationshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Reactive oxygen species are formed in physiological and pathological conditions in mammalian tissues. Because of their high reactivity, they may interact with biomolecules, inducing oxidative injury. Increases in lipid peroxidation can result in oxidative damage to cellular membranes. Protection against oxidative damage is provided by enzymatic and non-enzymatic antioxidant defenses. Antioxidant enzyme activities and lipid peroxidation, as an index of oxidative stress injury, were evaluated in different seasons over one year in the heart and liver of rats, maintained on a 12 h light and dark cycle. Glutathione peroxidase and catalase activities, in both tissues, were maximal in the summer season. Lipid peroxidation in the heart was maximal in the spring as compared to the other seasons and it did not vary in the liver during the year. These findings suggest that any study of antioxidants or oxidative stress must take into account such seasonal variations for a more precise analysis of changes due to any pathological condition. © 2000 Elsevier Science Inc. All rights reserved.Fil: Belló Klein, A.. Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saude; BrasilFil: Morgan Martins, M. I.. Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saude; BrasilFil: Barp, J.. Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saude; BrasilFil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Bello, A. A.. Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saude; BrasilFil: Singal, P. K.. St Boniface General Hospital Research Centre; CanadáElsevier Science Inc2000-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/44493Belló Klein, A.; Morgan Martins, M. I.; Barp, J.; Llesuy, Susana Francisca; Bello, A. A.; et al.; Circaannual changes in antioxidants and oxidative stress in the heart and liver in rats; Elsevier Science Inc; Comparative Biochemistry And Physiology. C, Comparative Pharmacology And Toxicology.; 126; 2; 6-2000; 203-2080742-84131878-1942CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0742841300001122info:eu-repo/semantics/altIdentifier/doi/10.1016/S0742-8413(00)00112-2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:05:11Zoai:ri.conicet.gov.ar:11336/44493instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:05:11.742CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Circaannual changes in antioxidants and oxidative stress in the heart and liver in rats
title Circaannual changes in antioxidants and oxidative stress in the heart and liver in rats
spellingShingle Circaannual changes in antioxidants and oxidative stress in the heart and liver in rats
Belló Klein, A.
Catalase
Glutathione Peroxidase (Gshpx)
Lipid Peroxidation
Seasonal Variations
title_short Circaannual changes in antioxidants and oxidative stress in the heart and liver in rats
title_full Circaannual changes in antioxidants and oxidative stress in the heart and liver in rats
title_fullStr Circaannual changes in antioxidants and oxidative stress in the heart and liver in rats
title_full_unstemmed Circaannual changes in antioxidants and oxidative stress in the heart and liver in rats
title_sort Circaannual changes in antioxidants and oxidative stress in the heart and liver in rats
dc.creator.none.fl_str_mv Belló Klein, A.
Morgan Martins, M. I.
Barp, J.
Llesuy, Susana Francisca
Bello, A. A.
Singal, P. K.
author Belló Klein, A.
author_facet Belló Klein, A.
Morgan Martins, M. I.
Barp, J.
Llesuy, Susana Francisca
Bello, A. A.
Singal, P. K.
author_role author
author2 Morgan Martins, M. I.
Barp, J.
Llesuy, Susana Francisca
Bello, A. A.
Singal, P. K.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Catalase
Glutathione Peroxidase (Gshpx)
Lipid Peroxidation
Seasonal Variations
topic Catalase
Glutathione Peroxidase (Gshpx)
Lipid Peroxidation
Seasonal Variations
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Reactive oxygen species are formed in physiological and pathological conditions in mammalian tissues. Because of their high reactivity, they may interact with biomolecules, inducing oxidative injury. Increases in lipid peroxidation can result in oxidative damage to cellular membranes. Protection against oxidative damage is provided by enzymatic and non-enzymatic antioxidant defenses. Antioxidant enzyme activities and lipid peroxidation, as an index of oxidative stress injury, were evaluated in different seasons over one year in the heart and liver of rats, maintained on a 12 h light and dark cycle. Glutathione peroxidase and catalase activities, in both tissues, were maximal in the summer season. Lipid peroxidation in the heart was maximal in the spring as compared to the other seasons and it did not vary in the liver during the year. These findings suggest that any study of antioxidants or oxidative stress must take into account such seasonal variations for a more precise analysis of changes due to any pathological condition. © 2000 Elsevier Science Inc. All rights reserved.
Fil: Belló Klein, A.. Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saude; Brasil
Fil: Morgan Martins, M. I.. Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saude; Brasil
Fil: Barp, J.. Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saude; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Bello, A. A.. Universidade Federal do Rio Grande do Sul. Instituto de Ciências Básicas da Saude; Brasil
Fil: Singal, P. K.. St Boniface General Hospital Research Centre; Canadá
description Reactive oxygen species are formed in physiological and pathological conditions in mammalian tissues. Because of their high reactivity, they may interact with biomolecules, inducing oxidative injury. Increases in lipid peroxidation can result in oxidative damage to cellular membranes. Protection against oxidative damage is provided by enzymatic and non-enzymatic antioxidant defenses. Antioxidant enzyme activities and lipid peroxidation, as an index of oxidative stress injury, were evaluated in different seasons over one year in the heart and liver of rats, maintained on a 12 h light and dark cycle. Glutathione peroxidase and catalase activities, in both tissues, were maximal in the summer season. Lipid peroxidation in the heart was maximal in the spring as compared to the other seasons and it did not vary in the liver during the year. These findings suggest that any study of antioxidants or oxidative stress must take into account such seasonal variations for a more precise analysis of changes due to any pathological condition. © 2000 Elsevier Science Inc. All rights reserved.
publishDate 2000
dc.date.none.fl_str_mv 2000-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/44493
Belló Klein, A.; Morgan Martins, M. I.; Barp, J.; Llesuy, Susana Francisca; Bello, A. A.; et al.; Circaannual changes in antioxidants and oxidative stress in the heart and liver in rats; Elsevier Science Inc; Comparative Biochemistry And Physiology. C, Comparative Pharmacology And Toxicology.; 126; 2; 6-2000; 203-208
0742-8413
1878-1942
CONICET Digital
CONICET
url http://hdl.handle.net/11336/44493
identifier_str_mv Belló Klein, A.; Morgan Martins, M. I.; Barp, J.; Llesuy, Susana Francisca; Bello, A. A.; et al.; Circaannual changes in antioxidants and oxidative stress in the heart and liver in rats; Elsevier Science Inc; Comparative Biochemistry And Physiology. C, Comparative Pharmacology And Toxicology.; 126; 2; 6-2000; 203-208
0742-8413
1878-1942
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0742841300001122
info:eu-repo/semantics/altIdentifier/doi/10.1016/S0742-8413(00)00112-2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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