Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment

Autores
Soba, Alejandro; Suárez, Cecilia Ana; Morales González, Maraelys; Bergues Cabrales, Luis Enrique; Bergues Pupo, Ana Elisa; Reyes, Juan Bory; Martínez Tassé, José Pablo
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The Electrochemical treatment can be used for local control of solid tumors in both preclinical and clinical studies. In thispaper, an integrated analysis of the spatial distributions of the electric potential, electric field, temperature and pH together withthe acidic and basic areas are computed, via Finite Element Methods, to improve the geometrical description of electrode arraysfor a better electrochemical treatment. These physical quantities are generated by different polarization modes and shapes ofelectrode arrays. Additionally, the equations over a rectangular two-dimensional domain, which represents the tumor tissue, aresolved. The results demonstrate how the electric potential, electric field, temperature and pH distributions depend strongly onthe electrode array. Furthermore, significant pH changes and temperature increments are shown after 60 min of treatment. Thenumerical results agree with the analytical ones reported in the literature. It is concluded that the numerical solution method permitsto make an integral analysis, prediction and rapid visualization of the most important electrochemical variables that take place in tumor destruction, thus, providing the possibility of a more effective therapeutic planning before electrochemical treatment isconducted.
Fil: Soba, Alejandro. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Suárez, Cecilia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Fil: Morales González, Maraelys. Universidad de la Habana; Cuba
Fil: Bergues Cabrales, Luis Enrique. Universidad de Oriente; Cuba
Fil: Bergues Pupo, Ana Elisa. Universidad de Oriente; Cuba
Fil: Reyes, Juan Bory. Instituto Politécnico Nacional. Escuela Superior de Ingeniería Mecánica y Eléctrica; México
Fil: Martínez Tassé, José Pablo. Universidad de Oriente; Cuba
Materia
Electrode Arrays
Electric Field Intensity
Ph Fronts
Tissue Damage
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/41429
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/41429
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatmentSoba, AlejandroSuárez, Cecilia AnaMorales González, MaraelysBergues Cabrales, Luis EnriqueBergues Pupo, Ana ElisaReyes, Juan BoryMartínez Tassé, José PabloElectrode ArraysElectric Field IntensityPh FrontsTissue Damagehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The Electrochemical treatment can be used for local control of solid tumors in both preclinical and clinical studies. In thispaper, an integrated analysis of the spatial distributions of the electric potential, electric field, temperature and pH together withthe acidic and basic areas are computed, via Finite Element Methods, to improve the geometrical description of electrode arraysfor a better electrochemical treatment. These physical quantities are generated by different polarization modes and shapes ofelectrode arrays. Additionally, the equations over a rectangular two-dimensional domain, which represents the tumor tissue, aresolved. The results demonstrate how the electric potential, electric field, temperature and pH distributions depend strongly onthe electrode array. Furthermore, significant pH changes and temperature increments are shown after 60 min of treatment. Thenumerical results agree with the analytical ones reported in the literature. It is concluded that the numerical solution method permitsto make an integral analysis, prediction and rapid visualization of the most important electrochemical variables that take place in tumor destruction, thus, providing the possibility of a more effective therapeutic planning before electrochemical treatment isconducted.Fil: Soba, Alejandro. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Suárez, Cecilia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; ArgentinaFil: Morales González, Maraelys. Universidad de la Habana; CubaFil: Bergues Cabrales, Luis Enrique. Universidad de Oriente; CubaFil: Bergues Pupo, Ana Elisa. Universidad de Oriente; CubaFil: Reyes, Juan Bory. Instituto Politécnico Nacional. Escuela Superior de Ingeniería Mecánica y Eléctrica; MéxicoFil: Martínez Tassé, José Pablo. Universidad de Oriente; CubaElsevier Science2017-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/41429Soba, Alejandro; Suárez, Cecilia Ana; Morales González, Maraelys; Bergues Cabrales, Luis Enrique; Bergues Pupo, Ana Elisa; et al.; Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment; Elsevier Science; Mathematics And Computers In Simulation; 146; 11-2017; 160-1760378-4754CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0378475417303749info:eu-repo/semantics/altIdentifier/doi/10.1016/j.matcom.2017.11.006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:40Zoai:ri.conicet.gov.ar:11336/41429instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:40.572CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment
title Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment
spellingShingle Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment
Soba, Alejandro
Electrode Arrays
Electric Field Intensity
Ph Fronts
Tissue Damage
title_short Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment
title_full Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment
title_fullStr Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment
title_full_unstemmed Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment
title_sort Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment
dc.creator.none.fl_str_mv Soba, Alejandro
Suárez, Cecilia Ana
Morales González, Maraelys
Bergues Cabrales, Luis Enrique
Bergues Pupo, Ana Elisa
Reyes, Juan Bory
Martínez Tassé, José Pablo
author Soba, Alejandro
author_facet Soba, Alejandro
Suárez, Cecilia Ana
Morales González, Maraelys
Bergues Cabrales, Luis Enrique
Bergues Pupo, Ana Elisa
Reyes, Juan Bory
Martínez Tassé, José Pablo
author_role author
author2 Suárez, Cecilia Ana
Morales González, Maraelys
Bergues Cabrales, Luis Enrique
Bergues Pupo, Ana Elisa
Reyes, Juan Bory
Martínez Tassé, José Pablo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Electrode Arrays
Electric Field Intensity
Ph Fronts
Tissue Damage
topic Electrode Arrays
Electric Field Intensity
Ph Fronts
Tissue Damage
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The Electrochemical treatment can be used for local control of solid tumors in both preclinical and clinical studies. In thispaper, an integrated analysis of the spatial distributions of the electric potential, electric field, temperature and pH together withthe acidic and basic areas are computed, via Finite Element Methods, to improve the geometrical description of electrode arraysfor a better electrochemical treatment. These physical quantities are generated by different polarization modes and shapes ofelectrode arrays. Additionally, the equations over a rectangular two-dimensional domain, which represents the tumor tissue, aresolved. The results demonstrate how the electric potential, electric field, temperature and pH distributions depend strongly onthe electrode array. Furthermore, significant pH changes and temperature increments are shown after 60 min of treatment. Thenumerical results agree with the analytical ones reported in the literature. It is concluded that the numerical solution method permitsto make an integral analysis, prediction and rapid visualization of the most important electrochemical variables that take place in tumor destruction, thus, providing the possibility of a more effective therapeutic planning before electrochemical treatment isconducted.
Fil: Soba, Alejandro. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Suárez, Cecilia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
Fil: Morales González, Maraelys. Universidad de la Habana; Cuba
Fil: Bergues Cabrales, Luis Enrique. Universidad de Oriente; Cuba
Fil: Bergues Pupo, Ana Elisa. Universidad de Oriente; Cuba
Fil: Reyes, Juan Bory. Instituto Politécnico Nacional. Escuela Superior de Ingeniería Mecánica y Eléctrica; México
Fil: Martínez Tassé, José Pablo. Universidad de Oriente; Cuba
description The Electrochemical treatment can be used for local control of solid tumors in both preclinical and clinical studies. In thispaper, an integrated analysis of the spatial distributions of the electric potential, electric field, temperature and pH together withthe acidic and basic areas are computed, via Finite Element Methods, to improve the geometrical description of electrode arraysfor a better electrochemical treatment. These physical quantities are generated by different polarization modes and shapes ofelectrode arrays. Additionally, the equations over a rectangular two-dimensional domain, which represents the tumor tissue, aresolved. The results demonstrate how the electric potential, electric field, temperature and pH distributions depend strongly onthe electrode array. Furthermore, significant pH changes and temperature increments are shown after 60 min of treatment. Thenumerical results agree with the analytical ones reported in the literature. It is concluded that the numerical solution method permitsto make an integral analysis, prediction and rapid visualization of the most important electrochemical variables that take place in tumor destruction, thus, providing the possibility of a more effective therapeutic planning before electrochemical treatment isconducted.
publishDate 2017
dc.date.none.fl_str_mv 2017-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/41429
Soba, Alejandro; Suárez, Cecilia Ana; Morales González, Maraelys; Bergues Cabrales, Luis Enrique; Bergues Pupo, Ana Elisa; et al.; Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment; Elsevier Science; Mathematics And Computers In Simulation; 146; 11-2017; 160-176
0378-4754
CONICET Digital
CONICET
url http://hdl.handle.net/11336/41429
identifier_str_mv Soba, Alejandro; Suárez, Cecilia Ana; Morales González, Maraelys; Bergues Cabrales, Luis Enrique; Bergues Pupo, Ana Elisa; et al.; Integrated analysis of the potential, electric field, temperature, pH and tissue damage generated by different electrode arrays in a tumor under electrochemical treatment; Elsevier Science; Mathematics And Computers In Simulation; 146; 11-2017; 160-176
0378-4754
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0378475417303749
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.matcom.2017.11.006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613457342627840
score 13.070432

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