6 Iodo-δ-lactone reproduces many but not all the effects of iodide

Autores
Thomasz, Lisa; Oglio, Romina; Dagrosa, María A.; Krawiec, León; Pisarev, Mario Alberto; Juvenal, Guillermo Juan
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Iodide has direct effects on thyroid function. Several iodinated lipids are biosynthesized by the thyroid and they were postulated as intermediaries in the action of iodide. Among them 6 iodo-δ-lactone (IL-δ) has been identified and proposed to play a role in thyroid autoregulation. The aim of this study was to compare the effect of iodide and IL-δ on several thyroid parameters. Methods: Thyroid bovine follicles were incubated with the different compounds during three days. Results: KI and IL-δ inhibited iodide uptake, total protein and Tg synthesis but only KI had an effect on NIS and Tg mRNAs levels. Both compounds inhibited Na+/K+ ATPase and deoxy-glucose uptake. As PAX 8, FOXE 1 and TITF1 are involved in the regulation of thyroid specific genes their mRNA levels were measured. While iodide inhibited the expression of the first two, the expression of TITF1 was stimulated by iodide and IL-δ had no effect on these parameters. Conclusion: These findings indicate that IL-δ reproduces some but not all the effects of excess iodide. These observations apply for higher micromolar concentrations of iodide while no such effects could be demonstrated at nanomolar iodide concentrations.
Fil: Thomasz, Lisa. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Oglio, Romina. Comisión Nacional de Energía Atómica; Argentina
Fil: Dagrosa, María A.. Comisión Nacional de Energía Atómica; Argentina
Fil: Krawiec, León. Comisión Nacional de Energía Atómica; Argentina
Fil: Pisarev, Mario Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Juvenal, Guillermo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
Materia
IODIDE
IODOLIPIDS
THYROID CELL REGULATION
THYROID FOLLICLES (BOVINE)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/190049
Acceder
id CONICETDig_2c50cb0a88e46aaf275e907a3fff3e7d
oai_identifier_str oai:ri.conicet.gov.ar:11336/190049
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling 6 Iodo-δ-lactone reproduces many but not all the effects of iodideThomasz, LisaOglio, RominaDagrosa, María A.Krawiec, LeónPisarev, Mario AlbertoJuvenal, Guillermo JuanIODIDEIODOLIPIDSTHYROID CELL REGULATIONTHYROID FOLLICLES (BOVINE)https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: Iodide has direct effects on thyroid function. Several iodinated lipids are biosynthesized by the thyroid and they were postulated as intermediaries in the action of iodide. Among them 6 iodo-δ-lactone (IL-δ) has been identified and proposed to play a role in thyroid autoregulation. The aim of this study was to compare the effect of iodide and IL-δ on several thyroid parameters. Methods: Thyroid bovine follicles were incubated with the different compounds during three days. Results: KI and IL-δ inhibited iodide uptake, total protein and Tg synthesis but only KI had an effect on NIS and Tg mRNAs levels. Both compounds inhibited Na+/K+ ATPase and deoxy-glucose uptake. As PAX 8, FOXE 1 and TITF1 are involved in the regulation of thyroid specific genes their mRNA levels were measured. While iodide inhibited the expression of the first two, the expression of TITF1 was stimulated by iodide and IL-δ had no effect on these parameters. Conclusion: These findings indicate that IL-δ reproduces some but not all the effects of excess iodide. These observations apply for higher micromolar concentrations of iodide while no such effects could be demonstrated at nanomolar iodide concentrations.Fil: Thomasz, Lisa. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Oglio, Romina. Comisión Nacional de Energía Atómica; ArgentinaFil: Dagrosa, María A.. Comisión Nacional de Energía Atómica; ArgentinaFil: Krawiec, León. Comisión Nacional de Energía Atómica; ArgentinaFil: Pisarev, Mario Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina. Comisión Nacional de Energía Atómica; ArgentinaFil: Juvenal, Guillermo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; ArgentinaElsevier Ireland2010-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/190049Thomasz, Lisa; Oglio, Romina; Dagrosa, María A.; Krawiec, León; Pisarev, Mario Alberto; et al.; 6 Iodo-δ-lactone reproduces many but not all the effects of iodide; Elsevier Ireland; Molecular and Cellular Endocrinology; 323; 2; 12-2010; 161-1660303-7207CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303720710001590info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2010.03.012info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:09:07Zoai:ri.conicet.gov.ar:11336/190049instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:09:07.75CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv 6 Iodo-δ-lactone reproduces many but not all the effects of iodide
title 6 Iodo-δ-lactone reproduces many but not all the effects of iodide
spellingShingle 6 Iodo-δ-lactone reproduces many but not all the effects of iodide
Thomasz, Lisa
IODIDE
IODOLIPIDS
THYROID CELL REGULATION
THYROID FOLLICLES (BOVINE)
title_short 6 Iodo-δ-lactone reproduces many but not all the effects of iodide
title_full 6 Iodo-δ-lactone reproduces many but not all the effects of iodide
title_fullStr 6 Iodo-δ-lactone reproduces many but not all the effects of iodide
title_full_unstemmed 6 Iodo-δ-lactone reproduces many but not all the effects of iodide
title_sort 6 Iodo-δ-lactone reproduces many but not all the effects of iodide
dc.creator.none.fl_str_mv Thomasz, Lisa
Oglio, Romina
Dagrosa, María A.
Krawiec, León
Pisarev, Mario Alberto
Juvenal, Guillermo Juan
author Thomasz, Lisa
author_facet Thomasz, Lisa
Oglio, Romina
Dagrosa, María A.
Krawiec, León
Pisarev, Mario Alberto
Juvenal, Guillermo Juan
author_role author
author2 Oglio, Romina
Dagrosa, María A.
Krawiec, León
Pisarev, Mario Alberto
Juvenal, Guillermo Juan
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv IODIDE
IODOLIPIDS
THYROID CELL REGULATION
THYROID FOLLICLES (BOVINE)
topic IODIDE
IODOLIPIDS
THYROID CELL REGULATION
THYROID FOLLICLES (BOVINE)
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Iodide has direct effects on thyroid function. Several iodinated lipids are biosynthesized by the thyroid and they were postulated as intermediaries in the action of iodide. Among them 6 iodo-δ-lactone (IL-δ) has been identified and proposed to play a role in thyroid autoregulation. The aim of this study was to compare the effect of iodide and IL-δ on several thyroid parameters. Methods: Thyroid bovine follicles were incubated with the different compounds during three days. Results: KI and IL-δ inhibited iodide uptake, total protein and Tg synthesis but only KI had an effect on NIS and Tg mRNAs levels. Both compounds inhibited Na+/K+ ATPase and deoxy-glucose uptake. As PAX 8, FOXE 1 and TITF1 are involved in the regulation of thyroid specific genes their mRNA levels were measured. While iodide inhibited the expression of the first two, the expression of TITF1 was stimulated by iodide and IL-δ had no effect on these parameters. Conclusion: These findings indicate that IL-δ reproduces some but not all the effects of excess iodide. These observations apply for higher micromolar concentrations of iodide while no such effects could be demonstrated at nanomolar iodide concentrations.
Fil: Thomasz, Lisa. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Oglio, Romina. Comisión Nacional de Energía Atómica; Argentina
Fil: Dagrosa, María A.. Comisión Nacional de Energía Atómica; Argentina
Fil: Krawiec, León. Comisión Nacional de Energía Atómica; Argentina
Fil: Pisarev, Mario Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Juvenal, Guillermo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
description Background: Iodide has direct effects on thyroid function. Several iodinated lipids are biosynthesized by the thyroid and they were postulated as intermediaries in the action of iodide. Among them 6 iodo-δ-lactone (IL-δ) has been identified and proposed to play a role in thyroid autoregulation. The aim of this study was to compare the effect of iodide and IL-δ on several thyroid parameters. Methods: Thyroid bovine follicles were incubated with the different compounds during three days. Results: KI and IL-δ inhibited iodide uptake, total protein and Tg synthesis but only KI had an effect on NIS and Tg mRNAs levels. Both compounds inhibited Na+/K+ ATPase and deoxy-glucose uptake. As PAX 8, FOXE 1 and TITF1 are involved in the regulation of thyroid specific genes their mRNA levels were measured. While iodide inhibited the expression of the first two, the expression of TITF1 was stimulated by iodide and IL-δ had no effect on these parameters. Conclusion: These findings indicate that IL-δ reproduces some but not all the effects of excess iodide. These observations apply for higher micromolar concentrations of iodide while no such effects could be demonstrated at nanomolar iodide concentrations.
publishDate 2010
dc.date.none.fl_str_mv 2010-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/190049
Thomasz, Lisa; Oglio, Romina; Dagrosa, María A.; Krawiec, León; Pisarev, Mario Alberto; et al.; 6 Iodo-δ-lactone reproduces many but not all the effects of iodide; Elsevier Ireland; Molecular and Cellular Endocrinology; 323; 2; 12-2010; 161-166
0303-7207
CONICET Digital
CONICET
url http://hdl.handle.net/11336/190049
identifier_str_mv Thomasz, Lisa; Oglio, Romina; Dagrosa, María A.; Krawiec, León; Pisarev, Mario Alberto; et al.; 6 Iodo-δ-lactone reproduces many but not all the effects of iodide; Elsevier Ireland; Molecular and Cellular Endocrinology; 323; 2; 12-2010; 161-166
0303-7207
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303720710001590
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2010.03.012
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980443607007232
score 12.993085

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