Molecular Basis of Redox Signaling

Autores
Franco, Maria Clara; Carreras, Maria Cecilia; Hannibal, Luciana
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Oxidants are produced in physiological and pathological conditions. The production of reactive nitrogen and oxygen species (RNS and ROS, respectively) can lead to vastly different cellular outcomes depending on their subcellular location, half-life, reactivity, gradients, and the antioxidant defenses. While oxidative stress caused by general oxidative damage is often nonspecific and linked to cell death by necrosis, at lower concentrations, ROS and RNS can act as second messengers regulating redox-sensitive signaling pathways, which elicit very specific cellular responses [1, 2]. Redox signaling is an intrinsic, tightly regulated component of cell metabolism, controlling cell growth, differentiation, and death. The interplay between the production of oxidants and the antioxidant defenses is highly regulated to maintain cellular redox homeostasis [3, 4]; thus, its dysregulation underlies many pathological conditions, including cancer, neurodegeneration, and cardiovascular and metabolic diseases. This special issue is focused on redox signaling in pathology and developments in redox-based therapies.
Fil: Franco, Maria Clara. State University of Oregon; Estados Unidos
Fil: Carreras, Maria Cecilia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Hannibal, Luciana. Albert Ludwigs University of Freiburg; Alemania
Materia
OXIDATIVE STRESS
REDOX SIGNALING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/108575
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Molecular Basis of Redox SignalingFranco, Maria ClaraCarreras, Maria CeciliaHannibal, LucianaOXIDATIVE STRESSREDOX SIGNALINGhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Oxidants are produced in physiological and pathological conditions. The production of reactive nitrogen and oxygen species (RNS and ROS, respectively) can lead to vastly different cellular outcomes depending on their subcellular location, half-life, reactivity, gradients, and the antioxidant defenses. While oxidative stress caused by general oxidative damage is often nonspecific and linked to cell death by necrosis, at lower concentrations, ROS and RNS can act as second messengers regulating redox-sensitive signaling pathways, which elicit very specific cellular responses [1, 2]. Redox signaling is an intrinsic, tightly regulated component of cell metabolism, controlling cell growth, differentiation, and death. The interplay between the production of oxidants and the antioxidant defenses is highly regulated to maintain cellular redox homeostasis [3, 4]; thus, its dysregulation underlies many pathological conditions, including cancer, neurodegeneration, and cardiovascular and metabolic diseases. This special issue is focused on redox signaling in pathology and developments in redox-based therapies.Fil: Franco, Maria Clara. State University of Oregon; Estados UnidosFil: Carreras, Maria Cecilia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Hannibal, Luciana. Albert Ludwigs University of Freiburg; AlemaniaLandes Bioscience2019-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/108575Franco, Maria Clara; Carreras, Maria Cecilia; Hannibal, Luciana; Molecular Basis of Redox Signaling; Landes Bioscience; Oxidative Medicine and Cellular Longevity; 2019; 5-2019; 1-31942-09001942-0994CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1155/2019/6414975info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/omcl/2019/6414975/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:52Zoai:ri.conicet.gov.ar:11336/108575instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:53.016CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Molecular Basis of Redox Signaling
title Molecular Basis of Redox Signaling
spellingShingle Molecular Basis of Redox Signaling
Franco, Maria Clara
OXIDATIVE STRESS
REDOX SIGNALING
title_short Molecular Basis of Redox Signaling
title_full Molecular Basis of Redox Signaling
title_fullStr Molecular Basis of Redox Signaling
title_full_unstemmed Molecular Basis of Redox Signaling
title_sort Molecular Basis of Redox Signaling
dc.creator.none.fl_str_mv Franco, Maria Clara
Carreras, Maria Cecilia
Hannibal, Luciana
author Franco, Maria Clara
author_facet Franco, Maria Clara
Carreras, Maria Cecilia
Hannibal, Luciana
author_role author
author2 Carreras, Maria Cecilia
Hannibal, Luciana
author2_role author
author
dc.subject.none.fl_str_mv OXIDATIVE STRESS
REDOX SIGNALING
topic OXIDATIVE STRESS
REDOX SIGNALING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Oxidants are produced in physiological and pathological conditions. The production of reactive nitrogen and oxygen species (RNS and ROS, respectively) can lead to vastly different cellular outcomes depending on their subcellular location, half-life, reactivity, gradients, and the antioxidant defenses. While oxidative stress caused by general oxidative damage is often nonspecific and linked to cell death by necrosis, at lower concentrations, ROS and RNS can act as second messengers regulating redox-sensitive signaling pathways, which elicit very specific cellular responses [1, 2]. Redox signaling is an intrinsic, tightly regulated component of cell metabolism, controlling cell growth, differentiation, and death. The interplay between the production of oxidants and the antioxidant defenses is highly regulated to maintain cellular redox homeostasis [3, 4]; thus, its dysregulation underlies many pathological conditions, including cancer, neurodegeneration, and cardiovascular and metabolic diseases. This special issue is focused on redox signaling in pathology and developments in redox-based therapies.
Fil: Franco, Maria Clara. State University of Oregon; Estados Unidos
Fil: Carreras, Maria Cecilia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Hannibal, Luciana. Albert Ludwigs University of Freiburg; Alemania
description Oxidants are produced in physiological and pathological conditions. The production of reactive nitrogen and oxygen species (RNS and ROS, respectively) can lead to vastly different cellular outcomes depending on their subcellular location, half-life, reactivity, gradients, and the antioxidant defenses. While oxidative stress caused by general oxidative damage is often nonspecific and linked to cell death by necrosis, at lower concentrations, ROS and RNS can act as second messengers regulating redox-sensitive signaling pathways, which elicit very specific cellular responses [1, 2]. Redox signaling is an intrinsic, tightly regulated component of cell metabolism, controlling cell growth, differentiation, and death. The interplay between the production of oxidants and the antioxidant defenses is highly regulated to maintain cellular redox homeostasis [3, 4]; thus, its dysregulation underlies many pathological conditions, including cancer, neurodegeneration, and cardiovascular and metabolic diseases. This special issue is focused on redox signaling in pathology and developments in redox-based therapies.
publishDate 2019
dc.date.none.fl_str_mv 2019-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/108575
Franco, Maria Clara; Carreras, Maria Cecilia; Hannibal, Luciana; Molecular Basis of Redox Signaling; Landes Bioscience; Oxidative Medicine and Cellular Longevity; 2019; 5-2019; 1-3
1942-0900
1942-0994
CONICET Digital
CONICET
url http://hdl.handle.net/11336/108575
identifier_str_mv Franco, Maria Clara; Carreras, Maria Cecilia; Hannibal, Luciana; Molecular Basis of Redox Signaling; Landes Bioscience; Oxidative Medicine and Cellular Longevity; 2019; 5-2019; 1-3
1942-0900
1942-0994
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1155/2019/6414975
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/omcl/2019/6414975/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Landes Bioscience
publisher.none.fl_str_mv Landes Bioscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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