Aquaporin membrane channels in oxidative stress, cell signaling, and aging: Recent advances and research trends

Autores
Tamma, Grazia; Valenti, Giovanna; Grossini, Elena; Donnini, Sandra; Marino, Angela; Marinelli, Raul Alberto; Calamita, Giuseppe
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis. Extensive investigation aims to elucidate the beneficial effects of ROS and NO, providing novel insights into the current medical treatment of oxidative stress-related diseases of high epidemiological impact. This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. The most recent advances regarding the modulation exerted by food phytocompounds with antioxidant action on AQPs are also reviewed.
Fil: Tamma, Grazia. Università degli Studi di Bari; Italia
Fil: Valenti, Giovanna. Università degli Studi di Bari; Italia
Fil: Grossini, Elena. University of Eastern Piedmont; Italia
Fil: Donnini, Sandra. Università degli Studi di Siena; Italia
Fil: Marino, Angela. University of Messina; Italia
Fil: Marinelli, Raul Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Calamita, Giuseppe. Università degli Studi di Bari; Italia
Materia
AQUAPORIN
OXIDATIVE STRESS
SIGNALING
AGING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/86347
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Aquaporin membrane channels in oxidative stress, cell signaling, and aging: Recent advances and research trendsTamma, GraziaValenti, GiovannaGrossini, ElenaDonnini, SandraMarino, AngelaMarinelli, Raul AlbertoCalamita, GiuseppeAQUAPORINOXIDATIVE STRESSSIGNALINGAGINGhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis. Extensive investigation aims to elucidate the beneficial effects of ROS and NO, providing novel insights into the current medical treatment of oxidative stress-related diseases of high epidemiological impact. This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. The most recent advances regarding the modulation exerted by food phytocompounds with antioxidant action on AQPs are also reviewed.Fil: Tamma, Grazia. Università degli Studi di Bari; ItaliaFil: Valenti, Giovanna. Università degli Studi di Bari; ItaliaFil: Grossini, Elena. University of Eastern Piedmont; ItaliaFil: Donnini, Sandra. Università degli Studi di Siena; ItaliaFil: Marino, Angela. University of Messina; ItaliaFil: Marinelli, Raul Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Calamita, Giuseppe. Università degli Studi di Bari; ItaliaHindawi Publishing Corporation2018-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/86347Tamma, Grazia; Valenti, Giovanna; Grossini, Elena; Donnini, Sandra; Marino, Angela; et al.; Aquaporin membrane channels in oxidative stress, cell signaling, and aging: Recent advances and research trends; Hindawi Publishing Corporation; Oxidative Medicine and Cellular Longevity; 2018; 3-2018; 1-14; 15018471942-09001942-0994CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/omcl/2018/1501847/info:eu-repo/semantics/altIdentifier/doi/10.1155/2018/1501847info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:07:08Zoai:ri.conicet.gov.ar:11336/86347instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:07:09.018CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Aquaporin membrane channels in oxidative stress, cell signaling, and aging: Recent advances and research trends
title Aquaporin membrane channels in oxidative stress, cell signaling, and aging: Recent advances and research trends
spellingShingle Aquaporin membrane channels in oxidative stress, cell signaling, and aging: Recent advances and research trends
Tamma, Grazia
AQUAPORIN
OXIDATIVE STRESS
SIGNALING
AGING
title_short Aquaporin membrane channels in oxidative stress, cell signaling, and aging: Recent advances and research trends
title_full Aquaporin membrane channels in oxidative stress, cell signaling, and aging: Recent advances and research trends
title_fullStr Aquaporin membrane channels in oxidative stress, cell signaling, and aging: Recent advances and research trends
title_full_unstemmed Aquaporin membrane channels in oxidative stress, cell signaling, and aging: Recent advances and research trends
title_sort Aquaporin membrane channels in oxidative stress, cell signaling, and aging: Recent advances and research trends
dc.creator.none.fl_str_mv Tamma, Grazia
Valenti, Giovanna
Grossini, Elena
Donnini, Sandra
Marino, Angela
Marinelli, Raul Alberto
Calamita, Giuseppe
author Tamma, Grazia
author_facet Tamma, Grazia
Valenti, Giovanna
Grossini, Elena
Donnini, Sandra
Marino, Angela
Marinelli, Raul Alberto
Calamita, Giuseppe
author_role author
author2 Valenti, Giovanna
Grossini, Elena
Donnini, Sandra
Marino, Angela
Marinelli, Raul Alberto
Calamita, Giuseppe
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv AQUAPORIN
OXIDATIVE STRESS
SIGNALING
AGING
topic AQUAPORIN
OXIDATIVE STRESS
SIGNALING
AGING
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis. Extensive investigation aims to elucidate the beneficial effects of ROS and NO, providing novel insights into the current medical treatment of oxidative stress-related diseases of high epidemiological impact. This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. The most recent advances regarding the modulation exerted by food phytocompounds with antioxidant action on AQPs are also reviewed.
Fil: Tamma, Grazia. Università degli Studi di Bari; Italia
Fil: Valenti, Giovanna. Università degli Studi di Bari; Italia
Fil: Grossini, Elena. University of Eastern Piedmont; Italia
Fil: Donnini, Sandra. Università degli Studi di Siena; Italia
Fil: Marino, Angela. University of Messina; Italia
Fil: Marinelli, Raul Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Calamita, Giuseppe. Università degli Studi di Bari; Italia
description Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis. Extensive investigation aims to elucidate the beneficial effects of ROS and NO, providing novel insights into the current medical treatment of oxidative stress-related diseases of high epidemiological impact. This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. The most recent advances regarding the modulation exerted by food phytocompounds with antioxidant action on AQPs are also reviewed.
publishDate 2018
dc.date.none.fl_str_mv 2018-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/86347
Tamma, Grazia; Valenti, Giovanna; Grossini, Elena; Donnini, Sandra; Marino, Angela; et al.; Aquaporin membrane channels in oxidative stress, cell signaling, and aging: Recent advances and research trends; Hindawi Publishing Corporation; Oxidative Medicine and Cellular Longevity; 2018; 3-2018; 1-14; 1501847
1942-0900
1942-0994
CONICET Digital
CONICET
url http://hdl.handle.net/11336/86347
identifier_str_mv Tamma, Grazia; Valenti, Giovanna; Grossini, Elena; Donnini, Sandra; Marino, Angela; et al.; Aquaporin membrane channels in oxidative stress, cell signaling, and aging: Recent advances and research trends; Hindawi Publishing Corporation; Oxidative Medicine and Cellular Longevity; 2018; 3-2018; 1-14; 1501847
1942-0900
1942-0994
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/omcl/2018/1501847/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2018/1501847
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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