Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors

Autores
Atkins, Paul W.; Perez, Hernán A.; Spence, John David; Muñoz, Sonia Edith; Armando, Luis J.; Garcia, Nestor Horacio
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: The hypothesis that relates atherosclerosis to traditional risk factors (TRF) seems to be not as adequate as previously thought; other risk factors (RF) need to be considered to prevent atherosclerosis progression. Although a family medical history of premature cardiovascular events (FHx) has been considered the putative RF for decades, it has not been incorporated routinely into cardiovascular risk evaluation along with another RF. The objective of this study was to investigate whether FHx is associated with a higher atherosclerotic burden, measured as carotid total plaque area (TPA) in a population having no traditional RF. Material and methods: The study included 4,351 primary care patients in Argentina. After excluding a personal history of cardiovascular disease (CVD) and TRF: Hypertension, diabetes mellitus, hypercholesterolemia, smoking history, and body mass index (BMI) > 25 kg/cm2, 34 patients with FHx were identified. Compared to 56 matched controls TPA was 86% higher in FHx patients (p < 0.05). A second analysis performed in hypertensive patients but no other TRF; 32 patients with FHx were identified. Results: Compared with 44 matched controls, TPA was 77% higher in FHx patients (p < 0.05). A final analysis using a generalized linear model with TPA progression as the response variable suggests that TPA progresses more rapidly in FHx patients compared to controls. Conclusions: The FHx was associated with increased TPA burden and progression in the absence of other TRF. This supports ultrasound screening in FHx patients in order to detect high-risk patients who may benefit from early intervention.
Fil: Atkins, Paul W.. Western University; Canadá
Fil: Perez, Hernán A.. Blossom Dmo; Argentina
Fil: Spence, John David. Robarts Research Institute; Canadá
Fil: Muñoz, Sonia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Armando, Luis J.. Blossom Dmo; Argentina
Fil: Garcia, Nestor Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Materia
ATHEROSCLEROSIS
CARDIOVASCULAR DISEASE
FAMILY HISTORY
PLAQUE
RISK FACTORS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/125586
Acceder
id CONICETDig_2b6060ffdc1dde32f09201edb012fcf3
oai_identifier_str oai:ri.conicet.gov.ar:11336/125586
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factorsAtkins, Paul W.Perez, Hernán A.Spence, John DavidMuñoz, Sonia EdithArmando, Luis J.Garcia, Nestor HoracioATHEROSCLEROSISCARDIOVASCULAR DISEASEFAMILY HISTORYPLAQUERISK FACTORShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction: The hypothesis that relates atherosclerosis to traditional risk factors (TRF) seems to be not as adequate as previously thought; other risk factors (RF) need to be considered to prevent atherosclerosis progression. Although a family medical history of premature cardiovascular events (FHx) has been considered the putative RF for decades, it has not been incorporated routinely into cardiovascular risk evaluation along with another RF. The objective of this study was to investigate whether FHx is associated with a higher atherosclerotic burden, measured as carotid total plaque area (TPA) in a population having no traditional RF. Material and methods: The study included 4,351 primary care patients in Argentina. After excluding a personal history of cardiovascular disease (CVD) and TRF: Hypertension, diabetes mellitus, hypercholesterolemia, smoking history, and body mass index (BMI) > 25 kg/cm2, 34 patients with FHx were identified. Compared to 56 matched controls TPA was 86% higher in FHx patients (p < 0.05). A second analysis performed in hypertensive patients but no other TRF; 32 patients with FHx were identified. Results: Compared with 44 matched controls, TPA was 77% higher in FHx patients (p < 0.05). A final analysis using a generalized linear model with TPA progression as the response variable suggests that TPA progresses more rapidly in FHx patients compared to controls. Conclusions: The FHx was associated with increased TPA burden and progression in the absence of other TRF. This supports ultrasound screening in FHx patients in order to detect high-risk patients who may benefit from early intervention.Fil: Atkins, Paul W.. Western University; CanadáFil: Perez, Hernán A.. Blossom Dmo; ArgentinaFil: Spence, John David. Robarts Research Institute; CanadáFil: Muñoz, Sonia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Armando, Luis J.. Blossom Dmo; ArgentinaFil: Garcia, Nestor Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaTermedia Publishing House Ltd2019-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/125586Atkins, Paul W.; Perez, Hernán A.; Spence, John David; Muñoz, Sonia Edith; Armando, Luis J.; et al.; Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors; Termedia Publishing House Ltd; Archives Of Medical Science; 15; 6; 11-2019; 1388-13961734-19221896-9151CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.5114/aoms.2019.84677info:eu-repo/semantics/altIdentifier/url/https://www.archivesofmedicalscience.com/Increased-carotid-plaque-burden-in-patients-with-family-medical-history-of-premature,89692,0,2.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:31:02Zoai:ri.conicet.gov.ar:11336/125586instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:31:03.093CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors
title Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors
spellingShingle Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors
Atkins, Paul W.
ATHEROSCLEROSIS
CARDIOVASCULAR DISEASE
FAMILY HISTORY
PLAQUE
RISK FACTORS
title_short Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors
title_full Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors
title_fullStr Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors
title_full_unstemmed Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors
title_sort Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors
dc.creator.none.fl_str_mv Atkins, Paul W.
Perez, Hernán A.
Spence, John David
Muñoz, Sonia Edith
Armando, Luis J.
Garcia, Nestor Horacio
author Atkins, Paul W.
author_facet Atkins, Paul W.
Perez, Hernán A.
Spence, John David
Muñoz, Sonia Edith
Armando, Luis J.
Garcia, Nestor Horacio
author_role author
author2 Perez, Hernán A.
Spence, John David
Muñoz, Sonia Edith
Armando, Luis J.
Garcia, Nestor Horacio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ATHEROSCLEROSIS
CARDIOVASCULAR DISEASE
FAMILY HISTORY
PLAQUE
RISK FACTORS
topic ATHEROSCLEROSIS
CARDIOVASCULAR DISEASE
FAMILY HISTORY
PLAQUE
RISK FACTORS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: The hypothesis that relates atherosclerosis to traditional risk factors (TRF) seems to be not as adequate as previously thought; other risk factors (RF) need to be considered to prevent atherosclerosis progression. Although a family medical history of premature cardiovascular events (FHx) has been considered the putative RF for decades, it has not been incorporated routinely into cardiovascular risk evaluation along with another RF. The objective of this study was to investigate whether FHx is associated with a higher atherosclerotic burden, measured as carotid total plaque area (TPA) in a population having no traditional RF. Material and methods: The study included 4,351 primary care patients in Argentina. After excluding a personal history of cardiovascular disease (CVD) and TRF: Hypertension, diabetes mellitus, hypercholesterolemia, smoking history, and body mass index (BMI) > 25 kg/cm2, 34 patients with FHx were identified. Compared to 56 matched controls TPA was 86% higher in FHx patients (p < 0.05). A second analysis performed in hypertensive patients but no other TRF; 32 patients with FHx were identified. Results: Compared with 44 matched controls, TPA was 77% higher in FHx patients (p < 0.05). A final analysis using a generalized linear model with TPA progression as the response variable suggests that TPA progresses more rapidly in FHx patients compared to controls. Conclusions: The FHx was associated with increased TPA burden and progression in the absence of other TRF. This supports ultrasound screening in FHx patients in order to detect high-risk patients who may benefit from early intervention.
Fil: Atkins, Paul W.. Western University; Canadá
Fil: Perez, Hernán A.. Blossom Dmo; Argentina
Fil: Spence, John David. Robarts Research Institute; Canadá
Fil: Muñoz, Sonia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Armando, Luis J.. Blossom Dmo; Argentina
Fil: Garcia, Nestor Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
description Introduction: The hypothesis that relates atherosclerosis to traditional risk factors (TRF) seems to be not as adequate as previously thought; other risk factors (RF) need to be considered to prevent atherosclerosis progression. Although a family medical history of premature cardiovascular events (FHx) has been considered the putative RF for decades, it has not been incorporated routinely into cardiovascular risk evaluation along with another RF. The objective of this study was to investigate whether FHx is associated with a higher atherosclerotic burden, measured as carotid total plaque area (TPA) in a population having no traditional RF. Material and methods: The study included 4,351 primary care patients in Argentina. After excluding a personal history of cardiovascular disease (CVD) and TRF: Hypertension, diabetes mellitus, hypercholesterolemia, smoking history, and body mass index (BMI) > 25 kg/cm2, 34 patients with FHx were identified. Compared to 56 matched controls TPA was 86% higher in FHx patients (p < 0.05). A second analysis performed in hypertensive patients but no other TRF; 32 patients with FHx were identified. Results: Compared with 44 matched controls, TPA was 77% higher in FHx patients (p < 0.05). A final analysis using a generalized linear model with TPA progression as the response variable suggests that TPA progresses more rapidly in FHx patients compared to controls. Conclusions: The FHx was associated with increased TPA burden and progression in the absence of other TRF. This supports ultrasound screening in FHx patients in order to detect high-risk patients who may benefit from early intervention.
publishDate 2019
dc.date.none.fl_str_mv 2019-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/125586
Atkins, Paul W.; Perez, Hernán A.; Spence, John David; Muñoz, Sonia Edith; Armando, Luis J.; et al.; Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors; Termedia Publishing House Ltd; Archives Of Medical Science; 15; 6; 11-2019; 1388-1396
1734-1922
1896-9151
CONICET Digital
CONICET
url http://hdl.handle.net/11336/125586
identifier_str_mv Atkins, Paul W.; Perez, Hernán A.; Spence, John David; Muñoz, Sonia Edith; Armando, Luis J.; et al.; Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors; Termedia Publishing House Ltd; Archives Of Medical Science; 15; 6; 11-2019; 1388-1396
1734-1922
1896-9151
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.5114/aoms.2019.84677
info:eu-repo/semantics/altIdentifier/url/https://www.archivesofmedicalscience.com/Increased-carotid-plaque-burden-in-patients-with-family-medical-history-of-premature,89692,0,2.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Termedia Publishing House Ltd
publisher.none.fl_str_mv Termedia Publishing House Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083447261495296
score 13.22299

Publicaciones similares