Comparative plasma pharmacokinetics, tissue distribution and efficacy of two formulations ciprofloxacin-based in mouse
- Autores
- Breda, Susana Andrea; González, Carlos; Confalonieri, Alejandra; Sanchez Bruni, Sergio Fabian; Manzo, Ruben Hilario; Olivera, María Eugenia
- Año de publicación
- 2009
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- The aim of this study was to assess the plasma pharmacokinetics, tissue distribution and efficacy of a formulation ciprofloxacin (CIP)-Aluminum complex based (CIP-Al) in comparison with a conventional CIP formulation. For this study 96 Balb-C mice were divided in two groups and treated as follows: Group I received orally a single dose of CIP 5 mg/kg. Animals of Group II were identically treated but with CIP-AL formulation. Samples of blood, lung, intestine and kidney, were taken over 12 h post-treatment, and frozen until analysis by HPLC. The experimental efficacy study was based in an experimental Salmonella infection model in mice. Mice were divided into 3 groups: Control (distilled water treatment), CIP and CIP-Al. After 5 days of treatment survival was recorded. The plasma pharmacokinetics study outcomes revealed similar AUC values for CIP and CIP-Al. However, CIP concentration levels were statistically (P< 0.05) higher in lung, intestine and kidney after CIP-Al administration than those obtained for CIP conventional formulation group after 1h post treatment. The higher tissue concentrations of CIP-Al may have contributed to the observed efficacy trend where survived 33% of mice treated compared with the conventional CIP formulation assayed (0%). This fact would be related to the improved aqueous compatibility of CIP after aluminum complexation. We found that CIP-Al is at least as effective as CIP and exhibited advantageous pharmacokinetic and dispositional properties. It may become a valuable asset based on its formulation versatility due to higher solubility.
Fil: Breda, Susana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: González, Carlos. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Confalonieri, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Sanchez Bruni, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Olivera, María Eugenia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina
LXI Reunion Anual de Sociedad Argentina de Farmacología Experimental
Rosario
Argentina
Sociedad Argentina de Farmacología Experimental - Materia
-
CIPROFLOXACIN-ALUMINIUM
PHARMACOKINETICS
MICE
TISSUE DISTRIBUTION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/242057
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Comparative plasma pharmacokinetics, tissue distribution and efficacy of two formulations ciprofloxacin-based in mouseBreda, Susana AndreaGonzález, CarlosConfalonieri, AlejandraSanchez Bruni, Sergio FabianManzo, Ruben HilarioOlivera, María EugeniaCIPROFLOXACIN-ALUMINIUMPHARMACOKINETICSMICETISSUE DISTRIBUTIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The aim of this study was to assess the plasma pharmacokinetics, tissue distribution and efficacy of a formulation ciprofloxacin (CIP)-Aluminum complex based (CIP-Al) in comparison with a conventional CIP formulation. For this study 96 Balb-C mice were divided in two groups and treated as follows: Group I received orally a single dose of CIP 5 mg/kg. Animals of Group II were identically treated but with CIP-AL formulation. Samples of blood, lung, intestine and kidney, were taken over 12 h post-treatment, and frozen until analysis by HPLC. The experimental efficacy study was based in an experimental Salmonella infection model in mice. Mice were divided into 3 groups: Control (distilled water treatment), CIP and CIP-Al. After 5 days of treatment survival was recorded. The plasma pharmacokinetics study outcomes revealed similar AUC values for CIP and CIP-Al. However, CIP concentration levels were statistically (P< 0.05) higher in lung, intestine and kidney after CIP-Al administration than those obtained for CIP conventional formulation group after 1h post treatment. The higher tissue concentrations of CIP-Al may have contributed to the observed efficacy trend where survived 33% of mice treated compared with the conventional CIP formulation assayed (0%). This fact would be related to the improved aqueous compatibility of CIP after aluminum complexation. We found that CIP-Al is at least as effective as CIP and exhibited advantageous pharmacokinetic and dispositional properties. It may become a valuable asset based on its formulation versatility due to higher solubility.Fil: Breda, Susana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; ArgentinaFil: González, Carlos. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Confalonieri, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Sanchez Bruni, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; ArgentinaFil: Olivera, María Eugenia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; ArgentinaLXI Reunion Anual de Sociedad Argentina de Farmacología ExperimentalRosarioArgentinaSociedad Argentina de Farmacología ExperimentalSociedad Argentina de Farmacología Experimental2009info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/242057Comparative plasma pharmacokinetics, tissue distribution and efficacy of two formulations ciprofloxacin-based in mouse; LXI Reunion Anual de Sociedad Argentina de Farmacología Experimental; Rosario; Argentina; 2009; 28-28CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/wp-content/uploads/2021/07/ACTA_2009.pdfInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:05:29Zoai:ri.conicet.gov.ar:11336/242057instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:05:30.122CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Comparative plasma pharmacokinetics, tissue distribution and efficacy of two formulations ciprofloxacin-based in mouse |
title |
Comparative plasma pharmacokinetics, tissue distribution and efficacy of two formulations ciprofloxacin-based in mouse |
spellingShingle |
Comparative plasma pharmacokinetics, tissue distribution and efficacy of two formulations ciprofloxacin-based in mouse Breda, Susana Andrea CIPROFLOXACIN-ALUMINIUM PHARMACOKINETICS MICE TISSUE DISTRIBUTION |
title_short |
Comparative plasma pharmacokinetics, tissue distribution and efficacy of two formulations ciprofloxacin-based in mouse |
title_full |
Comparative plasma pharmacokinetics, tissue distribution and efficacy of two formulations ciprofloxacin-based in mouse |
title_fullStr |
Comparative plasma pharmacokinetics, tissue distribution and efficacy of two formulations ciprofloxacin-based in mouse |
title_full_unstemmed |
Comparative plasma pharmacokinetics, tissue distribution and efficacy of two formulations ciprofloxacin-based in mouse |
title_sort |
Comparative plasma pharmacokinetics, tissue distribution and efficacy of two formulations ciprofloxacin-based in mouse |
dc.creator.none.fl_str_mv |
Breda, Susana Andrea González, Carlos Confalonieri, Alejandra Sanchez Bruni, Sergio Fabian Manzo, Ruben Hilario Olivera, María Eugenia |
author |
Breda, Susana Andrea |
author_facet |
Breda, Susana Andrea González, Carlos Confalonieri, Alejandra Sanchez Bruni, Sergio Fabian Manzo, Ruben Hilario Olivera, María Eugenia |
author_role |
author |
author2 |
González, Carlos Confalonieri, Alejandra Sanchez Bruni, Sergio Fabian Manzo, Ruben Hilario Olivera, María Eugenia |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
CIPROFLOXACIN-ALUMINIUM PHARMACOKINETICS MICE TISSUE DISTRIBUTION |
topic |
CIPROFLOXACIN-ALUMINIUM PHARMACOKINETICS MICE TISSUE DISTRIBUTION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The aim of this study was to assess the plasma pharmacokinetics, tissue distribution and efficacy of a formulation ciprofloxacin (CIP)-Aluminum complex based (CIP-Al) in comparison with a conventional CIP formulation. For this study 96 Balb-C mice were divided in two groups and treated as follows: Group I received orally a single dose of CIP 5 mg/kg. Animals of Group II were identically treated but with CIP-AL formulation. Samples of blood, lung, intestine and kidney, were taken over 12 h post-treatment, and frozen until analysis by HPLC. The experimental efficacy study was based in an experimental Salmonella infection model in mice. Mice were divided into 3 groups: Control (distilled water treatment), CIP and CIP-Al. After 5 days of treatment survival was recorded. The plasma pharmacokinetics study outcomes revealed similar AUC values for CIP and CIP-Al. However, CIP concentration levels were statistically (P< 0.05) higher in lung, intestine and kidney after CIP-Al administration than those obtained for CIP conventional formulation group after 1h post treatment. The higher tissue concentrations of CIP-Al may have contributed to the observed efficacy trend where survived 33% of mice treated compared with the conventional CIP formulation assayed (0%). This fact would be related to the improved aqueous compatibility of CIP after aluminum complexation. We found that CIP-Al is at least as effective as CIP and exhibited advantageous pharmacokinetic and dispositional properties. It may become a valuable asset based on its formulation versatility due to higher solubility. Fil: Breda, Susana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina Fil: González, Carlos. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina Fil: Confalonieri, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina Fil: Sanchez Bruni, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina Fil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina Fil: Olivera, María Eugenia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas; Argentina LXI Reunion Anual de Sociedad Argentina de Farmacología Experimental Rosario Argentina Sociedad Argentina de Farmacología Experimental |
description |
The aim of this study was to assess the plasma pharmacokinetics, tissue distribution and efficacy of a formulation ciprofloxacin (CIP)-Aluminum complex based (CIP-Al) in comparison with a conventional CIP formulation. For this study 96 Balb-C mice were divided in two groups and treated as follows: Group I received orally a single dose of CIP 5 mg/kg. Animals of Group II were identically treated but with CIP-AL formulation. Samples of blood, lung, intestine and kidney, were taken over 12 h post-treatment, and frozen until analysis by HPLC. The experimental efficacy study was based in an experimental Salmonella infection model in mice. Mice were divided into 3 groups: Control (distilled water treatment), CIP and CIP-Al. After 5 days of treatment survival was recorded. The plasma pharmacokinetics study outcomes revealed similar AUC values for CIP and CIP-Al. However, CIP concentration levels were statistically (P< 0.05) higher in lung, intestine and kidney after CIP-Al administration than those obtained for CIP conventional formulation group after 1h post treatment. The higher tissue concentrations of CIP-Al may have contributed to the observed efficacy trend where survived 33% of mice treated compared with the conventional CIP formulation assayed (0%). This fact would be related to the improved aqueous compatibility of CIP after aluminum complexation. We found that CIP-Al is at least as effective as CIP and exhibited advantageous pharmacokinetic and dispositional properties. It may become a valuable asset based on its formulation versatility due to higher solubility. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Reunión Book http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/242057 Comparative plasma pharmacokinetics, tissue distribution and efficacy of two formulations ciprofloxacin-based in mouse; LXI Reunion Anual de Sociedad Argentina de Farmacología Experimental; Rosario; Argentina; 2009; 28-28 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/242057 |
identifier_str_mv |
Comparative plasma pharmacokinetics, tissue distribution and efficacy of two formulations ciprofloxacin-based in mouse; LXI Reunion Anual de Sociedad Argentina de Farmacología Experimental; Rosario; Argentina; 2009; 28-28 CONICET Digital CONICET |
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eng |
language |
eng |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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Internacional |
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Sociedad Argentina de Farmacología Experimental |
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Sociedad Argentina de Farmacología Experimental |
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