Anaplasic large cell lymphoma ALK plus Anatomo pathological characterization of three pediatric cases

Autores
Cao, Gabriel Fernando; Mendez, Julian; Ottaviano, Graciela Mabel; Capani, Francisco
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The anaplastic large cell lymphoma ALK+ (ALCL ALK+) is a rare malignancy in childhood, which normally occurs in advanced clinical stages. The common histological subtype is composed by large cells with cytomorphology and immunohistochemistry feature of CD30 and T markers expression. The neoplasia presents a translocation t (2; 3) (p23; q35) related to up- regulated of kinase associated with anaplastic cells (ALK), whose overexpression is detectable by immunohistochemical techniques (ALK-1). The presence of lymphadenopathies and prolonged fever can simulate an infectious process. The presence of B symptoms, extranodal, mediastinal, visceral and cutaneous involvement, significantly reduce the prognosis of the patient. Medullary infiltration at the time of the diagnosis, together with the histological subtypes of small cells and lymphohistiocytic neoplasm, favouring frequent relapses. Treatment is based on different regimens and combine cytarabine, methotrexate, doxorubicin, prednisolone, vincristine, and 6-mercaptopurine. Other therapies include the use of an anti-CD30 antibody and an ALK enzyme inhibitor drug.
Fil: Cao, Gabriel Fernando. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires.; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mendez, Julian. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Ottaviano, Graciela Mabel. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Capani, Francisco. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Anaplastic large cell lymphoma
ALK +
Paediatrics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/247458
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/247458
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Anaplasic large cell lymphoma ALK plus Anatomo pathological characterization of three pediatric casesCao, Gabriel FernandoMendez, JulianOttaviano, Graciela MabelCapani, FranciscoAnaplastic large cell lymphomaALK +Paediatricshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The anaplastic large cell lymphoma ALK+ (ALCL ALK+) is a rare malignancy in childhood, which normally occurs in advanced clinical stages. The common histological subtype is composed by large cells with cytomorphology and immunohistochemistry feature of CD30 and T markers expression. The neoplasia presents a translocation t (2; 3) (p23; q35) related to up- regulated of kinase associated with anaplastic cells (ALK), whose overexpression is detectable by immunohistochemical techniques (ALK-1). The presence of lymphadenopathies and prolonged fever can simulate an infectious process. The presence of B symptoms, extranodal, mediastinal, visceral and cutaneous involvement, significantly reduce the prognosis of the patient. Medullary infiltration at the time of the diagnosis, together with the histological subtypes of small cells and lymphohistiocytic neoplasm, favouring frequent relapses. Treatment is based on different regimens and combine cytarabine, methotrexate, doxorubicin, prednisolone, vincristine, and 6-mercaptopurine. Other therapies include the use of an anti-CD30 antibody and an ALK enzyme inhibitor drug.Fil: Cao, Gabriel Fernando. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires.; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mendez, Julian. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Ottaviano, Graciela Mabel. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Capani, Francisco. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaJournal of Clinical and Medical Images Case Reports2023-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/247458Cao, Gabriel Fernando; Mendez, Julian; Ottaviano, Graciela Mabel; Capani, Francisco; Anaplasic large cell lymphoma ALK plus Anatomo pathological characterization of three pediatric cases; Journal of Clinical and Medical Images Case Reports; Journal of Clinical and Medical Images, Case Reports; 3; 5; 10-2023; 1569-15732771-019XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.55920/2771-019X/1569info:eu-repo/semantics/altIdentifier/url/https://jcmimagescasereports.org/article/JCM-V3-1569.pdfinfo:eu-repo/semantics/altIdentifier/url/https://www.jcmimagescasereports.org/volume3-issue5.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:17:31Zoai:ri.conicet.gov.ar:11336/247458instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:17:32.579CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Anaplasic large cell lymphoma ALK plus Anatomo pathological characterization of three pediatric cases
title Anaplasic large cell lymphoma ALK plus Anatomo pathological characterization of three pediatric cases
spellingShingle Anaplasic large cell lymphoma ALK plus Anatomo pathological characterization of three pediatric cases
Cao, Gabriel Fernando
Anaplastic large cell lymphoma
ALK +
Paediatrics
title_short Anaplasic large cell lymphoma ALK plus Anatomo pathological characterization of three pediatric cases
title_full Anaplasic large cell lymphoma ALK plus Anatomo pathological characterization of three pediatric cases
title_fullStr Anaplasic large cell lymphoma ALK plus Anatomo pathological characterization of three pediatric cases
title_full_unstemmed Anaplasic large cell lymphoma ALK plus Anatomo pathological characterization of three pediatric cases
title_sort Anaplasic large cell lymphoma ALK plus Anatomo pathological characterization of three pediatric cases
dc.creator.none.fl_str_mv Cao, Gabriel Fernando
Mendez, Julian
Ottaviano, Graciela Mabel
Capani, Francisco
author Cao, Gabriel Fernando
author_facet Cao, Gabriel Fernando
Mendez, Julian
Ottaviano, Graciela Mabel
Capani, Francisco
author_role author
author2 Mendez, Julian
Ottaviano, Graciela Mabel
Capani, Francisco
author2_role author
author
author
dc.subject.none.fl_str_mv Anaplastic large cell lymphoma
ALK +
Paediatrics
topic Anaplastic large cell lymphoma
ALK +
Paediatrics
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The anaplastic large cell lymphoma ALK+ (ALCL ALK+) is a rare malignancy in childhood, which normally occurs in advanced clinical stages. The common histological subtype is composed by large cells with cytomorphology and immunohistochemistry feature of CD30 and T markers expression. The neoplasia presents a translocation t (2; 3) (p23; q35) related to up- regulated of kinase associated with anaplastic cells (ALK), whose overexpression is detectable by immunohistochemical techniques (ALK-1). The presence of lymphadenopathies and prolonged fever can simulate an infectious process. The presence of B symptoms, extranodal, mediastinal, visceral and cutaneous involvement, significantly reduce the prognosis of the patient. Medullary infiltration at the time of the diagnosis, together with the histological subtypes of small cells and lymphohistiocytic neoplasm, favouring frequent relapses. Treatment is based on different regimens and combine cytarabine, methotrexate, doxorubicin, prednisolone, vincristine, and 6-mercaptopurine. Other therapies include the use of an anti-CD30 antibody and an ALK enzyme inhibitor drug.
Fil: Cao, Gabriel Fernando. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires.; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mendez, Julian. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Ottaviano, Graciela Mabel. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Capani, Francisco. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The anaplastic large cell lymphoma ALK+ (ALCL ALK+) is a rare malignancy in childhood, which normally occurs in advanced clinical stages. The common histological subtype is composed by large cells with cytomorphology and immunohistochemistry feature of CD30 and T markers expression. The neoplasia presents a translocation t (2; 3) (p23; q35) related to up- regulated of kinase associated with anaplastic cells (ALK), whose overexpression is detectable by immunohistochemical techniques (ALK-1). The presence of lymphadenopathies and prolonged fever can simulate an infectious process. The presence of B symptoms, extranodal, mediastinal, visceral and cutaneous involvement, significantly reduce the prognosis of the patient. Medullary infiltration at the time of the diagnosis, together with the histological subtypes of small cells and lymphohistiocytic neoplasm, favouring frequent relapses. Treatment is based on different regimens and combine cytarabine, methotrexate, doxorubicin, prednisolone, vincristine, and 6-mercaptopurine. Other therapies include the use of an anti-CD30 antibody and an ALK enzyme inhibitor drug.
publishDate 2023
dc.date.none.fl_str_mv 2023-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/247458
Cao, Gabriel Fernando; Mendez, Julian; Ottaviano, Graciela Mabel; Capani, Francisco; Anaplasic large cell lymphoma ALK plus Anatomo pathological characterization of three pediatric cases; Journal of Clinical and Medical Images Case Reports; Journal of Clinical and Medical Images, Case Reports; 3; 5; 10-2023; 1569-1573
2771-019X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/247458
identifier_str_mv Cao, Gabriel Fernando; Mendez, Julian; Ottaviano, Graciela Mabel; Capani, Francisco; Anaplasic large cell lymphoma ALK plus Anatomo pathological characterization of three pediatric cases; Journal of Clinical and Medical Images Case Reports; Journal of Clinical and Medical Images, Case Reports; 3; 5; 10-2023; 1569-1573
2771-019X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.55920/2771-019X/1569
info:eu-repo/semantics/altIdentifier/url/https://jcmimagescasereports.org/article/JCM-V3-1569.pdf
info:eu-repo/semantics/altIdentifier/url/https://www.jcmimagescasereports.org/volume3-issue5.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Journal of Clinical and Medical Images Case Reports
publisher.none.fl_str_mv Journal of Clinical and Medical Images Case Reports
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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