Testicular expression of the TGF-B1 system and the control of Leydig cell proliferation

Autores
Gonzalez, Candela Rocio; Calandra, Ricardo Saul; Gonzalez Calvar, Silvia Ines
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Transforming growth factor beta 1 (TGF-beta1) is a key regulator that modulates male reproductive function. Testicular TGF-beta1 modulates the steroidogenesis of Leydig cells, the organization of peritubular myoid cells, testis development and spermatogenesis. Several studies have indicated that TGF-beta1 is involved in the tight balance between proliferative and apoptotic re- sponses in the Leydig cells. In the present review, we summarize the direct effects of this cytokine in Ley- dig cells under normal and pathological conditions. We analyze the effect of TGF-beta1 in Leydig cells de- pending on the type of receptors involved in the sig- naling pathway of TGF-beta1. Our group has been ana- lyzing the canonical and non canonical intracellular signaling pathways of TGF-beta1 that are involved in the expression of proliferative and apoptotic markers in Leydig cells. On the basis of our studies and from those of other authors we conclude that the balance between the expression of TGF-beta1 receptors and co receptors is of relevance in Leydig cell physiology and pathophisiology.
Fil: Gonzalez, Candela Rocio. Universidad Maimonides. Area de Invest.biomedicas y Biotecnologicas; Argentina
Fil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Gonzalez Calvar, Silvia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Materia
TGF-B1
LEYDIG
ALK
ENDOGLIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/5538
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/5538
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Testicular expression of the TGF-B1 system and the control of Leydig cell proliferationGonzalez, Candela RocioCalandra, Ricardo SaulGonzalez Calvar, Silvia InesTGF-B1LEYDIGALKENDOGLINhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Transforming growth factor beta 1 (TGF-beta1) is a key regulator that modulates male reproductive function. Testicular TGF-beta1 modulates the steroidogenesis of Leydig cells, the organization of peritubular myoid cells, testis development and spermatogenesis. Several studies have indicated that TGF-beta1 is involved in the tight balance between proliferative and apoptotic re- sponses in the Leydig cells. In the present review, we summarize the direct effects of this cytokine in Ley- dig cells under normal and pathological conditions. We analyze the effect of TGF-beta1 in Leydig cells de- pending on the type of receptors involved in the sig- naling pathway of TGF-beta1. Our group has been ana- lyzing the canonical and non canonical intracellular signaling pathways of TGF-beta1 that are involved in the expression of proliferative and apoptotic markers in Leydig cells. On the basis of our studies and from those of other authors we conclude that the balance between the expression of TGF-beta1 receptors and co receptors is of relevance in Leydig cell physiology and pathophisiology.Fil: Gonzalez, Candela Rocio. Universidad Maimonides. Area de Invest.biomedicas y Biotecnologicas; ArgentinaFil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Gonzalez Calvar, Silvia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaScientific Research2013-10-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/5538Gonzalez, Candela Rocio; Calandra, Ricardo Saul; Gonzalez Calvar, Silvia Ines; Testicular expression of the TGF-B1 system and the control of Leydig cell proliferation; Scientific Research; Advances in Bioscience and Biotechnology; 4; 10C; 30-10-2013; 1-72156-8456enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.4236/abb.2013.410A4001info:eu-repo/semantics/altIdentifier/url/http://www.scirp.org/journal/PaperInformation.aspx?PaperID=36606info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:25:09Zoai:ri.conicet.gov.ar:11336/5538instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:25:09.876CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Testicular expression of the TGF-B1 system and the control of Leydig cell proliferation
title Testicular expression of the TGF-B1 system and the control of Leydig cell proliferation
spellingShingle Testicular expression of the TGF-B1 system and the control of Leydig cell proliferation
Gonzalez, Candela Rocio
TGF-B1
LEYDIG
ALK
ENDOGLIN
title_short Testicular expression of the TGF-B1 system and the control of Leydig cell proliferation
title_full Testicular expression of the TGF-B1 system and the control of Leydig cell proliferation
title_fullStr Testicular expression of the TGF-B1 system and the control of Leydig cell proliferation
title_full_unstemmed Testicular expression of the TGF-B1 system and the control of Leydig cell proliferation
title_sort Testicular expression of the TGF-B1 system and the control of Leydig cell proliferation
dc.creator.none.fl_str_mv Gonzalez, Candela Rocio
Calandra, Ricardo Saul
Gonzalez Calvar, Silvia Ines
author Gonzalez, Candela Rocio
author_facet Gonzalez, Candela Rocio
Calandra, Ricardo Saul
Gonzalez Calvar, Silvia Ines
author_role author
author2 Calandra, Ricardo Saul
Gonzalez Calvar, Silvia Ines
author2_role author
author
dc.subject.none.fl_str_mv TGF-B1
LEYDIG
ALK
ENDOGLIN
topic TGF-B1
LEYDIG
ALK
ENDOGLIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Transforming growth factor beta 1 (TGF-beta1) is a key regulator that modulates male reproductive function. Testicular TGF-beta1 modulates the steroidogenesis of Leydig cells, the organization of peritubular myoid cells, testis development and spermatogenesis. Several studies have indicated that TGF-beta1 is involved in the tight balance between proliferative and apoptotic re- sponses in the Leydig cells. In the present review, we summarize the direct effects of this cytokine in Ley- dig cells under normal and pathological conditions. We analyze the effect of TGF-beta1 in Leydig cells de- pending on the type of receptors involved in the sig- naling pathway of TGF-beta1. Our group has been ana- lyzing the canonical and non canonical intracellular signaling pathways of TGF-beta1 that are involved in the expression of proliferative and apoptotic markers in Leydig cells. On the basis of our studies and from those of other authors we conclude that the balance between the expression of TGF-beta1 receptors and co receptors is of relevance in Leydig cell physiology and pathophisiology.
Fil: Gonzalez, Candela Rocio. Universidad Maimonides. Area de Invest.biomedicas y Biotecnologicas; Argentina
Fil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Gonzalez Calvar, Silvia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
description Transforming growth factor beta 1 (TGF-beta1) is a key regulator that modulates male reproductive function. Testicular TGF-beta1 modulates the steroidogenesis of Leydig cells, the organization of peritubular myoid cells, testis development and spermatogenesis. Several studies have indicated that TGF-beta1 is involved in the tight balance between proliferative and apoptotic re- sponses in the Leydig cells. In the present review, we summarize the direct effects of this cytokine in Ley- dig cells under normal and pathological conditions. We analyze the effect of TGF-beta1 in Leydig cells de- pending on the type of receptors involved in the sig- naling pathway of TGF-beta1. Our group has been ana- lyzing the canonical and non canonical intracellular signaling pathways of TGF-beta1 that are involved in the expression of proliferative and apoptotic markers in Leydig cells. On the basis of our studies and from those of other authors we conclude that the balance between the expression of TGF-beta1 receptors and co receptors is of relevance in Leydig cell physiology and pathophisiology.
publishDate 2013
dc.date.none.fl_str_mv 2013-10-30
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/5538
Gonzalez, Candela Rocio; Calandra, Ricardo Saul; Gonzalez Calvar, Silvia Ines; Testicular expression of the TGF-B1 system and the control of Leydig cell proliferation; Scientific Research; Advances in Bioscience and Biotechnology; 4; 10C; 30-10-2013; 1-7
2156-8456
url http://hdl.handle.net/11336/5538
identifier_str_mv Gonzalez, Candela Rocio; Calandra, Ricardo Saul; Gonzalez Calvar, Silvia Ines; Testicular expression of the TGF-B1 system and the control of Leydig cell proliferation; Scientific Research; Advances in Bioscience and Biotechnology; 4; 10C; 30-10-2013; 1-7
2156-8456
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.4236/abb.2013.410A4001
info:eu-repo/semantics/altIdentifier/url/http://www.scirp.org/journal/PaperInformation.aspx?PaperID=36606
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Scientific Research
publisher.none.fl_str_mv Scientific Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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