Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparativ...
- Autores
- Mazzarino, Letícia; Silva, Luís F. C.; Curta, Juliana C.; Licínio, Marley A.; Costa, Aline; Pacheco, Letícia K.; Siqueira, Jarbas M.; Martinetti Montanari, Jorge Anibal; Romero, Eder; Assreuy, Jamil; Santos Silva, Maria C.; Lemos Senna, Elenara
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Curcumin is a polyphenol obtained from the plant Curcuma longa (called turmeric) that displays several pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial and antitumoral activity, but clinical use has been limited by its poor solubility in water and, consequently, minimal systemic bioavailability. We have therefore formulated the drug into nanocarrier systems in an attempt to improve its therapeutic properties. This study evaluates the effect of intraperitoneally administered nanocapsules containing curcumin on subcutaneous melanoma in mice inoculated with B16-F10 cells, and on the cytotoxicity activity against B16-F10 cells in vitro. Phagocytic uptake of formulations was also evaluated upon incubation with macrophage J774 cells by fluorescence microscopy. Lipid and polymeric nanocapsules were prepared by the phase inversion and nanoprecipitation methods, respectively. The uptake of the lipid nanocapsules prepared using Solutol HS15 was significantly reduced in J774 cells. Curcumin, as free drug or as drug-loaded nanocapsules, was administrated at a dose of 6 mg/kg twice a week for 21 days. Free drug and curcuminloaded nanocapsules significantly reduced tumor volume (P < 0.05 vs. control), but no difference was found in the antitumor activity displayed by lipid and polymeric nanocapsules. This assumption was supported by the in vitro study, in which free curcumin as well as loaded into nanocapsules caused significant reduction of cell viability in a concentration- and time-dependent manner.
Fil: Mazzarino, Letícia. Universidade Federal de Santa Catarina; Brasil
Fil: Silva, Luís F. C.. Universidade Federal de Santa Catarina; Brasil
Fil: Curta, Juliana C.. Universidade Federal de Santa Catarina; Brasil
Fil: Licínio, Marley A.. Universidade Federal de Santa Catarina; Brasil
Fil: Costa, Aline. Universidade Federal de Santa Catarina; Brasil
Fil: Pacheco, Letícia K.. Universidade Federal de Santa Catarina; Brasil
Fil: Siqueira, Jarbas M.. Universidade Federal de Santa Catarina; Brasil
Fil: Martinetti Montanari, Jorge Anibal. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Romero, Eder. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Assreuy, Jamil. Universidade Federal de Santa Catarina; Brasil
Fil: Santos Silva, Maria C.. Universidade Federal de Santa Catarina; Brasil
Fil: Lemos Senna, Elenara. Universidade Federal de Santa Catarina; Brasil - Materia
-
ANTITUMOR ACTIVITY
B16-F10 MELANOMA
CURCUMIN
CYTOTOXICITY
LIPID NANOCAPSULES
MACROPHAGE UPTAKE
POLYMERIC NANOCAPSULES - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/193149
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/193149 |
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repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative studyMazzarino, LetíciaSilva, Luís F. C.Curta, Juliana C.Licínio, Marley A.Costa, AlinePacheco, Letícia K.Siqueira, Jarbas M.Martinetti Montanari, Jorge AnibalRomero, EderAssreuy, JamilSantos Silva, Maria C.Lemos Senna, ElenaraANTITUMOR ACTIVITYB16-F10 MELANOMACURCUMINCYTOTOXICITYLIPID NANOCAPSULESMACROPHAGE UPTAKEPOLYMERIC NANOCAPSULEShttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Curcumin is a polyphenol obtained from the plant Curcuma longa (called turmeric) that displays several pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial and antitumoral activity, but clinical use has been limited by its poor solubility in water and, consequently, minimal systemic bioavailability. We have therefore formulated the drug into nanocarrier systems in an attempt to improve its therapeutic properties. This study evaluates the effect of intraperitoneally administered nanocapsules containing curcumin on subcutaneous melanoma in mice inoculated with B16-F10 cells, and on the cytotoxicity activity against B16-F10 cells in vitro. Phagocytic uptake of formulations was also evaluated upon incubation with macrophage J774 cells by fluorescence microscopy. Lipid and polymeric nanocapsules were prepared by the phase inversion and nanoprecipitation methods, respectively. The uptake of the lipid nanocapsules prepared using Solutol HS15 was significantly reduced in J774 cells. Curcumin, as free drug or as drug-loaded nanocapsules, was administrated at a dose of 6 mg/kg twice a week for 21 days. Free drug and curcuminloaded nanocapsules significantly reduced tumor volume (P < 0.05 vs. control), but no difference was found in the antitumor activity displayed by lipid and polymeric nanocapsules. This assumption was supported by the in vitro study, in which free curcumin as well as loaded into nanocapsules caused significant reduction of cell viability in a concentration- and time-dependent manner.Fil: Mazzarino, Letícia. Universidade Federal de Santa Catarina; BrasilFil: Silva, Luís F. C.. Universidade Federal de Santa Catarina; BrasilFil: Curta, Juliana C.. Universidade Federal de Santa Catarina; BrasilFil: Licínio, Marley A.. Universidade Federal de Santa Catarina; BrasilFil: Costa, Aline. Universidade Federal de Santa Catarina; BrasilFil: Pacheco, Letícia K.. Universidade Federal de Santa Catarina; BrasilFil: Siqueira, Jarbas M.. Universidade Federal de Santa Catarina; BrasilFil: Martinetti Montanari, Jorge Anibal. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Romero, Eder. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Assreuy, Jamil. Universidade Federal de Santa Catarina; BrasilFil: Santos Silva, Maria C.. Universidade Federal de Santa Catarina; BrasilFil: Lemos Senna, Elenara. Universidade Federal de Santa Catarina; BrasilAmerican Scientific Publishers2011-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/193149Mazzarino, Letícia; Silva, Luís F. C.; Curta, Juliana C.; Licínio, Marley A.; Costa, Aline; et al.; Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study; American Scientific Publishers; Journal of Biomedical Nanotechnology; 7; 3; 6-2011; 406-4141550-7033CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1166/jbn.2011.1296info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:58Zoai:ri.conicet.gov.ar:11336/193149instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:58.563CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study |
title |
Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study |
spellingShingle |
Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study Mazzarino, Letícia ANTITUMOR ACTIVITY B16-F10 MELANOMA CURCUMIN CYTOTOXICITY LIPID NANOCAPSULES MACROPHAGE UPTAKE POLYMERIC NANOCAPSULES |
title_short |
Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study |
title_full |
Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study |
title_fullStr |
Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study |
title_full_unstemmed |
Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study |
title_sort |
Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study |
dc.creator.none.fl_str_mv |
Mazzarino, Letícia Silva, Luís F. C. Curta, Juliana C. Licínio, Marley A. Costa, Aline Pacheco, Letícia K. Siqueira, Jarbas M. Martinetti Montanari, Jorge Anibal Romero, Eder Assreuy, Jamil Santos Silva, Maria C. Lemos Senna, Elenara |
author |
Mazzarino, Letícia |
author_facet |
Mazzarino, Letícia Silva, Luís F. C. Curta, Juliana C. Licínio, Marley A. Costa, Aline Pacheco, Letícia K. Siqueira, Jarbas M. Martinetti Montanari, Jorge Anibal Romero, Eder Assreuy, Jamil Santos Silva, Maria C. Lemos Senna, Elenara |
author_role |
author |
author2 |
Silva, Luís F. C. Curta, Juliana C. Licínio, Marley A. Costa, Aline Pacheco, Letícia K. Siqueira, Jarbas M. Martinetti Montanari, Jorge Anibal Romero, Eder Assreuy, Jamil Santos Silva, Maria C. Lemos Senna, Elenara |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
ANTITUMOR ACTIVITY B16-F10 MELANOMA CURCUMIN CYTOTOXICITY LIPID NANOCAPSULES MACROPHAGE UPTAKE POLYMERIC NANOCAPSULES |
topic |
ANTITUMOR ACTIVITY B16-F10 MELANOMA CURCUMIN CYTOTOXICITY LIPID NANOCAPSULES MACROPHAGE UPTAKE POLYMERIC NANOCAPSULES |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
Curcumin is a polyphenol obtained from the plant Curcuma longa (called turmeric) that displays several pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial and antitumoral activity, but clinical use has been limited by its poor solubility in water and, consequently, minimal systemic bioavailability. We have therefore formulated the drug into nanocarrier systems in an attempt to improve its therapeutic properties. This study evaluates the effect of intraperitoneally administered nanocapsules containing curcumin on subcutaneous melanoma in mice inoculated with B16-F10 cells, and on the cytotoxicity activity against B16-F10 cells in vitro. Phagocytic uptake of formulations was also evaluated upon incubation with macrophage J774 cells by fluorescence microscopy. Lipid and polymeric nanocapsules were prepared by the phase inversion and nanoprecipitation methods, respectively. The uptake of the lipid nanocapsules prepared using Solutol HS15 was significantly reduced in J774 cells. Curcumin, as free drug or as drug-loaded nanocapsules, was administrated at a dose of 6 mg/kg twice a week for 21 days. Free drug and curcuminloaded nanocapsules significantly reduced tumor volume (P < 0.05 vs. control), but no difference was found in the antitumor activity displayed by lipid and polymeric nanocapsules. This assumption was supported by the in vitro study, in which free curcumin as well as loaded into nanocapsules caused significant reduction of cell viability in a concentration- and time-dependent manner. Fil: Mazzarino, Letícia. Universidade Federal de Santa Catarina; Brasil Fil: Silva, Luís F. C.. Universidade Federal de Santa Catarina; Brasil Fil: Curta, Juliana C.. Universidade Federal de Santa Catarina; Brasil Fil: Licínio, Marley A.. Universidade Federal de Santa Catarina; Brasil Fil: Costa, Aline. Universidade Federal de Santa Catarina; Brasil Fil: Pacheco, Letícia K.. Universidade Federal de Santa Catarina; Brasil Fil: Siqueira, Jarbas M.. Universidade Federal de Santa Catarina; Brasil Fil: Martinetti Montanari, Jorge Anibal. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Romero, Eder. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina Fil: Assreuy, Jamil. Universidade Federal de Santa Catarina; Brasil Fil: Santos Silva, Maria C.. Universidade Federal de Santa Catarina; Brasil Fil: Lemos Senna, Elenara. Universidade Federal de Santa Catarina; Brasil |
description |
Curcumin is a polyphenol obtained from the plant Curcuma longa (called turmeric) that displays several pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial and antitumoral activity, but clinical use has been limited by its poor solubility in water and, consequently, minimal systemic bioavailability. We have therefore formulated the drug into nanocarrier systems in an attempt to improve its therapeutic properties. This study evaluates the effect of intraperitoneally administered nanocapsules containing curcumin on subcutaneous melanoma in mice inoculated with B16-F10 cells, and on the cytotoxicity activity against B16-F10 cells in vitro. Phagocytic uptake of formulations was also evaluated upon incubation with macrophage J774 cells by fluorescence microscopy. Lipid and polymeric nanocapsules were prepared by the phase inversion and nanoprecipitation methods, respectively. The uptake of the lipid nanocapsules prepared using Solutol HS15 was significantly reduced in J774 cells. Curcumin, as free drug or as drug-loaded nanocapsules, was administrated at a dose of 6 mg/kg twice a week for 21 days. Free drug and curcuminloaded nanocapsules significantly reduced tumor volume (P < 0.05 vs. control), but no difference was found in the antitumor activity displayed by lipid and polymeric nanocapsules. This assumption was supported by the in vitro study, in which free curcumin as well as loaded into nanocapsules caused significant reduction of cell viability in a concentration- and time-dependent manner. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/193149 Mazzarino, Letícia; Silva, Luís F. C.; Curta, Juliana C.; Licínio, Marley A.; Costa, Aline; et al.; Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study; American Scientific Publishers; Journal of Biomedical Nanotechnology; 7; 3; 6-2011; 406-414 1550-7033 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/193149 |
identifier_str_mv |
Mazzarino, Letícia; Silva, Luís F. C.; Curta, Juliana C.; Licínio, Marley A.; Costa, Aline; et al.; Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study; American Scientific Publishers; Journal of Biomedical Nanotechnology; 7; 3; 6-2011; 406-414 1550-7033 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1166/jbn.2011.1296 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Scientific Publishers |
publisher.none.fl_str_mv |
American Scientific Publishers |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614390395961344 |
score |
13.070432 |