Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparativ...

Autores
Mazzarino, Letícia; Silva, Luís F. C.; Curta, Juliana C.; Licínio, Marley A.; Costa, Aline; Pacheco, Letícia K.; Siqueira, Jarbas M.; Martinetti Montanari, Jorge Anibal; Romero, Eder; Assreuy, Jamil; Santos Silva, Maria C.; Lemos Senna, Elenara
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Curcumin is a polyphenol obtained from the plant Curcuma longa (called turmeric) that displays several pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial and antitumoral activity, but clinical use has been limited by its poor solubility in water and, consequently, minimal systemic bioavailability. We have therefore formulated the drug into nanocarrier systems in an attempt to improve its therapeutic properties. This study evaluates the effect of intraperitoneally administered nanocapsules containing curcumin on subcutaneous melanoma in mice inoculated with B16-F10 cells, and on the cytotoxicity activity against B16-F10 cells in vitro. Phagocytic uptake of formulations was also evaluated upon incubation with macrophage J774 cells by fluorescence microscopy. Lipid and polymeric nanocapsules were prepared by the phase inversion and nanoprecipitation methods, respectively. The uptake of the lipid nanocapsules prepared using Solutol HS15 was significantly reduced in J774 cells. Curcumin, as free drug or as drug-loaded nanocapsules, was administrated at a dose of 6 mg/kg twice a week for 21 days. Free drug and curcuminloaded nanocapsules significantly reduced tumor volume (P < 0.05 vs. control), but no difference was found in the antitumor activity displayed by lipid and polymeric nanocapsules. This assumption was supported by the in vitro study, in which free curcumin as well as loaded into nanocapsules caused significant reduction of cell viability in a concentration- and time-dependent manner.
Fil: Mazzarino, Letícia. Universidade Federal de Santa Catarina; Brasil
Fil: Silva, Luís F. C.. Universidade Federal de Santa Catarina; Brasil
Fil: Curta, Juliana C.. Universidade Federal de Santa Catarina; Brasil
Fil: Licínio, Marley A.. Universidade Federal de Santa Catarina; Brasil
Fil: Costa, Aline. Universidade Federal de Santa Catarina; Brasil
Fil: Pacheco, Letícia K.. Universidade Federal de Santa Catarina; Brasil
Fil: Siqueira, Jarbas M.. Universidade Federal de Santa Catarina; Brasil
Fil: Martinetti Montanari, Jorge Anibal. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Romero, Eder. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Assreuy, Jamil. Universidade Federal de Santa Catarina; Brasil
Fil: Santos Silva, Maria C.. Universidade Federal de Santa Catarina; Brasil
Fil: Lemos Senna, Elenara. Universidade Federal de Santa Catarina; Brasil
Materia
ANTITUMOR ACTIVITY
B16-F10 MELANOMA
CURCUMIN
CYTOTOXICITY
LIPID NANOCAPSULES
MACROPHAGE UPTAKE
POLYMERIC NANOCAPSULES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/193149

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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative studyMazzarino, LetíciaSilva, Luís F. C.Curta, Juliana C.Licínio, Marley A.Costa, AlinePacheco, Letícia K.Siqueira, Jarbas M.Martinetti Montanari, Jorge AnibalRomero, EderAssreuy, JamilSantos Silva, Maria C.Lemos Senna, ElenaraANTITUMOR ACTIVITYB16-F10 MELANOMACURCUMINCYTOTOXICITYLIPID NANOCAPSULESMACROPHAGE UPTAKEPOLYMERIC NANOCAPSULEShttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Curcumin is a polyphenol obtained from the plant Curcuma longa (called turmeric) that displays several pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial and antitumoral activity, but clinical use has been limited by its poor solubility in water and, consequently, minimal systemic bioavailability. We have therefore formulated the drug into nanocarrier systems in an attempt to improve its therapeutic properties. This study evaluates the effect of intraperitoneally administered nanocapsules containing curcumin on subcutaneous melanoma in mice inoculated with B16-F10 cells, and on the cytotoxicity activity against B16-F10 cells in vitro. Phagocytic uptake of formulations was also evaluated upon incubation with macrophage J774 cells by fluorescence microscopy. Lipid and polymeric nanocapsules were prepared by the phase inversion and nanoprecipitation methods, respectively. The uptake of the lipid nanocapsules prepared using Solutol HS15 was significantly reduced in J774 cells. Curcumin, as free drug or as drug-loaded nanocapsules, was administrated at a dose of 6 mg/kg twice a week for 21 days. Free drug and curcuminloaded nanocapsules significantly reduced tumor volume (P < 0.05 vs. control), but no difference was found in the antitumor activity displayed by lipid and polymeric nanocapsules. This assumption was supported by the in vitro study, in which free curcumin as well as loaded into nanocapsules caused significant reduction of cell viability in a concentration- and time-dependent manner.Fil: Mazzarino, Letícia. Universidade Federal de Santa Catarina; BrasilFil: Silva, Luís F. C.. Universidade Federal de Santa Catarina; BrasilFil: Curta, Juliana C.. Universidade Federal de Santa Catarina; BrasilFil: Licínio, Marley A.. Universidade Federal de Santa Catarina; BrasilFil: Costa, Aline. Universidade Federal de Santa Catarina; BrasilFil: Pacheco, Letícia K.. Universidade Federal de Santa Catarina; BrasilFil: Siqueira, Jarbas M.. Universidade Federal de Santa Catarina; BrasilFil: Martinetti Montanari, Jorge Anibal. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Romero, Eder. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Assreuy, Jamil. Universidade Federal de Santa Catarina; BrasilFil: Santos Silva, Maria C.. Universidade Federal de Santa Catarina; BrasilFil: Lemos Senna, Elenara. Universidade Federal de Santa Catarina; BrasilAmerican Scientific Publishers2011-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/193149Mazzarino, Letícia; Silva, Luís F. C.; Curta, Juliana C.; Licínio, Marley A.; Costa, Aline; et al.; Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study; American Scientific Publishers; Journal of Biomedical Nanotechnology; 7; 3; 6-2011; 406-4141550-7033CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1166/jbn.2011.1296info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:58Zoai:ri.conicet.gov.ar:11336/193149instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:58.563CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study
title Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study
spellingShingle Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study
Mazzarino, Letícia
ANTITUMOR ACTIVITY
B16-F10 MELANOMA
CURCUMIN
CYTOTOXICITY
LIPID NANOCAPSULES
MACROPHAGE UPTAKE
POLYMERIC NANOCAPSULES
title_short Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study
title_full Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study
title_fullStr Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study
title_full_unstemmed Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study
title_sort Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study
dc.creator.none.fl_str_mv Mazzarino, Letícia
Silva, Luís F. C.
Curta, Juliana C.
Licínio, Marley A.
Costa, Aline
Pacheco, Letícia K.
Siqueira, Jarbas M.
Martinetti Montanari, Jorge Anibal
Romero, Eder
Assreuy, Jamil
Santos Silva, Maria C.
Lemos Senna, Elenara
author Mazzarino, Letícia
author_facet Mazzarino, Letícia
Silva, Luís F. C.
Curta, Juliana C.
Licínio, Marley A.
Costa, Aline
Pacheco, Letícia K.
Siqueira, Jarbas M.
Martinetti Montanari, Jorge Anibal
Romero, Eder
Assreuy, Jamil
Santos Silva, Maria C.
Lemos Senna, Elenara
author_role author
author2 Silva, Luís F. C.
Curta, Juliana C.
Licínio, Marley A.
Costa, Aline
Pacheco, Letícia K.
Siqueira, Jarbas M.
Martinetti Montanari, Jorge Anibal
Romero, Eder
Assreuy, Jamil
Santos Silva, Maria C.
Lemos Senna, Elenara
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTITUMOR ACTIVITY
B16-F10 MELANOMA
CURCUMIN
CYTOTOXICITY
LIPID NANOCAPSULES
MACROPHAGE UPTAKE
POLYMERIC NANOCAPSULES
topic ANTITUMOR ACTIVITY
B16-F10 MELANOMA
CURCUMIN
CYTOTOXICITY
LIPID NANOCAPSULES
MACROPHAGE UPTAKE
POLYMERIC NANOCAPSULES
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Curcumin is a polyphenol obtained from the plant Curcuma longa (called turmeric) that displays several pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial and antitumoral activity, but clinical use has been limited by its poor solubility in water and, consequently, minimal systemic bioavailability. We have therefore formulated the drug into nanocarrier systems in an attempt to improve its therapeutic properties. This study evaluates the effect of intraperitoneally administered nanocapsules containing curcumin on subcutaneous melanoma in mice inoculated with B16-F10 cells, and on the cytotoxicity activity against B16-F10 cells in vitro. Phagocytic uptake of formulations was also evaluated upon incubation with macrophage J774 cells by fluorescence microscopy. Lipid and polymeric nanocapsules were prepared by the phase inversion and nanoprecipitation methods, respectively. The uptake of the lipid nanocapsules prepared using Solutol HS15 was significantly reduced in J774 cells. Curcumin, as free drug or as drug-loaded nanocapsules, was administrated at a dose of 6 mg/kg twice a week for 21 days. Free drug and curcuminloaded nanocapsules significantly reduced tumor volume (P < 0.05 vs. control), but no difference was found in the antitumor activity displayed by lipid and polymeric nanocapsules. This assumption was supported by the in vitro study, in which free curcumin as well as loaded into nanocapsules caused significant reduction of cell viability in a concentration- and time-dependent manner.
Fil: Mazzarino, Letícia. Universidade Federal de Santa Catarina; Brasil
Fil: Silva, Luís F. C.. Universidade Federal de Santa Catarina; Brasil
Fil: Curta, Juliana C.. Universidade Federal de Santa Catarina; Brasil
Fil: Licínio, Marley A.. Universidade Federal de Santa Catarina; Brasil
Fil: Costa, Aline. Universidade Federal de Santa Catarina; Brasil
Fil: Pacheco, Letícia K.. Universidade Federal de Santa Catarina; Brasil
Fil: Siqueira, Jarbas M.. Universidade Federal de Santa Catarina; Brasil
Fil: Martinetti Montanari, Jorge Anibal. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Romero, Eder. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Assreuy, Jamil. Universidade Federal de Santa Catarina; Brasil
Fil: Santos Silva, Maria C.. Universidade Federal de Santa Catarina; Brasil
Fil: Lemos Senna, Elenara. Universidade Federal de Santa Catarina; Brasil
description Curcumin is a polyphenol obtained from the plant Curcuma longa (called turmeric) that displays several pharmacological activities, including anti-inflammatory, antioxidant, antimicrobial and antitumoral activity, but clinical use has been limited by its poor solubility in water and, consequently, minimal systemic bioavailability. We have therefore formulated the drug into nanocarrier systems in an attempt to improve its therapeutic properties. This study evaluates the effect of intraperitoneally administered nanocapsules containing curcumin on subcutaneous melanoma in mice inoculated with B16-F10 cells, and on the cytotoxicity activity against B16-F10 cells in vitro. Phagocytic uptake of formulations was also evaluated upon incubation with macrophage J774 cells by fluorescence microscopy. Lipid and polymeric nanocapsules were prepared by the phase inversion and nanoprecipitation methods, respectively. The uptake of the lipid nanocapsules prepared using Solutol HS15 was significantly reduced in J774 cells. Curcumin, as free drug or as drug-loaded nanocapsules, was administrated at a dose of 6 mg/kg twice a week for 21 days. Free drug and curcuminloaded nanocapsules significantly reduced tumor volume (P < 0.05 vs. control), but no difference was found in the antitumor activity displayed by lipid and polymeric nanocapsules. This assumption was supported by the in vitro study, in which free curcumin as well as loaded into nanocapsules caused significant reduction of cell viability in a concentration- and time-dependent manner.
publishDate 2011
dc.date.none.fl_str_mv 2011-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/193149
Mazzarino, Letícia; Silva, Luís F. C.; Curta, Juliana C.; Licínio, Marley A.; Costa, Aline; et al.; Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study; American Scientific Publishers; Journal of Biomedical Nanotechnology; 7; 3; 6-2011; 406-414
1550-7033
CONICET Digital
CONICET
url http://hdl.handle.net/11336/193149
identifier_str_mv Mazzarino, Letícia; Silva, Luís F. C.; Curta, Juliana C.; Licínio, Marley A.; Costa, Aline; et al.; Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: An In Vitro and In Vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study; American Scientific Publishers; Journal of Biomedical Nanotechnology; 7; 3; 6-2011; 406-414
1550-7033
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1166/jbn.2011.1296
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Scientific Publishers
publisher.none.fl_str_mv American Scientific Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432