Seroprevalence of Bordetella pertussis among vaccinated and unvaccinated pregnant women and newborn infants in a university hospital of Buenos Aires

Autores
Bosch, Juan J.; Fernandez, Hilario; Polack, Fernando Pedro; Musante, Gabriel; Libster, Romina Paula; Rocca Rivarola, María Dolores
Año de publicación
2017
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
INTRODUCTION:Pertussis is a highly contagious disease caused by Bordetella pertussis. It poses a high morbidity and mortality rate, especially among infants younger than 6 months old. In Argentina, pertussis incidence and mortality have increased over the past three decades.OBJETIVE:To establish Bordetella pertussisantibody titers among pregnant women in their third trimester and among newborn infants, as measured in cord blood.METHODS:This was an observational, cross-sectional study. The study started in 2011; at that time, pertussis vaccination was not mandatory for pregnant women as per the national immunization schedule, only optional. Maternal antibodies were measured in the last trimester of pregnancy for women and in cord blood for newborn infants. Antibody titers were determined using Abcam´s anti-Bordetella pertussis toxin (PT) IgG in vitro ELISA kit. The χ² test was used to compare prevalence rates.RESULTS:The study included 111 mother-newborn infant dyads; 35 infants from unvaccinated mothers (before the introduction of the vaccine) and 76 from vaccinated mothers. Positive IgG antibodies were found in 92% (70/76) of infants born from vaccinated mothers whereas 100% (35/35) of infants born from unvaccinated mothers had negative results for antibodies; p < 0.001.CONCLUSION:In the vaccinated population of this study, 92% of infants had positive IgG antibodies. This study supports the need for maternal immunization against Bordetella pertussis to provide protection to newborn infants.
Fil: Bosch, Juan J.. Hospital Universitario Austral; Argentina
Fil: Fernandez, Hilario. Hospital Universitario Austral; Argentina
Fil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Musante, Gabriel. Hospital Universitario Austral; Argentina
Fil: Libster, Romina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Universitario Austral; Argentina
Fil: Rocca Rivarola, María Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Universitario Austral; Argentina
Materia
ANTIBODIES
MATERNAL IMMUNIZATION
PERTUSSIS
PERTUSSIS TOXIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/77987
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/77987
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Seroprevalence of Bordetella pertussis among vaccinated and unvaccinated pregnant women and newborn infants in a university hospital of Buenos AiresBosch, Juan J.Fernandez, HilarioPolack, Fernando PedroMusante, GabrielLibster, Romina PaulaRocca Rivarola, María DoloresANTIBODIESMATERNAL IMMUNIZATIONPERTUSSISPERTUSSIS TOXINhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3INTRODUCTION:Pertussis is a highly contagious disease caused by Bordetella pertussis. It poses a high morbidity and mortality rate, especially among infants younger than 6 months old. In Argentina, pertussis incidence and mortality have increased over the past three decades.OBJETIVE:To establish Bordetella pertussisantibody titers among pregnant women in their third trimester and among newborn infants, as measured in cord blood.METHODS:This was an observational, cross-sectional study. The study started in 2011; at that time, pertussis vaccination was not mandatory for pregnant women as per the national immunization schedule, only optional. Maternal antibodies were measured in the last trimester of pregnancy for women and in cord blood for newborn infants. Antibody titers were determined using Abcam´s anti-Bordetella pertussis toxin (PT) IgG in vitro ELISA kit. The χ² test was used to compare prevalence rates.RESULTS:The study included 111 mother-newborn infant dyads; 35 infants from unvaccinated mothers (before the introduction of the vaccine) and 76 from vaccinated mothers. Positive IgG antibodies were found in 92% (70/76) of infants born from vaccinated mothers whereas 100% (35/35) of infants born from unvaccinated mothers had negative results for antibodies; p < 0.001.CONCLUSION:In the vaccinated population of this study, 92% of infants had positive IgG antibodies. This study supports the need for maternal immunization against Bordetella pertussis to provide protection to newborn infants.Fil: Bosch, Juan J.. Hospital Universitario Austral; ArgentinaFil: Fernandez, Hilario. Hospital Universitario Austral; ArgentinaFil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Musante, Gabriel. Hospital Universitario Austral; ArgentinaFil: Libster, Romina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Universitario Austral; ArgentinaFil: Rocca Rivarola, María Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Universitario Austral; ArgentinaSociedad Argentina de Pediatría2017-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/77987Bosch, Juan J.; Fernandez, Hilario; Polack, Fernando Pedro; Musante, Gabriel; Libster, Romina Paula; et al.; Seroprevalence of Bordetella pertussis among vaccinated and unvaccinated pregnant women and newborn infants in a university hospital of Buenos Aires; Sociedad Argentina de Pediatría; Archivos Argentinos de Pediatría; 115; 04; 8-20170325-00751668-3501CONICET DigitalCONICETspainfo:eu-repo/semantics/altIdentifier/url/http://www.sap.org.ar/docs/publicaciones/archivosarg/2017/v115n4a04e.pdfinfo:eu-repo/semantics/altIdentifier/doi/10.5546/aap.2017.eng.311info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:05:42Zoai:ri.conicet.gov.ar:11336/77987instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:05:42.392CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Seroprevalence of Bordetella pertussis among vaccinated and unvaccinated pregnant women and newborn infants in a university hospital of Buenos Aires
title Seroprevalence of Bordetella pertussis among vaccinated and unvaccinated pregnant women and newborn infants in a university hospital of Buenos Aires
spellingShingle Seroprevalence of Bordetella pertussis among vaccinated and unvaccinated pregnant women and newborn infants in a university hospital of Buenos Aires
Bosch, Juan J.
ANTIBODIES
MATERNAL IMMUNIZATION
PERTUSSIS
PERTUSSIS TOXIN
title_short Seroprevalence of Bordetella pertussis among vaccinated and unvaccinated pregnant women and newborn infants in a university hospital of Buenos Aires
title_full Seroprevalence of Bordetella pertussis among vaccinated and unvaccinated pregnant women and newborn infants in a university hospital of Buenos Aires
title_fullStr Seroprevalence of Bordetella pertussis among vaccinated and unvaccinated pregnant women and newborn infants in a university hospital of Buenos Aires
title_full_unstemmed Seroprevalence of Bordetella pertussis among vaccinated and unvaccinated pregnant women and newborn infants in a university hospital of Buenos Aires
title_sort Seroprevalence of Bordetella pertussis among vaccinated and unvaccinated pregnant women and newborn infants in a university hospital of Buenos Aires
dc.creator.none.fl_str_mv Bosch, Juan J.
Fernandez, Hilario
Polack, Fernando Pedro
Musante, Gabriel
Libster, Romina Paula
Rocca Rivarola, María Dolores
author Bosch, Juan J.
author_facet Bosch, Juan J.
Fernandez, Hilario
Polack, Fernando Pedro
Musante, Gabriel
Libster, Romina Paula
Rocca Rivarola, María Dolores
author_role author
author2 Fernandez, Hilario
Polack, Fernando Pedro
Musante, Gabriel
Libster, Romina Paula
Rocca Rivarola, María Dolores
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ANTIBODIES
MATERNAL IMMUNIZATION
PERTUSSIS
PERTUSSIS TOXIN
topic ANTIBODIES
MATERNAL IMMUNIZATION
PERTUSSIS
PERTUSSIS TOXIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv INTRODUCTION:Pertussis is a highly contagious disease caused by Bordetella pertussis. It poses a high morbidity and mortality rate, especially among infants younger than 6 months old. In Argentina, pertussis incidence and mortality have increased over the past three decades.OBJETIVE:To establish Bordetella pertussisantibody titers among pregnant women in their third trimester and among newborn infants, as measured in cord blood.METHODS:This was an observational, cross-sectional study. The study started in 2011; at that time, pertussis vaccination was not mandatory for pregnant women as per the national immunization schedule, only optional. Maternal antibodies were measured in the last trimester of pregnancy for women and in cord blood for newborn infants. Antibody titers were determined using Abcam´s anti-Bordetella pertussis toxin (PT) IgG in vitro ELISA kit. The χ² test was used to compare prevalence rates.RESULTS:The study included 111 mother-newborn infant dyads; 35 infants from unvaccinated mothers (before the introduction of the vaccine) and 76 from vaccinated mothers. Positive IgG antibodies were found in 92% (70/76) of infants born from vaccinated mothers whereas 100% (35/35) of infants born from unvaccinated mothers had negative results for antibodies; p < 0.001.CONCLUSION:In the vaccinated population of this study, 92% of infants had positive IgG antibodies. This study supports the need for maternal immunization against Bordetella pertussis to provide protection to newborn infants.
Fil: Bosch, Juan J.. Hospital Universitario Austral; Argentina
Fil: Fernandez, Hilario. Hospital Universitario Austral; Argentina
Fil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Musante, Gabriel. Hospital Universitario Austral; Argentina
Fil: Libster, Romina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Universitario Austral; Argentina
Fil: Rocca Rivarola, María Dolores. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Universitario Austral; Argentina
description INTRODUCTION:Pertussis is a highly contagious disease caused by Bordetella pertussis. It poses a high morbidity and mortality rate, especially among infants younger than 6 months old. In Argentina, pertussis incidence and mortality have increased over the past three decades.OBJETIVE:To establish Bordetella pertussisantibody titers among pregnant women in their third trimester and among newborn infants, as measured in cord blood.METHODS:This was an observational, cross-sectional study. The study started in 2011; at that time, pertussis vaccination was not mandatory for pregnant women as per the national immunization schedule, only optional. Maternal antibodies were measured in the last trimester of pregnancy for women and in cord blood for newborn infants. Antibody titers were determined using Abcam´s anti-Bordetella pertussis toxin (PT) IgG in vitro ELISA kit. The χ² test was used to compare prevalence rates.RESULTS:The study included 111 mother-newborn infant dyads; 35 infants from unvaccinated mothers (before the introduction of the vaccine) and 76 from vaccinated mothers. Positive IgG antibodies were found in 92% (70/76) of infants born from vaccinated mothers whereas 100% (35/35) of infants born from unvaccinated mothers had negative results for antibodies; p < 0.001.CONCLUSION:In the vaccinated population of this study, 92% of infants had positive IgG antibodies. This study supports the need for maternal immunization against Bordetella pertussis to provide protection to newborn infants.
publishDate 2017
dc.date.none.fl_str_mv 2017-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/77987
Bosch, Juan J.; Fernandez, Hilario; Polack, Fernando Pedro; Musante, Gabriel; Libster, Romina Paula; et al.; Seroprevalence of Bordetella pertussis among vaccinated and unvaccinated pregnant women and newborn infants in a university hospital of Buenos Aires; Sociedad Argentina de Pediatría; Archivos Argentinos de Pediatría; 115; 04; 8-2017
0325-0075
1668-3501
CONICET Digital
CONICET
url http://hdl.handle.net/11336/77987
identifier_str_mv Bosch, Juan J.; Fernandez, Hilario; Polack, Fernando Pedro; Musante, Gabriel; Libster, Romina Paula; et al.; Seroprevalence of Bordetella pertussis among vaccinated and unvaccinated pregnant women and newborn infants in a university hospital of Buenos Aires; Sociedad Argentina de Pediatría; Archivos Argentinos de Pediatría; 115; 04; 8-2017
0325-0075
1668-3501
CONICET Digital
CONICET
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sap.org.ar/docs/publicaciones/archivosarg/2017/v115n4a04e.pdf
info:eu-repo/semantics/altIdentifier/doi/10.5546/aap.2017.eng.311
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Pediatría
publisher.none.fl_str_mv Sociedad Argentina de Pediatría
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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