ClinGen recuration of hearing loss-associated genes demonstrates significant changes in gene-disease validity over time

Autores
Tshering, Kezang C.; DiStefano, Marina T.; Oza, Andrea M.; Ajuyah, Pamela; Webb, Ryan; Edoh, Enyonam; Broeren, Ellie; Ratliff, Julie; Gitau, Vanessa; Paris, Kelley; Aburyyan, Amal; Alexander, John; Albano, Victoria; Bai, Donglin; Booth, Kevin; Buonfiglio, Paula Inés; Charfeddine, Cherine; Dalamon, Viviana Karina; Del Castillo, Ignacio; Moreno Pelayo, Miguel Angel; Smith, Richard J.; Azaiez, Hela; Amr, Sami
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose: The Clinical Genome Resource (ClinGen) Hearing Loss Gene Curation Expert Panel was assembled in 2016 and has since curated 174 gene-disease relationships (GDRs) using ClinGen’s semiquantitative framework. ClinGen mandates the timely recuration of all GDRs classified as Disputed, Limited, Moderate, and Strong every 2 to 3 years. Methods: Thirty-five GDRs met the criteria for recuration within 2 years of original curation. Previous evidence was reevaluated using the latest curation guidelines, and a comprehensive literature review was performed to obtain new evidence. Recurations were approved by the Gene Curation Expert Panel and published on the ClinGen website (www.clinicalgenome.org). Results: Eight of 35 GDRs (22%) changed their classification. Two Moderate and 5 Strong GDRs were upgraded to Definitive because of new case evidence. One Strong was subsumed under another Definitive GDR after evaluation of the lumping/splitting of disease entities. Twenty-seven of 35 patients remained unchanged, with little to no new evidence reported. Conclusion: Genes classified as Moderate and Strong were likely to build evidence and change their classification over time, whereas Limited were unlikely to gain evidence. These findings highlight the critical role of recuration in ensuring that genetic tests and research studies incorporate the most recent evidence into their efforts.
Fil: Tshering, Kezang C.. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: DiStefano, Marina T.. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Oza, Andrea M.. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Ajuyah, Pamela. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Webb, Ryan. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Edoh, Enyonam. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Broeren, Ellie. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Ratliff, Julie. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Gitau, Vanessa. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Paris, Kelley. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Aburyyan, Amal. University of Washington; Estados Unidos
Fil: Alexander, John. Myriad Women's Health; Estados Unidos
Fil: Albano, Victoria. Boston Children's Hospital; Estados Unidos
Fil: Bai, Donglin. Western University; Canadá
Fil: Booth, Kevin. Indiana University. School of Medicine; Estados Unidos
Fil: Buonfiglio, Paula Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Charfeddine, Cherine. University of Tunis El Manar; Túnez
Fil: Dalamon, Viviana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires; Argentina
Fil: Del Castillo, Ignacio. Consejería de Sanidad de la Comunidad de Madrid. Hospital Universitario Ramon y Cajal; España
Fil: Moreno Pelayo, Miguel Angel. Consejería de Sanidad de la Comunidad de Madrid. Hospital Universitario Ramon y Cajal; España
Fil: Smith, Richard J.. University of Iowa; Estados Unidos
Fil: Azaiez, Hela. University of Iowa; Estados Unidos
Fil: Amr, Sami. Mass General Brigham Personalized Medicen; Estados Unidos
Materia
ClinGen
Deafnes
Genetic diagnosis
Hearing loss
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/279887

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network_name_str CONICET Digital (CONICET)
spelling ClinGen recuration of hearing loss-associated genes demonstrates significant changes in gene-disease validity over timeTshering, Kezang C.DiStefano, Marina T.Oza, Andrea M.Ajuyah, PamelaWebb, RyanEdoh, EnyonamBroeren, EllieRatliff, JulieGitau, VanessaParis, KelleyAburyyan, AmalAlexander, JohnAlbano, VictoriaBai, DonglinBooth, KevinBuonfiglio, Paula InésCharfeddine, CherineDalamon, Viviana KarinaDel Castillo, IgnacioMoreno Pelayo, Miguel AngelSmith, Richard J.Azaiez, HelaAmr, SamiClinGenDeafnesGenetic diagnosisHearing losshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Purpose: The Clinical Genome Resource (ClinGen) Hearing Loss Gene Curation Expert Panel was assembled in 2016 and has since curated 174 gene-disease relationships (GDRs) using ClinGen’s semiquantitative framework. ClinGen mandates the timely recuration of all GDRs classified as Disputed, Limited, Moderate, and Strong every 2 to 3 years. Methods: Thirty-five GDRs met the criteria for recuration within 2 years of original curation. Previous evidence was reevaluated using the latest curation guidelines, and a comprehensive literature review was performed to obtain new evidence. Recurations were approved by the Gene Curation Expert Panel and published on the ClinGen website (www.clinicalgenome.org). Results: Eight of 35 GDRs (22%) changed their classification. Two Moderate and 5 Strong GDRs were upgraded to Definitive because of new case evidence. One Strong was subsumed under another Definitive GDR after evaluation of the lumping/splitting of disease entities. Twenty-seven of 35 patients remained unchanged, with little to no new evidence reported. Conclusion: Genes classified as Moderate and Strong were likely to build evidence and change their classification over time, whereas Limited were unlikely to gain evidence. These findings highlight the critical role of recuration in ensuring that genetic tests and research studies incorporate the most recent evidence into their efforts.Fil: Tshering, Kezang C.. The Broad Institute Of Mit And Harvard; Estados UnidosFil: DiStefano, Marina T.. The Broad Institute Of Mit And Harvard; Estados UnidosFil: Oza, Andrea M.. The Broad Institute Of Mit And Harvard; Estados UnidosFil: Ajuyah, Pamela. The Broad Institute Of Mit And Harvard; Estados UnidosFil: Webb, Ryan. The Broad Institute Of Mit And Harvard; Estados UnidosFil: Edoh, Enyonam. The Broad Institute Of Mit And Harvard; Estados UnidosFil: Broeren, Ellie. The Broad Institute Of Mit And Harvard; Estados UnidosFil: Ratliff, Julie. The Broad Institute Of Mit And Harvard; Estados UnidosFil: Gitau, Vanessa. The Broad Institute Of Mit And Harvard; Estados UnidosFil: Paris, Kelley. The Broad Institute Of Mit And Harvard; Estados UnidosFil: Aburyyan, Amal. University of Washington; Estados UnidosFil: Alexander, John. Myriad Women's Health; Estados UnidosFil: Albano, Victoria. Boston Children's Hospital; Estados UnidosFil: Bai, Donglin. Western University; CanadáFil: Booth, Kevin. Indiana University. School of Medicine; Estados UnidosFil: Buonfiglio, Paula Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Charfeddine, Cherine. University of Tunis El Manar; TúnezFil: Dalamon, Viviana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires; ArgentinaFil: Del Castillo, Ignacio. Consejería de Sanidad de la Comunidad de Madrid. Hospital Universitario Ramon y Cajal; EspañaFil: Moreno Pelayo, Miguel Angel. Consejería de Sanidad de la Comunidad de Madrid. Hospital Universitario Ramon y Cajal; EspañaFil: Smith, Richard J.. University of Iowa; Estados UnidosFil: Azaiez, Hela. University of Iowa; Estados UnidosFil: Amr, Sami. Mass General Brigham Personalized Medicen; Estados UnidosLippincott Williams2025-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/279887Tshering, Kezang C.; DiStefano, Marina T.; Oza, Andrea M.; Ajuyah, Pamela; Webb, Ryan; et al.; ClinGen recuration of hearing loss-associated genes demonstrates significant changes in gene-disease validity over time; Lippincott Williams; Genetics In Medicine; 27; 5; 5-2025; 1-71098-36001530-0366CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1098360025000395info:eu-repo/semantics/altIdentifier/doi/10.1016/j.gim.2025.101392info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-26T10:12:23Zoai:ri.conicet.gov.ar:11336/279887instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-26 10:12:23.662CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv ClinGen recuration of hearing loss-associated genes demonstrates significant changes in gene-disease validity over time
title ClinGen recuration of hearing loss-associated genes demonstrates significant changes in gene-disease validity over time
spellingShingle ClinGen recuration of hearing loss-associated genes demonstrates significant changes in gene-disease validity over time
Tshering, Kezang C.
ClinGen
Deafnes
Genetic diagnosis
Hearing loss
title_short ClinGen recuration of hearing loss-associated genes demonstrates significant changes in gene-disease validity over time
title_full ClinGen recuration of hearing loss-associated genes demonstrates significant changes in gene-disease validity over time
title_fullStr ClinGen recuration of hearing loss-associated genes demonstrates significant changes in gene-disease validity over time
title_full_unstemmed ClinGen recuration of hearing loss-associated genes demonstrates significant changes in gene-disease validity over time
title_sort ClinGen recuration of hearing loss-associated genes demonstrates significant changes in gene-disease validity over time
dc.creator.none.fl_str_mv Tshering, Kezang C.
DiStefano, Marina T.
Oza, Andrea M.
Ajuyah, Pamela
Webb, Ryan
Edoh, Enyonam
Broeren, Ellie
Ratliff, Julie
Gitau, Vanessa
Paris, Kelley
Aburyyan, Amal
Alexander, John
Albano, Victoria
Bai, Donglin
Booth, Kevin
Buonfiglio, Paula Inés
Charfeddine, Cherine
Dalamon, Viviana Karina
Del Castillo, Ignacio
Moreno Pelayo, Miguel Angel
Smith, Richard J.
Azaiez, Hela
Amr, Sami
author Tshering, Kezang C.
author_facet Tshering, Kezang C.
DiStefano, Marina T.
Oza, Andrea M.
Ajuyah, Pamela
Webb, Ryan
Edoh, Enyonam
Broeren, Ellie
Ratliff, Julie
Gitau, Vanessa
Paris, Kelley
Aburyyan, Amal
Alexander, John
Albano, Victoria
Bai, Donglin
Booth, Kevin
Buonfiglio, Paula Inés
Charfeddine, Cherine
Dalamon, Viviana Karina
Del Castillo, Ignacio
Moreno Pelayo, Miguel Angel
Smith, Richard J.
Azaiez, Hela
Amr, Sami
author_role author
author2 DiStefano, Marina T.
Oza, Andrea M.
Ajuyah, Pamela
Webb, Ryan
Edoh, Enyonam
Broeren, Ellie
Ratliff, Julie
Gitau, Vanessa
Paris, Kelley
Aburyyan, Amal
Alexander, John
Albano, Victoria
Bai, Donglin
Booth, Kevin
Buonfiglio, Paula Inés
Charfeddine, Cherine
Dalamon, Viviana Karina
Del Castillo, Ignacio
Moreno Pelayo, Miguel Angel
Smith, Richard J.
Azaiez, Hela
Amr, Sami
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ClinGen
Deafnes
Genetic diagnosis
Hearing loss
topic ClinGen
Deafnes
Genetic diagnosis
Hearing loss
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Purpose: The Clinical Genome Resource (ClinGen) Hearing Loss Gene Curation Expert Panel was assembled in 2016 and has since curated 174 gene-disease relationships (GDRs) using ClinGen’s semiquantitative framework. ClinGen mandates the timely recuration of all GDRs classified as Disputed, Limited, Moderate, and Strong every 2 to 3 years. Methods: Thirty-five GDRs met the criteria for recuration within 2 years of original curation. Previous evidence was reevaluated using the latest curation guidelines, and a comprehensive literature review was performed to obtain new evidence. Recurations were approved by the Gene Curation Expert Panel and published on the ClinGen website (www.clinicalgenome.org). Results: Eight of 35 GDRs (22%) changed their classification. Two Moderate and 5 Strong GDRs were upgraded to Definitive because of new case evidence. One Strong was subsumed under another Definitive GDR after evaluation of the lumping/splitting of disease entities. Twenty-seven of 35 patients remained unchanged, with little to no new evidence reported. Conclusion: Genes classified as Moderate and Strong were likely to build evidence and change their classification over time, whereas Limited were unlikely to gain evidence. These findings highlight the critical role of recuration in ensuring that genetic tests and research studies incorporate the most recent evidence into their efforts.
Fil: Tshering, Kezang C.. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: DiStefano, Marina T.. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Oza, Andrea M.. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Ajuyah, Pamela. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Webb, Ryan. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Edoh, Enyonam. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Broeren, Ellie. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Ratliff, Julie. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Gitau, Vanessa. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Paris, Kelley. The Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Aburyyan, Amal. University of Washington; Estados Unidos
Fil: Alexander, John. Myriad Women's Health; Estados Unidos
Fil: Albano, Victoria. Boston Children's Hospital; Estados Unidos
Fil: Bai, Donglin. Western University; Canadá
Fil: Booth, Kevin. Indiana University. School of Medicine; Estados Unidos
Fil: Buonfiglio, Paula Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Fil: Charfeddine, Cherine. University of Tunis El Manar; Túnez
Fil: Dalamon, Viviana Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires; Argentina
Fil: Del Castillo, Ignacio. Consejería de Sanidad de la Comunidad de Madrid. Hospital Universitario Ramon y Cajal; España
Fil: Moreno Pelayo, Miguel Angel. Consejería de Sanidad de la Comunidad de Madrid. Hospital Universitario Ramon y Cajal; España
Fil: Smith, Richard J.. University of Iowa; Estados Unidos
Fil: Azaiez, Hela. University of Iowa; Estados Unidos
Fil: Amr, Sami. Mass General Brigham Personalized Medicen; Estados Unidos
description Purpose: The Clinical Genome Resource (ClinGen) Hearing Loss Gene Curation Expert Panel was assembled in 2016 and has since curated 174 gene-disease relationships (GDRs) using ClinGen’s semiquantitative framework. ClinGen mandates the timely recuration of all GDRs classified as Disputed, Limited, Moderate, and Strong every 2 to 3 years. Methods: Thirty-five GDRs met the criteria for recuration within 2 years of original curation. Previous evidence was reevaluated using the latest curation guidelines, and a comprehensive literature review was performed to obtain new evidence. Recurations were approved by the Gene Curation Expert Panel and published on the ClinGen website (www.clinicalgenome.org). Results: Eight of 35 GDRs (22%) changed their classification. Two Moderate and 5 Strong GDRs were upgraded to Definitive because of new case evidence. One Strong was subsumed under another Definitive GDR after evaluation of the lumping/splitting of disease entities. Twenty-seven of 35 patients remained unchanged, with little to no new evidence reported. Conclusion: Genes classified as Moderate and Strong were likely to build evidence and change their classification over time, whereas Limited were unlikely to gain evidence. These findings highlight the critical role of recuration in ensuring that genetic tests and research studies incorporate the most recent evidence into their efforts.
publishDate 2025
dc.date.none.fl_str_mv 2025-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/279887
Tshering, Kezang C.; DiStefano, Marina T.; Oza, Andrea M.; Ajuyah, Pamela; Webb, Ryan; et al.; ClinGen recuration of hearing loss-associated genes demonstrates significant changes in gene-disease validity over time; Lippincott Williams; Genetics In Medicine; 27; 5; 5-2025; 1-7
1098-3600
1530-0366
CONICET Digital
CONICET
url http://hdl.handle.net/11336/279887
identifier_str_mv Tshering, Kezang C.; DiStefano, Marina T.; Oza, Andrea M.; Ajuyah, Pamela; Webb, Ryan; et al.; ClinGen recuration of hearing loss-associated genes demonstrates significant changes in gene-disease validity over time; Lippincott Williams; Genetics In Medicine; 27; 5; 5-2025; 1-7
1098-3600
1530-0366
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1098360025000395
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.gim.2025.101392
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
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repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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