A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period

Autores
Parodi, Roberto Leandro; Lagrutta, Mariana; Tortolo, Mauro; Navall, Estefanía; Rodríguez, María S.; Sasia, Gervasio F.; De Candia, Lucas F.; Gruvman, Matias A.; Bottasso, Oscar Adelmo; Greca, Alcides Alejandro
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
For better management of patients with febrile neutropenia, our study investigated the epidemiologic, microbiologic, and clinical characteristics of adult inpatients with febrile neutropenia and their mortality-associated factors. To this end, we carried out a prospective, observational, multicenter study in 28 Argentinian hospitals between 2007 and 2012. We included 515 episodes of febrile neutropenia from 346 patients, median age 49 years. Neutropenia followed chemotherapy in 77% of cases, half of the cases due to hematological malignancies. Most episodes were classified as high-risk according to MASCC criteria, and 53.6% of patients were already hospitalized at the onset of febrile neutropenia. Bloodstream infections were detected in 14% episodes; whereas an infectious source of fever was identified in 80% of cases. Mortality rate achieved to 14.95%. The binary regression analysis showed that persistence of fever at day 7, or neutropenia at day 14, dehydration and tachycardia at the onset of febrile neutropenia as well as prior infections were significantly associated with mortality. In addition to expanding our current knowledge on the features of adult patients with febrile neutropenia, present findings provide useful information for better management of them in Argentina, given the appropriate representativeness of centers participating in the study.
Fil: Parodi, Roberto Leandro. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Lagrutta, Mariana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Tortolo, Mauro. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Navall, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Rodríguez, María S.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Sasia, Gervasio F.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: De Candia, Lucas F.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Gruvman, Matias A.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Greca, Alcides Alejandro. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Materia
Neutropenia Febril
Enfermedades Oncohematológicas
Infección
Antibióticos
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/148754
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year periodParodi, Roberto LeandroLagrutta, MarianaTortolo, MauroNavall, EstefaníaRodríguez, María S.Sasia, Gervasio F.De Candia, Lucas F.Gruvman, Matias A.Bottasso, Oscar AdelmoGreca, Alcides AlejandroNeutropenia FebrilEnfermedades OncohematológicasInfecciónAntibióticoshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3For better management of patients with febrile neutropenia, our study investigated the epidemiologic, microbiologic, and clinical characteristics of adult inpatients with febrile neutropenia and their mortality-associated factors. To this end, we carried out a prospective, observational, multicenter study in 28 Argentinian hospitals between 2007 and 2012. We included 515 episodes of febrile neutropenia from 346 patients, median age 49 years. Neutropenia followed chemotherapy in 77% of cases, half of the cases due to hematological malignancies. Most episodes were classified as high-risk according to MASCC criteria, and 53.6% of patients were already hospitalized at the onset of febrile neutropenia. Bloodstream infections were detected in 14% episodes; whereas an infectious source of fever was identified in 80% of cases. Mortality rate achieved to 14.95%. The binary regression analysis showed that persistence of fever at day 7, or neutropenia at day 14, dehydration and tachycardia at the onset of febrile neutropenia as well as prior infections were significantly associated with mortality. In addition to expanding our current knowledge on the features of adult patients with febrile neutropenia, present findings provide useful information for better management of them in Argentina, given the appropriate representativeness of centers participating in the study.Fil: Parodi, Roberto Leandro. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Lagrutta, Mariana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Tortolo, Mauro. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Navall, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Rodríguez, María S.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Sasia, Gervasio F.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: De Candia, Lucas F.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Gruvman, Matias A.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Greca, Alcides Alejandro. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaPublic Library of Science2019-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/148754Parodi, Roberto Leandro; Lagrutta, Mariana; Tortolo, Mauro; Navall, Estefanía; Rodríguez, María S.; et al.; A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period; Public Library of Science; Plos One; 14; 10; 10-2019; 1-151932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224299info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0224299info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:22Zoai:ri.conicet.gov.ar:11336/148754instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:23.592CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
title A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
spellingShingle A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
Parodi, Roberto Leandro
Neutropenia Febril
Enfermedades Oncohematológicas
Infección
Antibióticos
title_short A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
title_full A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
title_fullStr A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
title_full_unstemmed A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
title_sort A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
dc.creator.none.fl_str_mv Parodi, Roberto Leandro
Lagrutta, Mariana
Tortolo, Mauro
Navall, Estefanía
Rodríguez, María S.
Sasia, Gervasio F.
De Candia, Lucas F.
Gruvman, Matias A.
Bottasso, Oscar Adelmo
Greca, Alcides Alejandro
author Parodi, Roberto Leandro
author_facet Parodi, Roberto Leandro
Lagrutta, Mariana
Tortolo, Mauro
Navall, Estefanía
Rodríguez, María S.
Sasia, Gervasio F.
De Candia, Lucas F.
Gruvman, Matias A.
Bottasso, Oscar Adelmo
Greca, Alcides Alejandro
author_role author
author2 Lagrutta, Mariana
Tortolo, Mauro
Navall, Estefanía
Rodríguez, María S.
Sasia, Gervasio F.
De Candia, Lucas F.
Gruvman, Matias A.
Bottasso, Oscar Adelmo
Greca, Alcides Alejandro
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neutropenia Febril
Enfermedades Oncohematológicas
Infección
Antibióticos
topic Neutropenia Febril
Enfermedades Oncohematológicas
Infección
Antibióticos
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv For better management of patients with febrile neutropenia, our study investigated the epidemiologic, microbiologic, and clinical characteristics of adult inpatients with febrile neutropenia and their mortality-associated factors. To this end, we carried out a prospective, observational, multicenter study in 28 Argentinian hospitals between 2007 and 2012. We included 515 episodes of febrile neutropenia from 346 patients, median age 49 years. Neutropenia followed chemotherapy in 77% of cases, half of the cases due to hematological malignancies. Most episodes were classified as high-risk according to MASCC criteria, and 53.6% of patients were already hospitalized at the onset of febrile neutropenia. Bloodstream infections were detected in 14% episodes; whereas an infectious source of fever was identified in 80% of cases. Mortality rate achieved to 14.95%. The binary regression analysis showed that persistence of fever at day 7, or neutropenia at day 14, dehydration and tachycardia at the onset of febrile neutropenia as well as prior infections were significantly associated with mortality. In addition to expanding our current knowledge on the features of adult patients with febrile neutropenia, present findings provide useful information for better management of them in Argentina, given the appropriate representativeness of centers participating in the study.
Fil: Parodi, Roberto Leandro. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Lagrutta, Mariana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Tortolo, Mauro. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Navall, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Rodríguez, María S.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Sasia, Gervasio F.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: De Candia, Lucas F.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Gruvman, Matias A.. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Greca, Alcides Alejandro. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
description For better management of patients with febrile neutropenia, our study investigated the epidemiologic, microbiologic, and clinical characteristics of adult inpatients with febrile neutropenia and their mortality-associated factors. To this end, we carried out a prospective, observational, multicenter study in 28 Argentinian hospitals between 2007 and 2012. We included 515 episodes of febrile neutropenia from 346 patients, median age 49 years. Neutropenia followed chemotherapy in 77% of cases, half of the cases due to hematological malignancies. Most episodes were classified as high-risk according to MASCC criteria, and 53.6% of patients were already hospitalized at the onset of febrile neutropenia. Bloodstream infections were detected in 14% episodes; whereas an infectious source of fever was identified in 80% of cases. Mortality rate achieved to 14.95%. The binary regression analysis showed that persistence of fever at day 7, or neutropenia at day 14, dehydration and tachycardia at the onset of febrile neutropenia as well as prior infections were significantly associated with mortality. In addition to expanding our current knowledge on the features of adult patients with febrile neutropenia, present findings provide useful information for better management of them in Argentina, given the appropriate representativeness of centers participating in the study.
publishDate 2019
dc.date.none.fl_str_mv 2019-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/148754
Parodi, Roberto Leandro; Lagrutta, Mariana; Tortolo, Mauro; Navall, Estefanía; Rodríguez, María S.; et al.; A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period; Public Library of Science; Plos One; 14; 10; 10-2019; 1-15
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/148754
identifier_str_mv Parodi, Roberto Leandro; Lagrutta, Mariana; Tortolo, Mauro; Navall, Estefanía; Rodríguez, María S.; et al.; A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period; Public Library of Science; Plos One; 14; 10; 10-2019; 1-15
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224299
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0224299
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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