llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause

Autores
Pereira, Camila Scacco; Stringhetta Garcia, Camila Tami; da Silva Xavier, Lilian; Tirapeli, Keny Gonçalves; Pereira, Ariana Aparecida Ferreira; Kayahara, GiselIi Mitsuy; Tramarim, José Marcelo; Crivelini, Marcelo Macedo; Padovani, Karina Stringhetta; Leopoldino, Andréia Machado; Louzada, Mário Jefferson Quirino; Belló Klein, Adriane; Llesuy, Susana Francisca; Ervolino, Edilson; Dornelles, Rita Cássia Menegati; Chaves Neto, Antonio Hernandes; Nakamune, Ana
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
During perimenopause, oxidative stress increases, which may result in disruption of bone turnover, and consequently in osteoporosis. The use of antioxidants may be an effective nutritional approach to reducing osteoporosis in this period of life. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense. Our hypothesis was that MT would decrease oxidative stress and mitigate bone deterioration. To test this, we analyzed oxidative stress markers of bone turnover, and local and systemic markers of bone metabolism of rats during natural perimenopause. Female Wistar rats (aged 16 months) in proven perimenopause period received 20 mg/kg BW/day of mate tea, by gavage (PM + MT Group, n = 10) or water (PM Group, n = 10). Female rats aged 4 months (AD Group, n = 10) received water. The treatment period was four weeks. MT minimized the deterioration of rat microarchitecture, characterized by increase in the bone trabecular area, number of osteocytes and areal bone mineral density. These results were accompanied by a lower level of malondialdehyde, an oxidative stress marker, in femoral tissue homogenate. Plasmatic tartrate-resistant acid phosphatase, a typical osteoclastic function marker, decreases after treatment, indicating a decrease in osteoclastic function. MT also modified the immunostaining pattern of bone metabolism markers, decreasing the receptor activator of nuclear factor kappa-B ligant (RANKL), superoxide dismutase isoform 2 (SOD2) and increasing osteoprotegerin (OPG), a decoy receptor for the RANKL, which positively modulates bone mass. These results suggested MT was capable of decreasing bone resorption by inhibiting the osteoclastogenesis in a RANKL-dependent signaling pathway activated by oxidative stress. Taken together, the results indicated that MT minimized bone loss in perimenopause and this effect is at least partly due to the decrease in oxidative stress, confirming our hypothesis.
Fil: Pereira, Camila Scacco. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Stringhetta Garcia, Camila Tami. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: da Silva Xavier, Lilian. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Tirapeli, Keny Gonçalves. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Pereira, Ariana Aparecida Ferreira. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Kayahara, GiselIi Mitsuy. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Tramarim, José Marcelo. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Crivelini, Marcelo Macedo. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Padovani, Karina Stringhetta. Universidade de Sao Paulo; Brasil
Fil: Leopoldino, Andréia Machado. Universidade de Sao Paulo; Brasil
Fil: Louzada, Mário Jefferson Quirino. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Ervolino, Edilson. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Dornelles, Rita Cássia Menegati. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Chaves Neto, Antonio Hernandes. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Nakamune, Ana. Universidade Federal do Rio Grande do Sul; Brasil
Materia
BONE
ILEX PARAGUARIENSIS
OXIDATIVE STRESS
PERIMENOPAUSE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/59623

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network_name_str CONICET Digital (CONICET)
spelling llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopausePereira, Camila ScaccoStringhetta Garcia, Camila Tamida Silva Xavier, LilianTirapeli, Keny GonçalvesPereira, Ariana Aparecida FerreiraKayahara, GiselIi MitsuyTramarim, José MarceloCrivelini, Marcelo MacedoPadovani, Karina StringhettaLeopoldino, Andréia MachadoLouzada, Mário Jefferson QuirinoBelló Klein, AdrianeLlesuy, Susana FranciscaErvolino, EdilsonDornelles, Rita Cássia MenegatiChaves Neto, Antonio HernandesNakamune, AnaBONEILEX PARAGUARIENSISOXIDATIVE STRESSPERIMENOPAUSEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1During perimenopause, oxidative stress increases, which may result in disruption of bone turnover, and consequently in osteoporosis. The use of antioxidants may be an effective nutritional approach to reducing osteoporosis in this period of life. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense. Our hypothesis was that MT would decrease oxidative stress and mitigate bone deterioration. To test this, we analyzed oxidative stress markers of bone turnover, and local and systemic markers of bone metabolism of rats during natural perimenopause. Female Wistar rats (aged 16 months) in proven perimenopause period received 20 mg/kg BW/day of mate tea, by gavage (PM + MT Group, n = 10) or water (PM Group, n = 10). Female rats aged 4 months (AD Group, n = 10) received water. The treatment period was four weeks. MT minimized the deterioration of rat microarchitecture, characterized by increase in the bone trabecular area, number of osteocytes and areal bone mineral density. These results were accompanied by a lower level of malondialdehyde, an oxidative stress marker, in femoral tissue homogenate. Plasmatic tartrate-resistant acid phosphatase, a typical osteoclastic function marker, decreases after treatment, indicating a decrease in osteoclastic function. MT also modified the immunostaining pattern of bone metabolism markers, decreasing the receptor activator of nuclear factor kappa-B ligant (RANKL), superoxide dismutase isoform 2 (SOD2) and increasing osteoprotegerin (OPG), a decoy receptor for the RANKL, which positively modulates bone mass. These results suggested MT was capable of decreasing bone resorption by inhibiting the osteoclastogenesis in a RANKL-dependent signaling pathway activated by oxidative stress. Taken together, the results indicated that MT minimized bone loss in perimenopause and this effect is at least partly due to the decrease in oxidative stress, confirming our hypothesis.Fil: Pereira, Camila Scacco. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Stringhetta Garcia, Camila Tami. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: da Silva Xavier, Lilian. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Tirapeli, Keny Gonçalves. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Pereira, Ariana Aparecida Ferreira. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Kayahara, GiselIi Mitsuy. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Tramarim, José Marcelo. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Crivelini, Marcelo Macedo. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Padovani, Karina Stringhetta. Universidade de Sao Paulo; BrasilFil: Leopoldino, Andréia Machado. Universidade de Sao Paulo; BrasilFil: Louzada, Mário Jefferson Quirino. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; BrasilFil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Ervolino, Edilson. Universidade Federal do Rio Grande do Sul; BrasilFil: Dornelles, Rita Cássia Menegati. Universidade Federal do Rio Grande do Sul; BrasilFil: Chaves Neto, Antonio Hernandes. Universidade Federal do Rio Grande do Sul; BrasilFil: Nakamune, Ana. Universidade Federal do Rio Grande do Sul; BrasilPergamon-Elsevier Science Ltd2017-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/59623Pereira, Camila Scacco; Stringhetta Garcia, Camila Tami; da Silva Xavier, Lilian; Tirapeli, Keny Gonçalves; Pereira, Ariana Aparecida Ferreira; et al.; llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause; Pergamon-Elsevier Science Ltd; Experimental Gerontology; 98; 11-2017; 148-1520531-5565CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.exger.2017.07.006info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S053155651730181Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:58:47Zoai:ri.conicet.gov.ar:11336/59623instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:58:47.317CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause
title llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause
spellingShingle llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause
Pereira, Camila Scacco
BONE
ILEX PARAGUARIENSIS
OXIDATIVE STRESS
PERIMENOPAUSE
title_short llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause
title_full llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause
title_fullStr llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause
title_full_unstemmed llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause
title_sort llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause
dc.creator.none.fl_str_mv Pereira, Camila Scacco
Stringhetta Garcia, Camila Tami
da Silva Xavier, Lilian
Tirapeli, Keny Gonçalves
Pereira, Ariana Aparecida Ferreira
Kayahara, GiselIi Mitsuy
Tramarim, José Marcelo
Crivelini, Marcelo Macedo
Padovani, Karina Stringhetta
Leopoldino, Andréia Machado
Louzada, Mário Jefferson Quirino
Belló Klein, Adriane
Llesuy, Susana Francisca
Ervolino, Edilson
Dornelles, Rita Cássia Menegati
Chaves Neto, Antonio Hernandes
Nakamune, Ana
author Pereira, Camila Scacco
author_facet Pereira, Camila Scacco
Stringhetta Garcia, Camila Tami
da Silva Xavier, Lilian
Tirapeli, Keny Gonçalves
Pereira, Ariana Aparecida Ferreira
Kayahara, GiselIi Mitsuy
Tramarim, José Marcelo
Crivelini, Marcelo Macedo
Padovani, Karina Stringhetta
Leopoldino, Andréia Machado
Louzada, Mário Jefferson Quirino
Belló Klein, Adriane
Llesuy, Susana Francisca
Ervolino, Edilson
Dornelles, Rita Cássia Menegati
Chaves Neto, Antonio Hernandes
Nakamune, Ana
author_role author
author2 Stringhetta Garcia, Camila Tami
da Silva Xavier, Lilian
Tirapeli, Keny Gonçalves
Pereira, Ariana Aparecida Ferreira
Kayahara, GiselIi Mitsuy
Tramarim, José Marcelo
Crivelini, Marcelo Macedo
Padovani, Karina Stringhetta
Leopoldino, Andréia Machado
Louzada, Mário Jefferson Quirino
Belló Klein, Adriane
Llesuy, Susana Francisca
Ervolino, Edilson
Dornelles, Rita Cássia Menegati
Chaves Neto, Antonio Hernandes
Nakamune, Ana
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BONE
ILEX PARAGUARIENSIS
OXIDATIVE STRESS
PERIMENOPAUSE
topic BONE
ILEX PARAGUARIENSIS
OXIDATIVE STRESS
PERIMENOPAUSE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv During perimenopause, oxidative stress increases, which may result in disruption of bone turnover, and consequently in osteoporosis. The use of antioxidants may be an effective nutritional approach to reducing osteoporosis in this period of life. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense. Our hypothesis was that MT would decrease oxidative stress and mitigate bone deterioration. To test this, we analyzed oxidative stress markers of bone turnover, and local and systemic markers of bone metabolism of rats during natural perimenopause. Female Wistar rats (aged 16 months) in proven perimenopause period received 20 mg/kg BW/day of mate tea, by gavage (PM + MT Group, n = 10) or water (PM Group, n = 10). Female rats aged 4 months (AD Group, n = 10) received water. The treatment period was four weeks. MT minimized the deterioration of rat microarchitecture, characterized by increase in the bone trabecular area, number of osteocytes and areal bone mineral density. These results were accompanied by a lower level of malondialdehyde, an oxidative stress marker, in femoral tissue homogenate. Plasmatic tartrate-resistant acid phosphatase, a typical osteoclastic function marker, decreases after treatment, indicating a decrease in osteoclastic function. MT also modified the immunostaining pattern of bone metabolism markers, decreasing the receptor activator of nuclear factor kappa-B ligant (RANKL), superoxide dismutase isoform 2 (SOD2) and increasing osteoprotegerin (OPG), a decoy receptor for the RANKL, which positively modulates bone mass. These results suggested MT was capable of decreasing bone resorption by inhibiting the osteoclastogenesis in a RANKL-dependent signaling pathway activated by oxidative stress. Taken together, the results indicated that MT minimized bone loss in perimenopause and this effect is at least partly due to the decrease in oxidative stress, confirming our hypothesis.
Fil: Pereira, Camila Scacco. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Stringhetta Garcia, Camila Tami. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: da Silva Xavier, Lilian. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Tirapeli, Keny Gonçalves. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Pereira, Ariana Aparecida Ferreira. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Kayahara, GiselIi Mitsuy. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Tramarim, José Marcelo. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Crivelini, Marcelo Macedo. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Padovani, Karina Stringhetta. Universidade de Sao Paulo; Brasil
Fil: Leopoldino, Andréia Machado. Universidade de Sao Paulo; Brasil
Fil: Louzada, Mário Jefferson Quirino. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Ervolino, Edilson. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Dornelles, Rita Cássia Menegati. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Chaves Neto, Antonio Hernandes. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Nakamune, Ana. Universidade Federal do Rio Grande do Sul; Brasil
description During perimenopause, oxidative stress increases, which may result in disruption of bone turnover, and consequently in osteoporosis. The use of antioxidants may be an effective nutritional approach to reducing osteoporosis in this period of life. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense. Our hypothesis was that MT would decrease oxidative stress and mitigate bone deterioration. To test this, we analyzed oxidative stress markers of bone turnover, and local and systemic markers of bone metabolism of rats during natural perimenopause. Female Wistar rats (aged 16 months) in proven perimenopause period received 20 mg/kg BW/day of mate tea, by gavage (PM + MT Group, n = 10) or water (PM Group, n = 10). Female rats aged 4 months (AD Group, n = 10) received water. The treatment period was four weeks. MT minimized the deterioration of rat microarchitecture, characterized by increase in the bone trabecular area, number of osteocytes and areal bone mineral density. These results were accompanied by a lower level of malondialdehyde, an oxidative stress marker, in femoral tissue homogenate. Plasmatic tartrate-resistant acid phosphatase, a typical osteoclastic function marker, decreases after treatment, indicating a decrease in osteoclastic function. MT also modified the immunostaining pattern of bone metabolism markers, decreasing the receptor activator of nuclear factor kappa-B ligant (RANKL), superoxide dismutase isoform 2 (SOD2) and increasing osteoprotegerin (OPG), a decoy receptor for the RANKL, which positively modulates bone mass. These results suggested MT was capable of decreasing bone resorption by inhibiting the osteoclastogenesis in a RANKL-dependent signaling pathway activated by oxidative stress. Taken together, the results indicated that MT minimized bone loss in perimenopause and this effect is at least partly due to the decrease in oxidative stress, confirming our hypothesis.
publishDate 2017
dc.date.none.fl_str_mv 2017-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/59623
Pereira, Camila Scacco; Stringhetta Garcia, Camila Tami; da Silva Xavier, Lilian; Tirapeli, Keny Gonçalves; Pereira, Ariana Aparecida Ferreira; et al.; llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause; Pergamon-Elsevier Science Ltd; Experimental Gerontology; 98; 11-2017; 148-152
0531-5565
CONICET Digital
CONICET
url http://hdl.handle.net/11336/59623
identifier_str_mv Pereira, Camila Scacco; Stringhetta Garcia, Camila Tami; da Silva Xavier, Lilian; Tirapeli, Keny Gonçalves; Pereira, Ariana Aparecida Ferreira; et al.; llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause; Pergamon-Elsevier Science Ltd; Experimental Gerontology; 98; 11-2017; 148-152
0531-5565
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.exger.2017.07.006
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
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application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
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repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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