llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause
- Autores
- Pereira, Camila Scacco; Stringhetta Garcia, Camila Tami; da Silva Xavier, Lilian; Tirapeli, Keny Gonçalves; Pereira, Ariana Aparecida Ferreira; Kayahara, GiselIi Mitsuy; Tramarim, José Marcelo; Crivelini, Marcelo Macedo; Padovani, Karina Stringhetta; Leopoldino, Andréia Machado; Louzada, Mário Jefferson Quirino; Belló Klein, Adriane; Llesuy, Susana Francisca; Ervolino, Edilson; Dornelles, Rita Cássia Menegati; Chaves Neto, Antonio Hernandes; Nakamune, Ana
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- During perimenopause, oxidative stress increases, which may result in disruption of bone turnover, and consequently in osteoporosis. The use of antioxidants may be an effective nutritional approach to reducing osteoporosis in this period of life. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense. Our hypothesis was that MT would decrease oxidative stress and mitigate bone deterioration. To test this, we analyzed oxidative stress markers of bone turnover, and local and systemic markers of bone metabolism of rats during natural perimenopause. Female Wistar rats (aged 16 months) in proven perimenopause period received 20 mg/kg BW/day of mate tea, by gavage (PM + MT Group, n = 10) or water (PM Group, n = 10). Female rats aged 4 months (AD Group, n = 10) received water. The treatment period was four weeks. MT minimized the deterioration of rat microarchitecture, characterized by increase in the bone trabecular area, number of osteocytes and areal bone mineral density. These results were accompanied by a lower level of malondialdehyde, an oxidative stress marker, in femoral tissue homogenate. Plasmatic tartrate-resistant acid phosphatase, a typical osteoclastic function marker, decreases after treatment, indicating a decrease in osteoclastic function. MT also modified the immunostaining pattern of bone metabolism markers, decreasing the receptor activator of nuclear factor kappa-B ligant (RANKL), superoxide dismutase isoform 2 (SOD2) and increasing osteoprotegerin (OPG), a decoy receptor for the RANKL, which positively modulates bone mass. These results suggested MT was capable of decreasing bone resorption by inhibiting the osteoclastogenesis in a RANKL-dependent signaling pathway activated by oxidative stress. Taken together, the results indicated that MT minimized bone loss in perimenopause and this effect is at least partly due to the decrease in oxidative stress, confirming our hypothesis.
Fil: Pereira, Camila Scacco. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Stringhetta Garcia, Camila Tami. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: da Silva Xavier, Lilian. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Tirapeli, Keny Gonçalves. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Pereira, Ariana Aparecida Ferreira. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Kayahara, GiselIi Mitsuy. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Tramarim, José Marcelo. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Crivelini, Marcelo Macedo. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Padovani, Karina Stringhetta. Universidade de Sao Paulo; Brasil
Fil: Leopoldino, Andréia Machado. Universidade de Sao Paulo; Brasil
Fil: Louzada, Mário Jefferson Quirino. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
Fil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Ervolino, Edilson. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Dornelles, Rita Cássia Menegati. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Chaves Neto, Antonio Hernandes. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Nakamune, Ana. Universidade Federal do Rio Grande do Sul; Brasil - Materia
-
BONE
ILEX PARAGUARIENSIS
OXIDATIVE STRESS
PERIMENOPAUSE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/59623
Ver los metadatos del registro completo
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spelling |
llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopausePereira, Camila ScaccoStringhetta Garcia, Camila Tamida Silva Xavier, LilianTirapeli, Keny GonçalvesPereira, Ariana Aparecida FerreiraKayahara, GiselIi MitsuyTramarim, José MarceloCrivelini, Marcelo MacedoPadovani, Karina StringhettaLeopoldino, Andréia MachadoLouzada, Mário Jefferson QuirinoBelló Klein, AdrianeLlesuy, Susana FranciscaErvolino, EdilsonDornelles, Rita Cássia MenegatiChaves Neto, Antonio HernandesNakamune, AnaBONEILEX PARAGUARIENSISOXIDATIVE STRESSPERIMENOPAUSEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1During perimenopause, oxidative stress increases, which may result in disruption of bone turnover, and consequently in osteoporosis. The use of antioxidants may be an effective nutritional approach to reducing osteoporosis in this period of life. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense. Our hypothesis was that MT would decrease oxidative stress and mitigate bone deterioration. To test this, we analyzed oxidative stress markers of bone turnover, and local and systemic markers of bone metabolism of rats during natural perimenopause. Female Wistar rats (aged 16 months) in proven perimenopause period received 20 mg/kg BW/day of mate tea, by gavage (PM + MT Group, n = 10) or water (PM Group, n = 10). Female rats aged 4 months (AD Group, n = 10) received water. The treatment period was four weeks. MT minimized the deterioration of rat microarchitecture, characterized by increase in the bone trabecular area, number of osteocytes and areal bone mineral density. These results were accompanied by a lower level of malondialdehyde, an oxidative stress marker, in femoral tissue homogenate. Plasmatic tartrate-resistant acid phosphatase, a typical osteoclastic function marker, decreases after treatment, indicating a decrease in osteoclastic function. MT also modified the immunostaining pattern of bone metabolism markers, decreasing the receptor activator of nuclear factor kappa-B ligant (RANKL), superoxide dismutase isoform 2 (SOD2) and increasing osteoprotegerin (OPG), a decoy receptor for the RANKL, which positively modulates bone mass. These results suggested MT was capable of decreasing bone resorption by inhibiting the osteoclastogenesis in a RANKL-dependent signaling pathway activated by oxidative stress. Taken together, the results indicated that MT minimized bone loss in perimenopause and this effect is at least partly due to the decrease in oxidative stress, confirming our hypothesis.Fil: Pereira, Camila Scacco. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Stringhetta Garcia, Camila Tami. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: da Silva Xavier, Lilian. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Tirapeli, Keny Gonçalves. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Pereira, Ariana Aparecida Ferreira. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Kayahara, GiselIi Mitsuy. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Tramarim, José Marcelo. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Crivelini, Marcelo Macedo. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Padovani, Karina Stringhetta. Universidade de Sao Paulo; BrasilFil: Leopoldino, Andréia Machado. Universidade de Sao Paulo; BrasilFil: Louzada, Mário Jefferson Quirino. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; BrasilFil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Ervolino, Edilson. Universidade Federal do Rio Grande do Sul; BrasilFil: Dornelles, Rita Cássia Menegati. Universidade Federal do Rio Grande do Sul; BrasilFil: Chaves Neto, Antonio Hernandes. Universidade Federal do Rio Grande do Sul; BrasilFil: Nakamune, Ana. Universidade Federal do Rio Grande do Sul; BrasilPergamon-Elsevier Science Ltd2017-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/59623Pereira, Camila Scacco; Stringhetta Garcia, Camila Tami; da Silva Xavier, Lilian; Tirapeli, Keny Gonçalves; Pereira, Ariana Aparecida Ferreira; et al.; llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause; Pergamon-Elsevier Science Ltd; Experimental Gerontology; 98; 11-2017; 148-1520531-5565CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.exger.2017.07.006info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S053155651730181Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:58:47Zoai:ri.conicet.gov.ar:11336/59623instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:58:47.317CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause |
title |
llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause |
spellingShingle |
llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause Pereira, Camila Scacco BONE ILEX PARAGUARIENSIS OXIDATIVE STRESS PERIMENOPAUSE |
title_short |
llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause |
title_full |
llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause |
title_fullStr |
llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause |
title_full_unstemmed |
llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause |
title_sort |
llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause |
dc.creator.none.fl_str_mv |
Pereira, Camila Scacco Stringhetta Garcia, Camila Tami da Silva Xavier, Lilian Tirapeli, Keny Gonçalves Pereira, Ariana Aparecida Ferreira Kayahara, GiselIi Mitsuy Tramarim, José Marcelo Crivelini, Marcelo Macedo Padovani, Karina Stringhetta Leopoldino, Andréia Machado Louzada, Mário Jefferson Quirino Belló Klein, Adriane Llesuy, Susana Francisca Ervolino, Edilson Dornelles, Rita Cássia Menegati Chaves Neto, Antonio Hernandes Nakamune, Ana |
author |
Pereira, Camila Scacco |
author_facet |
Pereira, Camila Scacco Stringhetta Garcia, Camila Tami da Silva Xavier, Lilian Tirapeli, Keny Gonçalves Pereira, Ariana Aparecida Ferreira Kayahara, GiselIi Mitsuy Tramarim, José Marcelo Crivelini, Marcelo Macedo Padovani, Karina Stringhetta Leopoldino, Andréia Machado Louzada, Mário Jefferson Quirino Belló Klein, Adriane Llesuy, Susana Francisca Ervolino, Edilson Dornelles, Rita Cássia Menegati Chaves Neto, Antonio Hernandes Nakamune, Ana |
author_role |
author |
author2 |
Stringhetta Garcia, Camila Tami da Silva Xavier, Lilian Tirapeli, Keny Gonçalves Pereira, Ariana Aparecida Ferreira Kayahara, GiselIi Mitsuy Tramarim, José Marcelo Crivelini, Marcelo Macedo Padovani, Karina Stringhetta Leopoldino, Andréia Machado Louzada, Mário Jefferson Quirino Belló Klein, Adriane Llesuy, Susana Francisca Ervolino, Edilson Dornelles, Rita Cássia Menegati Chaves Neto, Antonio Hernandes Nakamune, Ana |
author2_role |
author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
BONE ILEX PARAGUARIENSIS OXIDATIVE STRESS PERIMENOPAUSE |
topic |
BONE ILEX PARAGUARIENSIS OXIDATIVE STRESS PERIMENOPAUSE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
During perimenopause, oxidative stress increases, which may result in disruption of bone turnover, and consequently in osteoporosis. The use of antioxidants may be an effective nutritional approach to reducing osteoporosis in this period of life. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense. Our hypothesis was that MT would decrease oxidative stress and mitigate bone deterioration. To test this, we analyzed oxidative stress markers of bone turnover, and local and systemic markers of bone metabolism of rats during natural perimenopause. Female Wistar rats (aged 16 months) in proven perimenopause period received 20 mg/kg BW/day of mate tea, by gavage (PM + MT Group, n = 10) or water (PM Group, n = 10). Female rats aged 4 months (AD Group, n = 10) received water. The treatment period was four weeks. MT minimized the deterioration of rat microarchitecture, characterized by increase in the bone trabecular area, number of osteocytes and areal bone mineral density. These results were accompanied by a lower level of malondialdehyde, an oxidative stress marker, in femoral tissue homogenate. Plasmatic tartrate-resistant acid phosphatase, a typical osteoclastic function marker, decreases after treatment, indicating a decrease in osteoclastic function. MT also modified the immunostaining pattern of bone metabolism markers, decreasing the receptor activator of nuclear factor kappa-B ligant (RANKL), superoxide dismutase isoform 2 (SOD2) and increasing osteoprotegerin (OPG), a decoy receptor for the RANKL, which positively modulates bone mass. These results suggested MT was capable of decreasing bone resorption by inhibiting the osteoclastogenesis in a RANKL-dependent signaling pathway activated by oxidative stress. Taken together, the results indicated that MT minimized bone loss in perimenopause and this effect is at least partly due to the decrease in oxidative stress, confirming our hypothesis. Fil: Pereira, Camila Scacco. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Stringhetta Garcia, Camila Tami. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: da Silva Xavier, Lilian. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Tirapeli, Keny Gonçalves. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Pereira, Ariana Aparecida Ferreira. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Kayahara, GiselIi Mitsuy. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Tramarim, José Marcelo. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Crivelini, Marcelo Macedo. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Padovani, Karina Stringhetta. Universidade de Sao Paulo; Brasil Fil: Leopoldino, Andréia Machado. Universidade de Sao Paulo; Brasil Fil: Louzada, Mário Jefferson Quirino. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina Fil: Ervolino, Edilson. Universidade Federal do Rio Grande do Sul; Brasil Fil: Dornelles, Rita Cássia Menegati. Universidade Federal do Rio Grande do Sul; Brasil Fil: Chaves Neto, Antonio Hernandes. Universidade Federal do Rio Grande do Sul; Brasil Fil: Nakamune, Ana. Universidade Federal do Rio Grande do Sul; Brasil |
description |
During perimenopause, oxidative stress increases, which may result in disruption of bone turnover, and consequently in osteoporosis. The use of antioxidants may be an effective nutritional approach to reducing osteoporosis in this period of life. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense. Our hypothesis was that MT would decrease oxidative stress and mitigate bone deterioration. To test this, we analyzed oxidative stress markers of bone turnover, and local and systemic markers of bone metabolism of rats during natural perimenopause. Female Wistar rats (aged 16 months) in proven perimenopause period received 20 mg/kg BW/day of mate tea, by gavage (PM + MT Group, n = 10) or water (PM Group, n = 10). Female rats aged 4 months (AD Group, n = 10) received water. The treatment period was four weeks. MT minimized the deterioration of rat microarchitecture, characterized by increase in the bone trabecular area, number of osteocytes and areal bone mineral density. These results were accompanied by a lower level of malondialdehyde, an oxidative stress marker, in femoral tissue homogenate. Plasmatic tartrate-resistant acid phosphatase, a typical osteoclastic function marker, decreases after treatment, indicating a decrease in osteoclastic function. MT also modified the immunostaining pattern of bone metabolism markers, decreasing the receptor activator of nuclear factor kappa-B ligant (RANKL), superoxide dismutase isoform 2 (SOD2) and increasing osteoprotegerin (OPG), a decoy receptor for the RANKL, which positively modulates bone mass. These results suggested MT was capable of decreasing bone resorption by inhibiting the osteoclastogenesis in a RANKL-dependent signaling pathway activated by oxidative stress. Taken together, the results indicated that MT minimized bone loss in perimenopause and this effect is at least partly due to the decrease in oxidative stress, confirming our hypothesis. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/59623 Pereira, Camila Scacco; Stringhetta Garcia, Camila Tami; da Silva Xavier, Lilian; Tirapeli, Keny Gonçalves; Pereira, Ariana Aparecida Ferreira; et al.; llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause; Pergamon-Elsevier Science Ltd; Experimental Gerontology; 98; 11-2017; 148-152 0531-5565 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/59623 |
identifier_str_mv |
Pereira, Camila Scacco; Stringhetta Garcia, Camila Tami; da Silva Xavier, Lilian; Tirapeli, Keny Gonçalves; Pereira, Ariana Aparecida Ferreira; et al.; llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause; Pergamon-Elsevier Science Ltd; Experimental Gerontology; 98; 11-2017; 148-152 0531-5565 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.exger.2017.07.006 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S053155651730181X |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613749313372160 |
score |
13.070432 |