Spontaneous and cytokine induced natural killer cytotoxicity in patients with Cushing´s disease

Autores
Cardoso, Estela M. del Luján; Arregger, Alejandro Luis; Ofner, Luis M.; Estrada, Gabriela Margarita; Goldberg, Victoria; Contreras, Liliana Noemí
Año de publicación
2003
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Patients with endogenous hypercortisolism are prone to develop infectious diseases. In this study, we investigated the spontaneous and in vitro response to interleukin-2 (LAK) or interferon -a (IFN-a NK) natural  killer cytotoxicity in 12 ambulatory female patients with Cushing’s disease (CD) Twelve healthy age-matched women served as control subjects (C). Mean spontaneous NK activity in CD ( 1.82 ± 0.77 LU/106 PBL) was not different than C (2.38 ± 0.59 LU/106 PBL). Mean LAK activity in CD (4.27 ± 1.72 LU/106 PBL) was significantly lower than C (9.52 ± 1.19 LU/10 6 PBL; p<0.001). Mean IFN-a NK cytotoxicity response in CD (3.33 ± 1.57 LU/10 6 PBL) was significantly reduced compared with C (8.41 ± 1.24 LU/106 PBL, p< 0.001). Spontaneous and stimulated NK cytotoxicity did not show correlation with plasma corticotrophin, total urinary-free cortisol or late salivary cortisol. Although spontaneous NK cytotoxicity did not demonstrate differences from healthy women, this finding did not exclude an impairment of the NK response to immunomodulators like found in these high-risk patients.
Fil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Arregger, Alejandro Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ofner, Luis M.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Estrada, Gabriela Margarita. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Goldberg, Victoria. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Materia
Natural Killer
CUSHING'S SYNDROME
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/110045
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/110045
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Spontaneous and cytokine induced natural killer cytotoxicity in patients with Cushing´s diseaseCardoso, Estela M. del LujánArregger, Alejandro LuisOfner, Luis M.Estrada, Gabriela MargaritaGoldberg, VictoriaContreras, Liliana NoemíNatural KillerCUSHING'S SYNDROMEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Patients with endogenous hypercortisolism are prone to develop infectious diseases. In this study, we investigated the spontaneous and in vitro response to interleukin-2 (LAK) or interferon -a (IFN-a NK) natural  killer cytotoxicity in 12 ambulatory female patients with Cushing’s disease (CD) Twelve healthy age-matched women served as control subjects (C). Mean spontaneous NK activity in CD ( 1.82 ± 0.77 LU/106 PBL) was not different than C (2.38 ± 0.59 LU/106 PBL). Mean LAK activity in CD (4.27 ± 1.72 LU/106 PBL) was significantly lower than C (9.52 ± 1.19 LU/10 6 PBL; p<0.001). Mean IFN-a NK cytotoxicity response in CD (3.33 ± 1.57 LU/10 6 PBL) was significantly reduced compared with C (8.41 ± 1.24 LU/106 PBL, p< 0.001). Spontaneous and stimulated NK cytotoxicity did not show correlation with plasma corticotrophin, total urinary-free cortisol or late salivary cortisol. Although spontaneous NK cytotoxicity did not demonstrate differences from healthy women, this finding did not exclude an impairment of the NK response to immunomodulators like found in these high-risk patients.Fil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Arregger, Alejandro Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ofner, Luis M.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Estrada, Gabriela Margarita. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Goldberg, Victoria. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaLippincott Williams2003-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/110045Cardoso, Estela M. del Luján; Arregger, Alejandro Luis; Ofner, Luis M.; Estrada, Gabriela Margarita; Goldberg, Victoria; et al.; Spontaneous and cytokine induced natural killer cytotoxicity in patients with Cushing´s disease; Lippincott Williams; Endocrinologist; 13; 6; 11-2003; 459-4641051-2144CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/endocrinologist/endst/2003/11/000/spontaneous-cytokine-induced-natural-killer/6/00019616info:eu-repo/semantics/altIdentifier/doi/10.1097/01.ten.0000089861.71868.f2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:45Zoai:ri.conicet.gov.ar:11336/110045instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:45.364CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Spontaneous and cytokine induced natural killer cytotoxicity in patients with Cushing´s disease
title Spontaneous and cytokine induced natural killer cytotoxicity in patients with Cushing´s disease
spellingShingle Spontaneous and cytokine induced natural killer cytotoxicity in patients with Cushing´s disease
Cardoso, Estela M. del Luján
Natural Killer
CUSHING'S SYNDROME
title_short Spontaneous and cytokine induced natural killer cytotoxicity in patients with Cushing´s disease
title_full Spontaneous and cytokine induced natural killer cytotoxicity in patients with Cushing´s disease
title_fullStr Spontaneous and cytokine induced natural killer cytotoxicity in patients with Cushing´s disease
title_full_unstemmed Spontaneous and cytokine induced natural killer cytotoxicity in patients with Cushing´s disease
title_sort Spontaneous and cytokine induced natural killer cytotoxicity in patients with Cushing´s disease
dc.creator.none.fl_str_mv Cardoso, Estela M. del Luján
Arregger, Alejandro Luis
Ofner, Luis M.
Estrada, Gabriela Margarita
Goldberg, Victoria
Contreras, Liliana Noemí
author Cardoso, Estela M. del Luján
author_facet Cardoso, Estela M. del Luján
Arregger, Alejandro Luis
Ofner, Luis M.
Estrada, Gabriela Margarita
Goldberg, Victoria
Contreras, Liliana Noemí
author_role author
author2 Arregger, Alejandro Luis
Ofner, Luis M.
Estrada, Gabriela Margarita
Goldberg, Victoria
Contreras, Liliana Noemí
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Natural Killer
CUSHING'S SYNDROME
topic Natural Killer
CUSHING'S SYNDROME
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Patients with endogenous hypercortisolism are prone to develop infectious diseases. In this study, we investigated the spontaneous and in vitro response to interleukin-2 (LAK) or interferon -a (IFN-a NK) natural  killer cytotoxicity in 12 ambulatory female patients with Cushing’s disease (CD) Twelve healthy age-matched women served as control subjects (C). Mean spontaneous NK activity in CD ( 1.82 ± 0.77 LU/106 PBL) was not different than C (2.38 ± 0.59 LU/106 PBL). Mean LAK activity in CD (4.27 ± 1.72 LU/106 PBL) was significantly lower than C (9.52 ± 1.19 LU/10 6 PBL; p<0.001). Mean IFN-a NK cytotoxicity response in CD (3.33 ± 1.57 LU/10 6 PBL) was significantly reduced compared with C (8.41 ± 1.24 LU/106 PBL, p< 0.001). Spontaneous and stimulated NK cytotoxicity did not show correlation with plasma corticotrophin, total urinary-free cortisol or late salivary cortisol. Although spontaneous NK cytotoxicity did not demonstrate differences from healthy women, this finding did not exclude an impairment of the NK response to immunomodulators like found in these high-risk patients.
Fil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Arregger, Alejandro Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ofner, Luis M.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Estrada, Gabriela Margarita. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Goldberg, Victoria. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description Patients with endogenous hypercortisolism are prone to develop infectious diseases. In this study, we investigated the spontaneous and in vitro response to interleukin-2 (LAK) or interferon -a (IFN-a NK) natural  killer cytotoxicity in 12 ambulatory female patients with Cushing’s disease (CD) Twelve healthy age-matched women served as control subjects (C). Mean spontaneous NK activity in CD ( 1.82 ± 0.77 LU/106 PBL) was not different than C (2.38 ± 0.59 LU/106 PBL). Mean LAK activity in CD (4.27 ± 1.72 LU/106 PBL) was significantly lower than C (9.52 ± 1.19 LU/10 6 PBL; p<0.001). Mean IFN-a NK cytotoxicity response in CD (3.33 ± 1.57 LU/10 6 PBL) was significantly reduced compared with C (8.41 ± 1.24 LU/106 PBL, p< 0.001). Spontaneous and stimulated NK cytotoxicity did not show correlation with plasma corticotrophin, total urinary-free cortisol or late salivary cortisol. Although spontaneous NK cytotoxicity did not demonstrate differences from healthy women, this finding did not exclude an impairment of the NK response to immunomodulators like found in these high-risk patients.
publishDate 2003
dc.date.none.fl_str_mv 2003-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/110045
Cardoso, Estela M. del Luján; Arregger, Alejandro Luis; Ofner, Luis M.; Estrada, Gabriela Margarita; Goldberg, Victoria; et al.; Spontaneous and cytokine induced natural killer cytotoxicity in patients with Cushing´s disease; Lippincott Williams; Endocrinologist; 13; 6; 11-2003; 459-464
1051-2144
CONICET Digital
CONICET
url http://hdl.handle.net/11336/110045
identifier_str_mv Cardoso, Estela M. del Luján; Arregger, Alejandro Luis; Ofner, Luis M.; Estrada, Gabriela Margarita; Goldberg, Victoria; et al.; Spontaneous and cytokine induced natural killer cytotoxicity in patients with Cushing´s disease; Lippincott Williams; Endocrinologist; 13; 6; 11-2003; 459-464
1051-2144
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/endocrinologist/endst/2003/11/000/spontaneous-cytokine-induced-natural-killer/6/00019616
info:eu-repo/semantics/altIdentifier/doi/10.1097/01.ten.0000089861.71868.f2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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