Hormonal secretion and quality of life in Nelson syndrome and Cushing disease after long acting repeatable octreotide: a short series and update

Autores
Arregger, Alejandro Luis; Cardoso, Estela M. del Luján; Sandoval, Olga B.; Monardes, Élida Gloria; Sánchez, Rocío; Contreras, Liliana Noemí
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Clinical management of persistent ACTH excess in Nelson´s syndrome (NS) and Cushing´s disease (CD) remains a challenge. Somatostatin (SS) and its analogs as octreotide decrease ACTH secretion through SS receptors (sst) of pituitary cells. To our knowledge there are no reports on the effect of long-acting repeatable octreotide (oct-lar) on hormonal secretion and quality of life in patients with NS and CD who failed conventional therapy. Herein we describe the effects of treatment with oct-lar (20 mg/ i.m. month) in one woman with NS and two women with persistent CD . Oct-lar therapy reduced ACTH secretion and improved quality of life in NS, by contrast in CD it failed to control ACTH and cortisol secretion and quality of life remained unchanged.
Fil: Arregger, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Sandoval, Olga B.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Monardes, Élida Gloria. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sánchez, Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Materia
Nelson Syndrome
Cushing Disease
Octeotride-Lar
Quality of Life
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20763
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Hormonal secretion and quality of life in Nelson syndrome and Cushing disease after long acting repeatable octreotide: a short series and updateArregger, Alejandro LuisCardoso, Estela M. del LujánSandoval, Olga B.Monardes, Élida GloriaSánchez, RocíoContreras, Liliana NoemíNelson SyndromeCushing DiseaseOcteotride-LarQuality of Lifehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Clinical management of persistent ACTH excess in Nelson´s syndrome (NS) and Cushing´s disease (CD) remains a challenge. Somatostatin (SS) and its analogs as octreotide decrease ACTH secretion through SS receptors (sst) of pituitary cells. To our knowledge there are no reports on the effect of long-acting repeatable octreotide (oct-lar) on hormonal secretion and quality of life in patients with NS and CD who failed conventional therapy. Herein we describe the effects of treatment with oct-lar (20 mg/ i.m. month) in one woman with NS and two women with persistent CD . Oct-lar therapy reduced ACTH secretion and improved quality of life in NS, by contrast in CD it failed to control ACTH and cortisol secretion and quality of life remained unchanged.Fil: Arregger, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Sandoval, Olga B.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Monardes, Élida Gloria. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sánchez, Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaLippincott Williams2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20763Arregger, Alejandro Luis; Cardoso, Estela M. del Luján; Sandoval, Olga B.; Monardes, Élida Gloria; Sánchez, Rocío; et al.; Hormonal secretion and quality of life in Nelson syndrome and Cushing disease after long acting repeatable octreotide: a short series and update; Lippincott Williams; American Journal of Therapeutics; 21; 4; 7-2014; 110-1161075-2765CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1097/MJT.0b013e318255bc07info:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/americantherapeutics/pages/articleviewer.aspx?year=2014&issue=07000&article=00018&type=abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:10Zoai:ri.conicet.gov.ar:11336/20763instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:11.127CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hormonal secretion and quality of life in Nelson syndrome and Cushing disease after long acting repeatable octreotide: a short series and update
title Hormonal secretion and quality of life in Nelson syndrome and Cushing disease after long acting repeatable octreotide: a short series and update
spellingShingle Hormonal secretion and quality of life in Nelson syndrome and Cushing disease after long acting repeatable octreotide: a short series and update
Arregger, Alejandro Luis
Nelson Syndrome
Cushing Disease
Octeotride-Lar
Quality of Life
title_short Hormonal secretion and quality of life in Nelson syndrome and Cushing disease after long acting repeatable octreotide: a short series and update
title_full Hormonal secretion and quality of life in Nelson syndrome and Cushing disease after long acting repeatable octreotide: a short series and update
title_fullStr Hormonal secretion and quality of life in Nelson syndrome and Cushing disease after long acting repeatable octreotide: a short series and update
title_full_unstemmed Hormonal secretion and quality of life in Nelson syndrome and Cushing disease after long acting repeatable octreotide: a short series and update
title_sort Hormonal secretion and quality of life in Nelson syndrome and Cushing disease after long acting repeatable octreotide: a short series and update
dc.creator.none.fl_str_mv Arregger, Alejandro Luis
Cardoso, Estela M. del Luján
Sandoval, Olga B.
Monardes, Élida Gloria
Sánchez, Rocío
Contreras, Liliana Noemí
author Arregger, Alejandro Luis
author_facet Arregger, Alejandro Luis
Cardoso, Estela M. del Luján
Sandoval, Olga B.
Monardes, Élida Gloria
Sánchez, Rocío
Contreras, Liliana Noemí
author_role author
author2 Cardoso, Estela M. del Luján
Sandoval, Olga B.
Monardes, Élida Gloria
Sánchez, Rocío
Contreras, Liliana Noemí
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Nelson Syndrome
Cushing Disease
Octeotride-Lar
Quality of Life
topic Nelson Syndrome
Cushing Disease
Octeotride-Lar
Quality of Life
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Clinical management of persistent ACTH excess in Nelson´s syndrome (NS) and Cushing´s disease (CD) remains a challenge. Somatostatin (SS) and its analogs as octreotide decrease ACTH secretion through SS receptors (sst) of pituitary cells. To our knowledge there are no reports on the effect of long-acting repeatable octreotide (oct-lar) on hormonal secretion and quality of life in patients with NS and CD who failed conventional therapy. Herein we describe the effects of treatment with oct-lar (20 mg/ i.m. month) in one woman with NS and two women with persistent CD . Oct-lar therapy reduced ACTH secretion and improved quality of life in NS, by contrast in CD it failed to control ACTH and cortisol secretion and quality of life remained unchanged.
Fil: Arregger, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Sandoval, Olga B.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Monardes, Élida Gloria. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sánchez, Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description Clinical management of persistent ACTH excess in Nelson´s syndrome (NS) and Cushing´s disease (CD) remains a challenge. Somatostatin (SS) and its analogs as octreotide decrease ACTH secretion through SS receptors (sst) of pituitary cells. To our knowledge there are no reports on the effect of long-acting repeatable octreotide (oct-lar) on hormonal secretion and quality of life in patients with NS and CD who failed conventional therapy. Herein we describe the effects of treatment with oct-lar (20 mg/ i.m. month) in one woman with NS and two women with persistent CD . Oct-lar therapy reduced ACTH secretion and improved quality of life in NS, by contrast in CD it failed to control ACTH and cortisol secretion and quality of life remained unchanged.
publishDate 2014
dc.date.none.fl_str_mv 2014-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20763
Arregger, Alejandro Luis; Cardoso, Estela M. del Luján; Sandoval, Olga B.; Monardes, Élida Gloria; Sánchez, Rocío; et al.; Hormonal secretion and quality of life in Nelson syndrome and Cushing disease after long acting repeatable octreotide: a short series and update; Lippincott Williams; American Journal of Therapeutics; 21; 4; 7-2014; 110-116
1075-2765
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20763
identifier_str_mv Arregger, Alejandro Luis; Cardoso, Estela M. del Luján; Sandoval, Olga B.; Monardes, Élida Gloria; Sánchez, Rocío; et al.; Hormonal secretion and quality of life in Nelson syndrome and Cushing disease after long acting repeatable octreotide: a short series and update; Lippincott Williams; American Journal of Therapeutics; 21; 4; 7-2014; 110-116
1075-2765
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1097/MJT.0b013e318255bc07
info:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/americantherapeutics/pages/articleviewer.aspx?year=2014&issue=07000&article=00018&type=abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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