Spinal cord injury drives chronic brain changes

Autores
Jure, Ignacio; Labombarda, Maria Florencia
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rodents. Regarding the hippocampus, neurogenesis is reduced and reactive gliosis increased. These longterm abnormalities could explain behavioral impairments exhibited in humans patients suffering from spinal cord trauma.
Fil: Jure, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Materia
BRAIN NEURODEGENERATION
NEUROINFLAMMATION
SPINAL CORD INJURY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24528
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Spinal cord injury drives chronic brain changesJure, IgnacioLabombarda, Maria FlorenciaBRAIN NEURODEGENERATIONNEUROINFLAMMATIONSPINAL CORD INJURYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rodents. Regarding the hippocampus, neurogenesis is reduced and reactive gliosis increased. These longterm abnormalities could explain behavioral impairments exhibited in humans patients suffering from spinal cord trauma.Fil: Jure, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaShenyang Editorial Dept Neural Regeneration Res2017-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24528Jure, Ignacio; Labombarda, Maria Florencia; Spinal cord injury drives chronic brain changes; Shenyang Editorial Dept Neural Regeneration Res; Neural Regeneration Research; 12; 7; 7-2017; 1044-10471673-53741876-7958CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4103/1673-5374.211177info:eu-repo/semantics/altIdentifier/url/http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=7;spage=1044;epage=1047;aulast=Jureinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558477/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:29Zoai:ri.conicet.gov.ar:11336/24528instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:29.66CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Spinal cord injury drives chronic brain changes
title Spinal cord injury drives chronic brain changes
spellingShingle Spinal cord injury drives chronic brain changes
Jure, Ignacio
BRAIN NEURODEGENERATION
NEUROINFLAMMATION
SPINAL CORD INJURY
title_short Spinal cord injury drives chronic brain changes
title_full Spinal cord injury drives chronic brain changes
title_fullStr Spinal cord injury drives chronic brain changes
title_full_unstemmed Spinal cord injury drives chronic brain changes
title_sort Spinal cord injury drives chronic brain changes
dc.creator.none.fl_str_mv Jure, Ignacio
Labombarda, Maria Florencia
author Jure, Ignacio
author_facet Jure, Ignacio
Labombarda, Maria Florencia
author_role author
author2 Labombarda, Maria Florencia
author2_role author
dc.subject.none.fl_str_mv BRAIN NEURODEGENERATION
NEUROINFLAMMATION
SPINAL CORD INJURY
topic BRAIN NEURODEGENERATION
NEUROINFLAMMATION
SPINAL CORD INJURY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rodents. Regarding the hippocampus, neurogenesis is reduced and reactive gliosis increased. These longterm abnormalities could explain behavioral impairments exhibited in humans patients suffering from spinal cord trauma.
Fil: Jure, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
description Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rodents. Regarding the hippocampus, neurogenesis is reduced and reactive gliosis increased. These longterm abnormalities could explain behavioral impairments exhibited in humans patients suffering from spinal cord trauma.
publishDate 2017
dc.date.none.fl_str_mv 2017-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24528
Jure, Ignacio; Labombarda, Maria Florencia; Spinal cord injury drives chronic brain changes; Shenyang Editorial Dept Neural Regeneration Res; Neural Regeneration Research; 12; 7; 7-2017; 1044-1047
1673-5374
1876-7958
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24528
identifier_str_mv Jure, Ignacio; Labombarda, Maria Florencia; Spinal cord injury drives chronic brain changes; Shenyang Editorial Dept Neural Regeneration Res; Neural Regeneration Research; 12; 7; 7-2017; 1044-1047
1673-5374
1876-7958
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4103/1673-5374.211177
info:eu-repo/semantics/altIdentifier/url/http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=7;spage=1044;epage=1047;aulast=Jure
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558477/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Shenyang Editorial Dept Neural Regeneration Res
publisher.none.fl_str_mv Shenyang Editorial Dept Neural Regeneration Res
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270121391816704
score 13.13397

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