Enrofloxacin and ciprofloxacin residues in broiler chicken feathers after enrofloxacin oral administration

Autores
Marchetti, Maria Laura; Buchamer, Andrea Veronica; Buldain, Daniel Cornelio; Mestorino, Olga Nora
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Antibiotics in animal feed are a public health concern. Drug residues could eventually be detected in animal food products intended for human consumption. Our aim was to study the residue depletion of enrofloxacin and its metabolite ciprofloxacin in broiler chicken feathers. A validated HPLC-fluorescence method was used to quantify both compounds in feather samples. Broiler chickens were treated through drinking water with 10 mg Kg-1 d of enrofloxacin for 5 consecutive days. Feather samples were taken from 10 random birds per day until 9 days. Extraction was performed by a liquid/liquid technique. Both fluoroquinolones concentrations were determined by liquid chromatography with fluorescence detection. High levels of enrofloxacin and ciprofloxacin were found in feathers after oral administration and these compounds were detected for 9 days. Feather meal is a potential source of drug residues that can pass through the food chain when contaminated meal is fed to food-producing animals. In the present study enrofloxacin and ciprofloxacin concentrations were 0.20 to 5.46 µg g-1 between 1 to 9 days after final treatment, which means that withdrawal time fit for edible tissues is not adequate to reduce antimicrobial residues in chicken feathers. Further studies to establish a withdrawal time may be useful to avoid that drug residues could result in adverse health consequences like increase in antibiotic resistance.
Fil: Marchetti, Maria Laura. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacológicos y Toxicológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Buchamer, Andrea Veronica. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacológicos y Toxicológicos; Argentina
Fil: Buldain, Daniel Cornelio. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacológicos y Toxicológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Mestorino, Olga Nora. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacológicos y Toxicológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Materia
ANTIMICROBIALS
ENROFLOXACIN
CIPROFLOXACIN
FEATHERS
POULTRY
RESIDUES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/127848
Acceder
id CONICETDig_9561703af4982fe00d1b26d379d322a6
oai_identifier_str oai:ri.conicet.gov.ar:11336/127848
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Enrofloxacin and ciprofloxacin residues in broiler chicken feathers after enrofloxacin oral administrationMarchetti, Maria LauraBuchamer, Andrea VeronicaBuldain, Daniel CornelioMestorino, Olga NoraANTIMICROBIALSENROFLOXACINCIPROFLOXACINFEATHERSPOULTRYRESIDUEShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Antibiotics in animal feed are a public health concern. Drug residues could eventually be detected in animal food products intended for human consumption. Our aim was to study the residue depletion of enrofloxacin and its metabolite ciprofloxacin in broiler chicken feathers. A validated HPLC-fluorescence method was used to quantify both compounds in feather samples. Broiler chickens were treated through drinking water with 10 mg Kg-1 d of enrofloxacin for 5 consecutive days. Feather samples were taken from 10 random birds per day until 9 days. Extraction was performed by a liquid/liquid technique. Both fluoroquinolones concentrations were determined by liquid chromatography with fluorescence detection. High levels of enrofloxacin and ciprofloxacin were found in feathers after oral administration and these compounds were detected for 9 days. Feather meal is a potential source of drug residues that can pass through the food chain when contaminated meal is fed to food-producing animals. In the present study enrofloxacin and ciprofloxacin concentrations were 0.20 to 5.46 µg g-1 between 1 to 9 days after final treatment, which means that withdrawal time fit for edible tissues is not adequate to reduce antimicrobial residues in chicken feathers. Further studies to establish a withdrawal time may be useful to avoid that drug residues could result in adverse health consequences like increase in antibiotic resistance.Fil: Marchetti, Maria Laura. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacológicos y Toxicológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Buchamer, Andrea Veronica. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacológicos y Toxicológicos; ArgentinaFil: Buldain, Daniel Cornelio. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacológicos y Toxicológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Mestorino, Olga Nora. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacológicos y Toxicológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaECronicon2019-04-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/127848Marchetti, Maria Laura; Buchamer, Andrea Veronica; Buldain, Daniel Cornelio; Mestorino, Olga Nora; Enrofloxacin and ciprofloxacin residues in broiler chicken feathers after enrofloxacin oral administration; ECronicon; EC Veterinary Science; 4; 3; 30-4-2019; 180-1862306-7381CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ecronicon.com/ecve/volume4-issue3.phpinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:07Zoai:ri.conicet.gov.ar:11336/127848instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:08.19CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Enrofloxacin and ciprofloxacin residues in broiler chicken feathers after enrofloxacin oral administration
title Enrofloxacin and ciprofloxacin residues in broiler chicken feathers after enrofloxacin oral administration
spellingShingle Enrofloxacin and ciprofloxacin residues in broiler chicken feathers after enrofloxacin oral administration
Marchetti, Maria Laura
ANTIMICROBIALS
ENROFLOXACIN
CIPROFLOXACIN
FEATHERS
POULTRY
RESIDUES
title_short Enrofloxacin and ciprofloxacin residues in broiler chicken feathers after enrofloxacin oral administration
title_full Enrofloxacin and ciprofloxacin residues in broiler chicken feathers after enrofloxacin oral administration
title_fullStr Enrofloxacin and ciprofloxacin residues in broiler chicken feathers after enrofloxacin oral administration
title_full_unstemmed Enrofloxacin and ciprofloxacin residues in broiler chicken feathers after enrofloxacin oral administration
title_sort Enrofloxacin and ciprofloxacin residues in broiler chicken feathers after enrofloxacin oral administration
dc.creator.none.fl_str_mv Marchetti, Maria Laura
Buchamer, Andrea Veronica
Buldain, Daniel Cornelio
Mestorino, Olga Nora
author Marchetti, Maria Laura
author_facet Marchetti, Maria Laura
Buchamer, Andrea Veronica
Buldain, Daniel Cornelio
Mestorino, Olga Nora
author_role author
author2 Buchamer, Andrea Veronica
Buldain, Daniel Cornelio
Mestorino, Olga Nora
author2_role author
author
author
dc.subject.none.fl_str_mv ANTIMICROBIALS
ENROFLOXACIN
CIPROFLOXACIN
FEATHERS
POULTRY
RESIDUES
topic ANTIMICROBIALS
ENROFLOXACIN
CIPROFLOXACIN
FEATHERS
POULTRY
RESIDUES
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Antibiotics in animal feed are a public health concern. Drug residues could eventually be detected in animal food products intended for human consumption. Our aim was to study the residue depletion of enrofloxacin and its metabolite ciprofloxacin in broiler chicken feathers. A validated HPLC-fluorescence method was used to quantify both compounds in feather samples. Broiler chickens were treated through drinking water with 10 mg Kg-1 d of enrofloxacin for 5 consecutive days. Feather samples were taken from 10 random birds per day until 9 days. Extraction was performed by a liquid/liquid technique. Both fluoroquinolones concentrations were determined by liquid chromatography with fluorescence detection. High levels of enrofloxacin and ciprofloxacin were found in feathers after oral administration and these compounds were detected for 9 days. Feather meal is a potential source of drug residues that can pass through the food chain when contaminated meal is fed to food-producing animals. In the present study enrofloxacin and ciprofloxacin concentrations were 0.20 to 5.46 µg g-1 between 1 to 9 days after final treatment, which means that withdrawal time fit for edible tissues is not adequate to reduce antimicrobial residues in chicken feathers. Further studies to establish a withdrawal time may be useful to avoid that drug residues could result in adverse health consequences like increase in antibiotic resistance.
Fil: Marchetti, Maria Laura. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacológicos y Toxicológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Buchamer, Andrea Veronica. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacológicos y Toxicológicos; Argentina
Fil: Buldain, Daniel Cornelio. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacológicos y Toxicológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Mestorino, Olga Nora. Universidad Nacional de la Plata. Facultad de Cs.veterinarias. Laboratorio de Estudios Farmacológicos y Toxicológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
description Antibiotics in animal feed are a public health concern. Drug residues could eventually be detected in animal food products intended for human consumption. Our aim was to study the residue depletion of enrofloxacin and its metabolite ciprofloxacin in broiler chicken feathers. A validated HPLC-fluorescence method was used to quantify both compounds in feather samples. Broiler chickens were treated through drinking water with 10 mg Kg-1 d of enrofloxacin for 5 consecutive days. Feather samples were taken from 10 random birds per day until 9 days. Extraction was performed by a liquid/liquid technique. Both fluoroquinolones concentrations were determined by liquid chromatography with fluorescence detection. High levels of enrofloxacin and ciprofloxacin were found in feathers after oral administration and these compounds were detected for 9 days. Feather meal is a potential source of drug residues that can pass through the food chain when contaminated meal is fed to food-producing animals. In the present study enrofloxacin and ciprofloxacin concentrations were 0.20 to 5.46 µg g-1 between 1 to 9 days after final treatment, which means that withdrawal time fit for edible tissues is not adequate to reduce antimicrobial residues in chicken feathers. Further studies to establish a withdrawal time may be useful to avoid that drug residues could result in adverse health consequences like increase in antibiotic resistance.
publishDate 2019
dc.date.none.fl_str_mv 2019-04-30
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/127848
Marchetti, Maria Laura; Buchamer, Andrea Veronica; Buldain, Daniel Cornelio; Mestorino, Olga Nora; Enrofloxacin and ciprofloxacin residues in broiler chicken feathers after enrofloxacin oral administration; ECronicon; EC Veterinary Science; 4; 3; 30-4-2019; 180-186
2306-7381
CONICET Digital
CONICET
url http://hdl.handle.net/11336/127848
identifier_str_mv Marchetti, Maria Laura; Buchamer, Andrea Veronica; Buldain, Daniel Cornelio; Mestorino, Olga Nora; Enrofloxacin and ciprofloxacin residues in broiler chicken feathers after enrofloxacin oral administration; ECronicon; EC Veterinary Science; 4; 3; 30-4-2019; 180-186
2306-7381
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ecronicon.com/ecve/volume4-issue3.php
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv ECronicon
publisher.none.fl_str_mv ECronicon
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269015034036224
score 13.13397

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