Impact of probiotic administration on the health and fecal microbiota of young calves: A meta-analysis of randomized controlled trials of lactic acid bacteria

Autores
Signorini Porchietto, Marcelo Lisandro; Soto, Lorena Paola; Zbrun, María Virginia; Sequeira, Gabriel Jorge; Rosmini, Marcelo Raul; Frizzo, Laureano Sebastian
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Before weaning, dairy calves are susceptible to many pathogens which can affect their subsequent performance. The use of lactic acid bacteria (LAB) has been identified as a tool to maintain the intestinal microbial balance and to prevent the establishment of opportunistic pathogenic bacterial populations. However, a consensus has not been reached as to whether probiotics may be effective in reducing the prevalence of gastrointestinal diseases in young calves. The aim of this meta-analysis was to assess the effect of probiotics on diarrhea incidence and the intestinal microbial balance. LAB supplementation has been shown to exert a protective effect and to reduce the incidence of diarrhea (relative risk, RR =0.437, 95% confidence interval (CI) 0.251 ?0.761). In the subanalysis,this protective effect of the probiotics against diarrhea was observed only in trials that used whole milk (RR=0.154, 95%CI 0.079 ?0.301) and trials that used multistrain inocula (RR=0.415, 95%CI 0.227 ?0.759). Probiotics did not improve the fecal characteristics (standardized mean difference, SMD =0.4904, 95%CI 1.011 ?0.035) and were unable to change the LAB:coliforms ratio (SMD =0.016, 95%CI 0.701 ?0.733). Probiotics showed a beneficial impact on the LAB:coliforms ratio in the subanalysis that included trials that used whole milk (SMD =0.780, 95%CI 0.141 ?1.418)and monostrain inocula (SMD =0.990,95%CI 0.340 ?1.641).The probability of significant effects (probiotic positive effect) in a new study was >0.70 for diarrhea and fecal consistency. Whole milk feeding improved the action of the probiotic effect on the incidence of diarrhea and LAB:coliforms ratio.The probability to find significant effects in the diarrhea frequency and LAB:coliforms ratio was higher (P >0.85) if the new studies were conducted using whole milk to feed calves. This paper defines the guidelines to standardize the experimental designs of future trials. LAB can be used as growth promoters in calves instead of antibiotics to counteract the negative effects of their widespread use.
Fil: Signorini Porchietto, Marcelo Lisandro. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Soto, Lorena Paola. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Zbrun, María Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina
Fil: Sequeira, Gabriel Jorge. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina
Fil: Rosmini, Marcelo Raul. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina
Fil: Frizzo, Laureano Sebastian. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Materia
ANIMAL HEALTH
CALVES
DIARRHEA
LACTIC ACID BACTERIA
META-ANALYSIS
PROBIOTIC
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/196288
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/196288
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Impact of probiotic administration on the health and fecal microbiota of young calves: A meta-analysis of randomized controlled trials of lactic acid bacteriaSignorini Porchietto, Marcelo LisandroSoto, Lorena PaolaZbrun, María VirginiaSequeira, Gabriel JorgeRosmini, Marcelo RaulFrizzo, Laureano SebastianANIMAL HEALTHCALVESDIARRHEALACTIC ACID BACTERIAMETA-ANALYSISPROBIOTIChttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Before weaning, dairy calves are susceptible to many pathogens which can affect their subsequent performance. The use of lactic acid bacteria (LAB) has been identified as a tool to maintain the intestinal microbial balance and to prevent the establishment of opportunistic pathogenic bacterial populations. However, a consensus has not been reached as to whether probiotics may be effective in reducing the prevalence of gastrointestinal diseases in young calves. The aim of this meta-analysis was to assess the effect of probiotics on diarrhea incidence and the intestinal microbial balance. LAB supplementation has been shown to exert a protective effect and to reduce the incidence of diarrhea (relative risk, RR =0.437, 95% confidence interval (CI) 0.251 ?0.761). In the subanalysis,this protective effect of the probiotics against diarrhea was observed only in trials that used whole milk (RR=0.154, 95%CI 0.079 ?0.301) and trials that used multistrain inocula (RR=0.415, 95%CI 0.227 ?0.759). Probiotics did not improve the fecal characteristics (standardized mean difference, SMD =0.4904, 95%CI 1.011 ?0.035) and were unable to change the LAB:coliforms ratio (SMD =0.016, 95%CI 0.701 ?0.733). Probiotics showed a beneficial impact on the LAB:coliforms ratio in the subanalysis that included trials that used whole milk (SMD =0.780, 95%CI 0.141 ?1.418)and monostrain inocula (SMD =0.990,95%CI 0.340 ?1.641).The probability of significant effects (probiotic positive effect) in a new study was >0.70 for diarrhea and fecal consistency. Whole milk feeding improved the action of the probiotic effect on the incidence of diarrhea and LAB:coliforms ratio.The probability to find significant effects in the diarrhea frequency and LAB:coliforms ratio was higher (P >0.85) if the new studies were conducted using whole milk to feed calves. This paper defines the guidelines to standardize the experimental designs of future trials. LAB can be used as growth promoters in calves instead of antibiotics to counteract the negative effects of their widespread use.Fil: Signorini Porchietto, Marcelo Lisandro. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Soto, Lorena Paola. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Zbrun, María Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; ArgentinaFil: Sequeira, Gabriel Jorge. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; ArgentinaFil: Rosmini, Marcelo Raul. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; ArgentinaFil: Frizzo, Laureano Sebastian. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaElsevier2012-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/196288Signorini Porchietto, Marcelo Lisandro; Soto, Lorena Paola; Zbrun, María Virginia; Sequeira, Gabriel Jorge; Rosmini, Marcelo Raul; et al.; Impact of probiotic administration on the health and fecal microbiota of young calves: A meta-analysis of randomized controlled trials of lactic acid bacteria; Elsevier; Research in Veterinary Science; 93; 1; 5-2012; 250-2580034-5288CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0034528811001755info:eu-repo/semantics/altIdentifier/doi/10.1016/j.rvsc.2011.05.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:21:13Zoai:ri.conicet.gov.ar:11336/196288instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:21:13.928CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Impact of probiotic administration on the health and fecal microbiota of young calves: A meta-analysis of randomized controlled trials of lactic acid bacteria
title Impact of probiotic administration on the health and fecal microbiota of young calves: A meta-analysis of randomized controlled trials of lactic acid bacteria
spellingShingle Impact of probiotic administration on the health and fecal microbiota of young calves: A meta-analysis of randomized controlled trials of lactic acid bacteria
Signorini Porchietto, Marcelo Lisandro
ANIMAL HEALTH
CALVES
DIARRHEA
LACTIC ACID BACTERIA
META-ANALYSIS
PROBIOTIC
title_short Impact of probiotic administration on the health and fecal microbiota of young calves: A meta-analysis of randomized controlled trials of lactic acid bacteria
title_full Impact of probiotic administration on the health and fecal microbiota of young calves: A meta-analysis of randomized controlled trials of lactic acid bacteria
title_fullStr Impact of probiotic administration on the health and fecal microbiota of young calves: A meta-analysis of randomized controlled trials of lactic acid bacteria
title_full_unstemmed Impact of probiotic administration on the health and fecal microbiota of young calves: A meta-analysis of randomized controlled trials of lactic acid bacteria
title_sort Impact of probiotic administration on the health and fecal microbiota of young calves: A meta-analysis of randomized controlled trials of lactic acid bacteria
dc.creator.none.fl_str_mv Signorini Porchietto, Marcelo Lisandro
Soto, Lorena Paola
Zbrun, María Virginia
Sequeira, Gabriel Jorge
Rosmini, Marcelo Raul
Frizzo, Laureano Sebastian
author Signorini Porchietto, Marcelo Lisandro
author_facet Signorini Porchietto, Marcelo Lisandro
Soto, Lorena Paola
Zbrun, María Virginia
Sequeira, Gabriel Jorge
Rosmini, Marcelo Raul
Frizzo, Laureano Sebastian
author_role author
author2 Soto, Lorena Paola
Zbrun, María Virginia
Sequeira, Gabriel Jorge
Rosmini, Marcelo Raul
Frizzo, Laureano Sebastian
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ANIMAL HEALTH
CALVES
DIARRHEA
LACTIC ACID BACTERIA
META-ANALYSIS
PROBIOTIC
topic ANIMAL HEALTH
CALVES
DIARRHEA
LACTIC ACID BACTERIA
META-ANALYSIS
PROBIOTIC
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Before weaning, dairy calves are susceptible to many pathogens which can affect their subsequent performance. The use of lactic acid bacteria (LAB) has been identified as a tool to maintain the intestinal microbial balance and to prevent the establishment of opportunistic pathogenic bacterial populations. However, a consensus has not been reached as to whether probiotics may be effective in reducing the prevalence of gastrointestinal diseases in young calves. The aim of this meta-analysis was to assess the effect of probiotics on diarrhea incidence and the intestinal microbial balance. LAB supplementation has been shown to exert a protective effect and to reduce the incidence of diarrhea (relative risk, RR =0.437, 95% confidence interval (CI) 0.251 ?0.761). In the subanalysis,this protective effect of the probiotics against diarrhea was observed only in trials that used whole milk (RR=0.154, 95%CI 0.079 ?0.301) and trials that used multistrain inocula (RR=0.415, 95%CI 0.227 ?0.759). Probiotics did not improve the fecal characteristics (standardized mean difference, SMD =0.4904, 95%CI 1.011 ?0.035) and were unable to change the LAB:coliforms ratio (SMD =0.016, 95%CI 0.701 ?0.733). Probiotics showed a beneficial impact on the LAB:coliforms ratio in the subanalysis that included trials that used whole milk (SMD =0.780, 95%CI 0.141 ?1.418)and monostrain inocula (SMD =0.990,95%CI 0.340 ?1.641).The probability of significant effects (probiotic positive effect) in a new study was >0.70 for diarrhea and fecal consistency. Whole milk feeding improved the action of the probiotic effect on the incidence of diarrhea and LAB:coliforms ratio.The probability to find significant effects in the diarrhea frequency and LAB:coliforms ratio was higher (P >0.85) if the new studies were conducted using whole milk to feed calves. This paper defines the guidelines to standardize the experimental designs of future trials. LAB can be used as growth promoters in calves instead of antibiotics to counteract the negative effects of their widespread use.
Fil: Signorini Porchietto, Marcelo Lisandro. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Soto, Lorena Paola. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Zbrun, María Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina
Fil: Sequeira, Gabriel Jorge. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina
Fil: Rosmini, Marcelo Raul. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina
Fil: Frizzo, Laureano Sebastian. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Departamento de Salud Pública Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
description Before weaning, dairy calves are susceptible to many pathogens which can affect their subsequent performance. The use of lactic acid bacteria (LAB) has been identified as a tool to maintain the intestinal microbial balance and to prevent the establishment of opportunistic pathogenic bacterial populations. However, a consensus has not been reached as to whether probiotics may be effective in reducing the prevalence of gastrointestinal diseases in young calves. The aim of this meta-analysis was to assess the effect of probiotics on diarrhea incidence and the intestinal microbial balance. LAB supplementation has been shown to exert a protective effect and to reduce the incidence of diarrhea (relative risk, RR =0.437, 95% confidence interval (CI) 0.251 ?0.761). In the subanalysis,this protective effect of the probiotics against diarrhea was observed only in trials that used whole milk (RR=0.154, 95%CI 0.079 ?0.301) and trials that used multistrain inocula (RR=0.415, 95%CI 0.227 ?0.759). Probiotics did not improve the fecal characteristics (standardized mean difference, SMD =0.4904, 95%CI 1.011 ?0.035) and were unable to change the LAB:coliforms ratio (SMD =0.016, 95%CI 0.701 ?0.733). Probiotics showed a beneficial impact on the LAB:coliforms ratio in the subanalysis that included trials that used whole milk (SMD =0.780, 95%CI 0.141 ?1.418)and monostrain inocula (SMD =0.990,95%CI 0.340 ?1.641).The probability of significant effects (probiotic positive effect) in a new study was >0.70 for diarrhea and fecal consistency. Whole milk feeding improved the action of the probiotic effect on the incidence of diarrhea and LAB:coliforms ratio.The probability to find significant effects in the diarrhea frequency and LAB:coliforms ratio was higher (P >0.85) if the new studies were conducted using whole milk to feed calves. This paper defines the guidelines to standardize the experimental designs of future trials. LAB can be used as growth promoters in calves instead of antibiotics to counteract the negative effects of their widespread use.
publishDate 2012
dc.date.none.fl_str_mv 2012-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/196288
Signorini Porchietto, Marcelo Lisandro; Soto, Lorena Paola; Zbrun, María Virginia; Sequeira, Gabriel Jorge; Rosmini, Marcelo Raul; et al.; Impact of probiotic administration on the health and fecal microbiota of young calves: A meta-analysis of randomized controlled trials of lactic acid bacteria; Elsevier; Research in Veterinary Science; 93; 1; 5-2012; 250-258
0034-5288
CONICET Digital
CONICET
url http://hdl.handle.net/11336/196288
identifier_str_mv Signorini Porchietto, Marcelo Lisandro; Soto, Lorena Paola; Zbrun, María Virginia; Sequeira, Gabriel Jorge; Rosmini, Marcelo Raul; et al.; Impact of probiotic administration on the health and fecal microbiota of young calves: A meta-analysis of randomized controlled trials of lactic acid bacteria; Elsevier; Research in Veterinary Science; 93; 1; 5-2012; 250-258
0034-5288
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.rvsc.2011.05.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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