Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model

Autores
Katunar, Maria Rosa; Gomez Sanchez, Andrea Valeria; Ballarre, Josefina; Baca, Matías; Vottola, Carlos; Orellano, Juan C.; Schell, Hanna; Duffo, Gustavo Sergio; Cere, Silvia
Año de publicación
2014
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mechanical properties and good biocompatibility of zirconium and some of its alloys focus these materials as good candidates for biomedical applications. The attractive in vivo performance of zirconium is mainly due to the presence of a protective oxide layer. In this preliminary study, surface modification of pure zirconium was made by anodisation in acidic media at low potentials, enhancing the barrier protection given by the oxides and the osseointegration. Electrochemical and SEM (scanning electron microscopy) assays were done in commercially pure zirconium cylinders and two surface conditions were compared: pure and zirconium anodised at 30V. The in vivo assays were held in a tibia rat model. The histological features and fluorochrome labelling changes of newly bone formed around implants were evaluated on the non-decalcified sections 63 days after surgery. Electrochemical and SEM assays showed that anodisation treatment would increased the barrier effect over the material and the in vivo assays showed a continuous newly bone formation around the implant with a different amount of osteocytes in their lacunaes depending the region. There was no significant change in bone thickness around both kinds of implants but conversely a significant increase in the mineralization apposition rate was determined for the anodised condition suggesting that anodisation treatment would stimulate and assist to the osseointegration process. We conclude that anodisation treatment at 30 V can stimulate the implant fixation in a rat model and this study would propose the study of zirconium as candidate material for permanent implant.
Fil: Katunar, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
Fil: Gomez Sanchez, Andrea Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
Fil: Ballarre, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
Fil: Baca, Matías. Hospital Interzonal General de Agudos ‘‘Oscar Alende’’. Mar del Plata; Argentina
Fil: Vottola, Carlos. Hospital Interzonal General de Agudos ‘‘Oscar Alende’’; Argentina
Fil: Orellano, Juan C.. Hospital Interzonal General de Agudos ‘‘Oscar Alende’’. Mar del Plata; Argentina
Fil: Schell, Hanna. Universitatsmedizin Berlin; Alemania
Fil: Duffo, Gustavo Sergio. Comision Nacional de Energia Atomica. Gerencia D/area de Energia Nuclear. Unidad de Actividad de Materiales (cac); Argentina. Universidad Nacional de San Martín; Argentina
Fil: Cere, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
Materia
BONE
FLUOROCHOROMES
ZR IMPLANT
OSSEOINTEGRATION
ORTHOPAEDIC IMPLANT
ZIRCONIUM
ANODISATION
IN VIVO MODEL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/5015
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Can anodised zirconium implants stimulate bone formation? Preliminary study in rat modelKatunar, Maria RosaGomez Sanchez, Andrea ValeriaBallarre, JosefinaBaca, MatíasVottola, CarlosOrellano, Juan C.Schell, HannaDuffo, Gustavo SergioCere, SilviaBONEFLUOROCHOROMESZR IMPLANTOSSEOINTEGRATIONORTHOPAEDIC IMPLANTZIRCONIUMANODISATIONIN VIVO MODELhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Mechanical properties and good biocompatibility of zirconium and some of its alloys focus these materials as good candidates for biomedical applications. The attractive in vivo performance of zirconium is mainly due to the presence of a protective oxide layer. In this preliminary study, surface modification of pure zirconium was made by anodisation in acidic media at low potentials, enhancing the barrier protection given by the oxides and the osseointegration. Electrochemical and SEM (scanning electron microscopy) assays were done in commercially pure zirconium cylinders and two surface conditions were compared: pure and zirconium anodised at 30V. The in vivo assays were held in a tibia rat model. The histological features and fluorochrome labelling changes of newly bone formed around implants were evaluated on the non-decalcified sections 63 days after surgery. Electrochemical and SEM assays showed that anodisation treatment would increased the barrier effect over the material and the in vivo assays showed a continuous newly bone formation around the implant with a different amount of osteocytes in their lacunaes depending the region. There was no significant change in bone thickness around both kinds of implants but conversely a significant increase in the mineralization apposition rate was determined for the anodised condition suggesting that anodisation treatment would stimulate and assist to the osseointegration process. We conclude that anodisation treatment at 30 V can stimulate the implant fixation in a rat model and this study would propose the study of zirconium as candidate material for permanent implant.Fil: Katunar, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; ArgentinaFil: Gomez Sanchez, Andrea Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; ArgentinaFil: Ballarre, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; ArgentinaFil: Baca, Matías. Hospital Interzonal General de Agudos ‘‘Oscar Alende’’. Mar del Plata; ArgentinaFil: Vottola, Carlos. Hospital Interzonal General de Agudos ‘‘Oscar Alende’’; ArgentinaFil: Orellano, Juan C.. Hospital Interzonal General de Agudos ‘‘Oscar Alende’’. Mar del Plata; ArgentinaFil: Schell, Hanna. Universitatsmedizin Berlin; AlemaniaFil: Duffo, Gustavo Sergio. Comision Nacional de Energia Atomica. Gerencia D/area de Energia Nuclear. Unidad de Actividad de Materiales (cac); Argentina. Universidad Nacional de San Martín; ArgentinaFil: Cere, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; ArgentinaSpringer2014-06-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documenthttp://hdl.handle.net/11336/5015Katunar, Maria Rosa; Gomez Sanchez, Andrea Valeria; Ballarre, Josefina; Baca, Matías; Vottola, Carlos; et al.; Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model; Springer; Progress in Biomaterials; 3; 24; 11-6-2014; 1-102194-0517spainfo:eu-repo/semantics/altIdentifier/issn/2194-0517info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1007/s40204-014-0024-9info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs40204-014-0024-9info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:25Zoai:ri.conicet.gov.ar:11336/5015instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:25.501CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model
title Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model
spellingShingle Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model
Katunar, Maria Rosa
BONE
FLUOROCHOROMES
ZR IMPLANT
OSSEOINTEGRATION
ORTHOPAEDIC IMPLANT
ZIRCONIUM
ANODISATION
IN VIVO MODEL
title_short Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model
title_full Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model
title_fullStr Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model
title_full_unstemmed Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model
title_sort Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model
dc.creator.none.fl_str_mv Katunar, Maria Rosa
Gomez Sanchez, Andrea Valeria
Ballarre, Josefina
Baca, Matías
Vottola, Carlos
Orellano, Juan C.
Schell, Hanna
Duffo, Gustavo Sergio
Cere, Silvia
author Katunar, Maria Rosa
author_facet Katunar, Maria Rosa
Gomez Sanchez, Andrea Valeria
Ballarre, Josefina
Baca, Matías
Vottola, Carlos
Orellano, Juan C.
Schell, Hanna
Duffo, Gustavo Sergio
Cere, Silvia
author_role author
author2 Gomez Sanchez, Andrea Valeria
Ballarre, Josefina
Baca, Matías
Vottola, Carlos
Orellano, Juan C.
Schell, Hanna
Duffo, Gustavo Sergio
Cere, Silvia
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BONE
FLUOROCHOROMES
ZR IMPLANT
OSSEOINTEGRATION
ORTHOPAEDIC IMPLANT
ZIRCONIUM
ANODISATION
IN VIVO MODEL
topic BONE
FLUOROCHOROMES
ZR IMPLANT
OSSEOINTEGRATION
ORTHOPAEDIC IMPLANT
ZIRCONIUM
ANODISATION
IN VIVO MODEL
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Mechanical properties and good biocompatibility of zirconium and some of its alloys focus these materials as good candidates for biomedical applications. The attractive in vivo performance of zirconium is mainly due to the presence of a protective oxide layer. In this preliminary study, surface modification of pure zirconium was made by anodisation in acidic media at low potentials, enhancing the barrier protection given by the oxides and the osseointegration. Electrochemical and SEM (scanning electron microscopy) assays were done in commercially pure zirconium cylinders and two surface conditions were compared: pure and zirconium anodised at 30V. The in vivo assays were held in a tibia rat model. The histological features and fluorochrome labelling changes of newly bone formed around implants were evaluated on the non-decalcified sections 63 days after surgery. Electrochemical and SEM assays showed that anodisation treatment would increased the barrier effect over the material and the in vivo assays showed a continuous newly bone formation around the implant with a different amount of osteocytes in their lacunaes depending the region. There was no significant change in bone thickness around both kinds of implants but conversely a significant increase in the mineralization apposition rate was determined for the anodised condition suggesting that anodisation treatment would stimulate and assist to the osseointegration process. We conclude that anodisation treatment at 30 V can stimulate the implant fixation in a rat model and this study would propose the study of zirconium as candidate material for permanent implant.
Fil: Katunar, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
Fil: Gomez Sanchez, Andrea Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
Fil: Ballarre, Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
Fil: Baca, Matías. Hospital Interzonal General de Agudos ‘‘Oscar Alende’’. Mar del Plata; Argentina
Fil: Vottola, Carlos. Hospital Interzonal General de Agudos ‘‘Oscar Alende’’; Argentina
Fil: Orellano, Juan C.. Hospital Interzonal General de Agudos ‘‘Oscar Alende’’. Mar del Plata; Argentina
Fil: Schell, Hanna. Universitatsmedizin Berlin; Alemania
Fil: Duffo, Gustavo Sergio. Comision Nacional de Energia Atomica. Gerencia D/area de Energia Nuclear. Unidad de Actividad de Materiales (cac); Argentina. Universidad Nacional de San Martín; Argentina
Fil: Cere, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mar del Plata. Instituto de Investigación En Ciencia y Tecnología de Materiales (i); Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería; Argentina
description Mechanical properties and good biocompatibility of zirconium and some of its alloys focus these materials as good candidates for biomedical applications. The attractive in vivo performance of zirconium is mainly due to the presence of a protective oxide layer. In this preliminary study, surface modification of pure zirconium was made by anodisation in acidic media at low potentials, enhancing the barrier protection given by the oxides and the osseointegration. Electrochemical and SEM (scanning electron microscopy) assays were done in commercially pure zirconium cylinders and two surface conditions were compared: pure and zirconium anodised at 30V. The in vivo assays were held in a tibia rat model. The histological features and fluorochrome labelling changes of newly bone formed around implants were evaluated on the non-decalcified sections 63 days after surgery. Electrochemical and SEM assays showed that anodisation treatment would increased the barrier effect over the material and the in vivo assays showed a continuous newly bone formation around the implant with a different amount of osteocytes in their lacunaes depending the region. There was no significant change in bone thickness around both kinds of implants but conversely a significant increase in the mineralization apposition rate was determined for the anodised condition suggesting that anodisation treatment would stimulate and assist to the osseointegration process. We conclude that anodisation treatment at 30 V can stimulate the implant fixation in a rat model and this study would propose the study of zirconium as candidate material for permanent implant.
publishDate 2014
dc.date.none.fl_str_mv 2014-06-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/5015
Katunar, Maria Rosa; Gomez Sanchez, Andrea Valeria; Ballarre, Josefina; Baca, Matías; Vottola, Carlos; et al.; Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model; Springer; Progress in Biomaterials; 3; 24; 11-6-2014; 1-10
2194-0517
url http://hdl.handle.net/11336/5015
identifier_str_mv Katunar, Maria Rosa; Gomez Sanchez, Andrea Valeria; Ballarre, Josefina; Baca, Matías; Vottola, Carlos; et al.; Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model; Springer; Progress in Biomaterials; 3; 24; 11-6-2014; 1-10
2194-0517
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2194-0517
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1007/s40204-014-0024-9
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs40204-014-0024-9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
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application/vnd.openxmlformats-officedocument.wordprocessingml.document
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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